Nicholas Larson, MS, PhD

  • 532 Citations
  • 12 Scopus h-Index
20122019
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Research Output 2012 2019

  • 532 Citations
  • 12 Scopus h-Index
  • 46 Article
  • 1 Comment/debate
  • 1 Letter
  • 1 Review article
2019

An expanded variant list and assembly annotation identifies multiple novel coding and noncoding genes for prostate cancer risk using a normal prostate tissue eQTL data set

DeRycke, M. S., Larson, M. C., Nair, A. A., McDonnell, S. K., French, A. J., Tillmans, L. S., Riska, S. M., Baheti, S., Fogarty, Z. C., Larson, N., O'Brien, D. R., Cheville, J., Wang, L., Schaid, D. J. & Thibodeau, S. N., Apr 1 2019, In : PloS one. 14, 4, e0214588.

Research output: Contribution to journalArticle

Open Access
Quantitative Trait Loci
prostatic neoplasms
Prostate
quantitative trait loci
Prostatic Neoplasms

A review of kernel methods for genetic association studies

Larson, N. B., Chen, J. & Schaid, D. J., Jan 1 2019, (Accepted/In press) In : Genetic Epidemiology.

Research output: Contribution to journalArticle

Genetic Association Studies
Pedigree
4 Citations (Scopus)

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L. & 132 others, Richardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W. J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kerrison, N. D., Larson, N., Lin, K. H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H. H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpeläinen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, T. I. A., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y. D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., De Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., Jan 3 2019, In : American Journal of Human Genetics. 104, 1, p. 112-138 27 p.

Research output: Contribution to journalArticle

Mitochondrial Genes
Mitochondria
Mitochondrial DNA
Genes
Waist-Hip Ratio
1 Citation (Scopus)
Zygapophyseal Joint
Fluorodeoxyglucose F18
Arthralgia
Biomarkers
Prospective Studies
Hepatocyte Growth Factor
Coronary Disease
Atherosclerosis
Emotions

Genetic predictors of chemotherapy-related amenorrhea in women with breast cancer

Ruddy, K. J., Schaid, D. J., Partridge, A. H., Larson, N. B., Batzler, A., Häberle, L., Dittrich, R., Widschwendter, P., Fink, V., Bauer, E., Schwitulla, J., Rübner, M., Ekici, A. B., Aivazova-Fuchs, V., Stewart, E. A., Beckmann, M. W., Ginsburg, E., Wang, L., Weinshilboum, R. M., Couch, F. J. & 4 others, Janni, W., Rack, B., Vachon, C. & Fasching, P. A., Jan 1 2019, (Accepted/In press) In : Fertility and Sterility.

Research output: Contribution to journalArticle

Amenorrhea
Breast Neoplasms
Drug Therapy
Menstruation
Phosphopantothenoyl-cysteine decarboxylase

Increased hepatocyte growth factor levels over 2 years are associated with coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)

Decker, P. A., Larson, N., Bell, E. J., Pankow, J. S., Hanson, N. Q., Wassel, C. L., Tsai, M. Y. & Bielinski, S. J., Jul 1 2019, In : American Heart Journal. 213, p. 30-34 5 p.

Research output: Contribution to journalLetter

Hepatocyte Growth Factor
Coronary Disease
Atherosclerosis
Growth and Development
Biomarkers
1 Citation (Scopus)

Molecular signatures of X chromosome inactivation and associations with clinical outcomes in epithelial ovarian cancer

Winham, S. J., Larson, N., Armasu, S. M., Fogarty, Z. C., Larson, M. C., McCauley, B. M., Wang, C., Lawrenson, K., Gayther, S., Cunningham, J. M., Fridley, B. L. & Goode, E. L., Apr 15 2019, In : Human molecular genetics. 28, 8, p. 1331-1342 12 p.

Research output: Contribution to journalArticle

X Chromosome Inactivation
Ovarian Neoplasms
Neoplasms
DNA Methylation
Ovarian epithelial cancer
2 Citations (Scopus)

Pharmacogenomic next-generation DNA sequencing: Lessons from the identification and functional characterization of variants of unknown significance in CYP2C9 and CYP2C19

Devarajan, S., Moon, I., Ho, M. F., Larson, N., Neavin, D. R., Moyer, A., Black, J. L., Bielinski, S. J., Scherer, S. E., Wang, L. M., Weinshilboum, R. M. & Reid, J. M., Apr 1 2019, In : Drug Metabolism and Disposition. 47, 4, p. 425-435 11 p.

