• 33842 Citations
  • 92 Scopus h-Index
1976 …2020
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1976 2019

2019
2 Citations (Scopus)

53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer

Hurley, R. M., Wahner Hendrickson, A. E., Visscher, D. W., Ansell, P., Harrell, M. I., Wagner, J. M., Negron, V., Goergen, K. M., Maurer, M. J., Oberg, A. L., Meng, X. W., Flatten, K. S., De Jonge, M. J. A., Van Herpen, C. D., Gietema, J. A., Koornstra, R. H. T., Jager, A., den Hollander, M. W., Dudley, M., Shepherd, S. P. & 2 others, Swisher, E. M. & Kaufmann, S. H., Jan 1 2019, (Accepted/In press) In : Gynecologic Oncology.

Research output: Contribution to journalArticle

Homologous Recombination
Ovarian Neoplasms
DNA End-Joining Repair
Neoplasms
Gene Deletion
14 Citations (Scopus)

BRCA Reversion Mutations in Circulating Tumor DNA Predict Primary and Acquired Resistance to the PARP Inhibitor Rucaparib in High-Grade Ovarian Carcinoma

Lin, K. K., Harrell, M. I., Oza, A. M., Oaknin, A., Ray-Coquard, I., Tinker, A. V., Helman, E., Radke, M. R., Say, C., Vo, L. T., Mann, E., Isaacson, J. D., Maloney, L., O'Malley, D. M., Chambers, S. K., Kaufmann, S. H., Scott, C. L., Konecny, G. E., Coleman, R. L., Sun, J. X. & 5 others, Giordano, H., Brenton, J. D., Harding, T. C., McNeish, I. A. & Swisher, E. M., Feb 1 2019, In : Cancer discovery. 9, 2, p. 210-219 10 p.

Research output: Contribution to journalArticle

Open Access
Platinum
Carcinoma
Mutation
DNA
Neoplasms

Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo

Vincelette, N. D., Ding, H., Huehls, A. M., Flatten, K. S., Kelly, R. L., Kohorst, M. A., Webster, J., Hess, A. D., Pratz, K. W., Karnitz, L. M. & Kaufmann, S. H., Dec 1 2019, In : Scientific reports. 9, 1, 3617.

Research output: Contribution to journalArticle

Open Access
Acute Myeloid Leukemia
Cytarabine
Daunorubicin
G2 Phase Cell Cycle Checkpoints
In Vitro Techniques

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women

Grant, D. J., Manichaikul, A., Alberg, A. J., Bandera, E. V., Barnholtz-Sloan, J., Bondy, M., Cote, M. L., Funkhouser, E., Moorman, P. G., Peres, L. C., Peters, E. S., Schwartz, A. G., Terry, P. D., Wang, X. Q., Keku, T. O., Hoyo, C., Berchuck, A., Sandler, D. P., Taylor, J. A., O’Brien, K. M. & 70 others, Velez Edwards, D. R., Edwards, T. L., Beeghly-Fadiel, A., Wentzensen, N., Pearce, C. L., Wu, A. H., Whittemore, A. S., McGuire, V., Sieh, W., Rothstein, J. H., Modugno, F., Ness, R., Moysich, K., Rossing, M. A., Doherty, J. A., Sellers, T. A., Permuth-Way, J. B., Monteiro, A. N., Levine, D. A., Setiawan, V. W., Haiman, C. A., LeMarchand, L., Wilkens, L. R., Karlan, B. Y., Menon, U., Ramus, S., Gayther, S., Gentry-Maharaj, A., Terry, K. L., Cramer, D. W., Goode, E. L., Larson, M. C., Kaufmann, S. H., Cannioto, R., Odunsi, K., Etter, J. L., Huang, R. Y., Bernardini, M. Q., Tone, A. A., May, T., Goodman, M. T., Thompson, P. J., Carney, M. E., Tworoger, S. S., Poole, E. M., Lambrechts, D., Vergote, I., Vanderstichele, A., Van Nieuwenhuysen, E., Anton-Culver, H., Ziogas, A., Brenton, J. D., Bjorge, L., Salvensen, H. B., Kiemeney, L. A., Massuger, L. F. A. G., Pejovic, T., Bruegl, A., Moffitt, M., Cook, L., Le, N. D., Brooks-Wilson, A., Kelemen, L. E., Pharoah, P. D. P., Song, H., Campbell, I., Eccles, D., DeFazio, A., Kennedy, C. J. & Schildkraut, J. M., May 1 2019, In : Cancer medicine. 8, 5, p. 2503-2513 11 p.

