Matthew Philip Goetz, MD

  • 7633 Citations
  • 40 Scopus h-Index
20022021
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Research Output 2002 2019

2019

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Dudenkov, T. M., Liu, D., Cairns, J., Devarajan, S., Zhuang, Y., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Batzler, A., Barman, P., Jenkins, G. D., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Moreno Aspitia, A., Desta, Z., Reid, J. M., Kalari, K. R., Wang, L. M. & 1 others, Weinshilboum, R. M., Jan 1 2019, In : Clinical pharmacology and therapeutics.

Research output: Contribution to journalArticle

Open Access
Aromatase Inhibitors
Genome-Wide Association Study
Single Nucleotide Polymorphism
Pharmaceutical Preparations
Breast Neoplasms
4 Citations (Scopus)

Breast cancer, version 3.2018 featured updates to the NCCN guidelines

Goetz, M. P., Gradishar, W. J., Anderson, B. O., Abraham, J., Aft, R., Allison, K. H., Blair, S. L., Burstein, H. J., Dang, C., Elias, A. D., Farrar, W. B., Giordano, S. H., Goldstein, L. J., Isakoff, S. J., Lyons, J., Kelly Marcom, P., Mayer, I. A., Moran, M. S., Mortimer, J., O’Regan, R. M. & 13 others, Patel, S. A., Pierce, L. J., Reed, E. C., Rugo, H. S., Sitapati, A., Smith, K. L., Smith, M. L., Soliman, H., Telli, M. L., Ward, J. H., Young, J. S., Shead, D. A. & Kumar, R., Feb 1 2019, In : JNCCN Journal of the National Comprehensive Cancer Network. 17, 2, p. 118-126 9 p.

Research output: Contribution to journalArticle

Open Access
Adjuvant Chemotherapy
Hormones
Guidelines
Breast Neoplasms
Therapeutics
1 Citation (Scopus)
Technetium Tc 99m Sestamibi
Molecular Imaging
Breast
Breast Neoplasms
Drug Therapy

Deep sequencing across germline genome-wide association study signals relating to breast cancer events in women receiving aromatase inhibitors for adjuvant therapy of early breast cancer

Ingle, J. N., Kalari, K. R., Momozawa, Y., Kubo, M., Furukawa, Y., Shepherd, L. E., Ellis, M. J., Goss, P. E., Barman, P., Carlson, E. E., Sinnwell, J. P., Tang, X., Goetz, M. P., Chen, B. E., Cairns, J., Weinshilboum, R. M. & Wang, L. M., Oct 1 2019, In : Pharmacogenetics and genomics. 29, 8, p. 183-191 9 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Aromatase Inhibitors
Genome-Wide Association Study
Single Nucleotide Polymorphism
Breast Neoplasms

Metaplastic breast cancer has a poor response to neoadjuvant systemic therapy

Al-Hilli, Z., Choong, G., Keeney, M. G., Visscher, D. W., Ingle, J. N., Goetz, M. P. & Jakub, J. W., Aug 15 2019, In : Breast Cancer Research and Treatment. 176, 3, p. 709-716 8 p.

Research output: Contribution to journalArticle

Neoadjuvant Therapy
Breast Neoplasms
Drug Therapy
Cyclophosphamide
Anthracyclines

Tamoxifen Metabolism and Breast Cancer Recurrence: A Question Unanswered by CYPTAM

Goetz, M. P., Suman, V. J., Nakamura, Y., Kiyotani, K., Jordan, V. C. & Ingle, J. N., Aug 1 2019, In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37, 22, p. 1982-1983 2 p.

Research output: Contribution to journalArticle

Tamoxifen
Breast Neoplasms
Recurrence

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

Cairns, J., Ingle, J. N., Kalari, K. R., Shepherd, L. E., Kubo, M., Goetz, M. P., Weinshilboum, R. M. & Wang, L. M., Apr 3 2019, In : Breast Cancer Research. 21, 1, 47.

