Matthew Philip Goetz, MD

  • 7815 Citations
  • 40 Scopus h-Index
20022021
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Research Output 2002 2019

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Article
2017
15 Citations (Scopus)

Tumor Sequencing and Patient-Derived Xenografts in the Neoadjuvant Treatment of Breast Cancer

Goetz, M. P., Kalari, K. R., Suman, V. J., Moyer, A. M., Yu, J., Visscher, D. W., Dockter, T. J., Vedell, P. T., Sinnwell, J. P., Tang, X., Thompson, K. J., McLaughlin, S. A., Moreno-Aspitia, A., Copland, J. A., Northfelt, D. W., Gray, R. J., Hunt, K., Conners, A., Weinshilboum, R., Wang, L. & 1 others, Boughey, J. C., Jul 1 2017, In : Journal of the National Cancer Institute. 109, 7, djw306.

Research output: Contribution to journalArticle

Neoadjuvant Therapy
Heterografts
Breast Neoplasms
Drug Therapy
Neoplasms
2016
21 Citations (Scopus)

A first-in-human phase i study of the oral p38 MAPK inhibitor, ralimetinib (LY2228820 Dimesylate), in patients with advanced cancer

Patnaik, A., Haluska, P., Tolcher, A. W., Erlichman, C., Papadopoulos, K. P., Lensing, J. L., Beeram, M., Molina, J. R., Rasco, D. W., Arcos, R. R., Kelly, C. S., Wijayawardana, S. R., Zhang, X., Stancato, L. F., Bell, R., Shi, P., Kulanthaivel, P., Pitou, C., Mulle, L. B., Farrington, D. L. & 2 others, Chan, E. M. & Goetz, M. P., Mar 1 2016, In : Clinical Cancer Research. 22, 5, p. 1095-1102 8 p.

Research output: Contribution to journalArticle

LY2228820
p38 Mitogen-Activated Protein Kinases
Tamoxifen
Neoplasms
Safety
16 Citations (Scopus)

Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy

Park, J. H., Jang, M., Tarhan, Y. E., Katagiri, T., Sasa, M., Miyoshi, Y., Kalari, K. R., Suman, V. J., Weinshilboum, R. M., Wang, L. M., Boughey, J. C., Goetz, M. P. & Nakamura, Y., Aug 1 2016, In : International Journal of Oncology. 49, 2, p. 471-478 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
T-Lymphocytes
Drug Therapy
T-Cell Antigen Receptor
Neoplasms
15 Citations (Scopus)

Estrogen, SNP-dependent chemokine expression and selective estrogen receptor modulator regulation

Ho, M. F., Bongartz, T., Liu, M., Kalari, K. R., Goss, P. E., Shepherd, L. E., Goetz, M. P., Kubo, M., Ingle, J. N., Wang, L. M. & Weinshilboum, R. M., Mar 1 2016, In : Molecular Endocrinology. 30, 3, p. 382-398 17 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Chemokines
T-Cell Leukemia
Single Nucleotide Polymorphism
Estrogens
12 Citations (Scopus)

Gene expression profiling identifies responsive patients with cancer of unknown primary treated with carboplatin, paclitaxel, and everolimus: NCCTG N0871 (alliance)

Yoon, H. H., Foster, N. R., Meyers, J. P., Steen, P. D., Visscher, D. W., Pillai, R., Prow, D. M., Reynolds, C. M., Marchello, B. T., Mowat, R. B., Mattar, B. I., Erlichman, C. & Goetz, M. P., Feb 1 2016, In : Annals of Oncology. 27, 2, p. 339-344 6 p., mdv543.