Research output: Contribution to journalArticle

Open Access
Vitamin D
African Americans
Single Nucleotide Polymorphism
Odds Ratio
Confidence Intervals

Genes associated with bowel metastases in ovarian cancer

Mariani, A., Wang, C., Oberg, A. L., Riska, S. M., Torres, M., Kumka, J., Multinu, F., Sagar, G., Roy, D., Jung, DB. B., Zhang, Q., Grassi, T., Visscher, D. W., Patel, V. P., Jin, L., Staub, J. K., Cliby, W. A., Weroha, S. J., Kalli, K. R., Hartmann, L. C. & 3 others, Kaufmann, S. H., Goode, E. L. & Shridhar, V., Jan 1 2019, In : Gynecologic oncology.

Research output: Contribution to journalArticle

Open Access
Ovarian Neoplasms
Neoplasm Metastasis
Genes
Neoplasms
Immunohistochemistry
9 Citations (Scopus)

Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial

Konstantinopoulos, P. A., Barry, W. T., Birrer, M., Westin, S. N., Cadoo, K. A., Shapiro, G. I., Mayer, E. L., O'Cearbhaill, R. E., Coleman, R. L., Kochupurakkal, B., Whalen, C., Curtis, J., Farooq, S., Luo, W., Eismann, J., Buss, M. K., Aghajanian, C., Mills, G. B., Palakurthi, S., Kirschmeier, P. & 8 others, Liu, J., Cantley, L. C., Kaufmann, S. H., Swisher, E. M., D'Andrea, A. D., Winer, E., Wulf, G. M. & Matulonis, U. A., Apr 1 2019, In : The Lancet Oncology. 20, 4, p. 570-580 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Breast Neoplasms
Histology
Ovarian Neoplasms
Recombinational DNA Repair

Topoisomerases and cancer chemotherapy: recent advances and unanswered questions

Bjornsti, M. A. & Kaufmann, S. H., Jan 1 2019, In : F1000Research. 8

Research output: Contribution to journalReview article

Open Access
Chemotherapy
Ribonucleotides
Drug Therapy
DNA
Chromosomes
2018
7 Citations (Scopus)

A phase i clinical trial of the Poly(ADP-ribose) polymerase inhibitor veliparib and weekly topotecan in patients with solid tumors

Wahner Hendrickson, A. E., Menefee, M. E., Hartmann, L. C., Long, H. J., Northfelt, D. W., Reid, J. M., Boakye-Agyeman, F., Kayode, O., Flatten, K. S., Harrell, M. I., Swisher, E. M., Poirer, G. G., Satele, D., Allred, J., Lensing, J. L., Chen, A., Ji, J., Zang, Y., Erlichman, C., Haluska, P. & 1 others, Kaufmann, S. H., Feb 15 2018, In : Clinical Cancer Research. 24, 4, p. 744-752 9 p.

Research output: Contribution to journalArticle

Topotecan
Clinical Trials
Neoplasms
Maximum Tolerated Dose
Mutation
tipifarnib
Farnesyltranstransferase
Epidermal Growth Factor
Protein-Tyrosine Kinases
Maximum Tolerated Dose
2 Citations (Scopus)

A randomized trial of three novel regimens for recurrent acute myeloid leukemia demonstrates the continuing challenge of treating this difficult disease

Litzow, M. R., Wang, X. V., Carroll, M. P., Karp, J. E., Ketterling, R. P., Zhang, Y., Kaufmann, S. H., Lazarus, H. M., Luger, S. M., Paietta, E. M., Pratz, K. W., Tun, H. W., Altman, J. K., Broun, E. R., Rybka, W. B., Rowe, J. M. & Tallman, M. S., Jan 1 2018, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

alvocidib
Mitoxantrone
Cytarabine
Acute Myeloid Leukemia
Topotecan
3 Citations (Scopus)

Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma

Kabashima, A., Hirsova, P., Bronk, S. F., Hernandez, M. C., Truty, M., Rizvi, S., Kaufmann, S. H. & Gores, G. J., Jan 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Myeloid Leukemia
Cholangiocarcinoma
Myeloid Cells
Necrosis

Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker γH2AX

McDonald, J. S., McDonald, R., Ekins, J. B., Tin, A. S., Costes, S., Hudson, T. M., Schroeder, D. J., Kallmes, K., Kaufmann, S. H., Young, P. M., Lu, A., Kadirvel, R. D. & Kallmes, D. F., Jan 1 2018, In : PLoS One. 13, 1, e0190890.