Research output: Contribution to journalArticle

Open Access
Early Growth Response Protein 1
Lemur
Long Noncoding RNA
Aromatase Inhibitors
Protein-Tyrosine Kinases
2018
239 Citations (Scopus)

Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer

Sparano, J. A., Gray, R. J., Makower, D. F., Pritchard, K. I., Albain, K. S., Hayes, D. F., Geyer, C. E., Dees, E. C., Goetz, M. P., Olson, J. A., Lively, T., Badve, S. S., Saphner, T. J., Wagner, L. I., Whelan, T. J., Ellis, M. J., Paik, S., Wood, W. C., Ravdin, P. M., Keane, M. M. & 10 others, Gomez Moreno, H. L., Reddy, P. S., Goggins, T. F., Mayer, I. A., Brufsky, A. M., Toppmeyer, D. L., Kaklamani, V. G., Berenberg, J. L., Abrams, J. & Sledge, G. W., Jul 12 2018, In : New England Journal of Medicine. 379, 2, p. 111-121 11 p.

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Breast Neoplasms
Gene Expression
Recurrence
Drug Therapy
tipifarnib
Farnesyltranstransferase
Epidermal Growth Factor
Protein-Tyrosine Kinases
Maximum Tolerated Dose
2 Citations (Scopus)

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular Cancer Therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Radiotherapy
Exome
Homologous Recombination
Neoplasms
9 Citations (Scopus)

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye-Agyeman, F., Gonsalves, W., Lou, Z., Karnitz, L. M., Goetz, M. P. & Hitosugi, T. D., Feb 6 2018, In : Cell Reports. 22, 6, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

Carnitine O-Palmitoyltransferase
Lysine
Phosphopyruvate Hydratase
Isotope Labeling
Mutation
36 Citations (Scopus)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy

Goetz, M. P., Sangkuhl, K., Guchelaar, H. J., Schwab, M., Province, M., Whirl-Carrillo, M., Symmans, W. F., Mcleod, H. L., Ratain, M. J., Zembutsu, H., Gaedigk, A., van Schaik, R. H., Ingle, J. N., Caudle, K. E. & Klein, T. E., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Pharmacogenetics
Tamoxifen
Guidelines
Genetic Polymorphisms
61 Citations (Scopus)

Clinical practice guidelines in oncology

Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A., Elias, A. D., Farrar, W. B., Forero, A., Giordano, S. H., Goetz, M. P., Goldstein, L. J., Isakoff, S. J., Lyons, J., Kelly Marcom, P., Mayer, I. A., McCormick, B., Moran, M. S., O’Regan, R. M., Patel, S. A. & 13 others, Pierce, L. J., Reed, E. C., Salerno, K. E., Schwartzberg, L. S., Sitapati, A., Smith, K. L., Smith, M. L., Soliman, H., Somlo, G., Telli, M. L., Ward, J. H., Kumar, R. & Shead, D. A., Mar 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 3, p. 310-320 11 p.

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
Practice Guidelines
Breast
Risk Reduction Behavior
Guidelines
5 Citations (Scopus)

Discovery of a glucocorticoid receptor (gr) activity signature using selective gr antagonis in er-negative breast cancer

West, D. C., Kocherginsky, M., Tonsing-Carter, E. Y., Dolcen, D. N., Hosfield, D. J., Lastra, R. R., Sinnwell, J. P., Thompson, K. J., Bowie, K. R., Harkless, R. V., Skor, M. N., Pierce, C. F., Styke, S. C., Kim, C. R., De Wet, L., Greene, G. L., Boughey, J. C., Goetz, M. P., Kalari, K. R., Wang, L. M. & 3 others, Fleming, G. F., Gyorffy, B. & Conzen, S. D., Jul 15 2018, In : Clinical Cancer Research. 24, 14, p. 3433-3446 14 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Breast Neoplasms
Estrogen Receptors
Genes
Gene Expression
8 Citations (Scopus)

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Yu, J., Qin, B., Moyer, A., Nowsheen, S., Liu, T., Qin, S., Zhuang, Y., Liu, D., Lu, S. W., Kalari, K. R., Visscher, D. W., Copland, J. A. III., McLaughlin, S. A., Moreno Aspitia, A., Northfelt, D. W., Gray, R. J., Lou, Z., Suman, V. J., Weinshilboum, R. M., Boughey, J. C. & 2 others, Goetz, M. P. & Wang, L. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2376-2388 13 p.