Research output: Contribution to journalArticle

Carboplatin
Gene Expression Profiling
Paclitaxel
Neoplasms
Carcinoma
13 Citations (Scopus)

Genetic polymorphisms in the long noncoding RNA MIR2052HG offer a pharmacogenomic basis for the response of breast cancer patients to aromatase inhibitor therapy

Ingle, J. N., Xie, F., Ellis, M. J., Goss, P. E., Shepherd, L. E., Chapman, J. A. W., Chen, B. E., Kubo, M., Furukawa, Y., Momozawa, Y., Stearns, V., Pritchard, K. I., Barman, P., Carlson, E. E., Goetz, M. P., Weinshilboum, R. M., Kalari, K. R. & Wang, L. M., Dec 1 2016, In : Cancer Research. 76, 23, p. 7012-7023 12 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Aromatase Inhibitors
Pharmacogenetics
Genetic Polymorphisms
Estrogen Receptors
170 Citations (Scopus)

Invasive breast cancer version 1.2016

Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A., Elias, A. D., Farrar, W. B., Forero, A., Giordano, S. H., Goetz, M. P., Goldstein, L. J., Hudis, C. A., Isakoff, S. J., Kelly Marcom, P., Mayer, I. A., McCormick, B., Moran, M., Patel, S. A., Pierce, L. J. & 11 others, Reed, E. C., Salerno, K. E., Schwartzberg, L. S., Smith, K. L., Smith, M. L., Soliman, H., Somlo, G., Telli, M., Ward, J. H., Shead, D. A. & Kumar, R., Mar 1 2016, In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 3, p. 324-354 31 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Guidelines
Neoplasms
Body Regions
Biological Therapy
16 Citations (Scopus)

Phase i Study of Panobinostat (LBH589) and Letrozole in Postmenopausal Metastatic Breast Cancer Patients

Tan, W., Allred, J. B., Moreno Aspitia, A., Northfelt, D. W., Ingle, J. N., Goetz, M. P. & Perez, E. A., Apr 1 2016, In : Clinical Breast Cancer. 16, 2, p. 82-86 5 p.

Research output: Contribution to journalArticle

letrozole
Breast Neoplasms
Histone Deacetylase Inhibitors
Triple Negative Breast Neoplasms
Maximum Tolerated Dose
2015
8 Citations (Scopus)

Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression

Polo, M. L., Riggio, M., May, M., Rodríguez, M. J., Perrone, M. C., Stallings-Mann, M., Kaen, D., Frost, M., Goetz, M. P., Boughey, J. C., Lanari, C., Radisky, D. C. & Novaro, V., 2015, In : Oncotarget. 6, 26, p. 22081-22097 17 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Breast Neoplasms
Neoadjuvant Therapy
Neoplasms
S 6
14 Citations (Scopus)

A polygenic risk score for breast cancer in women receiving tamoxifen or raloxifene on NSABP P-1 and P-2

Vachon, C. M., Schaid, D. J., Ingle, J. N., Wickerham, D. L., Kubo, M., Mushiroda, T., Goetz, M. P., Carlson, E. E., Paik, S., Wolmark, N., Nakamura, Y., Wang, L. M., Weinshilboum, R. M. & Couch, F. J., 2015, In : Breast Cancer Research and Treatment. 149, 2, p. 517-523 7 p.

Research output: Contribution to journalArticle

Tamoxifen
Breast Neoplasms
Selective Estrogen Receptor Modulators
Raloxifene Hydrochloride
Single Nucleotide Polymorphism
91 Citations (Scopus)

Breast cancer, version 1.2016 featured updates to the NCCN guidelines

Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A., Elias, A. D., Farrar, W. B., Forero, A., Giordano, S. H., Goetz, M. P., Goldstein, L. J., Hudis, C. A., Isakoff, S. J., Marcom, P. K., Mayer, I. A., McCormick, B., Moran, M., Patel, S. A., Pierce, L. J. & 11 others, Reed, E. C., Salerno, K. E., Schwartzberg, L. S., Smith, K. L., Smith, M. L., Soliman, H., Somlo, G., Telli, M., Ward, J. H., Shead, D. A. & Kumar, R., Dec 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 12, p. 1475-1485 11 p.