Research output: Contribution to journalArticle

gadolinium
Gadolinium
Magnetic resonance
DNA repair
Genetic Markers
6 Citations (Scopus)

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

Ho, M. F., Correia, C., Ingle, J. N., Kaddurah-Daouk, R., Wang, L. M., Kaufmann, S. H. & Weinshilboum, R. M., Jun 1 2018, In : Biochemical Pharmacology. 152, p. 279-292 14 p.

Research output: Contribution to journalArticle

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
AMPA Receptors
Glutamate Receptors
Ketamine
Metabolites
4 Citations (Scopus)

Measurement of BH3-only protein tolerance

Dai, H., Ding, H., Peterson, K. L., Meng, X. W., Schneider, P. A., Knorr, K. L. B. & Kaufmann, S. H., Jan 1 2018, In : Cell Death and Differentiation. 25, 2, p. 282-293 12 p.

Research output: Contribution to journalArticle

Proteins
Proto-Oncogene Proteins c-bcl-2
Antineoplastic Combined Chemotherapy Protocols
Cell Death
Up-Regulation
17 Citations (Scopus)

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Australian Ovarian Cancer Study (AOCS), Dec 1 2018, In : Nature Communications. 9, 1, 3970.

Research output: Contribution to journalArticle

methylation
Methylation
inhibitors
Heterografts
cancer
4 Citations (Scopus)

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

Kurmi, K., Hitosugi, S., Yu, J., Boakye-Agyeman, F., Wiese, E. K., Larson, T. R., Dai, Q., Machida, Y., Lou, Z., Wang, L. M., Boughey, J. C., Kaufmann, S. H., Goetz, M. P., Karnitz, L. M. & Hitosugi, T. D., Dec 4 2018, In : Cell Metabolism. 28, 6, p. 833-847.e8

Research output: Contribution to journalArticle

Mitochondrial Form Creatine Kinase
Phosphocreatine
Tyrosine
Phosphorylation
Breast Neoplasms
2017
19 Citations (Scopus)

A phase 1 study of the PARP inhibitor veliparib in combination with temozolomide in acute myeloid leukemia

Gojo, I., Beumer, J. H., Pratz, K. W., McDevitt, M. A., Baer, M. R., Blackford, A. L., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Levis, M. J., Dezern, A. E., Gladstone, D. E., Ji, J. J., Wang, L., Kinders, R. J., Pouquet, M., Ali-Walbi, I., Rudek, M. A., Poh, W. & 5 others, Herman, J. G., Karnitz, L. M., Kaufmann, S. H., Chen, A. & Karp, J. E., Feb 1 2017, In : Clinical Cancer Research. 23, 3, p. 697-706 10 p.

Research output: Contribution to journalArticle

temozolomide
Acute Myeloid Leukemia
Methylation
Phosphorylation
Polymers
13 Citations (Scopus)

A phase I study of topotecan, carboplatin and the PARP inhibitor veliparib in acute leukemias, aggressive myeloproliferative neoplasms, and chronic myelomonocytic leukemia

Pratz, K. W., Rudek, M. A., Gojo, I., Litzow, M. R., McDevitt, M. A., Ji, J., Karnitz, L. M., Herman, J. G., Kinders, R. J., Smith, B. D., Gore, S. D., Carraway, H. E., Showel, M. M., Gladstone, D. E., Levis, M. J., Tsai, H. L., Rosner, G., Chen, A., Kaufmann, S. H. & Karp, J. E., Feb 15 2017, In : Clinical Cancer Research. 23, 4, p. 899-907 9 p.