Research output: Contribution to journalArticle

decitabine
Triple Negative Breast Neoplasms
Methyltransferases
DNA
Biomarkers
1 Citation (Scopus)

Endocrine therapy and related issues in hormone receptor-positive early breast cancer: a roundtable discussion by the breast cancer therapy expert group (BCTEG)

Abraham, J., Caldera, H., Coleman, R., Elias, A., Goetz, M. P., Kittaneh, M., Lower, E., Mahtani, R., Terry Mamounas, E., Pegram, M., Rugo, H., Schwartzberg, L., Traina, T. & Vogel, C., Jan 19 2018, (Accepted/In press) In : Breast Cancer Research and Treatment. p. 1-7 7 p.

Research output: Contribution to journalArticle

Group Psychotherapy
Hormones
Breast Neoplasms
Therapeutics
Recurrence
2 Citations (Scopus)

ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis

Reese, J. M., Bruinsma, E. S., Nelson, A. W., Chernukhin, I., Carroll, J. S., Li, Y., Subramaniam, M., Suman, V. J., Negron, V., Monroe, D. G., Ingle, J. N., Goetz, M. P. & Hawse, J. R., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. E9580-E9589

Research output: Contribution to journalArticle

Cystatins
Triple Negative Breast Neoplasms
Estrogen Receptor beta
Neoplasm Metastasis
Therapeutics

Germline genome-wide association studies in women receiving neoadjuvant chemotherapy with or without bevacizumab

Ingle, J. N., Kalari, K. R., Wickerham, D. L., Von Minckwitz, G., Fasching, P. A., Furukawa, Y., Mushiroda, T., Goetz, M. P., Barman, P., Carlson, E. E., Rastogi, P., Costantino, J. P., Cairns, J., Paik, S., Bear, H. D., Kubo, M., Wang, L. M., Wolmark, N. & Weinshilboum, R. M., Jan 1 2018, In : Pharmacogenetics and Genomics. 28, 6, p. 147-152 6 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Single Nucleotide Polymorphism
Drug Therapy
Disease-Free Survival
Genome
Gene transfer
Horizontal Gene Transfer
Workflow
Sequencing
Work Flow

Hormonal agents

Giridhar, K., Kohli, M. & Goetz, M. P., Nov 16 2018, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology. Wolters Kluwer Health Pharma Solutions (Europe) Ltd, p. 348-358 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Innovative Strategies: Targeting Subtypes in Metastatic Breast Cancer

Pegram, M. D., Zong, Y., Yam, C., Goetz, M. P. & Moulder, S. L., May 23 2018, In : American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 38, p. 65-77 13 p.

Research output: Contribution to journalReview article

Breast Neoplasms
Disease-Free Survival
Pharmaceutical Preparations
Triple Negative Breast Neoplasms
Drug Approval
7 Citations (Scopus)

NOTCH3 expression is linked to breast cancer seeding and distant metastasis

Leontovich, A. A., Jalalirad, M., Salisbury, J. L., Mills, L., Haddox, C., Schroeder, M., Tuma, A., Guicciardi, M. E., Zammataro, L., Gambino, M. W., Amato, A., Di Leonardo, A., McCubrey, J., Lange, C. A., Liu, M. C., Haddad, T. C., Goetz, M. P., Boughey, J. C., Sarkaria, J. N., Wang, L. M. & 3 others, Ingle, J. N., Galanis, E. & D'Assoro, A., Sep 4 2018, In : Breast Cancer Research. 20, 1, 105.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Phenotype
63 Citations (Scopus)