Research output: Contribution to journalArticle

Guidelines
Breast Neoplasms
Therapeutics
Hormones
106 Citations (Scopus)

Breast cancer version 2.2015: Clinical practice guidelines in oncology

Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A., Elias, A. D., Farrar, W. B., Forero, A., Giordano, S. H., Goetz, M. P., Goldstein, L. J., Hudis, C. A., Isakoff, S. J., Marcom, P. K., Mayer, I. A., McCormick, B., Moran, M., Patel, S. A., Pierce, L. J. & 11 others, Reed, E. C., Salerno, K. E., Schwartzberg, L. S., Smith, K. L., Smith, M. L., Soliman, H., Somlo, G., Telli, M., Ward, J. H., Shead, D. A. & Kumar, R., Apr 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 4, p. 448-475 28 p.

Research output: Contribution to journalArticle

Practice Guidelines
Breast Neoplasms
Neoplasms
Biological Therapy
Cause of Death
7 Citations (Scopus)

Evaluation of CYP2D6 enzyme activity using a 13C-dextromethorphan breath test in women receiving adjuvant tamoxifen

Safgren, S. L., Suman, V. J., Kosel, M. L., Gilbert, J. A., Buhrow, S. A., Black, J. L., Northfelt, D. W., Modak, A. S., Rosen, D., Ingle, J. N., Ames, M. M., Reid, J. M. & Goetz, M. P., Mar 27 2015, In : Pharmacogenetics and Genomics. 25, 4, p. 157-163 7 p.

Research output: Contribution to journalArticle

Dextromethorphan
Cytochrome P-450 CYP2D6
Breath Tests
Tamoxifen
Enzymes
11 Citations (Scopus)

Exome sequencing reveals frequent deleterious germline variants in cancer susceptibility genes in women with invasive breast cancer undergoing neoadjuvant chemotherapy

Ellingson, M. S., Hart, S., Kalari, K. R., Suman, V. J., Schahl, K. A., Dockter, T. J., Felten, S. J., Sinnwell, J. P., Thompson, K. J., Tang, X., Vedell, P. T., Barman, P., Sicotte, H., Eckel-Passow, J. E., Northfelt, D. W., Gray, R. J., McLaughlin, S. A., Moreno Aspitia, A., Ingle, J. N., Moyer, A. & 9 others, Visscher, D. W., Jones, K., Conners, A., McDonough, M., Wieben, E. D., Wang, L. M., Weinshilboum, R. M., Boughey, J. C. & Goetz, M. P., Sep 7 2015, In : Breast Cancer Research and Treatment. 153, 2, p. 435-443 9 p.

Research output: Contribution to journalArticle

Exome
Neoplasm Genes
Breast Neoplasms
Drug Therapy
Genes
18 Citations (Scopus)

Landscape of Neoadjuvant Therapy for Breast Cancer

Haddad, T. C. & Goetz, M. P., May 1 2015, In : Annals of Surgical Oncology. 22, 5, p. 1408-1415 8 p.

Research output: Contribution to journalArticle

Neoadjuvant Therapy
Breast Neoplasms
Therapeutics
Drug Therapy
Tumor Burden
31 Citations (Scopus)
Cytochrome P-450 CYP2D6
Loss of Heterozygosity
Breast Neoplasms
Genotype
Neoplasms
32 Citations (Scopus)

TBCRC 008: Early change in 18F-FDG uptake on PET predicts response to preoperative systemic therapy in human epidermal growth factor receptor 2-negative primary operable breast cancer

Connolly, R. M., Leal, J. P., Goetz, M. P., Zhang, Z., Zhou, X. C., Jacobs, L. K., Mhlanga, J., Joo, H. O., Carpenter, J., Storniolo, A. M., Watkins, S., Fetting, J. H., Miller, R. S., Sideras, K., Jeter, S. C., Walsh, B., Powers, P., Zorzi, J., Boughey, J. C., Davidson, N. E. & 6 others, Carey, L. A., Wolff, A. C., Khouri, N., Gabrielson, E., Wahl, R. L. & Stearns, V., Jan 1 2015, In : Journal of Nuclear Medicine. 56, 1, p. 31-37 7 p.