Research output: Contribution to journalArticle

Leukemia, Myelomonocytic, Chronic
Topotecan
Carboplatin
Leukemia
Neoplasms
3 Citations (Scopus)

Assessment of drug sensitivity in hematopoietic stem and progenitor cells from acute myelogenous leukemia and myelodysplastic syndrome ex vivo

Knorr, K. L. B., Finn, L. E., Douglas Smith, B., Hess, A. D., Foran, J. M., Karp, J. E. & Kaufmann, S. H., Mar 1 2017, In : Stem cells translational medicine. 6, 3, p. 840-850 11 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Hematopoietic Stem Cells
Acute Myeloid Leukemia
Myeloid Progenitor Cells
Stem Cells
1 Citation (Scopus)

Doubling Down on BRCA-Mutated Cancer

Wahner Hendrickson, A. E., Kaufmann, S. H. & Swisher, E. M., 2017, (Accepted/In press) In : Trends in Cancer.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Neoplasms
Immunotherapy
Breast Neoplasms
Drug Therapy

Getting a GRP on histone deacetylase inhibitor selectivity

Ding, H., Correia, C. & Kaufmann, S. H., 2017, In : Oncotarget. 8, 45, p. 78249-78250 2 p.

Research output: Contribution to journalEditorial

Histone Deacetylase Inhibitors
1 Citation (Scopus)

Histone deacetylase inhibitors reduce differentiating osteoblastmediated protection of acute myeloid leukemia cells from cytarabine

Sterner, R. M., Kremer, K. N., Al-Kali, A., Patnaik, M. M., Gangat, N., Litzow, M. R., Kaufmann, S. H., Westendorf, J. J., van Wijnen, A. J. & Hedin, K. E., Nov 1 2017, In : Oncotarget. 8, 55, p. 94569-94579 11 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Cytarabine
Myeloid Cells
Acute Myeloid Leukemia
Osteoblasts
16 Citations (Scopus)

Maintenance of the HIV reservoir is antagonized by selective BCL2 inhibition

Cummins, N. W., Sainski-Nguyen, A. M., Natesampillai, S., Aboulnasr, F., Kaufmann, S. H. & Badley, A. D., Jun 1 2017, In : Journal of Virology. 91, 11, e00012-17.

Research output: Contribution to journalArticle

Maintenance
HIV
cells
Infection
deterioration
22 Citations (Scopus)

Pooled clustering of high-grade serous ovarian cancer gene expression leads to novel consensus subtypes associated with survival and surgical outcomes

Wang, C., Armasu, S. M., Kalli, K. R., Maurer, M. J., Heinzen, E. P., Keeney, G., Cliby, W. A., Oberg, A. L., Kaufmann, S. H. & Goode, E. L., Aug 1 2017, In : Clinical Cancer Research. 23, 15, p. 4077-4085 9 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Ovarian Neoplasms
Cluster Analysis
Gene Expression
Survival
11 Citations (Scopus)

Randomized phase II trial of cytosine arabinoside with and without the CHK1 inhibitor MK-8776 in relapsed and refractory acute myeloid leukemia

Webster, J. A., Tibes, R., Morris, L., Blackford, A. L., Litzow, M. R., Patnaik, M. M., Rosner, G. L., Gojo, I., Kinders, R., Wang, L., Doyle, L. A., Huntoon, C. J., Karnitz, L. M., Kaufmann, S. H., Karp, J. E. & Smith, B. D., Oct 1 2017, In : Leukemia Research. 61, p. 108-116 9 p.

Research output: Contribution to journalArticle

Cytarabine
Acute Myeloid Leukemia
DNA Damage
Cell Cycle Checkpoints
MK-8776
318 Citations (Scopus)

Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial

Swisher, E. M., Lin, K. K., Oza, A. M., Scott, C. L., Giordano, H., Sun, J., Konecny, G. E., Coleman, R. L., Tinker, A. V., O'Malley, D. M., Kristeleit, R. S., Ma, L., Bell-McGuinn, K. M., Brenton, J. D., Cragun, J. M., Oaknin, A., Ray-Coquard, I., Harrell, M. I., Mann, E., Kaufmann, S. H. & 11 others, Floquet, A., Leary, A., Harding, T. C., Goble, S., Maloney, L., Isaacson, J., Allen, A. R., Rolfe, L., Yelensky, R., Raponi, M. & McNeish, I. A., Jan 1 2017, In : The Lancet Oncology. 18, 1, p. 75-87 13 p.

Research output: Contribution to journalArticle

Loss of Heterozygosity
Platinum
Carcinoma
Homologous Recombination
Disease-Free Survival
68 Citations (Scopus)
Carcinoma
Mutation
Homologous Recombination
Platinum
Biopsy
17 Citations (Scopus)

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis

Maskey, R. S., Flatten, K. S., Sieben, C. J., Peterson, K. L., Baker, D. J., Nam, H. J., Kim, M. S., Smyrk, T. C., Kojima, Y., Machida, Y., Santiago, A., Van Deursen, J., Kaufmann, S. H. & Machida, Y., 2017, In : Nucleic Acids Research. 45, 8, p. 4564-4576 13 p.