Tailoring adjuvant endocrine therapy for premenopausal breast cancer

Francis, P. A., Pagani, O., Fleming, G. F., Walley, B. A., Colleoni, M., Láng, I., Gómez, H. L., Tondini, C., Ciruelos, E., Burstein, H. J., Bonnefoi, H. R., Bellet, M., Martino, S., Geyer, C. E., Goetz, M. P., Stearns, V., Pinotti, G., Puglisi, F., Spazzapan, S., Climent, M. A. & 16 others, Pavesi, L., Ruhstaller, T., Davidson, N. E., Coleman, R., Debled, M., Buchholz, S., Ingle, J. N., Winer, E. P., Maibach, R., Rabaglio-Poretti, M., Ruepp, B., Di Leo, A., Coates, A. S., Gelber, R. D., Goldhirsch, A. & Regan, M. M., Jul 12 2018, In : New England Journal of Medicine. 379, 2, p. 122-137 16 p.

Research output: Contribution to journalArticle

exemestane
Tamoxifen
Breast Neoplasms
Therapeutics
Recurrence

The development of endoxifen for breast cancer

Goetz, M. P., Feb 1 2018, In : Clinical Advances in Hematology and Oncology. 16, 2, p. 102-105 4 p.

Research output: Contribution to journalComment/debate

Breast Neoplasms
4-hydroxy-N-desmethyltamoxifen
4 Citations (Scopus)

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

Kurmi, K., Hitosugi, S., Yu, J., Boakye-Agyeman, F., Wiese, E. K., Larson, T. R., Dai, Q., Machida, Y., Lou, Z., Wang, L. M., Boughey, J. C., Kaufmann, S. H., Goetz, M. P., Karnitz, L. M. & Hitosugi, T. D., Dec 4 2018, In : Cell Metabolism. 28, 6, p. 833-847.e8

Research output: Contribution to journalArticle

Mitochondrial Form Creatine Kinase
Phosphocreatine
Tyrosine
Phosphorylation
Breast Neoplasms
2017
8 Citations (Scopus)

A comprehensive analysis of breast cancer microbiota and host gene expression

Thompson, K. J., Ingle, J. N., Tang, X., Chia, N. D., Jeraldo, P. R., Walther-Antonio, M., Kandimalla, K. K., Johnson, S., Yao, J. Z., Harrington, S. C., Suman, V. J., Wang, L. M., Weinshilboum, R. M., Boughey, J. C., Kocher, J-P., Nelson, H., Goetz, M. P. & Kalari, K. R., Nov 1 2017, In : PLoS One. 12, 11, e0188873.

Research output: Contribution to journalArticle

Microbiota
Gene expression
breast neoplasms
Tumors
Breast Neoplasms
19 Citations (Scopus)

A phase II trial of neoadjuvant MK-2206, an AKT inhibitor, with anastrozole in clinical stage II or III PIK3CA-mutant ER-positive and HER2-negative breast cancer

Ma, C. X., Suman, V. J., Goetz, M. P., Northfelt, D. W., Burkard, M. E., Ademuyiwa, F., Naughton, M., Margenthaler, J., Aft, R., Gray, R., Tevaarwerk, A., Wilke, L., Haddad, T. C., Moynihan, T., Loprinzi, C. L., Hieken, T. J., Barnell, E. K., Skidmore, Z. L., Feng, Y. Y., Krysiak, K. & 14 others, Hoog, J., Guo, Z., Nehring, L., Wisinski, K. B., Mardis, E., Hagemann, I. S., Vij, K., Sanati, S., Al-Kateb, H., Griffith, O. L., Griffith, M., Doyle, L., Erlichman, C. & Ellis, M. J., Nov 15 2017, In : Clinical Cancer Research. 23, 22, p. 6823-6832 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Estrogens
Phosphorylation
Goserelin
Apoptosis
12 Citations (Scopus)

A phase I study of cilengitide and paclitaxel in patients with advanced solid tumors

Haddad, T. C., Qin, R., Lupu, R., Satele, D., Eadens, M., Goetz, M. P., Erlichman, C. & Molina, J. R., Jun 1 2017, In : Cancer Chemotherapy and Pharmacology. 79, 6, p. 1221-1227 7 p.

