Ian R Lanza, PhD

Accepting PhD Students

  • 2810 Citations
  • 29 Scopus h-Index
20032019
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Research Output 2003 2019

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Article
2019

A comprehensive protocol for multiplatform metabolomics analysis in patient-derived skin fibroblasts

Wilkins, J., Sakrikar, D., Petterson, X. M., Lanza, I. R. & Trushina, E. D., Jun 1 2019, In : Metabolomics. 15, 6, 83.

Research output: Contribution to journalArticle

Metabolomics
Fibroblasts
Metabolites
Skin
Mass Spectrometry

Lysosomal Storage and Albinism Due to Effects of a De Novo CLCN7 Variant on Lysosomal Acidification

Undiagnosed Diseases Network, Jun 6 2019, In : American journal of human genetics. 104, 6, p. 1127-1138 12 p.

Research output: Contribution to journalArticle

Albinism
Hypopigmentation
Fibroblasts
Vacuoles
Osteopetrosis

TFAM enhances fat oxidation and attenuates high-fat diet-induced insulin resistance in skeletal muscle

Koh, J. H., Johnson, M. L., Dasari, S., LeBrasseur, N. K., Vuckovic, I., Henderson, G. C., Cooper, S. A., Manjunatha, S., Ruegsegger, G. N., Shulman, G. I., Lanza, I. R. & Nair, K. S., Aug 1 2019, In : Diabetes. 68, 8, p. 1552-1564 13 p.

Research output: Contribution to journalArticle

High Fat Diet
Insulin Resistance
Skeletal Muscle
Fats
Muscles

The clinical impact and biological mechanisms of skeletal muscle aging

Aversa, Z., Zhang, X., Fielding, R. A., Lanza, I. R. & LeBrasseur, N. K., Oct 1 2019, In : Bone. 127, p. 26-36 11 p.

Research output: Contribution to journalArticle

Sarcopenia
Skeletal Muscle
Muscles
Muscular Atrophy
Cell Aging
2018
2 Citations (Scopus)

1α,25-dihydroxyvitamin D3 mitigates cancer cell mediated mitochondrial dysfunction in human skeletal muscle cells

Ryan, Z. C., Craig, T. A., Wang, X., Delmotte, P., Salisbury, J. L., Lanza, I. R., Sieck, G. C. & Kumar, R., Feb 5 2018, In : Biochemical and Biophysical Research Communications. 496, 2, p. 746-752 7 p.

Research output: Contribution to journalArticle

Calcitriol
Skeletal Myoblasts
Oxygen Consumption
Muscle Cells
Muscle

Mitochondrial ADP Sensitivity and Transport: New Insights Into Diet-Induced Mitochondrial Impairments

Hart, C. R. & Lanza, I. R., Nov 1 2018, In : Diabetes. 67, 11, p. 2152-2153 2 p.

Research output: Contribution to journalArticle

Adenosine Diphosphate
Diet
4 Citations (Scopus)

Urinary metabolites associated with blood pressure on a low- or high-sodium diet

Cheng, Y., Song, H., Pan, X., Xue, H., Wan, Y., Wang, T., Tian, Z., Hou, E., Lanza, I. R., Liu, P., Liu, Y., Laud, P. W., Usa, K., He, Y. & Liang, M., Jan 1 2018, In : Theranostics. 8, 6, p. 1468-1480 13 p.

Research output: Contribution to journalArticle

Sodium
Diet
Blood Pressure
Salts
Inbred Dahl Rats
2017
13 Citations (Scopus)
Longitudinal Studies
Liver
Insulin Resistance
Diet
Fast Foods
82 Citations (Scopus)

Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans

Robinson, M. M., Dasari, S., Konopka, A. R., Johnson, M. L., Manjunatha, S., Esponda, R. R., Carter, R. E., Lanza, I. R. & Nair, K. S., Mar 7 2017, In : Cell Metabolism. 25, 3, p. 581-592 12 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Protein Biosynthesis
Proteome
Exercise
DNA Methylation
23 Citations (Scopus)

Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults

Lalia, A. Z., Dasari, S., Robinson, M. M., Abid, H., Morse, D. M., Klaus, K. A. & Lanza, I. R., 2017, In : Aging. 9, 4, p. 1096-1129 34 p.