Research output: Contribution to journalArticle

Carcinogenesis
DNA
Proteins
Progeria
Genomic Instability
2016
25 Citations (Scopus)

4EBP1/c-MYC/PUMA and NF-kB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells

Yun, S., Vincelette, N. D., Knorr, K. L. B., Almada, L. L., Schneider, P. A., Peterson, K. L., Flatten, K. S., Dai, H., Pratz, K. W., Hess, A. D., Smith, B. D., Karp, J. E., Wahner Hendrickson, A. E., Fernandez-Zapico, M. E. & Kaufmann, S. H., Jun 2 2016, In : Blood. 127, 22, p. 2711-2722 12 p.

Research output: Contribution to journalArticle

NF-kappa B
Sirolimus
Cytotoxicity
Lymphocytes
Growth
41 Citations (Scopus)

A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice

Zhang, H., Liu, H., Chen, Y., Yang, X., Wang, P., Liu, T., Deng, M., Qin, B., Correia, C., Lee, S., Kim, J., Sparks, M., Nair, A. A., Evans, D. L., Kalari, K. R., Zhang, P., Wang, L. M., You, Z., Kaufmann, S. H., Lou, Z. & 1 others, Pei, H., Jan 5 2016, In : Nature Communications. 7, 10201.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
Homologous Recombination
S Phase
strands
Cell Cycle
13 Citations (Scopus)

APOBEC3G expression correlates with T-cell infiltration and improved clinical outcomes in high-grade serous ovarian carcinoma

Leonard, B., Starrett, G. J., Maurer, M. J., Oberg, A. L., Van Bockstal, M., Van Dorpe, J., De Wever, O., Helleman, J., Sieuwerts, A. M., Berns, E. M. J. J., Martens, J. W. M., Anderson, B. D., Brown, W. L., Kalli, K. R., Kaufmann, S. H. & Harris, R. S., Sep 15 2016, In : Clinical Cancer Research. 22, 18, p. 4746-4755 10 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Carcinoma
T-Lymphocytes
Neoplasms
Tumor-Infiltrating Lymphocytes
6 Citations (Scopus)

Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells

Ding, H., Peterson, K. L., Correia, C., Koh, B., Schneider, P. A., Nowakowski, G. S. & Kaufmann, S. H., Dec 16 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

HSP90 Heat-Shock Proteins
Histone Deacetylase Inhibitors
Drug Resistance
Lymphoma
Up-Regulation
15 Citations (Scopus)

Immunodetection of human topoisomerase I-DNA covalent complexes

Patel, A. G., Flatten, K. S., Peterson, K. L., Beito, T. G., Schneider, P. A., Perkins, A. L., Harki, D. A. & Kaufmann, S. H., Feb 24 2016, In : Nucleic Acids Research. 44, 6, p. 2816-2826 11 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Topotecan
NSC 724998
Topoisomerase Inhibitors
human TOP1 protein
17 Citations (Scopus)

In vivo anti-tumor activity of the PARP inhibitor niraparib in homologous recombination deficient and proficient ovarian carcinoma

AlHilli, M. M., Becker, M. A., Weroha, S. J., Flatten, K. S., Hurley, R. M., Harrell, M. I., Oberg, A. L., Maurer, M. J., Hawthorne, K. M., Hou, X., Harrington, S. C., McKinstry, S., Meng, X. W., Wilcoxen, K. M., Kalli, K. R., Swisher, E. M., Kaufmann, S. H. & Haluska, P., Nov 1 2016, In : Gynecologic Oncology. 143, 2, p. 379-388 10 p.

Research output: Contribution to journalArticle

Homologous Recombination
Carcinoma
Heterografts
Neoplasms
Mutation
17 Citations (Scopus)

Mitochondrial apoptosis and BH3 mimetics

Dai, H., Meng, X. W. & Kaufmann, S. H., 2016, In : F1000Research. 5, 2804.

