Mercedes Prudencio, PhD

  • 1452 Citations
  • 19 Scopus h-Index
20062019
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Fingerprint Dive into the research topics where Mercedes Prudencio is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 13 Similar Profiles
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Frontotemporal Lobar Degeneration Medicine & Life Sciences
Mutation Medicine & Life Sciences
Dipeptides Medicine & Life Sciences
Superoxide Dismutase Chemical Compounds
RNA Medicine & Life Sciences
Proteins Medicine & Life Sciences
RNA-Binding Proteins Medicine & Life Sciences

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Research Output 2006 2019

  • 1452 Citations
  • 19 Scopus h-Index
  • 30 Article
  • 1 Chapter
  • 1 Short survey

eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS

Goodman, L. D., Prudencio, M., Srinivasan, A. R., Rifai, O. M., Lee, V. M. Y., Petrucelli, L. & Bonini, N. M., Apr 25 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Drosophila
Dipeptides
Poisons
Down-Regulation
Reading Frames
4 Citations (Scopus)

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

Zhang, Y., Guo, L., Gonzales, P. K., Gendron, T. D., Wu, Y., Jansen-West, K., O’Raw, A. D., Pickles, S. R., Prudencio, M., Carlomagno, Y., Gachechiladze, M. A., Ludwig, C., Tian, R., Chew, J., DeTure, M., Lin, W. L., Tong, J., Daughrity, L. M., Yue, M., Song, Y. & 15 others, Andersen, J. W., Castanedes-Casey, M., Kurti, A., Datta, A., Antognetti, G., McCampbell, A., Rademakers, R. V., Oskarsson, B., Dickson, D. W., Kampmann, M., Ward, M. E., Fryer, J. D., Link, C. D., Shorter, J. & Petrucelli, L., Feb 15 2019, In : Science. 363, 6428, eaav2606.

Research output: Contribution to journalArticle

Double-Stranded RNA
Heterochromatin
Proline
Arginine
Proteins

Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD

Goodman, L. D., Prudencio, M., Kramer, N. J., Martinez-Ramirez, L. F., Srinivasan, A. R., Lan, M., Parisi, M. J., Zhu, Y., Chew, J., Cook, C., Berson, A., Gitler, A. D., Petrucelli, L. & Bonini, N. M., Jan 1 2019, In : Nature Neuroscience.

Research output: Contribution to journalArticle

Poisons
Drosophila
RNA Polymerase II
Dipeptides
Amyotrophic Lateral Sclerosis
2 Citations (Scopus)

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients

Mordes, D. A., Prudencio, M., Goodman, L. D., Klim, J. R., Moccia, R., Limone, F., Pietilainen, O., Chowdhary, K., Dickson, D. W., Rademakers, R. V., Bonini, N. M., Petrucelli, L. & Eggan, K., Jul 4 2018, In : Acta Neuropathologica Communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Heat-Shock Response
Dipeptides
Amyotrophic Lateral Sclerosis
Heat-Shock Proteins
11 Citations (Scopus)

Long-read sequencing across the C9orf72 'GGGGCC' repeat expansion: Implications for clinical use and genetic discovery efforts in human disease

Ebbert, M. T. W., Farrugia, S. L., Sens, J. P., Jansen-West, K., Gendron, T. D., Prudencio, M., McLaughlin, I. J., Bowman, B., Seetin, M., Dejesus-Hernandez, M., Jackson, J., Brown, P. H., Dickson, D. W., Van Blitterswijk, M., Rademakers, R. V., Petrucelli, L. & Fryer, J. D., Aug 21 2018, In : Molecular Neurodegeneration. 13, 1, 46.

Research output: Contribution to journalArticle

Technology
Nucleotides
Nanopores
Plasmids
Clustered Regularly Interspaced Short Palindromic Repeats