Research output: Contribution to journalArticle

Fluorodeoxyglucose F18
Breast Neoplasms
Placebos
Carboplatin
Therapeutics
125 Citations (Scopus)

Use of biomarkers to guide decisions on systemic therapy for women with metastatic breast cancer: American Society of Clinical Oncology clinical practice guideline

Van Poznak, C., Somerfield, M. R., Bast, R. C., Cristofanilli, M., Goetz, M. P., Gonzalez-Angulo, A. M., Hicks, D. G., Hill, E. G., Liu, M. C., Lucas, W., Mayer, I. A., Mennel, R. G., Symmans, W. F., Hayes, D. F. & Harris, L. N., Aug 20 2015, In : Journal of Clinical Oncology. 33, 24, p. 2695-2704 10 p.

Research output: Contribution to journalArticle

Practice Guidelines
Biomarkers
Breast Neoplasms
Progesterone Receptors
Tumor Biomarkers
2014
72 Citations (Scopus)

Androgen receptor-positive triple negative breast cancer: A unique breast cancer subtype

McGhan, L. J., McCullough, A. E., Protheroe, C. A., Dueck, A., Lee, J. J., Nunez-Nateras, R., Castle, E. P., Gray, R. J., Wasif, N., Goetz, M. P., Hawse, J. R., Henry, T. J., Barrett, M., Cunliffe, H. E. & Pockaj, B. A., Feb 2014, In : Annals of Surgical Oncology. 21, 2, p. 361-367 7 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Androgen Receptors
Breast Neoplasms
Lymph Nodes
Carcinoma, Intraductal, Noninfiltrating
13 Citations (Scopus)

Aurora-A mitotic kinase induces endocrine resistance through down-regulation of ERα expression in initially ERα+ breast cancer cells

Opyrchal, M., Salisbury, J. L., Zhang, S., McCubrey, J., Hawse, J. R., Goetz, M. P., Lomberk, G. A., Haddad, T. C., Degnim, A. C., Lange, C., Ingle, J. N., Galanis, E. & D'Assoro, A., May 9 2014, In : PLoS One. 9, 5, e96995.

Research output: Contribution to journalArticle

Aurora Kinase A
Estrogen Receptor alpha
breast neoplasms
phosphotransferases (kinases)
Phosphotransferases
10 Citations (Scopus)

Comparative uterotrophic effects of endoxifen and tamoxifen in ovariectomized sprague-dawley rats

Schweikart, K. M., Eldridge, S. R., Safgren, S. L., Parman, T., Reid, J. M., Ames, M. M., Goetz, M. P. & Davis, M. A., Dec 29 2014, In : Toxicologic Pathology. 42, 8, p. 1188-1196 9 p.

Research output: Contribution to journalArticle

Tamoxifen
Sprague Dawley Rats
Rats
Estradiol
Estrogen Antagonists
109 Citations (Scopus)

CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-Analysis of Heterogeneous Study Populations