Research output: Contribution to journalArticle

Pharmacogenetics
DNA Sequence Analysis
Cytochrome P-450 Enzyme System
Oxidoreductases
Proteins

Robust hierarchical density estimation and regression for re-stained histological whole slide image co-registration

Jiang, J., Larson, N., Prodduturi, N., Flotte, T. J. & Hart, S., Jan 1 2019, In : PloS one. 14, 7, e0220074.

Research output: Contribution to journalArticle

Open Access
Image registration
Coloring Agents
dyes
Pathology
Benchmarking
2018
46 Citations (Scopus)

From genome-wide associations to candidate causal variants by statistical fine-mapping

Schaid, D. J., Chen, W. & Larson, N., Aug 1 2018, In : Nature Reviews Genetics. 19, 8, p. 491-504 14 p.

Research output: Contribution to journalReview article

Genome-Wide Association Study
Linkage Disequilibrium
Genetic Markers
Genome
Data Curation
1 Citation (Scopus)

Hepatocyte growth factor is associated with progression of atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA)

Bell, E. J., Decker, P. A., Tsai, M. Y., Pankow, J. S., Hanson, N. Q., Wassel, C. L., Larson, N., Cohoon, K. P., Budoff, M. J., Polak, J. F., Stein, J. H. & Bielinski, S. J., May 1 2018, In : Atherosclerosis. 272, p. 162-167 6 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Atherosclerosis
Coronary Vessels
Calcium
Confounding Factors (Epidemiology)
1 Citation (Scopus)

Improving Single-Nucleotide Polymorphism-Based Fetal Fraction Estimation of Maternal Plasma Circulating Cell-Free DNA Using Bayesian Hierarchical Models

Larson, N., Wang, C., Na, J., Rowsey, R. A., Highsmith, W. E. J., Hoppman, N. L., Kocher, J-P. & Klee, E. W., Sep 1 2018, In : Journal of Computational Biology. 25, 9, p. 1040-1049 10 p.

Research output: Contribution to journalArticle

Bayesian Hierarchical Model
Single nucleotide Polymorphism
Nucleotides
Plasma Cells
Polymorphism
39 Citations (Scopus)

Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19

Hua, J. T., Ahmed, M., Guo, H., Zhang, Y., Chen, S., Soares, F., Lu, J., Zhou, S., Wang, M., Li, H., Larson, N., McDonnell, S. K., Patel, P. S., Liang, Y., Yao, C. Q., van der Kwast, T., Lupien, M., Feng, F. Y., Zoubeidi, A., Tsao, M. S. & 3 others, Thibodeau, S. N., Boutros, P. C. & He, H. H., Jan 1 2018, (Accepted/In press) In : Cell.

Research output: Contribution to journalArticle

Long Noncoding RNA
Single Nucleotide Polymorphism
Prostatic Neoplasms
YY1 Transcription Factor
Protein Isoforms
9 Citations (Scopus)

Yield of the RYR2 Genetic Test in Suspected Catecholaminergic Polymorphic Ventricular Tachycardia and Implications for Test Interpretation

Kapplinger, J. D., Pundi, K. N., Larson, N., Callis, T. E., Tester, D. J., Bikker, H., Wilde, A. A. M. & Ackerman, M. J., Feb 1 2018, In : Circulation. Genomic and precision medicine. 11, 2, p. e001424

Research output: Contribution to journalArticle

Genetic Testing
Computer Simulation
Exome
Phenotype
Polymorphic catecholergic ventricular tachycardia
2017
1 Citation (Scopus)

ABO blood group is associated with peripheral arterial disease in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA)

Pike, M. M., Larson, N., Wassel, C. L., Cohoon, K. P., Tsai, M. Y., Pankow, J. S., Hanson, N. Q., Decker, P. A., Berardi, C., Alexander, K. S., Cushman, M., Zakai, N. A. & Bielinski, S. J., May 1 2017, In : Thrombosis Research. 153, p. 1-6 6 p.