Research output: Contribution to journalArticle

Muscle Proteins
Omega-3 Fatty Acids
Energy Metabolism
Skeletal Muscle
Exercise
9 Citations (Scopus)

Very-long-chain ω-3 fatty acid supplements and adipose tissue functions: A randomized controlled trial

Hames, K. C., Morgan-Bathke, M., Harteneck, D. A., Zhou, L., Port, J. D., Lanza, I. R. & Jensen, M. D., Jun 1 2017, In : American Journal of Clinical Nutrition. 105, 6, p. 1552-1558 7 p.

Research output: Contribution to journalArticle

Adipocytes
Adipose Tissue
Eicosapentaenoic Acid
Fatty Acids
Randomized Controlled Trials
2016
38 Citations (Scopus)

1α,25-dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells

Ryan, Z. C., Craig, T. A., Folmes, C., Wang, X., Lanza, I. R., Schaible, N. S., Salisbury, J. L., Nair, K. S., Terzic, A., Sieck, G. C. & Kumar, R., Jan 15 2016, In : Journal of Biological Chemistry. 291, 3, p. 1514-1528 15 p., 15.

Research output: Contribution to journalArticle

Calcitriol
Oxygen Consumption
Muscle Cells
Muscle
Skeletal Muscle

Aging metabolism: Evitable or inevitable?

Lanza, I. R., Feb 3 2016, In : Science Translational Medicine. 8, 324, 324ec19.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Altered skeletal muscle mitochondrial proteome as the basis of disruption of mitochondrial function in diabetic mice

Zabielski, P., Lanza, I. R., Gopala, S., Heppelmann, C. J. H., Bergen, H. R. B. III., Dasari, S. & Nair, K. S., Mar 1 2016, In : Diabetes. 65, 3, p. 561-573 13 p.

Research output: Contribution to journalArticle

Proteome
Skeletal Muscle
Insulin
Fatty Acids
Oxidative Stress
18 Citations (Scopus)

Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes

Konopka, A. R., Esponda, R. R., Robinson, M. M., Johnson, M. L., Carter, R. E., Schiavon, M., Cobelli, C., Wondisford, F. E., Lanza, I. R. & Nair, K. S., May 17 2016, In : Cell Reports. 15, 7, p. 1394-1400 7 p.

Research output: Contribution to journalArticle

Prediabetic State
Metformin
Glucagon
Glucose
Cross-Over Studies
32 Citations (Scopus)

Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults

Johnson, M. L., Distelmaier, K., Lanza, I. R., Irving, B. A., Robinson, M. M., Konopka, A. R., Shulman, G. I. & Nair, K. S., Jan 1 2016, In : Diabetes. 65, 1, p. 74-84 11 p.

Research output: Contribution to journalArticle

Caloric Restriction
Insulin Resistance
Thioredoxins
Skeletal Muscle
Glucose

Noninvasive Monitoring of the Mitochondrial Function in Mesenchymal Stromal Cells

Franchi, F., Peterson, K. M., Paulmurugan, R., Folmes, C., Lanza, I. R., Lerman, A. & Rodriguez-Porcel, M. G., Feb 10 2016, (Accepted/In press) In : Molecular Imaging and Biology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Reporter Genes
Firefly Luciferases
Stem Cells
Myocardial Reperfusion
22 Citations (Scopus)

Predictors of whole-body insulin sensitivity across ages and adiposity in adult humans

Lalia, A. Z., Dasari, S., Johnson, M. L., Robinson, M. M., Konopka, A. R., DIstelmaier, K., Port, J. D., Glavin, M. T., Esponda, R. R., Nair, K. S. & Lanza, I. R., Feb 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 2, p. 626-634 9 p.

Research output: Contribution to journalArticle

Adiposity
Insulin Resistance
Insulin
Fats
Abdominal Subcutaneous Fat
2015

A dose of exercise to kick-start your gastric bypass

Lanza, I. R., Sep 23 2015, In : Science Translational Medicine. 7, 306

Research output: Contribution to journalArticle

Gastric Bypass
6 Citations (Scopus)

Application of high-resolution mass spectrometry to measure low abundance isotope enrichment in individual muscle proteins

Hines, K. M., Ford, G. C., Klaus, K. A., Irving, B. A., Ford, B. L., Johnson, K. L., Lanza, I. R. & Nair, K. S., May 28 2015, In : Analytical and Bioanalytical Chemistry. 407, 14, p. 4045-4052 8 p., 8641.