Research output: Contribution to journalArticle

Paclitaxel
Tumors
Neoplasms
Clinical Trials, Phase I
Maximum Tolerated Dose
39 Citations (Scopus)

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

Liu, T., Yu, J., Deng, M., Yin, Y., Zhang, H., Luo, K., Qin, B., Li, Y., Wu, C., Ren, T., Han, Y., Yin, P., Kim, J. J., Lee, S. B., Lin, J., Zhang, L., Zhang, J., Nowsheen, S., Wang, L. M., Boughey, J. C. & 3 others, Goetz, M. P., Yuan, J. & Lou, Z., Jan 9 2017, In : Nature Communications. 8, 13923.

Research output: Contribution to journalArticle

metastasis
Tumors
breast
cancer
Chemical activation
35 Citations (Scopus)

Efficacy of the PARP inhibitor veliparib with carboplatin or as a single agent in patients with germline BRCA1- or BRCA2-associated metastatic breast cancer: California Cancer Consortium trial NCT01149083

Somlo, G., Frankel, P. H., Arun, B. K., Ma, C. X., Garcia, A. A., Cigler, T., Cream, L. V., Harvey, H. A., Sparano, J. A., Nanda, R., Chew, H. K., Moynihan, T. J., Vahdat, L. T., Goetz, M. P., Beumer, J. H., Hurria, A., Mortimer, J., Piekarz, R., Sand, S., Herzog, J. & 7 others, Van Tongeren, L. R., Ferry-Galow, K. V., Chen, A. P., Ruel, C., Newman, E. M., Gandara, D. R. & Weitzel, J. N., Aug 1 2017, In : Clinical Cancer Research. 23, 15, p. 4066-4076 11 p.

Research output: Contribution to journalArticle

Carboplatin
Proxy
Breast Neoplasms
Neoplasms
Disease-Free Survival
3 Citations (Scopus)

ERβ inhibits cyclin dependent kinases 1 and 7 in triple negative breast cancer

Reese, J. M., Bruinsma, E. S., Monroe, D. G., Negron, V., Suman, V. J., Ingle, J. N., Goetz, M. P. & Hawse, J. R., Jan 1 2017, In : Oncotarget. 8, 57, p. 96506-96521 16 p.

Research output: Contribution to journalArticle

CDC2 Protein Kinase
Triple Negative Breast Neoplasms
Estrogen Receptor beta
Cell Cycle
Cyclin H
10 Citations (Scopus)

Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study

Yu, J., Qin, B., Moyer, A., Sinnwell, J. P., Thompson, K. J., Copland, J. A. III., Marlow, L. A., Miller, J. L., Yin, P., Gao, B., Minter-Dykhouse, K., Tang, X., McLaughlin, S. A., Moreno Aspitia, A., Schweitzer, A., Lu, Y., Hubbard, J., Northfelt, D. W., Gray, R. J., Hunt, K. & 10 others, Conners, A. L., Suman, V. J., Kalari, K. R., Ingle, J. N., Lou, Z., Visscher, D. W., Weinshilboum, R. M., Boughey, J. C., Goetz, M. P. & Wang, L. M., Dec 6 2017, In : Breast cancer research : BCR. 19, 1, 1 p.

