Raymond Hickey, PhD

  • 712 Citations
  • 11 Scopus h-Index
20092019

Research output per year

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Research Output

  • 712 Citations
  • 11 Scopus h-Index
  • 21 Article
  • 1 Review article
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Article
2019

Autologous Gene and Cell Therapy Provides Safe and Long-Term Curative Therapy in A Large Pig Model of Hereditary Tyrosinemia Type 1

Hickey, R., Nicolas, C. T., Allen, K., Mao, S., Elgilani, F., Glorioso, J., Amiot, B., VanLith, C., Guthman, R., Du, Z., Chen, H., Harding, C. O., Kaiser, R. A., Nyberg, S. & Lillegard, J. B., Jan 1 2019, In : Cell Transplantation. 28, 1, p. 79-88 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Hepatotoxicity and Toxicology of In Vivo Lentiviral Vector Administration in Healthy and Liver-Injury Mouse Models

Kaiser, R. A., Nicolas, C. T., Allen, K. L., Chilton, J. A., Du, Z., Hickey, R. D. & Lillegard, J. B., Jun 2019, In : Human Gene Therapy Clinical Development. 30, 2, p. 57-66 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Curative Ex Vivo Hepatocyte-Directed Gene Editing in a Mouse Model of Hereditary Tyrosinemia Type 1

Vanlith, C., Guthman, R., Nicolas, C. T., Allen, K., Du, Z., Joo, D. J., Nyberg, S., Lillegard, J. B. & Hickey, R., Nov 1 2018, In : Human Gene Therapy. 29, 11, p. 1315-1326 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ectopic expansion of engineered human liver tissue seeds using mature cell populations

Hickey, R. & Naugler, W. E., Jun 1 2018, In : Hepatology. 67, 6, p. 2465-2467 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hepatocyte spheroids as an alternative to single cells for transplantation after ex vivo gene therapy in mice and pig models

Nicolas, C. T., Hickey, R., Allen, K. L., Du, Z., Guthman, R. M., Kaiser, R. A., Amiot, B., Bansal, A., Pandey, M., Suksanpaisan, L., DeGrado, T. R., Nyberg, S. & Lillegard, J. B., Jan 1 2018, (Accepted/In press) In : Surgery (United States).

Research output: Contribution to journalArticle

4 Scopus citations

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

Kaiser, R. A., Mao, S. A., Glorioso, J., Amiot, B., Nicolas, C. T., Allen, K. L., Du, Z., VanLith, C. J., Hickey, R., Nyberg, S. & Lillegard, J. B., Nov 4 2018, In : Journal of visualized experiments : JoVE. 141

Research output: Contribution to journalArticle

2 Scopus citations
2017

Chronic Phenotype Characterization of a Large-Animal Model of Hereditary Tyrosinemia Type 1

Elgilani, F., Mao, S. A., Glorioso, J. M., Yin, M., Iankov, I. D., Singh, A., Amiot, B., Rinaldo, P., Marler, R. J., Ehman, R. L., Grompe, M., Lillegard, J. B., Hickey, R. & Nyberg, S., Jan 1 2017, In : American Journal of Pathology. 187, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Effect of amine content and chemistry on long-term, three-dimensional hepatocyte spheroid culture atop aminated elastin-like polypeptide coatings

Weeks, C. A., Aden, B., Zhang, J., Singh, A., Hickey, R. D., Kilbey, S. M., Nyberg, S. L. & Janorkar, A. V., Feb 1 2017, In : Journal of Biomedical Materials Research - Part A. 105, 2, p. 377-388 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1

Hickey, R., Mao, S. A., Glorioso, J., Elgilani, F., Amiot, B., Chen, H., Rinaldo, P., Marler, R. J., Jiang, H., DeGrado, T. R., Suksanpaisan, L., O'Connor, M. K., Freeman, B. L., Ibrahim, S. C., Peng, K-W., Harding, C. O., Ho, C. S., Grompe, M., Ikeda, Y. H., Lillegard, J. B. & 2 others, Russell, S. J. & Nyberg, S., Jul 27 2016, In : Science Translational Medicine. 8, 349, 349ra99.