Research output: Contribution to journalArticle

Peripheral Arterial Disease
Blood Group Antigens
African Americans
Atherosclerosis
Ankle Brachial Index
4 Citations (Scopus)

A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA)

Cannone, V., Scott, C. G., Decker, P. A., Larson, N., Palmas, W., Taylor, K. D., Wang, T. J., Gupta, D. K., Bielinski, S. J. & Burnett, J. C. J., Dec 1 2017, In : PLoS One. 12, 12, e0189858.

Research output: Contribution to journalArticle

Atrial Natriuretic Factor
African Americans
atherosclerosis
Atherosclerosis
Brain Natriuretic Peptide
1 Citation (Scopus)

An integrative approach to assess X-chromosome inactivation using allele-specific expression with applications to epithelial ovarian cancer

Larson, N., Fogarty, Z. C., Larson, M. C., Kalli, K. R., Lawrenson, K., Gayther, S., Fridley, B. L., Goode, E. L. & Winham, S. J., 2017, (Accepted/In press) In : Genetic Epidemiology.

Research output: Contribution to journalArticle

X Chromosome Inactivation
Alleles
Neoplasms
Genes
Ovarian Neoplasms
6 Citations (Scopus)

CYP2D6 phenotypes are associated with adverse outcomes related to opioid medications

St. Sauver, J., Olson, J. E., Roger, V. L., Nicholson, W. T., Black, J. L., Takahashi, P. Y., Caraballo, P., Bell, E. J., Jacobson, D. J., Larson, N. & Bielinski, S. J., Jul 24 2017, In : Pharmacogenomics and Personalized Medicine. 10, p. 217-227 11 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Opioid Analgesics
Phenotype
Pain
Prescriptions
1 Citation (Scopus)

Elevated Levels of Adhesion Proteins Are Associated with Low Ankle-Brachial Index: Multi-Ethnic Study of Atherosclerosis

Berardi, C., Wassel, C. L., Decker, P. A., Larson, N., Kirsch, P. S., De Andrade, M., Tsai, M. Y., Pankow, J. S., Sale, M. M., Sicotte, H., Tang, W., Hanson, N. Q., McDermott, M. M., Criqui, M. H., Allison, M. A. & Bielinski, S. J., Apr 1 2017, In : Angiology. 68, 4, p. 322-329 8 p.

Research output: Contribution to journalArticle

Ankle Brachial Index
Atherosclerosis
Proteins
Peripheral Arterial Disease
Secretory Leukocyte Peptidase Inhibitor
4 Citations (Scopus)

FIRE: Functional inference of genetic variants that regulate gene expression

Ioannidis, N. M., Davis, J. R., DeGorter, M. K., Larson, N., McDonnell, S. K., French, A. J., Battle, A. J., Hastie, T. J., Thibodeau, S. N., Montgomery, S. B., Bustamante, C. D., Sieh, W. & Whittemore, A. S., Dec 15 2017, In : Bioinformatics. 33, 24, p. 3895-3901 7 p.

Research output: Contribution to journalArticle

Nucleotides
Gene expression
Regulator
Gene Expression
Quantitative Trait Loci
2 Citations (Scopus)

gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels

Larson, N., Mcdonnell, S., Cannon Albright, L., Teerlink, C., Stanford, J., Ostrander, E. A., Isaacs, W. B., Xu, J., Cooney, K. A., Lange, E., Schleutker, J., Carpten, J. D., Powell, I., Bailey-Wilson, J. E., Cussenot, O., Cancel-Tassin, G., Giles, G. G., Macinnis, R. J., Maier, C., Whittemore, A. S. & 12 others, Hsieh, C. L., Wiklund, F., Catolona, W. J., Foulkes, W., Mandal, D., Eeles, R., Kote-Jarai, Z., Ackerman, M. J., Olson, T. M., Klein, C. J., Thibodeau, S. N. & Schaid, D. J., 2017, (Accepted/In press) In : Genetic Epidemiology.

