Jonathan Graff-Radford, MD

  • 1600 Citations
  • 22 Scopus h-Index
20062019
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Research Output 2006 2019

2019
4 Citations (Scopus)
Lewy Body Disease
Atrophy
Occipital Lobe
Lewy Bodies
Atlases

Amyloid, Vascular, and Resilience Pathways Associated with Cognitive Aging

Vemuri, P., Lesnick, T. G., Knopman, D. S., Przybelski, S. A., Reid, R. I., Mielke, M. M., Graff-Radford, J., Lowe, V. J., Machulda, M. M., Petersen, R. C. & Jack, C. R., Jan 1 2019, (Accepted/In press) In : Annals of neurology.

Research output: Contribution to journalArticle

Open Access
Amyloid
Blood Vessels
Health
Occupations
Diffusion Tensor Imaging
Open Access
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Executive Function
Dementia
Clinical Trials
Open Access
Apolipoprotein E4
Entorhinal Cortex
Amyloidosis
Amyloid
Education
3 Citations (Scopus)
Amyloid
Dementia
Biomarkers
Positron-Emission Tomography
National Institute on Aging (U.S.)

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers

Chen, Q., Boeve, B. F., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J. A., Forsberg, L., Gavrilova, R. M., Gearhart, D., Haley, D., Gunter, J. L., Graff-Radford, J., Jones, D. T., Knopman, D. S., Graff Radford, N. R., Kraft, R., Lapid, M. I., Rademakers, R. V., Wszolek, Z. K. & 3 others, Rosen, H., Boxer, A. L. & Kantarci, K. M., Jan 1 2019, In : Journal of Neuroimaging.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Magnetic Resonance Spectroscopy
Mutation
Brain
Gyrus Cinguli

Cardiometabolic Health and Longitudinal Progression of White Matter Hyperintensity: The Mayo Clinic Study of Aging

Scharf, E. L., Graff-Radford, J., Przybelski, S. A., Lesnick, T. G., Mielke, M. M., Knopman, D. S., Preboske, G. M., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Machulda, M., Kantarci, K., Petersen, R. C., Jack, C. R. & Vemuri, P., Nov 1 2019, In : Stroke. 50, 11, p. 3037-3044 8 p.

Research output: Contribution to journalArticle

Health
Hypertension
Glucose
White Matter
Fasting
3 Citations (Scopus)

Cerebral microbleeds: Prevalence and relationship to amyloid burden

Graff-Radford, J., Botha, H., Rabinstein, A., Gunter, J. L., Przybelski, S. A., Lesnick, T., Huston, J., Flemming, K., Preboske, G. M., Senjem, M. L., Brown, R. D. J., Mielke, M. M., Roberts, R. O., Lowe, V., Knopman, D. S., Petersen, R. C., Kremers, W. K., Vemuri, P. D., Jack, C. R. J. & Kantarci, K. M., Jan 15 2019, In : Neurology. 92, 3, p. e253-e262

Research output: Contribution to journalArticle

Amyloid
Parietal Lobe
Logistic Models
Population
Hypertension
1 Citation (Scopus)
Intelligence Tests
Dementia
Alzheimer Disease
Referral and Consultation
Research

Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin

Mielke, M. M., Syrjanen, J. A., Blennow, K., Zetterberg, H., Skoog, I., Vemuri, P., Machulda, M. M., Graff-Radford, J., Knopman, D. S., Jack, C. R., Petersen, R. C. & Kern, S., Nov 2019, In : Alzheimer's and Dementia. 15, 11, p. 1437-1447 11 p.

Research output: Contribution to journalArticle

Neurogranin
Intermediate Filaments
Cerebrospinal Fluid
Light
Amyloid

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V. J., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M. K., Murray, M. E., Kantarci, K., Jones, D. T., Vemuri, P., Graff-Radford, J., Schwarz, C. G., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R., Jul 2 2019, In : Neurology. 93, 1, p. e29-e39

Research output: Contribution to journalArticle

Entorhinal Cortex
Temporal Lobe
Cognition
Amyloid
Brain

CSF1R mutation presenting as dementia with Lewy bodies

Sharma, R., Graff-Radford, J., Rademakers, R. V., Boeve, B. F., Petersen, R. C. & Jones, D. T., Jan 1 2019, In : Neurocase.

