Leonard Petrucelli, PhD

Professor

  • 13055 Citations
  • 62 h-Index
1992 …2021
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  • 27 Similar Profiles
Amyotrophic Lateral Sclerosis Medicine & Life Sciences
Frontotemporal Dementia Medicine & Life Sciences
DNA-Binding Proteins Medicine & Life Sciences
Tauopathies Medicine & Life Sciences
Mutation Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Frontotemporal Lobar Degeneration Medicine & Life Sciences
RNA Medicine & Life Sciences

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Projects 1999 2021

Identifying genes and Pathways that impact Tau Toxicity in FTD

Dickson, D. W. & Petrucelli, L.

National Institutes of Health

9/30/166/30/21

Project: Research projectSpecialized Center--Cooperative Agreements

Tauopathies
Genes
Progressive Supranuclear Palsy
Research
Parkinsonian Disorders
Dipeptides
Proteins
Yeasts
Karyopherins
Neurons

Pathobiology of Neurodegeneration in C9ORF72 Repeat Expansion

Boylan, K. B., Petrucelli, L. & Dickson, D. W.

National Institutes of Health

9/30/146/30/19

Project: Research projectResearch Program Projects

Amyotrophic Lateral Sclerosis
Frontotemporal Lobar Degeneration
Methylation
RNA-Binding Proteins
Histones

The role of acetylation in regulating pathophysiology of tau

Petrucelli, L. & Wolozin, B.

National Institutes of Health

9/1/148/31/19

Project: Research projectResearch Project

Histone Deacetylases
Acetylation
Tauopathies
Antisense Oligonucleotides
Pathology

MAYO ALZHEIMERS DISEASE RESEARCH CENTER

Petrucelli, L., Tangalos, E. G., Jack, C. R. J., Dickson, D. W., Boeve, B. F., Younkin, S. G., Kantarci, K. M., Smith, G. E., Rademakers, R. V., Petersen, R. C., Pankratz, V. S., Yen, S. C., Tangalos, E. G., Jack, C. R. J., Dickson, D. W., Vemuri, P. D., Lucas, J. A., Knopman, D. S., Hutton, M. L., Bu, G. D., Edland, S. D., Hutton, M. L., Clifford, J., Kokman, E., Ertekin-Taner, N., Hutton, M. L. & Ertekin-Taner, N.

National Institutes of Health

5/1/994/30/19

Project: Research projectSpecialized Center

Alzheimer Disease
Research
Dementia
Lewy Body Disease
Brain

Research Output 1992 2019

  • 13055 Citations
  • 62 h-Index
  • 176 Article
  • 4 Chapter
  • 2 Review article

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Carlomagno, Y., Chung, D. E. C., Yue, M., Kurti, A., Avendano, N. M., Castanedes-Casey, M., Hinkle, K. M., Jansen-West, K., Daughrity, L. M., Tong, J., Phillips, V., Rademakers, R. V., Deture, M., Fryer, J. D., Dickson, D. W., Petrucelli, L. & Cook, C., Jan 23 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Dependovirus
Phosphorylation
Tauopathies
Brain
Progressive Supranuclear Palsy

Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains

Josephs, K. A., Murray, M. E., Tosakulwong, N., Weigand, S. D., Serie, A. M., Perkerson, R. B., Matchett, B. J., Jack, C. R. J., Knopman, D. S., Petersen, R. C., Parisi, J. E., Petrucelli, L., Baker, M., Rademakers, R. V., Whitwell, J. L. & Dickson, D. W., Jan 1 2019, (Accepted/In press) In : Acta neuropathologica.

Research output: Contribution to journalArticle

Amygdala
Frontotemporal Lobar Degeneration
Brain
Neuroimaging
Hippocampus
1 Citations

APOE ε2 is associated with increased tau pathology in primary tauopathy

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R. V., Murray, M. E., Koga, S. & 3 othersDickson, D. W., Ross, O. A. & Bu, G. D., Dec 1 2018, In : Nature communications. 9, 1, 4388.

Research output: Contribution to journalArticle

Tauopathies
pathology
Apolipoproteins E
Pathology
mice
1 Citations

Association of Apolipoprotein e ϵ4 with Transactive Response DNA-Binding Protein 43

Wennberg, A. M., Tosakulwong, N., Lesnick, T. G., Murray, M. E., Whitwell, J. L., Liesinger, A. M., Petrucelli, L., Boeve, B. F., Parisi, J. E., Knopman, D. S., Petersen, R. C., Dickson, D. W. & Josephs, K. A., Jan 1 2018, (Accepted/In press) In : JAMA neurology. p. E1-E8

Research output: Contribution to journalArticle

Apolipoproteins
DNA-Binding Proteins
Apolipoproteins E
Alzheimer Disease
Alleles
6 Citations

A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism

Swinnen, B., Bento-Abreu, A., Gendron, T. D., Boeynaems, S., Bogaert, E., Nuyts, R., Timmers, M., Scheveneels, W., Hersmus, N., Wang, J., Mizielinska, S., Isaacs, A. M., Petrucelli, L., Lemmens, R., van Damme, P., van Den Bosch, L. & Robberecht, W., Jan 4 2018, (Accepted/In press) In : Acta Neuropathologica. p. 1-17 17 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Zebrafish
Dipeptides
RNA
Arginine