Province, M. A., Goetz, M. P., Brauch, H., Flockhart, D. A., Hebert, J. M., Whaley, R., Suman, V. J., Schroth, W., Winter, S., Zembutsu, H., Mushiroda, T., Newman, W. G., Lee, M. T. M., Ambrosone, C. B., Beckmann, M. W., Choi, J. Y., Dieudonné, A. S., Fasching, P. A., Ferraldeschi, R., Gong, L. & 89 others, Haschke-Becher, E., Howell, A., Jordan, L. B., Hamann, U., Kiyotani, K., Krippl, P., Lambrechts, D., Latif, A., Langsenlehner, U., Lorizio, W., Neven, P., Nguyen, A. T., Park, B. W., Purdie, C. A., Quinlan, P., Renner, W., Schmidt, M., Schwab, M., Shin, J. G., Stingl, J. C., Wegman, P., Wingren, S., Wu, A. H. B., Ziv, E., Zirpoli, G., Thompson, A. M., Jordan, V. C., Nakamura, Y., Ingle, J. N., Ames, M. M., Weinshilboum, R. M., Eichelbaum, M., Ingle, J. N., Klein, T. E., Hamann, U., Boländer, J., Ulmer, H. U., Fischer-Bosch, M., Brauch, H., Schroth, W., Schwab, M., Winter, S., Eichelbaum, M., Fritz, P., Simon, W., Stingl, J. C., Flockhart, D. A., Nguyen, A. T., Shin, J. G., Choi, J. Y., Goetz, M. P., Ingle, J. N., Suman, V. J., Weinshilboum, R. M., Purdie, C. A., Jordan, L. B., Wegman, P., Zembutsu, H., Mushiroda, T., Kiyotani, K., Ambrosone, C. B., Fasching, P. A., Strick, R., Beckmann, M. W., Neven, P., Dieudonné, A. S., Haschke-Becher, E., Wu, A. H. B., Lorizio, W., Ziv, E., Quinlan, P., Schmidt, M., Koelbl, H., Newman, W. G., Ferraldeschi, R., Howell, A., Latif, A., Lambrechts, D., Park, B. W., Klein, T. E., Whaley, R., Province, M. A., Hebert, J. M., Gong, L., Altman, R. B., Ambrosone, C. A., Thompson, A. M., Wingren, S. & H, E. Z., Feb 2014, In : Clinical Pharmacology and Therapeutics. 95, 2, p. 216-227 12 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Tamoxifen
Meta-Analysis
Genotype
Population
8 Citations (Scopus)

CYP2D6 genotype and tamoxifen: Considerations for proper nonprospective studies

Goetz, M. P. & Ingle, J. N., 2014, In : Clinical Pharmacology and Therapeutics. 96, 2, p. 141-144 4 p.

Research output: Contribution to journalArticle

Hormonal Antineoplastic Agents
Cytochrome P-450 CYP2D6
Tamoxifen
Genotype
Neoplasms
22 Citations (Scopus)

ERβ1: Characterization, prognosis, and evaluation of treatment strategies in ERα-positive and -negative breast cancer

Reese, J. M., Suman, V. J., Subramaniam, M., Wu, X., Negron, V., Gingery, A., Pitel, K. S., Shah, S. M., Cunliffe, H. E., McCullough, A. E., Pockaj, B. A., Couch, F. J., Olson, J. E., Reynolds, C., Lingle, W. L., Spelsberg, T. C., Goetz, M. P., Ingle, J. N. & Hawse, J. R., Oct 7 2014, In : BMC Cancer. 14, 1, 749.

Research output: Contribution to journalArticle

Breast Neoplasms
Tamoxifen
Triple Negative Breast Neoplasms
Selective Estrogen Receptor Modulators
Antibodies
22 Citations (Scopus)

Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole

Ingle, J. N., Kalari, K. R., Buzdar, A. U., Robson, M. E., Goetz, M. P., Desta, Z., Barman, P., Dudenkov, T. T., Northfelt, D. W., Perez, E. A., Flockhart, D. A., Williard, C. V., Wang, L. M. & Weinshilboum, R. M., May 1 2014, (Accepted/In press) In : Steroids.

Research output: Contribution to journalArticle

Estrogens
Breast Neoplasms
Estrone
Metabolites
Hormones
26 Citations (Scopus)

Inhibition of Cdk2 kinase activity selectively targets the CD44 +/CD24-/Low stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells

Opyrchal, M., Salisbury, J. L., Iankov, I., Goetz, M. P., McCubrey, J., Gambino, M. W., Malatino, L., Puccia, G., Ingle, J. N., Galanis, E. & D'Assoro, A., 2014, In : International Journal of Oncology. 45, 3, p. 1193-1199 7 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 2
Triple Negative Breast Neoplasms
Inflammatory Breast Neoplasms
Phosphotransferases
Breast Neoplasms
11 Citations (Scopus)

Once-daily radiation therapy for inflammatory breast cancer

Brown, L., Harmsen, W., Blanchard, M., Goetz, M. P., Jakub, J. W., Mutter, R., Petersen, I. A., Rooney, J., Stauder, M., Yan, E. & Laack, N. N., Aug 1 2014, In : International Journal of Radiation Oncology Biology Physics. 89, 5, p. 997-1003 7 p.