Research output: Contribution to journalArticle

Muscle Proteins
Isotopes
Mass spectrometry
Mass Spectrometry
Electrophoresis, Gel, Two-Dimensional
4 Citations (Scopus)

Association of UCP-3 rs1626521 with obesity and stomach functions in humans

Acosta, A., Camilleri, M., Shin, A., Vazquez Roque, M. I., Iturrino, J., Lanza, I. R., Nair, K. S., Burton, D., O'Neill, J., Eckert, D., Carlson, P., Vella, A. & Zinsmeister, A. R., Apr 1 2015, In : Obesity. 23, 4, p. 898-906 9 p.

Research output: Contribution to journalArticle

Stomach
Obesity
Body Weight
Genes
Meals

Bed rest, then rehab

Lanza, I. R., Aug 12 2015, In : Science Translational Medicine. 7, 300

Research output: Contribution to journalArticle

Bed Rest
35 Citations (Scopus)

Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age

Irving, B. A., Lanza, I. R., Henderson, G. C., Rao, R. R., Spiegelman, B. M. & Nair, K. S., Apr 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 4, p. 1654-1663 10 p.

Research output: Contribution to journalArticle

Resistance Training
Muscle
Skeletal Muscle
Mitochondrial Proteins
Muscle Strength
39 Citations (Scopus)

Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training

Konopka, A. R., Asante, A., Lanza, I. R., Robinson, M. M., Johnson, M. L., Dalla Man, C., Cobelli, C., Amols, M. H., Irving, B. A. & Nair, K. S., Jun 1 2015, In : Diabetes. 64, 6, p. 2104-2115 12 p.

Research output: Contribution to journalArticle

Exercise
Phenotype
Meals
Insulin Resistance
Obesity
30 Citations (Scopus)

Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging

Johnson, M. L., Irving, B. A., Lanza, I. R., Vendelbo, M. H., Konopka, A. R., Robinson, M. M., Henderson, G. C., Klaus, K. A., Morse, D. M., Heppelmann, C., Bergen, H. R. B. III., Dasari, S., Schimke, J. M., Jakaitis, D. R. & Nair, K. S., Nov 1 2015, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 70, 11, p. 1386-1393 8 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Acetylation
Proteolysis
Exercise
Muscle Proteins
22 Citations (Scopus)

Effects of dietary n-3 fatty acids on hepatic and peripheral insulin sensitivity in insulin-resistant humans

Lalia, A. Z., Johnson, M. L., Jensen, M. D., Hames, K. C., Port, J. D. & Lanza, I. R., Jul 1 2015, In : Diabetes Care. 38, 7, p. 1228-1237 10 p.

Research output: Contribution to journalArticle

Eicosapentaenoic Acid
Docosahexaenoic Acids
Omega-3 Fatty Acids
Insulin Resistance
Insulin
22 Citations (Scopus)

Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice

Johnson, M. L., Lalia, A. Z., Dasari, S., Pallauf, M., Fitch, M., Hellerstein, M. K. & Lanza, I. R., Oct 1 2015, In : Aging Cell. 14, 5, p. 734-743 10 p.

Research output: Contribution to journalArticle

Eicosapentaenoic Acid
Docosahexaenoic Acids
Omega-3 Fatty Acids
Skeletal Muscle
Mitochondrial Proteins
1 Citation (Scopus)

Enhancing the Metabolic Benefits of Bariatric Surgery: Tipping the Scales With Exercise

Lanza, I. R., Nov 1 2015, In : Diabetes. 64, 11, p. 3656-3658 3 p.

Research output: Contribution to journalArticle

Muscle Mitochondrion
Bariatric Surgery
Gastric Bypass
Lipid Metabolism
Insulin Resistance

Exercise adaptations: A red herring?

Lanza, I. R., Jul 1 2015, In : Science Translational Medicine. 7, 294, 294ec110.