Research output: Contribution to journalArticle

Lewy Body Disease
Mutation
Colony-Stimulating Factor Receptors
Leukoencephalopathies
Macrophage Colony-Stimulating Factor

Dementia untangled

Graff-Radford, J. & Lewis, S. L., Feb 1 2019, In : CONTINUUM Lifelong Learning in Neurology. 25, 1, p. 12-13 2 p.

Research output: Contribution to journalEditorial

Dementia
Open Access
Ceramides
Sphingolipids
Cerebrovascular Disorders
Hypertension
Electrospray Ionization Mass Spectrometry
9 Citations (Scopus)
Entorhinal Cortex
Amyloid
Biomarkers
Repression (Psychology)
Verbal Learning
Dementia
Lewy Body Disease
Alzheimer Disease
Frontotemporal Dementia

Exposure to surgery under general anaesthesia and brain magnetic resonance imaging changes in older adults

Sprung, J., Kruthiventi, S. C., Warner, D. O., Knopman, D. S., Petersen, R. C., Mielke, M. M., Jack, C. R., Graff-Radford, J., Martin, D. P., Hanson, A. C., Schroeder, D. R., Przybelski, S. A., Schulte, P. J., Weingarten, T. N. & Vemuri, P., Jan 1 2019, (Accepted/In press) In : British journal of anaesthesia.

Research output: Contribution to journalArticle

General Anesthesia
Magnetic Resonance Imaging
Brain
Alzheimer Disease
Confidence Intervals
1 Citation (Scopus)

Frontal lobe 1H MR spectroscopy in asymptomatic and symptomatic MAPT mutation carriers

Chen, Q., Boeve, B. F., Tosakulwong, N., Lesnick, T., Brushaber, D., Dheel, C., Fields, J. A., Forsberg, L., Gavrilova, R. M., Gearhart, D., Haley, D., Gunter, J. L., Graff-Radford, J., Jones, D. T., Knopman, D. S., Graff Radford, N. R., Kraft, R., Lapid, M. I., Rademakers, R. V., Syrjanen, J. & 4 others, Wszolek, Z. K., Rosen, H., Boxer, A. L. & Kantarci, K. M., Jan 1 2019, In : Neurology. 93, 8, p. E758-E765

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Frontal Lobe
Magnetic Resonance Spectroscopy
Creatine
Inositol

Incidence of Convexal Subarachnoid Hemorrhage in the Elderly: The Mayo Clinic Study of Aging

Yost, M., Fiebelkorn, C. A., Rabinstein, A. A., Klaas, J., Aakre, J. A., Brown, R. D., Mielke, M. M., Knopman, D. S., Lowe, V., Petersen, R. C., Jack, C. R., Vemuri, P. & Graff-Radford, J., Dec 2019, In : Journal of Stroke and Cerebrovascular Diseases. 28, 12, 104451.

Research output: Contribution to journalArticle

Subarachnoid Hemorrhage
Cerebral Hemorrhage
Incidence
Population
Medical Record Linkage
2 Citations (Scopus)

Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration

ARTFL/LEFFTDS consortium, Jan 1 2019, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Atrophy
Dementia
Logistic Models
Brain
1 Citation (Scopus)

Longitudinal tau-PET uptake and atrophy in atypical Alzheimer's disease

Sintini, I., Martin, P. R., Graff-Radford, J., Senjem, M. L., Schwarz, C., Machulda, M. M., Spychalla, A. J., Drubach, D., Knopman, D. S., Petersen, R. C., Lowe, V., Jack, C. R. J., Josephs, K. A. & Whitwell, J. L., Jan 1 2019, In : NeuroImage: Clinical. 23, 101823.

