• 20994 Citations
  • 82 Scopus h-Index
1985 …2020

Research output per year

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Research Output

2020

Cl- and H+ coupling properties and subcellular localizations of wildtype and disease-associated variants of the voltagegated Cl-/H+ exchanger ClC-5

Chang, M. D., Brown, M. R., Liu, Y., Gainullin, V. G., Harris, P. C., Romero, M. F. & Lieske, J. C., Jan 1 2020, In : Journal of Biological Chemistry. 295, 6, p. 1464-1473 10 p.

Research output: Contribution to journalArticle

Open Access

Epidemiology of autosomal dominant polycystic kidney disease in Olmsted county

Suwabe, T., Shukoor, S., Chamberlain, A. M., Killian, J. M., King, B. F., Edwards, M., Senum, S. R., Madsen, C. D., Chebib, F. T., Hogan, M. C., Le Gall, E. C., Harris, P. C. & Torres, V. E., Jan 2020, In : Clinical Journal of the American Society of Nephrology. 15, 1, p. 69-79 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Expanded Imaging Classification of Autosomal Dominant Polycystic Kidney Disease

HALT PKD Consortium, Jul 1 2020, In : Journal of the American Society of Nephrology : JASN. 31, 7, p. 1640-1651 12 p.

Research output: Contribution to journalArticle

Metalloproteinase PAPP - A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis

Kashyap, S., Hein, K. Z., Chini, C. C. S., Lika, J., Warner, G. M., Bale, L. K., Torres, V. E., Harris, P. C., Oxvig, C., Conover, C. A. & Chini, E. N., Feb 27 2020, In : JCI Insight. 5, 4, e135700.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
1 Scopus citations

Prevalence of low molecular weight proteinuria and Dent disease 1 CLCN5 mutations in proteinuric cohorts

On behalf of the investigators of the Rare Kidney Stone Consortium, Apr 1 2020, In : Pediatric Nephrology. 35, 4, p. 633-640 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pyridoxine Responsiveness in a Type 1 Primary Hyperoxaluria Patient With a Rare (Atypical) AGXT Gene Mutation

Singh, P., Chebib, F. T., Cogal, A. G., Gavrilov, D. K., Harris, P. C. & Lieske, J. C., Jun 2020, In : Kidney International Reports. 5, 6, p. 955-958 4 p.

Research output: Contribution to journalArticle

Open Access

Regulation of polycystin expression, maturation and trafficking

Hu, J. & Harris, P. C., Aug 2020, In : Cellular Signalling. 72, 109630.

Research output: Contribution to journalArticle

2019
Open Access

Detection and characterization of mosaicism in autosomal dominant polycystic kidney disease

HALT Progression of Polycystic Kidney Disease Group, the ADPKD Modifier Study, Jan 1 2019, (Accepted/In press) In : Kidney international.

Research output: Contribution to journalArticle

3 Scopus citations

Growth pattern of kidney cyst number and volume in autosomal dominant polycystic kidney disease

Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP), Jun 7 2019, In : Clinical Journal of the American Society of Nephrology. 14, 6, p. 823-833 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

International consensus statement on the diagnosis and management of autosomal dominant polycystic kidney disease in children and young people

Gimpel, C., Bergmann, C., Bockenhauer, D., Breysem, L., Cadnapaphornchai, M. A., Cetiner, M., Dudley, J., Emma, F., Konrad, M., Harris, T., Harris, P. C., König, J., Liebau, M. C., Marlais, M., Mekahli, D., Metcalfe, A. M., Oh, J., Perrone, R. D., Sinha, M. D., Titieni, A. & 4 others, Torra, R., Weber, S., Winyard, P. J. D. & Schaefer, F., Nov 1 2019, In : Nature Reviews Nephrology. 15, 11, p. 713-726 14 p.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations

Long-term trajectory of kidney function in autosomal-dominant polycystic kidney disease

Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP), May 2019, In : Kidney international. 95, 5, p. 1253-1261 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Multiple unilateral subcapsular cortical hemorrhagic cystic disease of the kidney: CT and MRI findings and clinical characteristic

Yoshida, K., Takahashi, N., King, B. F., Kawashima, A., Harris, P. C., Cornell, L. D., Cornec-Le Gall, E., Inoue, D., Mizushima, I., Kawano, M., Thervet, E., de Cotret, P. R. & Torres, V. E., Sep 1 2019, In : European radiology. 29, 9, p. 4843-4850 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pancreatic Cysts and Intraductal Papillary Mucinous Neoplasm in Autosomal Dominant Polycystic Kidney Disease

McNicholas, B. A., Kotaro, Y., Martin, W., Sharma, A., Kamath, P. S., Edwards, M. E., Kremers, W. K., Chari, S. T., Torres, V. E., Harris, P. C., Takahashi, N. & Hogan, M. C., May 1 2019, In : Pancreas. 48, 5, p. 698-705 8 p.

