Hu Zeng, PhD

  • 1634 Citations
  • 18 Scopus h-Index
20042020

Research output per year

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Research Output

  • 1634 Citations
  • 18 Scopus h-Index
  • 30 Article
  • 6 Comment/debate
  • 6 Review article
  • 1 Short survey
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Article
2020

Homeostasis and transitional activation of regulatory T cells require c-Myc

Saravia, J., Zeng, H., Dhungana, Y., Blanco, D. B., Nguyen, T. L. M., Chapman, N. M., Wang, Y., Kanneganti, A., Liu, S., Raynor, J. L., Vogel, P., Neale, G., Carmeliet, P. & Chi, H., Jan 1 2020, In : Science Advances. 6, 1, eaaw6443.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Immune checkpoint inhibitor-induced inflammatory arthritis: a novel clinical entity with striking similarities to seronegative rheumatoid arthritis

Liu, Y., Jaquith, J. M., Mccarthy-Fruin, K., Zhu, X., Zhou, X., Li, Y., Crowson, C., Davis, J. M., Thanarajasingam, U. & Zeng, H., 2020, (Accepted/In press) In : Clinical rheumatology.

Research output: Contribution to journalArticle

1 Scopus citations

Mevalonate metabolism-dependent protein geranylgeranylation regulates thymocyte egress

Du, X., Zeng, H., Liu, S., Guy, C., Dhungana, Y., Neale, G., Bergo, M. O., Bergo, M. O. & Chi, H., Feb 3 2020, In : Journal of Experimental Medicine. 217, 2, e20190969.

Research output: Contribution to journalArticle

2019

Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis

Zhang, Z., Huang, Z., Ong, B., Sahu, C., Zeng, H. & Ruan, H. B., Aug 31 2019, In : Haematologica. 104, 9, p. 1731-1743 13 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis

Zeng, H., Yu, M., Tan, H., Li, Y., Su, W., Shi, H., Dhungana, Y., Guy, C., Neale, G., Cloer, C., Peng, J., Wang, D. & Chi, H., Jan 1 2018, In : Science advances. 4, 1, eaar5701.

Research output: Contribution to journalArticle

9 Scopus citations

Double safety reins in wayward B cells

Zeng, H., Mar 28 2018, In : Science Translational Medicine. 10, 434, eaat3886.

Research output: Contribution to journalArticle

Exploiting human Tregs’ sweet tooth to improve cancer immunotherapy

Zeng, H., Nov 7 2018, In : Science Translational Medicine. 10, 466

Research output: Contribution to journalArticle

Graft-versus-host disease: Tread carefully on T cell suppression

Zeng, H., Sep 12 2018, In : Science Translational Medicine. 10, 458, eaav0338.

Research output: Contribution to journalArticle

HNRNPH1 is required for rhabdomyosarcoma cell growth and survival

Li, Y., Bakke, J., Finkelstein, D., Zeng, H., Wu, J. & Chen, T., Jan 1 2018, In : Oncogenesis. 7, 1, 0024.

Research output: Contribution to journalArticle

6 Scopus citations

MTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis

Chapman, N. M., Zeng, H., Nguyen, T. L. M., Wang, Y., Vogel, P., Dhungana, Y., Liu, X., Neale, G., Locasale, J. W. & Chi, H., Dec 1 2018, In : Nature Communications. 9, 1, 2095.

Research output: Contribution to journalArticle

35 Scopus citations
2017

Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes

Shi, L. Z., Saravia, J., Zeng, H., Kalupahana, N. S., Guy, C. S., Neale, G. & Chi, H., Jan 3 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 1, p. E67-E74

Research output: Contribution to journalArticle

3 Scopus citations

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

Yu, M., Chen, Y., Zeng, H., Zheng, Y., Fu, G., Zhu, W., Broeckel, U., Aggarwal, P., Turner, A., Neale, G., Guy, C., Zhu, N., Chi, H., Wen, R. & Wang, D., Dec 1 2017, In : Nature Communications. 8, 1, 1457.

Research output: Contribution to journalArticle

6 Scopus citations
2016

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

Zeng, H., Cohen, S., Guy, C., Shrestha, S., Neale, G., Brown, S. A., Cloer, C., Kishton, R. J., Gao, X., Youngblood, B., Do, M., Li, M. O., Locasale, J. W., Rathmell, J. C. & Chi, H., Sep 20 2016, In : Immunity. 45, 3, p. 540-554 15 p.

Research output: Contribution to journalArticle

126 Scopus citations
2014

mTOR signaling and transcriptional regulation in T lymphocytes

Zeng, H. & Chi, H., 2014, In : Transcription. 5, FEB, p. e282631-e282636

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Mutation in the first Ig-Like domain of kit leads to JAK2 activation and myeloproliferation in mice

Huang, Z., Ruan, H. B., Zhang, Z. D., Chen, W., Lin, Z., Zeng, H. & Gao, X., Jan 1 2014, In : American Journal of Pathology. 184, 1, p. 122-132 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

MTORC1 couples immune signals and metabolic programming to establish T reg-cell function

Zeng, H., Yang, K., Cloer, C., Neale, G., Vogel, P. & Chi, H., Jul 8 2013, In : Nature. 499, 7459, p. 485-490 6 p.