Research output: Contribution to journalArticle

Heterografts
Breast Neoplasms
Biopsy
Drug Therapy
Neoplasms
1 Citation (Scopus)

Factors Influencing Use of Hormone Therapy for Ductal Carcinoma In Situ: A National Cancer Database Study

Nguyen, T. T., Hoskin, T. L., Day, C. N., Habermann, E. B., Goetz, M. P. & Boughey, J. C., Aug 1 2017, (Accepted/In press) In : Annals of Surgical Oncology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
Databases
Hormones
Neoplasms
Mastectomy
22 Citations (Scopus)

First-in-human phase I Study of the tamoxifen metabolite Z-endoxifen in women with endocrine-refractory metastatic breast cancer

Goetz, M. P., Suman, V. J., Reid, J. M., Northfelt, D. W., Mahr, M. A., Ralya, A. T., Kuffel, M., Visscher, S. A., Kipp, B. R., Liu, M. C., Hawse, J. R., Ames, M. M., Ingle Buhrow, J. N., Safgren, S. L., McGovern, R. M., Black, J., Dockter, T., Haddad, T. C., Erlichman, C., Adjei, A. & 7 others, Collins, D., Streicher, H., Chalmers, Z. R., Frampton, G., Hawse, J. R., Doroshow, J. H. & Collins, J. M., Oct 20 2017, In : Journal of Clinical Oncology. 35, 30, p. 3391-3400 10 p.

Research output: Contribution to journalArticle

Tamoxifen
Breast Neoplasms
Maximum Tolerated Dose
Mutation
Cytochrome P-450 CYP2D6
8 Citations (Scopus)
Axilla
Hormones
Breast Neoplasms
10 Citations (Scopus)

Impact of histopathology, tumor-infiltrating lymphocytes, and adjuvant chemotherapy on prognosis of triple-negative breast cancer

Leon-Ferre, R. A., Polley, M-Y., Liu, H., Gilbert, J. A., Cafourek, V., Hillman, D. W., Elkhanany, A., Akinhanmi, M., Lilyquist, J., Thomas, A., Negron, V., Boughey, J. C., Liu, M. C., Ingle, J. N., Kalari, K. R., Couch, F. J., Visscher, D. W. & Goetz, M. P., Sep 14 2017, (Accepted/In press) In : Breast Cancer Research and Treatment. p. 1-11 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Tumor-Infiltrating Lymphocytes
Adjuvant Chemotherapy
Disease-Free Survival
Survival
10 Citations (Scopus)

Low PTEN levels and PIK3CA mutations predict resistance to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2 over-expressing breast cancer

Rimawi, M. F., de Angelis, C., Contreras, A., Pareja, F., Geyer, F. C., Burke, K. A., Herrera, S., Wang, T., Mayer, I. A., Forero, A., Nanda, R., Goetz, M. P., Chang, J. C., Krop, I. E., Wolff, A. C., Pavlick, A. C., Fuqua, S. A. W., Gutierrez, C., Hilsenbeck, S. G., Li, M. M. & 4 others, Weigelt, B., Reis-Filho, J. S., Kent Osborne, C. & Schiff, R., Nov 7 2017, (Accepted/In press) In : Breast Cancer Research and Treatment. p. 1-10 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Drug Therapy
Mutation
Phosphatidylinositol 3-Kinases
Estrogen Receptors
5 Citations (Scopus)

Molecular targeting of the Aurora-A/SMAD5 oncogenic axis restores chemosensitivity in human breast cancer cells

Opyrchal, M., Malgorzata, G., Salisbury, J. L., Goetz, M. P., Suman, V. J., Degnim, A. C., McCubrey, J., Haddad, T. C., Iankov, I., Kurokawa, C. B., Shumacher, N., Ingle, J. N., Galanis, E. & D'Assoro, A., 2017, In : Oncotarget. 8, 53, p. 91803-91816 14 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplastic Stem Cells
Aurora Kinase A
Drug Resistance
Epithelial-Mesenchymal Transition
214 Citations (Scopus)