Research output: Contribution to journalArticle

Open Access
Atrophy
Alzheimer Disease
Frontal Lobe
Occipital Lobe
Disease Progression

Population-based evaluation of lumbar puncture opening pressures

Wang, F., Lesser, E. R., Cutsforth-Gregory, J. K., Bhatti, M. T., Kilgore, K. P., Hodge, D. O., Graff-Radford, J., Petersen, R. C., Knopman, D. S., Mielke, M. M., Lanzino, G., Leavitt, J. A. & Chen, J., Jan 1 2019, In : Frontiers in Neurology. 10, AUG, 899.

Research output: Contribution to journalArticle

Open Access
Spinal Puncture
Pressure
Population
Body Mass Index
Obstructive Sleep Apnea
5 Citations (Scopus)
National Institute on Aging (U.S.)
Alzheimer Disease
Amyloid
Research
Positron-Emission Tomography
1 Citation (Scopus)

Rates of lobar atrophy in asymptomatic MAPT mutation carriers

Chen, Q., Boeve, B. F., Senjem, M., Tosakulwong, N., Lesnick, T. G., Brushaber, D., Dheel, C., Fields, J., Forsberg, L., Gavrilova, R., Gearhart, D., Graff-Radford, J., Graff-Radford, N. R., Jack, C. R., Jones, D. T., Knopman, D. S., Kremers, W. K., Lapid, M., Rademakers, R., Syrjanen, J. & 4 others, Boxer, A. L., Rosen, H., Wszolek, Z. K. & Kantarci, K., Jan 1 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 338-346 9 p.

Research output: Contribution to journalArticle

Open Access
Microtubule-Associated Proteins
Atrophy
Temporal Lobe
Mutation
Parietal Lobe
1 Citation (Scopus)
Open Access
Amyloid
Alzheimer Disease
Tauopathies
Lewy Body Disease
Amyloidosis
1 Citation (Scopus)

The influence of β-amyloid on [ 18 F]AV-1451 in semantic variant of primary progressive aphasia

Whitwell, J. L., Martin, P. R., Duffy, J. R., Clark, H., Machulda, M. M., Schwarz, C., Weigand, S. D., Sintini, I., Senjem, M. L., Taner, N., Botha, H., Utianski, R., Graff-Radford, J., Jones, D. T., Boeve, B. F., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Josephs, K. A., Feb 12 2019, In : Neurology. 92, 7, p. e710-e722

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Semantics
Amyloid
Alzheimer Disease
Temporal Lobe
1 Citation (Scopus)

The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology

LEFFTDS Consortium, Jan 1 2019, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Dementia
tau Proteins
Chromosomes, Human, Pair 9
2 Citations (Scopus)

The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies

Arenaza-Urquijo, E. M., Przybelski, S. A., Lesnick, T. L., Graff-Radford, J., Machulda, M. M., Knopman, D. S., Schwarz, C., Lowe, V., Mielke, M. M., Petersen, R. C., Jack, C. R. J. & Vemuri, P. D., Apr 1 2019, In : Brain : a journal of neurology. 142, 4, p. 1134-1147 14 p.

Research output: Contribution to journalArticle

Cognition
Alzheimer Disease
Pathology
Brain
Biomarkers

The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease

Whitwell, J. L., Martin, P., Graff-Radford, J., Machulda, M. M., Senjem, M. L., Schwarz, C., Weigand, S. D., Spychalla, A. J., Drubach, D., Jack, C. R. J., Lowe, V. & Josephs, K. A., Jan 1 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Amyloid
Atrophy
Alzheimer Disease
Parietal Lobe
Positron-Emission Tomography

Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers

LEFFTDS Consortium, Nov 2019, In : Neurobiology of aging. 83, p. 54-62 9 p.

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Mutation
Diffusion Tensor Imaging
Anisotropy
Disease Progression

Transient epileptic amnesia: A treatable cause of spells associated with persistent cognitive symptoms

Ramanan, V. K., Morris, K. A., Graff-Radford, J., Jones, D. T., Burkholder, D. B., Britton, J. W., Josephs, K. A., Boeve, B. F. & Savica, R., Jan 1 2019, In : Frontiers in Neurology. 10, AUG, 939.