Research output: Contribution to journalArticle

Hormonal response to energy restriction

Lanza, I. R., Nov 4 2015, In : Science Translational Medicine. 7, 312, 312ec189.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Mitochondrial Aging and Physical Decline: Insights From Three Generations of Women

Hebert, S. L., Marquet-De Rougé, P., Lanza, I. R., McCrady-Spitzer, S. K., Levine, J. A., Middha, S., Carter, R. E., Klaus, K. A., Therneau, T. M., Highsmith, W. E. J. & Nair, K. S., Nov 1 2015, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 70, 11, p. 1409-1417 9 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Muscles
Citrate (si)-Synthase
Muscle Proteins
Sequence Deletion

Muscle movement and loss

Lanza, I. R., Dec 16 2015, In : Science Translational Medicine. 7, 318, 318ec215.

Research output: Contribution to journalArticle

Muscles

Obesity: The bitter price of sweetness

Lanza, I. R., May 20 2015, In : Science Translational Medicine. 7, 288

Research output: Contribution to journalArticle

Obesity
2014
64 Citations (Scopus)

Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size

Xiao, Y. X., Lanza, I. R., Swain, J. M., Sarr, M. G., Nair, K. S. & Jensen, M. D., Feb 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 2

Research output: Contribution to journalArticle

Cell Size
Adipocytes
Citrate (si)-Synthase
Obesity
Fats
12 Citations (Scopus)
Mitochondrial Genes
Skeletal Muscle
Age Groups
Gene Expression
Genes
11 Citations (Scopus)

Impact of insulin deprivation and treatment on sphingolipid distribution in different muscle subcellular compartments of streptozotocin-diabetic C57Bl/6 mice

Zabielski, P., Blachnio-Zabielska, A., Lanza, I. R., Gopala, S., Manjunatha, S., Jakaitis, D. R., Persson, X. M., Gransee, J., Klaus, K. A., Schimke, J. M., Jensen, M. D. & Nair, K. S., 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 5

Research output: Contribution to journalArticle

Sphingolipids
Streptozocin
Insulin
Ceramides
Muscles
2013
91 Citations (Scopus)

Cystathionine Beta-Synthase (CBS) Contributes to Advanced Ovarian Cancer Progression and Drug Resistance

Bhattacharyya, S., Saha, S., Giri, K., Lanza, I. R., Nair, K. S., Jennings, N. B., Rodriguez-Aguayo, C., Lopez-Berestein, G., Basal, E., Weaver, A. L., Visscher, D. W., Cliby, W. A., Sood, A. K., Bhattacharya, R. & Mukherjee, P., Nov 13 2013, In : PLoS One. 8, 11, e79167.

Research output: Contribution to journalArticle

cystathionine beta-synthase
Cystathionine beta-Synthase
ovarian neoplasms
drug resistance
Drug Resistance
52 Citations (Scopus)

Influence of fish oil on skeletal muscle mitochondrial energetics and lipid metabolites during high-fat diet.

Lanza, I. R., Blachnio-Zabielska, A., Johnson, M. L., Schimke, J. M., Jakaitis, D. R., LeBrasseur, N. K., Jensen, M. D., Nair, K. S. & Zabielski, P., Jun 15 2013, In : American journal of physiology. Endocrinology and metabolism. 304, 12

Research output: Contribution to journalArticle

Fish Oils
High Fat Diet
Skeletal Muscle
Lipids
Omega-3 Fatty Acids
76 Citations (Scopus)

Methods for assessing mitochondrial function in diabetes

Perry, C. G. R., Kane, D. A., Lanza, I. R. & Neufer, P. D., Apr 2013, In : Diabetes. 62, 4, p. 1041-1053 13 p.

Research output: Contribution to journalArticle

Mitochondria
Technology
Oxygen Consumption
Type 2 Diabetes Mellitus
Energy Metabolism
2012
313 Citations (Scopus)

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., Lanza, I. R., Rasbach, K. A., Okutsu, M., Nair, K. S., Yan, Z., Leinwand, L. A. & Spiegelman, B. M., Dec 7 2012, In : Cell. 151, 6, p. 1319-1331 13 p.

