Leonard Petrucelli, PhD

Professor

  • 12757 Citations
  • 62 h-Index
1992 …2021
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Amyotrophic Lateral Sclerosis Medicine & Life Sciences
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Tauopathies Medicine & Life Sciences
Mutation Medicine & Life Sciences
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Frontotemporal Lobar Degeneration Medicine & Life Sciences
RNA Medicine & Life Sciences

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Projects 1999 2021

Identifying genes and Pathways that impact Tau Toxicity in FTD

Dickson, D. W. & Petrucelli, L.

National Institutes of Health

9/30/166/30/21

Project: Research projectSpecialized Center--Cooperative Agreements

Tauopathies
Genes
Progressive Supranuclear Palsy
Research
Parkinsonian Disorders
Dipeptides
Proteins
Yeasts
Karyopherins
Neurons

Pathobiology of Neurodegeneration in C9ORF72 Repeat Expansion

Boylan, K. B., Petrucelli, L. & Dickson, D. W.

National Institutes of Health

9/30/146/30/19

Project: Research projectResearch Program Projects

Amyotrophic Lateral Sclerosis
Frontotemporal Lobar Degeneration
Methylation
RNA-Binding Proteins
Histones

The role of acetylation in regulating pathophysiology of tau

Petrucelli, L. & Wolozin, B.

National Institutes of Health

9/1/148/31/19

Project: Research projectResearch Project

Histone Deacetylases
Acetylation
Tauopathies
Antisense Oligonucleotides
Pathology

MAYO ALZHEIMERS DISEASE RESEARCH CENTER

Petrucelli, L., Tangalos, E. G., Jack, C. R. J., Dickson, D. W., Boeve, B. F., Younkin, S. G., Kantarci, K. M., Smith, G. E., Rademakers, R. V., Petersen, R. C., Pankratz, V. S., Yen, S. C., Tangalos, E. G., Jack, C. R. J., Dickson, D. W., Vemuri, P. D., Lucas, J. A., Knopman, D. S., Hutton, M. L., Bu, G. D., Edland, S. D., Hutton, M. L., Clifford, J., Kokman, E., Ertekin-Taner, N., Hutton, M. L. & Ertekin-Taner, N.

National Institutes of Health

5/1/994/30/19

Project: Research projectSpecialized Center

Alzheimer Disease
Research
Dementia
Lewy Body Disease
Brain

Research Output 1992 2018

  • 12757 Citations
  • 62 h-Index
  • 174 Article
  • 4 Chapter
  • 2 Review article

APOE ε2 is associated with increased tau pathology in primary tauopathy

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R. V., Murray, M. E., Koga, S. & 3 othersDickson, D. W., Ross, O. A. & Bu, G. D., Dec 1 2018, In : Nature communications. 9, 1, 4388.

Research output: Contribution to journalArticle

Tauopathies
pathology
Apolipoproteins E
Pathology
mice

Association of Apolipoprotein e ϵ4 with Transactive Response DNA-Binding Protein 43

Wennberg, A. M., Tosakulwong, N., Lesnick, T. G., Murray, M. E., Whitwell, J. L., Liesinger, A. M., Petrucelli, L., Boeve, B. F., Parisi, J. E., Knopman, D. S., Petersen, R. C., Dickson, D. W. & Josephs, K. A., Jan 1 2018, (Accepted/In press) In : JAMA neurology. p. E1-E8

Research output: Contribution to journalArticle

Apolipoproteins
DNA-Binding Proteins
Apolipoproteins E
Alzheimer Disease
Alleles
6 Citations

A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism

Swinnen, B., Bento-Abreu, A., Gendron, T. D., Boeynaems, S., Bogaert, E., Nuyts, R., Timmers, M., Scheveneels, W., Hersmus, N., Wang, J., Mizielinska, S., Isaacs, A. M., Petrucelli, L., Lemmens, R., van Damme, P., van Den Bosch, L. & Robberecht, W., Jan 4 2018, (Accepted/In press) In : Acta Neuropathologica. p. 1-17 17 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Zebrafish
Dipeptides
RNA
Arginine

Converging pathways in neurodegeneration, from genetics to mechanisms

Gan, L., Cookson, M. R., Petrucelli, L. & La Spada, A. R., Oct 1 2018, In : Nature Neuroscience. 21, 10, p. 1300-1309 10 p.

Research output: Contribution to journalReview article

Neurodegenerative Diseases
Medical Genetics
Rare Diseases
Innate Immunity
Quality Control

CRISPR expands insight into the mechanisms of ALS and FTD

Pickles, S. & Petrucelli, L., Apr 25 2018, (Accepted/In press) In : Nature Reviews Neurology. p. 1-2 2 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Hand Strength
Therapeutics
Frontotemporal Dementia With Motor Neuron Disease
Gene Editing