Research output: Contribution to journalArticle

Inflammatory Breast Neoplasms
breast
radiation therapy
Radiotherapy
cancer
10 Citations (Scopus)

Pharmacokinetics of endoxifen and tamoxifen in female mice: Implications for comparative in vivo activity studies

Reid, J. M., Goetz, M. P., Buhrow, S. A., Walden, C., Safgren, S. L., Kuffel, M. J., Reinicke, K. E., Suman, V. J., Haluska, P., Hou, X. & Ames, M. M., Oct 9 2014, In : Cancer Chemotherapy and Pharmacology. 74, 6, p. 1271-1278 8 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Tamoxifen
Cytochrome P-450 CYP2D6
Metabolism
Area Under Curve
13 Citations (Scopus)

Pregnancy-associated plasma protein-A expression in human breast cancer

Mansfield, A., Visscher, D. W., Hart, S., Wang, C., Goetz, M. P., Oxvig, C. & Conover, C. A., Dec 1 2014, In : Growth Hormone and IGF Research. 24, 6, p. 264-267 4 p.

Research output: Contribution to journalArticle

Pregnancy-Associated Plasma Protein-A
Breast Neoplasms
Estrogen Receptors
Neoplasms
Metalloproteases
3 Citations (Scopus)

Re: Concordance between CYP2D6 genotypes obtained from tumor-derived and germline DNA

Goetz, M. P., Brauch, H., Ratain, M. J., Cox, N. J., Nakamura, Y., Weinshilboum, R. M. & Ingle, J. N., May 14 2014, In : Journal of the National Cancer Institute. 106, 5, dju063.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Genotype
DNA
Neoplasms
2 Citations (Scopus)

The effects of a novel hormonal breast cancer therapy, endoxifen, on the mouse skeleton

Gingery, A., Subramaniam, M., Pitel, K. S., Reese, J. M., Cicek, M., Lindenmaier, L. B., Ingle, J. N., Goetz, M. P., Turner, R. T., Iwaniec, U. T., Spelsberg, T. C. & Hawse, J. R., May 22 2014, In : PLoS One. 9, 5, e98219.

Research output: Contribution to journalArticle

Skeleton
breast neoplasms
osteoblasts
skeleton
bones
2013
45 Citations (Scopus)

A phase i trial of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer

Ma, C. X., Suman, V. J., Goetz, M. P., Haluska, P., Moynihan, T., Nanda, R., Olopade, O., Pluard, T., Guo, Z., Chen, H. X., Erlichman, C., Ellis, M. J. & Fleming, G. F., May 2013, In : Breast Cancer Research and Treatment. 139, 1, p. 145-153 9 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Maximum Tolerated Dose
Breast Neoplasms
Antibodies
Insulin-Like Growth Factor Binding Protein 3
78 Citations (Scopus)

CYP2D6 metabolism and patient outcome in the Austrian breast and colorectal cancer study group trial (ABCSG) 8

Goetz, M. P., Suman, V. J., Hoskin, T. L., Gnant, M., Filipits, M., Safgren, S. L., Kuffel, M., Jakesz, R., Rudas, M., Greil, R., Dietze, O., Lang, A., Offner, F., Reynolds, C. A., Weinshilboum, R. M., Ames, M. M. & Ingle, J. N., Jan 15 2013, In : Clinical Cancer Research. 19, 2, p. 500-507 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Tamoxifen
Colorectal Neoplasms
Alleles
Breast Neoplasms
32 Citations (Scopus)

Endoxifen's Molecular Mechanisms of Action Are Concentration Dependent and Different than That of Other Anti-Estrogens

Hawse, J. R., Subramaniam, M., Cicek, M., Wu, X., Gingery, A., Grygo, S. B., Sun, Z., Pitel, K. S., Lingle, W. L., Goetz, M. P., Ingle, J. N. & Spelsberg, T. C., Jan 28 2013, In : PLoS One. 8, 1, e54613.