Research output: Contribution to journalArticle

Genes
Gene Components
Case-Control Studies
Schizophrenia
Technology
3 Citations (Scopus)

Hepatocyte growth factor demonstrates racial heterogeneity as a biomarker for coronary heart disease

Bielinski, S. J., Berardi, C., Decker, P. A., Larson, N., Bell, E. J., Pankow, J. S., Sale, M. M., Tang, W., Hanson, N. Q., Wassel, C. L., De Andrade, M., Budoff, M. J., Polak, J. F., Sicotte, H. & Tsai, M. Y., Aug 1 2017, In : Heart. 103, 15, p. 1185-1193 9 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Coronary Disease
Biomarkers
Hispanic Americans
African Americans
1 Citation (Scopus)

Low high-density lipoprotein cholesterol and particle concentrations are associated with greater levels of endothelial activation markers in Multi-Ethnic Study of Atherosclerosis participants

Steffen, B. T., Bielinski, S. J., Decker, P. A., Berardi, C., Larson, N., Pankow, J. S., Michos, E. D., Hanson, N. Q., Herrington, D. M. & Tsai, M. Y., 2017, (Accepted/In press) In : Journal of Clinical Lipidology.

Research output: Contribution to journalArticle

HDL Lipoproteins
LDL Cholesterol
HDL Cholesterol
Atherosclerosis
Selectins

Network-directed cis-mediator analysis of normal prostate tissue expression profiles reveals downstream regulatory associations of prostate cancer susceptibility loci

Larson, N., McDonnell, S. K., Fogarty, Z., Larson, M. C., Cheville, J., Riska, S., Baheti, S., Weber, A. M., Nair, A. A., Wang, L., O'Brien, D., Davila, J., Schaid, D. J. & Thibodeau, S. N., Oct 17 2017, In : Oncotarget. 8, 49, p. 85896-85908 13 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Prostate
Prostatic Neoplasms
Transcription Factors
Gene Expression
2016
7 Citations (Scopus)

ABO blood group associations with markers of endothelial dysfunction in the Multi-Ethnic Study of Atherosclerosis

Larson, N., Bell, E. J., Decker, P. A., Pike, M., Wassel, C. L., Tsai, M. Y., Pankow, J. S., Tang, W., Hanson, N. Q., Alexander, K., Zakai, N. A., Cushman, M. & Bielinski, S. J., Aug 1 2016, In : Atherosclerosis. 251, p. 422-429 8 p.

Research output: Contribution to journalArticle

Selectins
Blood Group Antigens
Atherosclerosis
Alleles
von Willebrand Factor
5 Citations (Scopus)

A targeted genetic association study of epithelial ovarian cancer susceptibility

Earp, M., Winham, S. J., Larson, N., Permuth, J. B., Sicotte, H., Chien, J., Anton-Culver, H., Bandera, E. V., Berchuck, A., Cook, L. S., Cramer, D., Doherty, J. A., Goodman, M. T., Levine, D. A., Monteiro, A. N. A., Ness, R. B., Pearce, C. L., Rossing, M. A., Tworoger, S. S., Wentzensen, N. & 34 others, Bisogna, M., Brinton, L., Brooks-Wilson, A., Carney, M. E., Cunningham, J. M., Edwards, R. P., Fogarty, Z. C., Iversen, E. S., Kraft, P., Larson, M. C., Le, N. D., Lin, H. Y., Lissowska, J., Modugno, F., Moysich, K. B., Olson, S. H., Pike, M. C., Poole, E. M., Rider, D. N., Terry, K. L., Thompson, P. J., Van Den Berg, D., Vierkant, R. A., Vitonis, A. F., Wilkens, L. R., Wu, A. H., Yang, H. P., Ziogas, A., Phelan, C. M., Schildkraut, J. M., Chen, Y. A., Sellers, T. A., Fridley, B. L. & Goode, E. L., 2016, In : Oncotarget. 7, 7, p. 7381-7389 9 p.

Research output: Contribution to journalArticle

Genetic Association Studies
Genome-Wide Association Study
Alleles
Genome
Ovarian epithelial cancer

Blood group antigen loci demonstrate multivariate genetic associations with circulating cellular adhesion protein levels in the Multi-Ethnic Study of Atherosclerosis

Larson, N., Decker, P. A., Wassel, C. L., Pankow, J. S., Tang, W., Hanson, N. Q., Tsai, M. Y. & Bielinski, S. J., Feb 16 2016, (Accepted/In press) In : Human Genetics. p. 1-9 9 p.