Research output: Contribution to journalArticle

PKD1 Duplicated regions limit clinical Utility of Whole Exome Sequencing for Genetic Diagnosis of Autosomal Dominant Polycystic Kidney Disease

Ali, H., Al-Mulla, F., Hussain, N., Naim, M., Asbeutah, A. M., AlSahow, A., Abu-Farha, M., Abubaker, J., Al Madhoun, A., Ahmad, S. & Harris, P. C., Dec 1 2019, In : Scientific reports. 9, 1, 4141.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
Open Access
3 Scopus citations

Progress in the understanding of polycystic kidney disease

Torres, V. & Harris, P. C., Jan 1 2019, (Accepted/In press) In : Nature Reviews Nephrology.

Research output: Contribution to journalArticle

2 Scopus citations

Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease

Jafree, D. J., Moulding, D., Kolatsi-Joannou, M., Tejedor, N. P., Price, K. L., Milmoe, N., Walsh, C., Correra, R. M., Winyard, P. J. D., Harris, P. C., Ruhrberg, C., Walker-Samuel, S., Riley, P. R., Woolf, A. S., Scambler, P. J. & Long, D. A., Dec 2019, In : eLife. 8, e48183.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Synergistic genetic interactions between pkhd1 and pkd1 result in an arpkd-like phenotype in murine models

Olson, R. J., Hopp, K., Wells, H., Smith, J. M., Furtado, J., Constans, M. M., Escobar, D. L., Geurts, A. M., Torres, V. E. & Harris, P. C., Jan 1 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2113-2127 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

The role of DNA damage as a therapeutic target in autosomal dominant polycystic kidney disease

Zhang, J. Q. J., Saravanabavan, S., Munt, A., Wong, A. T. Y., Harris, D. C., Harris, P. C., Wang, Y. & Rangan, G. K., Nov 26 2019, In : Expert reviews in molecular medicine. 21, p. e6

Research output: Contribution to journalReview article

1 Scopus citations
2018

A potentially crucial role of the PKD1 C-terminal tail in renal prognosis

Higashihara, E., Horie, S., Kinoshita, M., Harris, P. C., Okegawa, T., Tanbo, M., Hara, H., Yamaguchi, T., Shigemori, K., Kawano, H., Miyazaki, I., Kaname, S. & Nutahara, K., Jan 1 2018, In : Clinical and Experimental Nephrology. 22, 2, p. 395-404 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

A practical guide for treatment of rapidly progressive ADPKD with tolvaptan

Chebib, F. T., Perrone, R. D., Chapman, A. B., Dahl, N. K., Harris, P. C., Mrug, M., Mustafa, R. A., Rastogi, A., Watnick, T., Yu, A. S. L. & Torres, V. E., Oct 2018, In : Journal of the American Society of Nephrology. 29, 10, p. 2458-2470 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease

Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP), Mar 2018, In : Kidney international. 93, 3, p. 691-699 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Can we further enrich autosomal dominant polycystic kidney disease clinical trials for rapidly progressive patients? Application of the PROPKD score in the TEMPO trial

Cornec-Le Gall, E., Blais, J. D., Irazabal, M. V., Devuyst, O., Gansevoort, R. T., Perrone, R. D., Chapman, A. B., Czerwiec, F. S., Ouyang, J., Heyer, C. M., Senum, S. R., Le Meur, Y., Torres, V. E. & Harris, P. C., Apr 1 2018, In : Nephrology Dialysis Transplantation. 33, 4, p. 645-652 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