Research output: Contribution to journalArticle

tamoxifen
estrogens
mechanism of action
Estrogens
Tamoxifen
9 Citations (Scopus)

Matrix detachment and proteasomal inhibitors diminish Sulf-2 expression in breast cancer cell lines and mouse xenografts

Khurana, A., Jung-Beom, D., He, X., Kim, S. H., Busby, R. C., Lorenzon, L., Villa, M., Baldi, A., Molina, J. R., Goetz, M. P. & Shridhar, V., Apr 2013, In : Clinical and Experimental Metastasis. 30, 4, p. 407-415 9 p.

Research output: Contribution to journalArticle

Sulfatases
Heterografts
Breast Neoplasms
Cell Line
Cell Death
153 Citations (Scopus)

Multicenter phase II study of neoadjuvant lapatinib and trastuzumab with hormonal therapy and without chemotherapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer: TBCRC 006.

Rimawi, M. F., Mayer, I. A., Forero, A., Nanda, R., Goetz, M. P., Rodriguez, A. A., Pavlick, A. C., Wang, T., Hilsenbeck, S. G., Gutierrez, C., Schiff, R., Osborne, C. K. & Chang, J. C., May 10 2013, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 31, 14, p. 1726-1731 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Breast Neoplasms
Drug Therapy
letrozole
Therapeutics
139 Citations (Scopus)

Percutaneous image-guided cryoablation of painful metastases involving bone: Multicenter trial

Callstrom, M. R., Dupuy, D. E., Solomon, S. B., Beres, R. A., Littrup, P. J., Davis, K. W., Paz-Fumagalli, R., Hoffman, C., Atwell, T. D., Charboneau, J. W., Schmit, G. D., Goetz, M. P., Rubin, J., Brown, K. J., Novotny, P. J. & Sloan, J. A., Mar 1 2013, In : Cancer. 119, 5, p. 1033-1041 9 p.

Research output: Contribution to journalArticle

Cryosurgery
Multicenter Studies
Neoplasm Metastasis
Bone and Bones
Pain
4 Citations (Scopus)

Reply to A.-S. Dieudonné et al and J.M. Rae et al

Brauch, H., Schroth, W., Goetz, M. P., Mürdter, T. E., Winter, S., Ingle, J. N., Schwab, M. & Eichelbaum, M., Jul 20 2013, In : Journal of Clinical Oncology. 31, 21, p. 2755-2756 2 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression: Individualized breast cancer prevention

Ingle, J. N., Liu, M., Lawrence Wickerham, D., Schaid, D. J., Wang, L. M., Mushiroda, T., Kubo, M., Costantino, J. P., Vogel, V. G., Paik, S., Goetz, M. P., Ames, M. M., Jenkins, G. D., Batzler, A., Carlson, E. E., Flockhart, D. A., Wolmark, N., Nakamura, Y. & Weinshilboum, R. M., Jul 2013, In : Cancer Discovery. 3, 7, p. 812-825 14 p.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Pharmacogenetics
Breast Neoplasms
Estrogens
Genome-Wide Association Study
80 Citations (Scopus)

Tamoxifen use in postmenopausal breast cancer: CYP2D6 matters

Brauch, H., Schroth, W., Goetz, M. P., Mürdter, T. E., Winter, S., Ingle, J. N., Schwab, M. & Eichelbaum, M., Jan 10 2013, In : Journal of Clinical Oncology. 31, 2, p. 176-180 5 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

TSPYl5 SNPs: Association with plasma estradiol concentrations and aromatase expression

Liu, M., Ingle, J. N., Fridley, B. L., Buzdar, A. U., Robson, M. E., Kubo, M., Wang, L. M., Batzler, A., Jenkins, G. D., Pietrzak, T. L., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Perez, E. A., Williard, C. V., Schaid, D. J., Nakamura, Y. & Weinshilboum, R. M., Apr 1 2013, In : Molecular Endocrinology. 27, 4, p. 657-670 14 p.