Research output: Contribution to journalArticle

Blood Group Antigens
Atherosclerosis
Proteins
Quantitative Trait Loci
Genome
10 Citations (Scopus)

Circulating cellular adhesion molecules and risk of diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA)

Pankow, J. S., Decker, P. A., Berardi, C., Hanson, N. Q., Sale, M., Tang, W., Kanaya, A. M., Larson, N., Tsai, M. Y., Wassel, C. L. & Bielinski, S. J., Jul 1 2016, In : Diabetic Medicine. 33, 7, p. 985-991 7 p.

Research output: Contribution to journalArticle

E-Selectin
Intercellular Adhesion Molecule-1
Atherosclerosis
Vascular Cell Adhesion Molecule-1
Cadherins
10 Citations (Scopus)

Circulating level of hepatocyte growth factor predicts incidence of type 2 diabetes mellitus: The Multi-Ethnic Study of Atherosclerosis (MESA)

Bancks, M. P., Bielinski, S. J., Decker, P. A., Hanson, N. Q., Larson, N., Sicotte, H., Wassel, C. L. & Pankow, J. S., Mar 1 2016, In : Metabolism: Clinical and Experimental. 65, 3, p. 64-72 9 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Type 2 Diabetes Mellitus
Atherosclerosis
Incidence
Social Adjustment
5 Citations (Scopus)

Clinical and Emergent Biomarkers and Their Relationship to the Prognosis of Ovarian Cancer

Jatoi, A., Vierkant, R. A., Hawthorne, K. M., Block, M. S., Ramus, S. J., Larson, N., Fridley, B. L. & Goode, E. L., Jan 19 2016, (Accepted/In press) In : Oncology (Switzerland).

Research output: Contribution to journalArticle

Ovarian Neoplasms
Biomarkers
Recurrence
Ascites
Neoplasms
4 Citations (Scopus)

Hepatocyte growth factor is positively associated with risk of stroke: The MESA (Multi-Ethnic Study of Atherosclerosis)

Bell, E. J., Larson, N., Decker, P. A., Pankow, J. S., Tsai, M. Y., Hanson, N. Q., Wassel, C. L., Longstreth, W. T. & Bielinski, S. J., Nov 1 2016, In : Stroke. 47, 11, p. 2689-2694 6 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Atherosclerosis
Stroke
Confidence Intervals
Confounding Factors (Epidemiology)
6 Citations (Scopus)

Impact of adiposity on cellular adhesion: The Multi-Ethnic Study of atherosclerosis (MESA)

Christoph, M. J., Allison, M. A., Pankow, J. S., Decker, P. A., Kirsch, P. S., Tsai, M. Y., Sale, M. M., De Andrade, M., Sicotte, H., Tang, W., Hanson, N. Q., Berardi, C., Wassel, C. L., Larson, N. & Bielinski, S. J., Jan 1 2016, In : Obesity. 24, 1, p. 223-230 8 p.

Research output: Contribution to journalArticle

Adiposity
Atherosclerosis
Intra-Abdominal Fat
Waist-Hip Ratio
Selectins
13 Citations (Scopus)

Improvement in Cardiovascular Risk Prediction with Electronic Health Records

Pike, M. M., Decker, P. A., Larson, N., St. Sauver, J., Takahashi, P. Y., Roger, V. L., Rocca, W. A., Miller, V. M., Olson, J. E., Pathak, J. & Bielinski, S. J., Mar 9 2016, (Accepted/In press) In : Journal of Cardiovascular Translational Research. p. 1-9 9 p.

Research output: Contribution to journalArticle

Electronic Health Records
Cardiovascular Diseases
Area Under Curve
Health
3 Citations (Scopus)

Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Case-Control Sequencing Studies

Larson, N., McDonnell, S., Albright, L. C., Teerlink, C., Stanford, J., Ostrander, E. A., Isaacs, W. B., Xu, J., Cooney, K. A., Lange, E., Schleutker, J., Carpten, J. D., Powell, I., Bailey-Wilson, J., Cussenot, O., Cancel-Tassin, G., Giles, G., MacInnis, R., Maier, C., Whittemore, A. S. & 12 others, Hsieh, C. L., Wiklund, F., Catolona, W. J., Foulkes, W., Mandal, D., Eeles, R., Kote-Jarai, Z., Ackerman, M. J., Olson, T. M., Klein, C. J., Thibodeau, S. N. & Schaid, D. J., Sep 1 2016, In : Genetic Epidemiology. 40, 6, p. 461-469 9 p.

