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Tania D Gendron, PhD

  • 5398 Citations
  • 38 Scopus h-Index
20002019
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  • 21 Similar Profiles
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Dipeptides Medicine & Life Sciences
Frontotemporal Lobar Degeneration Medicine & Life Sciences
Frontotemporal Dementia Medicine & Life Sciences
RNA Medicine & Life Sciences
DNA-Binding Proteins Medicine & Life Sciences
Proteins Medicine & Life Sciences
Tauopathies Medicine & Life Sciences

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Projects 2011 2016

c9RAN proteins as a biomarker for C9ORF72-associated ALS and FTD

Gendron, T. D. & Boylan, K. B.

National Institutes of Health

9/15/14 → 8/31/16

Project: Research project

Biomarkers
Amyotrophic Lateral Sclerosis
Proteins
Frontotemporal Dementia With Motor Neuron Disease
Immunoassay

Pathologically modified TDP-43 in neurodegenerative diseases

Gendron, T. D.

National Institutes of Health

6/1/11 → 5/31/14

Project: Research project

Amyotrophic Lateral Sclerosis
Neurodegenerative Diseases
Frontotemporal Dementia
Alzheimer Disease
Pathology

Research Output 2000 2019

  • 5398 Citations
  • 38 Scopus h-Index
  • 79 Article
  • 2 Chapter
8 Citations (Scopus)

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

Chew, J., Cook, C., Gendron, T. D., Jansen-West, K., Del Rosso, G., Daughrity, L. M., Castanedes-Casey, M., Kurti, A., Stankowski, J. N., Disney, M. D., Rothstein, J. D., Dickson, D. W., Fryer, J. D., Zhang, Y. & Petrucelli, L., Feb 15 2019, In : Molecular neurodegeneration. 14, 1, 1 p.

Research output: Contribution to journal › Article

TDP-43 Proteinopathies
Dipeptides
RNA
Proteins
Antisense RNA

Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers

Dickson, D. W., Baker, M. C., Jackson, J. L., Dejesus-Hernandez, M., Finch, N. C. A., Tian, S., Heckman, M. G., Pottier, C., Gendron, T. F., Murray, M. E., Ren, Y., Reddy, J. S., Graff-Radford, N. R., Boeve, B. F., Petersen, R. C., Knopman, D. S., Josephs, K. A., Petrucelli, L., Oskarsson, B., Sheppard, J. W. & 3 others, Asmann, Y. W., Rademakers, R. & Van Blitterswijk, M., Oct 8 2019, In : Acta Neuropathologica Communications. 7, 1, 150.

Research output: Contribution to journal › Article

Open Access
Frontotemporal Lobar Degeneration
Motor Neuron Disease
Monomeric GTP-Binding Proteins
Dipeptides
GTP Phosphohydrolase Activators
9 Citations (Scopus)

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

Zhang, Y., Guo, L., Gonzales, P. K., Gendron, T. D., Wu, Y., Jansen-West, K., O’Raw, A. D., Pickles, S. R., Prudencio, M., Carlomagno, Y., Gachechiladze, M. A., Ludwig, C., Tian, R., Chew, J., DeTure, M., Lin, W. L., Tong, J., Daughrity, L. M., Yue, M., Song, Y. & 15 others, Andersen, J. W., Castanedes-Casey, M., Kurti, A., Datta, A., Antognetti, G., McCampbell, A., Rademakers, R. V., Oskarsson, B., Dickson, D. W., Kampmann, M., Ward, M. E., Fryer, J. D., Link, C. D., Shorter, J. & Petrucelli, L., Feb 15 2019, In : Science. 363, 6428, eaav2606.

Research output: Contribution to journal › Article

Double-Stranded RNA
Heterochromatin
Proline
Arginine
Proteins
4 Citations (Scopus)

RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats

Yamada, S. B., Gendron, T. D., Niccoli, T., Genuth, N. R., Grosely, R., Shi, Y., Glaria, I., Kramer, N. J., Nakayama, L., Fang, S., Dinger, T. J. I., Thoeng, A., Rocha, G., Barna, M., Puglisi, J. D., Partridge, L., Ichida, J. K., Isaacs, A. M., Petrucelli, L. & Gitler, A. D., Sep 1 2019, In : Nature Neuroscience. 22, 9, p. 1383-1388 6 p.

Research output: Contribution to journal › Article

Ribosome Subunits
Ribosomal Proteins
Protein Subunits
Neurodegenerative Diseases
Nucleotides
10 Citations (Scopus)

The Hairpin Form of r(G 4 C 2 ) exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules

Wang, Z. F., Ursu, A., Childs-Disney, J. L., Guertler, R., Yang, W. Y., Bernat, V., Rzuczek, S. G., Fuerst, R., Zhang, Y., Gendron, T. D., Yildirim, I., Dwyer, B. G., Rice, J. E., Petrucelli, L. & Disney, M. D., Feb 21 2019, In : Cell Chemical Biology. 26, 2, p. 179-190.e12

Research output: Contribution to journal › Article

Frontotemporal Dementia
RNA-Binding Proteins
Toxicity
RNA
G-Quadruplexes