MONARCH 3: Abemaciclib as initial therapy for advanced breast cancer

Goetz, M. P., Toi, M., Campone, M., Trédan, O., Bourayou, N., Sohn, J., Park, I. H., Paluch-Shimon, S., Huober, J., Chen, S. C., Manso, L., Barriga, S., Freedman, O. C., Jaliffe, G. G., Forrester, T., Frenzel, M., Smith, I. C. & Di Leo, A., Nov 10 2017, In : Journal of Clinical Oncology. 35, 32, p. 3638-3646 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Placebos
Disease-Free Survival
Aromatase Inhibitors
Therapeutics
120 Citations (Scopus)

NCCN Guidelines® insights breast cancer, version 1.2017: Featured updates to the NCCN Guidelines

Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A., Elias, A. D., Farrar, W. B., Forero, A., Giordano, S. H., Goetz, M. P., Goldstein, L. J., Isakoff, S. J., Lyons, J., Kelly Marcom, P., Mayer, I. A., McCormick, B., Moran, M. S., O'Regan, R. M., Patel, S. A. & 13 others, Pierce, L. J., Reed, E. C., Salerno, K. E., Schwartzberg, L. S., Sitapati, A., Smith, K. L., Smith, M. L., Soliman, H., Somlo, G., Telli, M., Ward, J. H., Shead, D. A. & Kumar, R., Apr 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 4, p. 433-451 19 p.

Research output: Contribution to journalArticle

Guidelines
Breast Neoplasms
Drug Approval
Radiotherapy
Hormones
61 Citations (Scopus)

NeoPalAna: Neoadjuvant palbociclib, a cyclin-dependent kinase 4/6 inhibitor, and anastrozole for clinical stage 2 or 3 estrogen receptor–positive breast cancer

Ma, C. X., Gao, F., Luo, J., Northfelt, D. W., Goetz, M. P., Forero, A., Hoog, J., Naughton, M., Ademuyiwa, F., Suresh, R., Anderson, K. S., Margenthaler, J., Aft, R., Hobday, T. J., Moynihan, T., Gillanders, W., Cyr, A., Eberlein, T. J., Hieken, T. J., Krontiras, H. & 14 others, Guo, Z., Lee, M. V., Spies, N. C., Skidmore, Z. L., Griffith, O. L., Griffith, M., Thomas, S., Bumb, C., Vij, K., Huang Bartlett, C., Koehler, M., Al-Kateb, H., Sanati, S. & Ellis, M. J., Aug 1 2017, In : Clinical Cancer Research. 23, 15, p. 4055-4065 11 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 6
Cyclin-Dependent Kinase 4
Estrogens
Breast Neoplasms
Cell Cycle Checkpoints
34 Citations (Scopus)

Neratinib efficacy and circulating tumor DNA detection of HER2 mutations in HER2 nonamplified metastatic breast cancer

Ma, C. X., Bose, R., Gao, F., Freedman, R. A., Telli, M. L., Kimmick, G., Winer, E., Naughton, M., Goetz, M. P., Russell, C., Tripathy, D., Cobleigh, M., Forero, A., Pluard, T. J., Anders, C., Niravath, P. A., Thomas, S., Anderson, J., Bumb, C., Banks, K. C. & 10 others, Lanman, R. B., Bryce, R., Lalani, A. S., Pfeifer, J., Hayes, D. F., Pegram, M., Blackwell, K., Bedard, P. L., Al-Kateb, H. & Ellis, M. J. C., Oct 1 2017, In : Clinical Cancer Research. 23, 19, p. 5687-5695 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Mutation
DNA
Neoplasms
DNA Sequence Analysis
7 Citations (Scopus)

North Central Cancer Treatment Group N0543 (Alliance): A phase 2 trial of pharmacogenetic-based dosing of irinotecan, oxaliplatin, and capecitabine as first-line therapy for patients with advanced small bowel adenocarcinoma

Mc Williams, R. R., Foster, N. R., Mahoney, M. R., Smyrk, T. C., Murray, J. A., Ames, M. M., Horvath, L. E., Schneider, D. J., Hobday, T. J., Jatoi, A., Meyers, J. P. & Goetz, M. P., 2017, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

irinotecan
oxaliplatin
Pharmacogenetics
Adenocarcinoma
Genotype
33 Citations (Scopus)

Pembrolizumab induced bulbar myopathy and respiratory failure with necrotizing myositis of the diaphragm

Haddox, C. L., Shenoy, N., Shah, K. K., Kao, J. C., Jain, S., Halfdanarson, T. R., Wijdicks, E. F. & Goetz, M. P., 2017, In : Annals of Oncology. 28, 3, p. 673-675 3 p.