CD8+ T cells modulate autosomal dominant polycystic kidney disease progression

Kleczko, E. K., Marsh, K. H., Tyler, L. C., Furgeson, S. B., Bullock, B. L., Altmann, C. J., Miyazaki, M., Gitomer, B. Y., Harris, P. C., Weiser-Evans, M. C. M., Chonchol, M. B., Clambey, E. T., Nemenoff, R. A. & Hopp, K., Dec 1 2018, In : Kidney International. 94, 6, p. 1127-1140 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Characterization of three ciliopathy pedigrees expands the phenotype associated with biallelic C2CD3 variants

Boczek, N. J., Hopp, K., Benoit, L., Kraft, D., Cousin, M. A., Blackburn, P. R., Madsen, C. D., Oliver, G. R., Nair, A. A., Na, J., Bianchi, D. W., Beek, G., Harris, P. C., Pichurin, P. & Klee, E. W., Jan 1 2018, (Accepted/In press) In : European Journal of Human Genetics.

Research output: Contribution to journalArticle

5 Scopus citations

Classical polycystic kidney disease: Gene structures and mutations and protein structures and functions

Gall, E. C. L. & Harris, P. C., Jan 1 2018, Polycystic Kidney Disease: Translating Mechanisms into Therapy. Taylor and Francis, p. 3-26 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Genetic complexity of autosomal dominant polycystic kidney and liver diseases

Cornec-Le Gall, E., Torres, V. & Harris, P. C., Jan 1 2018, In : Journal of the American Society of Nephrology. 29, 1, p. 13-23 11 p.

Research output: Contribution to journalReview article

49 Scopus citations

Long-term administration of tolvaptan in autosomal dominant polycystic kidney disease

Edwards, M. E., Chebib, F., Irazabal Mira, M., Ofstie, T. G., Bungum, L. A., Metzger, A. J., Senum, S. R., Hogan, M. C., El-Zoghby, Z. M., Kline, T., Harris, P. C., Czerwiec, F. S. & Torres, V., Aug 7 2018, In : Clinical Journal of the American Society of Nephrology. 13, 8, p. 1153-1161 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

MicroRNA501-5p induces p53 proteasome degradation through the activation of the mTOR/MDM2 pathway in ADPKD cells

de Stephanis, L., Mangolini, A., Servello, M., Harris, P. C., Dell'Atti, L., Pinton, P. & Aguiari, G., Sep 1 2018, In : Journal of Cellular Physiology. 233, 9, p. 6911-6924 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Monoallelic Mutations to DNAJB11 Cause Atypical Autosomal-Dominant Polycystic Kidney Disease

Genkyst Study Group, the HALT Progression of Polycystic Kidney Disease Group & the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease, May 3 2018, In : American journal of human genetics. 102, 5, p. 832-844 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease

Nowak, K. L., You, Z., Gitomer, B., Brosnahan, G., Torres, V. E., Chapman, A. B., Perrone, R. D., Steinman, T. I., Abebe, K. Z., Rahbari-Oskoui, F. F., Yu, A. S. L., Harris, P. C., Bae, K. T., Hogan, M., Miskulin, D. & Chonchol, M., Feb 2018, In : Journal of the American Society of Nephrology. 29, 2, p. 571-578 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Patterns of Kidney Function Decline in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis From the HALT-PKD Trials

HALT-PKD Trial Investigators, May 2018, In : American Journal of Kidney Diseases. 71, 5, p. 666-676 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Polycystic kidney disease

Bergmann, C., Guay-Woodford, L. M., Harris, P. C., Horie, S., Peters, D. J. M. & Torres, V. E., Dec 1 2018, In : Nature Reviews Disease Primers. 4, 1, 50.

Research output: Contribution to journalReview article

30 Scopus citations

Population data improves variant interpretation in autosomal dominant polycystic kidney disease

Mallawaarachchi, A. C., Furlong, T. J., Shine, J., Harris, P. C. & Cowley, M. J., Jan 1 2018, (Accepted/In press) In : Genetics in Medicine.

Research output: Contribution to journalArticle

1 Scopus citations

Precision gene editing technology and applications in nephrology

WareJoncas, Z., Campbell, J. M., Martínez-Gálvez, G., Gendron, W. A. C., Barry, M. A., Harris, P. C., Sussman, C. R. & Ekker, S. C., Jan 1 2018, (Accepted/In press) In : Nature Reviews Nephrology.