Research output: Contribution to journalReview article

Apoptosis
B-Cell Chronic Lymphocytic Leukemia
Chromosomes
Antineoplastic Agents
Tumors
10 Citations (Scopus)

Poly (ADP-Ribose) polymerase inhibitor hypersensitivity in aggressive myeloproliferative neoplasms

Pratz, K. W., Koh, B. D., Patel, A. G., Flatten, K. S., Poh, W., Herman, J. G., Dilley, R., Harrell, M. I., Smith, B. D., Karp, J. E., Swisher, E. M., McDevitt, M. A. & Kaufmann, S. H., Aug 1 2016, In : Clinical Cancer Research. 22, 15, p. 3894-3902 9 p.

Research output: Contribution to journalArticle

Hypersensitivity
Homologous Recombination
Neoplasms
Ionizing Radiation
Poly(ADP-ribose) Polymerase Inhibitors
32 Citations (Scopus)

Prime, shock, and kill: Priming CD4 T cells from HIV patients with a BCL-2 antagonist before HIV reactivation reduces HIV reservoir size

Cummins, N. W., Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., De Araujo Correia, M. C. M., Sampath, R., Rizza, S., O'Brien, D., Yao, J. D., Kaufmann, S. H. & Badley, A. D., Apr 1 2016, In : Journal of Virology. 90, 8, p. 4032-4048 17 p.

Research output: Contribution to journalArticle

antagonists
Shock
T-lymphocytes
HIV
T-Lymphocytes
38 Citations (Scopus)

Somatic mosaic mutations in PPM1D and TP53 in the blood of women with ovarian carcinoma

Swisher, E. M., Harrell, M. I., Norquist, B. M., Walsh, T., Brady, M., Lee, M., Hershberg, R., Kalli, K. R., Lankes, H., Konnick, E. Q., Pritchard, C. C., Monk, B. J., Chan, J. K., Burger, R., Kaufmann, S. H. & Birrer, M. J., Mar 1 2016, In : JAMA oncology. 2, 3, p. 370-372 3 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Carcinoma
Mutation
Drug Therapy
Blood Cells
2 Citations (Scopus)

Synthesis of a peptide-universal nucleotide antigen: Towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes

Perkins, A. L., Peterson, K. L., Beito, T. G., Flatten, K. S., Kaufmann, S. H. & Harki, D. A., 2016, In : Organic and Biomolecular Chemistry. 14, 17, p. 4103-4109 7 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
nucleotides
antigens
antibodies
peptides
2015
52 Citations (Scopus)

BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma

Correia, C., Schneider, P. A., Dai, H., Dogan, A., Maurer, M. J., Church, A. K., Novak, A. J., Feldman, A. L., Wu, X., Ding, H., Meng, X. W., Cerhan, J. R., Slager, S. L., Macon, W. R., Habermann, T. M., Karp, J. E., Gore, S. D., Kay, N. E., Jelinek, D. F., Witzig, T. E. & 2 others, Nowakowski, G. S. & Kaufmann, S. H., Jan 22 2015, In : Blood. 125, 4, p. 658-667 10 p.

Research output: Contribution to journalArticle

Follicular Lymphoma
Mutation
Lymphoma
Immunoglobulins
Hazards
66 Citations (Scopus)

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

Phillips-Krawczak, C. A., Singla, A., Starokadomskyy, P., Deng, Z., Osborne, D. G., Li, H., Dick, C. J., Gomez, T. S., Koenecke, M., Zhang, J. S., Dai, H., Sifuentes-Dominguez, L. F., Geng, L. N., Kaufmann, S. H., Hein, M. Y., Wallis, M., McGaughran, J., Gecz, J., Van De Sluis, B., Billadeau, D. D. & 1 others, Burstein, E., Jan 1 2015, In : Molecular Biology of the Cell. 26, 1, p. 91-103 13 p.

Research output: Contribution to journalArticle

Copper
Endosomes
Homeostasis
Recycling
Actins
19 Citations (Scopus)

Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells

Dai, H., Ding, H., Meng, X. W., Peterson, K. L., Schneider, P. A., Karp, J. E. & Kaufmann, S. H., Oct 15 2015, In : Genes and Development. 29, 20, p. 2140-2152 13 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Pharmaceutical Preparations
Apoptosis Regulatory Proteins
Aptitude
Acute Myeloid Leukemia
1 Citation (Scopus)

Efficient method to optimize antibodies using avian leukosis virus display and eukaryotic cells

Yu, C., Pike, G. M., Rinkoski, T. A., Correia, C., Kaufmann, S. H., Federspiel, M. J. & Weiss, R. A., Aug 11 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 32, p. 9860-9865 6 p.