Research output: Contribution to journalArticle

Case-Control Studies
Gene Frequency
Sample Size
Prostatic Neoplasms
Genome
2015
11 Citations (Scopus)

A Robust e-Epidemiology Tool in Phenotyping Heart Failure with Differentiation for Preserved and Reduced Ejection Fraction: the Electronic Medical Records and Genomics (eMERGE) Network

Bielinski, S. J., Pathak, J., Carrell, D. S., Takahashi, P. Y., Olson, J. E., Larson, N., Liu, H. D., Sohn, S., Wells, Q. S., Denny, J. C., Rasmussen-Torvik, L. J., Pacheco, J. A., Jackson, K. L., Lesnick, T. G., Gullerud, R. E., Decker, P. A., Pereira, N. L., Ryu, E., Dart, R. A., Peissig, P. & 7 others, Linneman, J. G., Jarvik, G. P., Larson, E. B., Bock, J. A., Tromp, G. C., De Andrade, M. & Roger, V. L., Jul 21 2015, (Accepted/In press) In : Journal of Cardiovascular Translational Research.

Research output: Contribution to journalArticle

Electronic Health Records
Genomics
Epidemiology
Heart Failure
Research
28 Citations (Scopus)

Identification of candidate genes for prostate cancer-risk SNPs utilizing a normal prostate tissue eQTL data set

Thibodeau, S. N., French, A. J., McDonnell, S. K., Cheville, J., Middha, S., Tillmans, L., Riska, S., Baheti, S., Larson, M. C., Fogarty, Z., Zhang, Y., Larson, N., Nair, A., O'Brien, D., Wang, L. & Schaid, D. J., Nov 27 2015, In : Nature Communications. 6, 8653.

Research output: Contribution to journalArticle

Genetic Association Studies
genes
Single Nucleotide Polymorphism
Prostate
Prostatic Neoplasms
7 Citations (Scopus)

Multi-ethnic analysis reveals soluble l-selectin may be post-transcriptionally regulated by 3′UTR polymorphism: the Multi-Ethnic Study of Atherosclerosis (MESA)

Berardi, C., Larson, N., Decker, P. A., Wassel, C. L., Kirsch, P. S., Pankow, J. S., Sale, M. M., De Andrade, M., Sicotte, H., Tang, W., Hanson, N. Q., Tsai, M. Y., Chen, Y. D. I. & Bielinski, S. J., 2015, In : Human Genetics. 134, 4, p. 393-403 11 p.

Research output: Contribution to journalArticle

Selectins
Atherosclerosis
Linear Models
Cardiovascular Diseases
African Americans
26 Citations (Scopus)

P-selectin and subclinical and clinical atherosclerosis: The Multi-Ethnic Study of Atherosclerosis (MESA)

Bielinski, S. J., Berardi, C., Decker, P. A., Kirsch, P. S., Larson, N., Pankow, J. S., Sale, M., De Andrade, M., Sicotte, H., Tang, W., Hanson, N. Q., Wassel, C. L., Polak, J. F. & Tsai, M. Y., May 1 2015, In : Atherosclerosis. 240, 1, p. 3-9 7 p.

Research output: Contribution to journalArticle

P-Selectin
Atherosclerosis
Coronary Disease
Coronary Vessels
Calcium
9 Citations (Scopus)

Soluble P-selectin predicts lower extremity peripheral artery disease incidence and change in the ankle brachial index: The Multi-Ethnic Study of Atherosclerosis (MESA)

Wassel, C. L., Berardi, C., Pankow, J. S., Larson, N., Decker, P. A., Hanson, N. Q., Tsai, M. Y., Criqui, M. H., Allison, M. A. & Bielinski, S. J., Apr 1 2015, In : Atherosclerosis. 239, 2, p. 405-411 7 p.