Research output: Contribution to journalLetter

Myositis
Muscular Diseases
Diaphragm
Respiratory Insufficiency
pembrolizumab
2 Citations (Scopus)

Phase I trial to evaluate the addition of alisertib to fulvestrant in women with endocrine-resistant, ER+ metastatic breast cancer

Haddad, T. C., D'Assoro, A., Suman, V. J., Opyrchal, M., Peethambaram, P., Liu, M. C., Goetz, M. P. & Ingle, J. N., Dec 30 2017, (Accepted/In press) In : Breast Cancer Research and Treatment. p. 1-9 9 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Aurora Kinase A
Aromatase Inhibitors
fulvestrant
MLN 8237
13 Citations (Scopus)
Hormones
Guidelines
Breast Neoplasms
Area Under Curve
Logistic Models
14 Citations (Scopus)

Serum thymidine kinase 1 activity as a pharmacodynamic marker of cyclin-dependent kinase 4/6 inhibition in patients with early-stage breast cancer receiving neoadjuvant palbociclib

Bagegni, N., Thomas, S., Liu, N., Luo, J., Hoog, J., Northfelt, D. W., Goetz, M. P., Forero, A., Bergqvist, M., Karen, J., Neumüller, M., Suh, E. M., Guo, Z., Vij, K., Sanati, S., Ellis, M. & Ma, C. X., Nov 21 2017, In : Breast Cancer Research. 19, 1, 123.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 6
Cyclin-Dependent Kinase 4
Breast Neoplasms
Serum
Neoplasms

Skeletal and uterotrophic effects of endoxifen in female rats

Gingery, A., Iwaniec, U. T., Subramaniam, M., Turner, R. T., Pitel, K. S., McGovern, R. M., Reid, J. M., Marler, R. J., Ingle, J. N., Goetz, M. P. & Hawse, J. R., Oct 1 2017, In : Endocrinology. 158, 10, p. 3354-3368 15 p.

Research output: Contribution to journalArticle

Tamoxifen
Uterus
Bone and Bones
Epithelial Cells
Breast Neoplasms
6 Citations (Scopus)

SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway

Dudenkov, T. M., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Ibrahim-zada, I., Batzler, A., Jenkins, G. D., Pietrzak, T. L., Carlson, E. E., Barman, P., Goetz, M. P., Northfelt, D. W., Moreno-Aspita, A., Williard, C. V., Kalari, K. R., Nakamura, Y., Wang, L. M. & Weinshilboum, R. M., Jul 1 2017, In : Breast Cancer Research and Treatment. 164, 1, p. 189-199 11 p.

Research output: Contribution to journalArticle

Estrone
Genome-Wide Association Study
Androstenedione
Single Nucleotide Polymorphism
Steryl-Sulfatase
2 Citations (Scopus)

Tumor and serum DNA methylation in women receiving preoperative chemotherapy with or without vorinostat in TBCRC008

Connolly, R. M., Fackler, M. J., Zhang, Z., Zhou, X. C., Goetz, M. P., Boughey, J. C., Walsh, B., Carpenter, J. T., Storniolo, A. M., Watkins, S. P., Gabrielson, E. W., Stearns, V. & Sukumar, S., Sep 16 2017, (Accepted/In press) In : Breast Cancer Research and Treatment. p. 1-10 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Methylation
Drug Therapy
Serum
Neoplasms