Research output: Contribution to journalArticle

Open Access
Neurobehavioral Manifestations
Amnesia
Electroencephalography
Behavioral Symptoms
Seizures
2 Citations (Scopus)

Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium

ARTFL/LEFFTDS consortium, Jan 1 2019, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Dementia
Language
Personality
Primary Progressive Nonfluent Aphasia
3 Citations (Scopus)

Vascular cognitive impairment

Graff-Radford, J., Feb 1 2019, In : CONTINUUM Lifelong Learning in Neurology. 25, 1, p. 147-164 18 p.

Research output: Contribution to journalReview article

Blood Vessels
Cerebrovascular Disorders
Neuroimaging
Neurodegenerative Diseases
Dementia

White matter hyperintensities: relationship to amyloid and tau burden

Graff-Radford, J., Arenaza-Urquijo, E. M., Knopman, D. S., Schwarz, C. G., Brown, R. D., Rabinstein, A. A., Gunter, J. L., Senjem, M. L., Przybelski, S. A., Lesnick, T., Ward, C., Mielke, M. M., Lowe, V. J., Petersen, R. C., Kremers, W. K., Kantarci, K., Jack, C. R. & Vemuri, P., Aug 1 2019, In : Brain : a journal of neurology. 142, 8, p. 2483-2491 9 p.

Research output: Contribution to journalArticle

Amyloid
White Matter
Alzheimer Disease
Biomarkers
Cerebral Amyloid Angiopathy
2018
17 Citations (Scopus)

[18F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease

Whitwell, J. L., Graff-Radford, J., Tosakulwong, N., Weigand, S. D., Machulda, M. M., Senjem, M. L., Schwarz, C., Spychalla, A. J., Jones, D. T., Drubach, D., Knopman, D. S., Boeve, B. F., Taner, N., Petersen, R. C., Lowe, V., Jack, C. R. J. & Josephs, K. A., Feb 1 2018, In : Annals of Neurology. 83, 2, p. 248-257 10 p.

Research output: Contribution to journalArticle

Cluster Analysis
Alzheimer Disease
Apolipoprotein E4
Entorhinal Cortex
Neocortex
16 Citations (Scopus)

[18F]AV-1451 tau-PET and primary progressive aphasia

Josephs, K. A., Martin, P. R., Botha, H., Schwarz, C., Duffy, J. R., Clark, H., Machulda, M. M., Graff-Radford, J., Weigand, S. D., Senjem, M. L., Utianski, R., Drubach, D., Boeve, B. F., Jones, D. T., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Whitwell, J. L., Jan 1 2018, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Semantics
Principal Component Analysis
5 Citations (Scopus)

18F-FDG PET-CT pattern in idiopathic normal pressure hydrocephalus

Townley, R. A., Botha, H., Graff-Radford, J., Boeve, B. F., Petersen, R. C., Senjem, M. L., Knopman, D. S., Lowe, V., Jack, C. R. J. & Jones, D. T., Jan 1 2018, In : NeuroImage: Clinical. 18, p. 897-902 6 p.

Research output: Contribution to journalArticle

Normal Pressure Hydrocephalus
Fluorodeoxyglucose F18
Dementia
Alzheimer Disease
Frontotemporal Dementia

Amyloid- and tau-PET imaging in a familial prion kindred

Jones, D. T., Townley, R. A., Graff-Radford, J., Botha, H., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Boeve, B. F., Dec 1 2018, In : Neurology: Genetics. 4, 6, e290.

Research output: Contribution to journalArticle

Prions
Amyloid
Alzheimer Disease
Neurobiology
Amyloid Plaques
9 Citations (Scopus)

Association between microinfarcts and blood pressure trajectories

Graff-Radford, J., Raman, M. R., Rabinstein, A., Przybelski, S. A., Lesnick, T. G., Boeve, B. F., Murray, M. E., Dickson, D. W., Ross Reichard, R., Parisi, J. E., Knopman, D. S., Petersen, R. C., Jack, C. R. J. & Kantarci, K. M., Feb 1 2018, In : JAMA Neurology. 75, 2, p. 212-218 7 p.