Research output: Contribution to journalArticle

Aromatase
Single Nucleotide Polymorphism
Estradiol
Estrogen Receptors
Genotype
7 Citations (Scopus)

UGT1A1 genotype-guided phase i study of irinotecan, oxaliplatin, and capecitabine

Goetz, M. P., McKean, H. A., Reid, J. M., Mandrekar, S. J., Tan, A. D., Kuffel, M. A., Safgren, S. L., McGovern, R. M., Goldberg, R. M., Grothey, A. F., Mc Williams, R. R., Erlichman, C. & Ames, M. M., Dec 2013, In : Investigational New Drugs. 31, 6, p. 1559-1567 9 p.

Research output: Contribution to journalArticle

oxaliplatin
irinotecan
Genotype
Maximum Tolerated Dose
Pharmacokinetics
1 Citation (Scopus)

Update on CYP2D6 and tamoxifen

Goetz, M. P., Apr 2013, In : Clinical Advances in Hematology and Oncology. 11, 4, p. 178-180 3 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Tamoxifen
2012
17 Citations (Scopus)
Electronic Health Records
Drug Discovery
Breast Neoplasms
Tamoxifen
Aromatase Inhibitors
33 Citations (Scopus)

Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody

Wu, X., Subramaniam, M., Negron, V., Cicek, M., Reynolds, C., Lingle, W. L., Goetz, M. P., Ingle, J. N., Spelsberg, T. C. & Hawse, J. R., Feb 2012, In : Journal of Cellular Biochemistry. 113, 2, p. 711-723 13 p.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Estrogen Receptor alpha
Monoclonal Antibodies
Antibodies
Breast Neoplasms
4 Citations (Scopus)

Gemcitabine and irinotecan as first-line therapy for carcinoma of unknown primary: Results of a multicenter phase II trial

Holtan, S. G., Steen, P. D., Foster, N. R., Erlichman, C., Medeiros, F., Ames, M. M., Safgren, S. L., Graham, D. L., Behrens, R. J. & Goetz, M. P., Jul 17 2012, In : PLoS One. 7, 7, e39285.

Research output: Contribution to journalArticle

irinotecan
gemcitabine
carcinoma
Carcinoma
therapeutics
45 Citations (Scopus)

Phase I-II study of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: Evidence for vorinostat-induced tubulin acetylation and Hsp90 inhibition in vivo

Ramaswamy, B., Fiskus, W., Cohen, B., Pellegrino, C., Hershman, D. L., Chuang, E., Luu, T., Somlo, G., Goetz, M. P., Swaby, R., Shapiro, C. L., Stearns, V., Christos, P., Espinoza-Delgado, I., Bhalla, K. & Sparano, J. A., Apr 2012, In : Breast Cancer Research and Treatment. 132, 3, p. 1063-1072 10 p.

Research output: Contribution to journalArticle

Tubulin
Acetylation
Paclitaxel
Breast Neoplasms
vorinostat
11 Citations (Scopus)

Silencing of HSulf-2 expression in MCF10DCIS.com cells attenuate ductal carcinoma in situ progression to invasive ductal carcinoma in vivo

Khurana, A., McKean, H., Kim, H., Kim, S. H., Mcguire, J., Roberts, L. R., Goetz, M. P. & Shridhar, V., Mar 12 2012, In : Breast Cancer Research. 14, 2, R43.

Research output: Contribution to journalArticle

Ductal Carcinoma
Carcinoma, Intraductal, Noninfiltrating
Heterografts
Breast
Breast Neoplasms
2011
20 Citations (Scopus)

Breast medical oncologists' use of standard prognostic factors to predict a 21-gene recurrence score

Kamal, A. H., Loprinzi, C. L., Reynolds, C., Dueck, A., Geiger, X. J., Ingle, J. N., Carlson, R. W., Hobday, T. J., Winer, E. P. & Goetz, M. P., 2011, In : Oncologist. 16, 10, p. 1359-1366 8 p.

Research output: Contribution to journalArticle

Breast
Recurrence
Genes
Oncologists
Drug Therapy