Research output: Contribution to journalArticle

13 Scopus citations

Prevalence estimates of polycystic kidney and liver disease by population sequencing

Lanktree, M. B., Haghighi, A., Guiard, E., Iliuta, I. A., Song, X., Harris, P. C., Paterson, A. D. & Pei, Y., Oct 1 2018, In : Journal of the American Society of Nephrology. 29, 10, p. 2593-2600 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Recent advances in the identification and management of inherited hyperoxalurias

Sas, D., Harris, P. C. & Milliner, D. S., Jan 1 2018, (Accepted/In press) In : Urolithiasis.

Research output: Contribution to journalArticle

8 Scopus citations

Relationship between caffeine intake and autosomal dominant polycystic kidney disease progression: A retrospective analysis using the CRISP cohort

McKenzie, K. A., El Ters, M., Torres, V. E., Harris, P. C., Chapman, A. B., Mrug, M., Rahbari-Oskoui, F. F., Bae, K. T., Landsittel, D. P., Bennett, W. M., Yu, A. S. L. & Mahnken, J. D., Dec 27 2018, In : BMC Nephrology. 19, 1, 378.

Research output: Contribution to journalArticle

1 Scopus citations

The time for next-generation molecular genetic diagnostics in nephrology is now!

Harris, P. C., Aug 1 2018, In : Kidney International. 94, 2, p. 237-239 3 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

The underestimated burden of monogenic diseases in adult-onset ESRD

Gall, E. C. L. & Harris, P. C., Jun 1 2018, In : Journal of the American Society of Nephrology. 29, 6, p. 1583-1584 2 p.

Research output: Contribution to journalEditorial

The Value of Genetic Testing in Polycystic Kidney Diseases Illustrated by a Family With PKD2 and COL4A1 Mutations

HALT Progression of Polycystic Kidney Disease Group Investigators, Aug 2018, In : American Journal of Kidney Diseases. 72, 2, p. 302-308 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
2017

ADPKD Progression in Patients With No Apparent Family History and No Mutation Detected by Sanger Sequencing

Braun, W. E., Abebe, K. Z., Brosnahan, G., Patterson, C. G., Chapman, A. B., Harris, P. C., Hogan, M. C., Perrone, R. D., Torres, V., Miskulin, D. C., Steinman, T. I., Winklhofer, F. T., Rahbari-Oskoui, F. F., Czarnecki, P. G., Bae, K. T., Grantham, J. J., Flessner, M. F. & Schrier, R. W., Jan 1 2017, (Accepted/In press) In : American Journal of Kidney Diseases.

Research output: Contribution to journalArticle

5 Scopus citations

Autophagy activators suppress cystogenesis in an autosomal dominant polycystic kidney disease model

Zhu, P., Sieben, C. J., Xu, X., Harris, P. C. & Lin, X., Jan 1 2017, In : Human molecular genetics. 26, 1, p. 158-172 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Autosomal Dominant Polycystic Kidney Patients May Be Predisposed to Various Cardiomyopathies

Chebib, F., Hogan, M. C., El-Zoghby, Z. M., Irazabal Mira, M., Senum, S. R., Heyer, C. M., Madsen, C. D., Cornec-Le Gall, E., Behfar, A., Harris, P. C. & Torres, V., Sep 1 2017, In : Kidney International Reports. 2, 5, p. 913-923 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Common Elements in Rare Kidney Diseases: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Conference Participants & Conference Participants, Oct 2017, In : Kidney international. 92, 4, p. 796-808 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Distinguishing between hepatic inflammation and fibrosis with MR elastography

Yin, M., Glaser, K. J., Manduca, A., Mounajjed, T., Malhi, H., Simonetto, D. A., Wang, R., Yang, L., Mao, S. A., Glorioso, J. M., Elgilani, F. M., Ward, C. J., Harris, P. C., Nyberg, S. L., Shah, V. H. & Ehman, R. L., Sep 1 2017, In : Radiology. 284, 3, p. 694-705 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Effect of statin therapy on the progression of autosomal dominant polycystic kidney disease. A secondary analysis of the HALT PKD trials

the HALT PKD Investigators, 2017, In : Current Hypertension Reviews. 13, 2, p. 109-120 12 p.

Research output: Contribution to journalArticle

14 Scopus citations