Research output: Contribution to journalArticle

Blood Pressure
Autopsy
Cohort Studies
Logistic Models
Regression Analysis
2 Citations (Scopus)
Subarachnoid Space
Hydrocephalus
Cerebrospinal Fluid
ROC Curve
Normal Pressure Hydrocephalus
2 Citations (Scopus)
Lewy Body Disease
Single-Photon Emission-Computed Tomography
Dementia
Corpus Striatum
Putamen
8 Citations (Scopus)

Cognitive dysfunction in atrial fibrillation

Madhavan, M., Graff-Radford, J., Piccini, J. P. & Gersh, B. J., Jan 1 2018, (Accepted/In press) In : Nature Reviews Cardiology.

Research output: Contribution to journalArticle

Atrial Fibrillation
Dementia
Cognition
Cognitive Dysfunction
Catheter Ablation
4 Citations (Scopus)

Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging

Vemuri, P. D., Lesnick, T. G., Przybelski, S. A., Graff-Radford, J., Reid, R. I., Lowe, V., Zuk, S. M., Senjem, M. L., Schwarz, C., Gunter, J. L., Kantarci, K. M., Machulda, M. M., Mielke, M. M., Petersen, R. C., Knopman, D. S. & Jack, C. R. J., Jan 1 2018, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

Biomarkers
Magnetic Resonance Imaging
Health
Blood Vessels
Amyloid
13 Citations (Scopus)

Efficacy of Warfarin Anticoagulation and Incident Dementia in a Community-Based Cohort of Atrial Fibrillation

Madhavan, M., Hu, T. Y., Gersh, B. J., Roger, V. L., Killian, J., Weston, S. A., Graff-Radford, J., Asirvatham, S. J. & Chamberlain, A., Jan 1 2018, (Accepted/In press) In : Mayo Clinic Proceedings.

Research output: Contribution to journalArticle

Warfarin
Atrial Fibrillation
Dementia
Therapeutics
International Normalized Ratio
10 Citations (Scopus)

FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis

Botha, H., Mantyh, W. G., Murray, M. E., Knopman, D. S., Przybelski, S. A., Wiste, H. J., Graff-Radford, J., Josephs, K. A., Schwarz, C., Kremers, W. K., Boeve, B. F., Petersen, R. C., Machulda, M. M., Parisi, J. E., Dickson, D. W., Lowe, V., Jack, C. R. J. & Jones, D. T., Apr 1 2018, In : Brain. 141, 4, p. 1201-1217 17 p.

Research output: Contribution to journalArticle

Sclerosis
Dementia
Autopsy
Amyloid
Fluorodeoxyglucose F18
1 Citation (Scopus)
Cerebral Infarction
Population
Magnetic Resonance Imaging
Diffusion Tensor Imaging
Incidental Findings
12 Citations (Scopus)
Amyloid
Positron-Emission Tomography
Atrophy
Alzheimer Disease
Neuroimaging
13 Citations (Scopus)
Microtubule-Associated Proteins
Protein Isoforms
Mutation
Exons
Alzheimer Disease
42 Citations (Scopus)

Longitudinal tau PET in ageing and Alzheimer's disease

Jack, C. R. J., Wiste, H. J., Schwarz, C., Lowe, V., Senjem, M. L., Vemuri, P. D., Weigand, S. D., Therneau, T. M., Knopman, D. S., Gunter, J. L., Jones, D. T., Graff-Radford, J., Kantarci, K. M., Roberts, R. O., Mielke, M. M., Machulda, M. M. & Petersen, R. C., May 1 2018, In : Brain. 141, 5, p. 1517-1528 12 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Sample Size
Brain
Outcome Assessment (Health Care)

Microinfarcts and blood pressure trajectories: response to Dr Niu et al.

Graff-Radford, J., Rabinstein, A., Lesnick, T. G., Reichard, R. R., Knopman, D. S. & Kantarci, K. M., Apr 3 2018, (Accepted/In press) In : Journal of Human Hypertension. 1 p.

Research output: Contribution to journalArticle

Blood Pressure