Research output: Contribution to journalArticle

Resistance Training
Hypertrophy
Muscle
Protein Isoforms
Skeletal Muscle
92 Citations (Scopus)

Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis

Lanza, I. R., Zabielski, P., Klaus, K. A., Morse, D. M., Heppelmann, C. J., Bergen, H. R. B. III., Dasari, S., Walrand, S., Short, K. R., Johnson, M. L., Robinson, M. M., Schimke, J. M., Jakaitis, D. R., Asmann, Y., Sun, Z. D. & Nair, K. S., Dec 5 2012, In : Cell Metabolism. 16, 6, p. 777-788 12 p.

Research output: Contribution to journalArticle

Caloric Restriction
Organelle Biogenesis
Muscle Mitochondrion
Mitochondrial Proteins
Oxidants

Endurance exercise as a countermeasure for aging (Diabetes (2008) 57, (2933-2942))

Lanza, I. R., Short, D. K., Short, K. R., Raghavakaimal, S., Basu, R., Joyner, M. J., McConnell, J. P. & Nair, K. S., Oct 2012, In : Diabetes. 61, 10, p. 2653 1 p.

Research output: Contribution to journalArticle

2011
3 Citations (Scopus)

Can dietary nitrates enhance the efficiency of mitochondria?

Nair, K. S., Irving, B. A. & Lanza, I. R., Feb 2 2011, In : Cell Metabolism. 13, 2, p. 117-118 2 p.

Research output: Contribution to journalArticle

Nitrates
Mitochondria
Muscles
58 Citations (Scopus)
Skeletal Muscle
Magnetic Resonance Spectroscopy
Muscle Mitochondrion
Gold
Knee
16 Citations (Scopus)

The impact of old age on skeletal muscle energetics: Supply and demand

Russ, D. W. & Lanza, I. R., Dec 2011, In : Current Aging Science. 4, 3, p. 234-247 14 p.

Research output: Contribution to journalArticle

Skeletal Muscle
Adenosine Triphosphate
Muscles
Morbidity
Oxidative Phosphorylation
33 Citations (Scopus)

Unique cellular and mitochondrial defects mediate FK506-induced islet β-cell dysfunction

Rostambeigi, N., Lanza, I. R., Dzeja, P. P., Deeds, M. C., Irving, B. A., Reddi, H. V., Madde, P., Zhang, S., Asmann, Y., Anderson, J. M., Schimke, J. M., Nair, K. S., Eberhardt, N. L. & Kudva, Y. C., Mar 27 2011, In : Transplantation. 91, 6, p. 615-623 9 p.

Research output: Contribution to journalArticle

Tacrolimus
Islets of Langerhans
Microarray Analysis
Insulin
Apoptosis
2010
13 Citations (Scopus)

Intracellular energetics and critical PO2 in resting ischemic human skeletal muscle in vivo

Lanza, I. R., Tevald, M. A., Befroy, D. E. & Kent-Braun, J. A., Nov 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 299, 5

Research output: Contribution to journalArticle

Skeletal Muscle
Ischemia
Adenosine Triphosphate
Magnetic Resonance Spectroscopy
Myoglobin
33 Citations (Scopus)

Lower energy cost of skeletal muscle contractions in older humans

Tevald, M. A., Foulis, S. A., Lanza, I. R. & Kent-Braun, J. A., Mar 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 3

Research output: Contribution to journalArticle

Muscle Contraction
Skeletal Muscle
Costs and Cost Analysis
Adenosine Triphosphate
Tetanus
49 Citations (Scopus)

Mitochondrial DNA alterations and reduced mitochondrial function in aging

Hebert, S. L., Lanza, I. R. & Nair, K. S., Jul 2010, In : Mechanisms of Ageing and Development. 131, 7-8, p. 451-462 12 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Mitochondrial Proteins
DNA Replication
90 Citations (Scopus)

Mitochondrial function as a determinant of life span

Lanza, I. R. & Nair, K. S., Jan 2010, In : Pflugers Archiv European Journal of Physiology. 459, 2, p. 277-289 13 p.

Research output: Contribution to journalArticle

Life Expectancy
Nutrition
Mitochondrial DNA
Caloric Restriction
Muscle