Research output: Contribution to journalArticle

Ankle Brachial Index
P-Selectin
Peripheral Arterial Disease
Lower Extremity
Atherosclerosis
4 Citations (Scopus)

Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the multi-ethnic study of atherosclerosis (MESA)

Larson, N., Berardi, C., Decker, P. A., Wassel, C. L., Kirsch, P. S., Pankow, J. S., Sale, M. M., De Andrade, M., Sicotte, H., Tang, W., Hanson, N. Q., Tsai, M. Y., Taylor, K. D. & Bielinski, S. J., Jul 1 2015, In : Annals of Human Genetics. 79, 4, p. 264-274 11 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Meta-Analysis
Atherosclerosis
Asian Americans
Mesoderm
2014
53 Citations (Scopus)

Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status

Cunningham, J. M., Cicek, M., Larson, N., Davila, J., Wang, C., Larson, M. C., Song, H., Dicks, E. M., Harrington, P., Wick, M. J., Winterhoff, B. J., Hamidi, H., Konecny, G. E., Chien, J., Bibikova, M., Fan, J. B., Kalli, K. R., Lindor, N. M., Fridley, B. L., Pharoah, P. P. D. & 1 others, Goode, E. L., Feb 7 2014, In : Scientific Reports. 4, 4026.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Homologous Recombination
Germ-Line Mutation
Phenotype
Epigenomics
19 Citations (Scopus)

Comprehensively Evaluating cis-Regulatory Variation in the Human Prostate Transcriptome by Using Gene-Level Allele-Specific Expression

Larson, N., McDonnell, S., French, A. J., Fogarty, Z., Cheville, J., Middha, S., Riska, S., Baheti, S., Nair, A. A., Wang, L., Schaid, D. J. & Thibodeau, S. N., Dec 30 2014, (Accepted/In press) In : American Journal of Human Genetics.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Transcriptome
Prostate
Alleles
RNA Sequence Analysis
26 Citations (Scopus)

Kernel canonical correlation analysis for assessing gene-gene interactions and application to ovarian cancer

Larson, N., Jenkins, G. D., Larson, M. C., Vierkant, R. A., Sellers, T. A., Phelan, C. M., Schildkraut, J. M., Sutphen, R., Pharoah, P. P. D., Gayther, S. A., Wentzensen, N., Goode, E. L. & Fridley, B. L., Jan 2014, In : European Journal of Human Genetics. 22, 1, p. 126-131 6 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Genes
Single Nucleotide Polymorphism
Genetic Association Studies
25 Citations (Scopus)

Nonsyntenic genes drive highly dynamic complementation of gene expression in Maize hybrids

Paschold, A., Larson, N., Marcon, C., Schnable, J. C., Yeh, C. T., Lanz, C., Nettleton, D., Piepho, H. P., Schnable, P. S. & Hochholdinger, F., Oct 1 2014, In : Plant Cell. 26, 10, p. 3939-3948 10 p.

Research output: Contribution to journalArticle

single parents
Zea mays
Gene Expression
gene expression
corn
7 Citations (Scopus)

Regularized Rare Variant Enrichment Analysis for Case-Control Exome Sequencing Data

Larson, N. & Schaid, D. J., Feb 2014, In : Genetic Epidemiology. 38, 2, p. 104-113 10 p.

Research output: Contribution to journalArticle

Exome
Genes
Exons
Genome-Wide Association Study
Sample Size
2013
15 Citations (Scopus)

A kernel regression approach to gene-gene interaction detection for case-control studies

Larson, N. & Schaid, D. J., Nov 2013, In : Genetic Epidemiology. 37, 7, p. 695-703 9 p.

Research output: Contribution to journalArticle

Case-Control Studies
Genes
Single Nucleotide Polymorphism
Genetic Models
Inborn Genetic Diseases
45 Citations (Scopus)

PurBayes: Estimating tumor cellularity and subclonality in next-generation sequencing data

Larson, N. & Fridley, B. L., Aug 1 2013, In : Bioinformatics. 29, 15, p. 1888-1889 2 p.

Research output: Contribution to journalArticle

Cellularity
Sequencing
Tumors
Tumor
Bayes Theorem
2012
67 Citations (Scopus)

Complementation contributes to transcriptome complexity in maize (Zea mays L.) hybrids relative to their inbred parents

Paschold, A., Jia, Y., Marcon, C., Lund, S., Larson, N., Yeh, C. T., Ossowski, S., Lanz, C., Nettleton, D., Schnable, P. S. & Hochholdinger, F., Dec 1 2012, In : Genome Research. 22, 12, p. 2445-2454 10 p.

Research output: Contribution to journalArticle

Transcriptome
Zea mays
Genes
Hybrid Vigor
Alleles