Research output: Contribution to journalArticle

386 Scopus citations

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

Yang, K., Shrestha, S., Zeng, H., Karmaus, P. W. F., Neale, G., Vogel, P., Guertin, D. A., Lamb, R. F. & Chi, H., Dec 12 2013, In : Immunity. 39, 6, p. 1043-1056 14 p.

Research output: Contribution to journalArticle

181 Scopus citations

Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells

Wang, Y., Huang, G., Zeng, H., Yang, K., Lamb, R. F. & Chi, H., Dec 10 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 50, p. E4894-E4903

Research output: Contribution to journalArticle

53 Scopus citations
2011

Nuclear Export of the NF-κB Inhibitor IκBα Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation

Wuerzberger-Davis, S. M., Chen, Y., Yang, D. T., Kearns, J. D., Bates, P. W., Lynch, C., Ladell, N. C., Yu, M., Podd, A., Zeng, H., Huang, T. T., Wen, R., Hoffmann, A., Wang, D. & Miyamoto, S., Feb 25 2011, In : Immunity. 34, 2, p. 188-200 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
2010

Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation

Yokosuka, T., Kobayashi, W., Takamatsu, M., Sakata-Sogawa, K., Zeng, H., Hashimoto-Tane, A., Yagita, H., Tokunaga, M. & Saito, T., Sep 2010, In : Immunity. 33, 3, p. 326-339 14 p.

Research output: Contribution to journalArticle

104 Scopus citations
2008

T cell receptor-mediated activation of CD4+CD44hi T cells bypasses Bcl10: An implication of differential NF-κB dependence of naïve and memory T cells during T cell receptor-mediated responses

Zeng, H., Chen, Y., Yu, M., Xue, L., Gao, X., Morris, S. W., Wang, D. & Wen, R., Sep 5 2008, In : Journal of Biological Chemistry. 283, 36, p. 24392-24399 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2007

B cell lymphoma 10 is essential for FcεR-mediated degranulation and IL-6 production in mast cells

Chen, Y., Pappu, B. P., Zeng, H., Xue, L., Morris, S. W., Lin, X., Wen, R. & Wang, D., Jan 1 2007, In : Journal of Immunology. 178, 1, p. 49-57 9 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Bcl10 plays a critical role in NF-κB activation induced by G protein-couple receptors

Wang, D., You, Y., Lin, P. C., Xue, L., Morris, S. W., Zeng, H., Wen, R. & Lin, X., Jan 2 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 1, p. 145-150 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

Bcl10 plays a divergent role in NK cell-mediated cytotoxicity and cytokine generation

Malarkannan, S., Regunathan, J., Chu, H., Kutlesa, S., Chen, Y., Zeng, H., Wen, R. & Wang, D., Sep 15 2007, In : Journal of Immunology. 179, 6, p. 3752-3762 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-κB activation

Zeng, H., Di, L., Fu, G., Chen, Y., Gao, X., Xu, L., Lin, X. & Wen, R., Jul 1 2007, In : Molecular and cellular biology. 27, 14, p. 5235-5245 11 p.

Research output: Contribution to journalArticle

31 Scopus citations
2006

Alternative 3′ UTR polyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression

Yu, M., Sha, H., Gao, Y., Zeng, H., Zhu, M. & Gao, X., Jun 23 2006, In : Biochemical and Biophysical Research Communications. 345, 1, p. 479-485 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Essential role of phospholipase Cγ2 in early B-cell development and Myc-mediated lymphomagenesis

Wen, R., Chen, Y., Bai, L., Fu, G., Schuman, J., Dai, X., Zeng, H., Yang, C., Stephan, R. P., Cleveland, J. L. & Wang, D., Dec 1 2006, In : Molecular and cellular biology. 26, 24, p. 9364-9376 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Quantitative analysis of EcoR1 methylase-DNA complex by atomic force microscopy

Zhu, Y., Zeng, H., Gao, X. & Lu, Z., Jan 1 2006, In : Scanning. 28, 1, p. 15-19 5 p.

Research output: Contribution to journalArticle

2004

Atomic force microscopy studies on DNA structural changes induced by vincristine sulfate and aspirin

Zhu, Y., Zeng, H., Xie, J., Ba, L., Gao, X. & Lu, Z., Apr 1 2004, In : Microscopy and Microanalysis. 10, 2, p. 286-290 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells

Wu, X., Zeng, H., Zhang, X., Zhao, Y., Sha, H., Ge, X., Zhang, M., Gao, X. & Xu, Q., Jun 2004, In : American Journal of Pathology. 164, 6, p. 2039-2054 16 p.

Research output: Contribution to journalArticle

131 Scopus citations