Research output: Contribution to journalArticle

Avian Leukosis Virus
Eukaryotic Cells
Antibody Affinity
Antibodies
Bacteriophages
79 Citations (Scopus)

Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment

Correia, C., Lee, S. H., Meng, X. W., Vincelette, N. D., Knorr, K. L. B., Ding, H., Nowakowski, G. S., Dai, H. & Kaufmann, S. H., Jul 1 2015, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 7, p. 1658-1671 14 p.

Research output: Contribution to journalArticle

Puma
Noxae
Apoptosis Regulatory Proteins
Follicular Lymphoma
Mitochondrial Membranes
11 Citations (Scopus)

Histone deacetylase inhibitors target the leukemic microenvironment by enhancing a Nherf1-protein phosphatase 1α-TAZ signaling pathway in osteoblasts

Kremer, K. N., Dudakovic, A., Hess, A. D., Smith, B. D., Karp, J. E., Kaufmann, S. H., Westendorf, J. J., van Wijnen, A. J. & Hedin, K. E., Dec 4 2015, In : Journal of Biological Chemistry. 290, 49, p. 29478-29492 15 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Histone Deacetylase Inhibitors
Osteoblasts
Acute Myeloid Leukemia
Myeloid Cells
29 Citations (Scopus)

MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors

Knorr, K. L. B., Schneider, P. A., Meng, X. W., Dai, H., Smith, B. D., Hess, A. D., Karp, J. E. & Kaufmann, S. H., Dec 1 2015, In : Cell Death and Differentiation. 22, 12, p. 2133-2142 10 p.

Research output: Contribution to journalArticle

Noxae
Acute Myeloid Leukemia
Up-Regulation
Cullin Proteins
Ligases
179 Citations (Scopus)

Poly (ADP-Ribose) polymerase inhibitors: Recent advances and future development

Scott, C. L., Swisher, E. M. & Kaufmann, S. H., Apr 20 2015, In : Journal of Clinical Oncology. 33, 12, p. 1397-1406 10 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Platinum
Ovarian Neoplasms
Mutation
Poly(ADP-ribose) Polymerase Inhibitors
21 Citations (Scopus)

TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer

Chien, J., Sicotte, H., Fan, J. B., Humphray, S., Cunningham, J. M., Kalli, K. R., Oberg, A. L., Hart, S., Li, Y., Davila, J. I., Baheti, S., Wang, C., Dietmann, S., Atkinson, E. J., Asmann, Y., Bell, D. A., Ota, T., Tarabishy, Y., Kuang, R., Bibikova, M. & 10 others, Cheetham, R. K., Grocock, R. J., Swisher, E. M., Peden, J., Bentley, D., Kocher, J-P., Kaufmann, S. H., Hartmann, L. C., Shridhar, V. & Goode, E. L., Feb 2 2015, In : Nucleic Acids Research. 43, 14, p. 6945-6958 14 p.

Research output: Contribution to journalArticle

Recombinational DNA Repair
Tetraploidy
Ovarian Neoplasms
Loss of Heterozygosity
Homologous Recombination
2014
16 Citations (Scopus)

Auxin-induced rapid degradation of inhibitor of caspase-activated DNase (ICAD) induces apoptotic DNA fragmentation, caspase activation, and cell death: A cell suicide module

Samejima, K., Ogawa, H., Ageichik, A. V., Peterson, K. L., Kaufmann, S. H., Kanemaki, M. T. & Earnshaw, W. C., Nov 7 2014, In : Journal of Biological Chemistry. 289, 45, p. 31617-31623 7 p.

Research output: Contribution to journalArticle

Indoleacetic Acids
DNA Fragmentation
Cell death
Caspases
Suicide
3 Citations (Scopus)

Bim regulation miRrors microRNA 17∼92 cluster expression in endothelial cells in vivo

Meng, X. W. & Kaufmann, S. H., Nov 1 2014, In : Cell Death and Differentiation. 21, 11, p. 1665-1666 2 p.

Research output: Contribution to journalEditorial

Proto-Oncogene Proteins
Forkhead Transcription Factors
Apoptosis Regulatory Proteins
MicroRNAs
Membrane Proteins