Research output: Contribution to journalArticle

25 Scopus citations

Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma

Blackburn, P. R., Hickey, R. D., Nace, R. A., Giama, N. H., Kraft, D. L., Bordner, A. J., Chaiteerakij, R., McCormick, J. B., Radulovic, M., Graham, R. P., Torbenson, M. S., Tortorelli, S., Scott, C. R., Lindor, N. M., Milliner, D. S., Oglesbee, D., Al-Qabandi, W., Grompe, M., Gavrilov, D. K., El-Youssef, M. & 5 others, Clark, K. J., Atwal, P. S., Roberts, L. R., Klee, E. W. & Ekker, S. C., Oct 1 2016, In : Human mutation. 37, 10, p. 1097-1105 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses

Schreiber, C. A., Sakuma, T., Izumiya, Y., Holditch, S. J., Hickey, R. D., Bressin, R. K., Basu, U., Koide, K., Asokan, A. & Ikeda, Y., Aug 1 2015, In : PLoS pathogens. 11, 8, e1005082.

Research output: Contribution to journalArticle

19 Scopus citations

Noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using the sodium iodide symporter gene

Hickey, R., Mao, S. A., Amiot, B., Suksanpaisan, L., Miller, A., Nace, R., Glorioso, J., O'Connor, M. K., Peng, K-W., Ikeda, Y. H., Russell, S. J. & Nyberg, S., Apr 1 2015, In : Liver Transplantation. 21, 4, p. 442-453 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pivotal preclinical trial of the spheroid reservoir bioartificial liver

Glorioso, J. M., Mao, S. A., Rodysill, B., Mounajjed, T., Kremers, W. K., Elgilani, F., Hickey, R., Haugaa, H., Rose, C. F., Amiot, B. & Nyberg, S., 2015, In : Journal of Hepatology. 63, 2, p. 388-398 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Reply to: "pivotal preclinical trial of the spheroid reservoir bioartificial liver"

Glorioso, J. M., Mao, S. A., Rodysill, B., Mounajjed, T., Kremers, W. K., Elgilani, F., Hickey, R., Haugaa, H., Rose, C. F., Amiot, B. & Nyberg, S., Oct 1 2015, In : Journal of Hepatology. 63, 4, p. 1052-1053 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease

Hickey, R. D., Mao, S. A., Glorioso, J., Lillegard, J. B., Fisher, J. E., Amiot, B., Rinaldo, P., Harding, C. O., Marler, R., Finegold, M. J., Grompe, M. & Nyberg, S. L., Jul 2014, In : Stem Cell Research. 13, 1, p. 144-153 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2013

Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming

Hickey, R. D., Galivo, F., Schug, J., Brehm, M. A., Haft, A., Wang, Y., Benedetti, E., Gu, G., Magnuson, M. A., Shultz, L. D., Lagasse, E., Greiner, D. L., Kaestner, K. H. & Grompe, M., Jul 1 2013, In : Stem Cell Research. 11, 1, p. 503-515 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Suspension culture of hepatocyte-derived reporter cells in presence of albumin to form stable three-dimensional spheroids

Weeks, C. A., Newman, K., Turner, P. A., Rodysill, B., Hickey, R. D., Nyberg, S. L. & Janorkar, A. V., Sep 1 2013, In : Biotechnology and Bioengineering. 110, 9, p. 2548-2555 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2011

Efficient production of Fah-null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer

Hickey, R. D., Lillegard, J. B., Fisher, J. E., McKenzie, T. J., Hofherr, S. E., Finegold, M. J., Nyberg, S. L. & Grompe, M., Oct 1 2011, In : Hepatology. 54, 4, p. 1351-1359 9 p.

Research output: Contribution to journalArticle

51 Scopus citations
2010

Glycosylation of PrPC determines timing of neuroinvasion and targeting in the brain following transmissible spongiform encephalopathy infection by a peripheral route

Cancellotti, E., Bradford, B. M., Tuzi, N. L., Hickey, R. D., Brown, D., Brown, K. L., Barron, R. M., Kisielewski, D., Piccardo, P. & Manson, J. C., Apr 2010, In : Journal of virology. 84, 7, p. 3464-3475 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

The ploidy conveyor of mature hepatocytes as a source of genetic variation

Duncan, A. W., Taylor, M. H., Hickey, R. D., Hanlon Newell, A. E., Lenzi, M. L., Olson, S. B., Finegold, M. J. & Grompe, M., Oct 7 2010, In : Nature. 467, 7316, p. 707-710 4 p.

Research output: Contribution to journalArticle

289 Scopus citations
2009

Ploidy reductions in murine fusion-derived hepatocytes

Duncan, A. W., Hickey, R. D., Paulk, N. K., Culberson, A. J., Olson, S. B., Finegold, M. J. & Grompe, M., Feb 2009, In : PLoS genetics. 5, 2, e1000385.

Research output: Contribution to journalArticle

70 Scopus citations