Projects per year
Personal profile
Research Interests
The laboratory-based research program of Gregory J. Gores, M.D., is focused on mechanisms of liver cell death, especially apoptosis. He employs disease-relevant models to unravel the fundamental cellular processes contributing to liver injury during cholestasis and fatty liver diseases. In addition, Dr. Gores' lab is also interested in the mechanisms by which cancer cells escape from cell death in order to undergo malignant transformation and metastases.
URL
Areas of Research
- Gastrointestinal Cancer Program
- Cholestatic Liver Diseases
- Mayo Clinic Cancer Center - Research
- Advanced Liver Diseases: Patrick S. Kamath, Vijay Shah
- Center for Clinical and Translational Science (CCaTS)
- Liver Pathobiology - Gregory J. Gores
- Center for Cell Signaling in Gastroenterology (C-SiG)
- Physiology and Biomedical Engineering
- Gastroenterology and Hepatology Research
- Transplant Research Center
- Center for Regenerative Medicine
Faculty Profile:
Clinical Profile:
Gastroenterologist, Internist
Research Interests
The laboratory-based research program of Gregory J. Gores, M.D., is focused on mechanisms of liver cell death, especially apoptosis. He employs disease-relevant models to unravel the fundamental cellular processes contributing to liver injury during cholestasis and fatty liver diseases. In addition, Dr. Gores' lab is also interested in the mechanisms by which cancer cells escape from cell death in order to undergo malignant transformation and metastases.
URL
Areas of Research
- Gastrointestinal Cancer Program
- Cholestatic Liver Diseases
- Mayo Clinic Cancer Center - Research
- Advanced Liver Diseases: Patrick S. Kamath, Vijay Shah
- Center for Clinical and Translational Science (CCaTS)
- Liver Pathobiology - Gregory J. Gores
- Center for Cell Signaling in Gastroenterology (C-SiG)
- Physiology and Biomedical Engineering
- Gastroenterology and Hepatology Research
- Transplant Research Center
- Center for Regenerative Medicine
Faculty Profile:
Clinical Profile:
Gastroenterologist, Internist
Education/Academic qualification
Mayo Graduate School of Medicine, Mayo Clinic College of Medicine
University of North Dakota
Fingerprint Dive into the research topics where Gregory James Gores is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Cholangiocarcinoma
Medicine & Life Sciences
Apoptosis
Medicine & Life Sciences
Liver
Medicine & Life Sciences
Liver Transplantation
Medicine & Life Sciences
Hepatocytes
Medicine & Life Sciences
Sclerosing Cholangitis
Medicine & Life Sciences
Hepatocellular Carcinoma
Medicine & Life Sciences
Klatskin Tumor
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 1976 2020
Liver
Wounds and Injuries
Apoptosis
Bile Acids and Salts
Hepatocytes
Organelles
Epithelium
Apoptosis
Cathepsin B
Liver
Cholangiocarcinoma
Carcinogenesis
Epithelium
Apoptosis
Nitric Oxide Synthase Type II
Research Output 1979 2019
1
Citation
(Scopus)
Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice
Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., Nelson, G., Bronk, S., Fierro Velasco, R. O., van Deursen, E. J., O'Brien, D. R., Kocher, J-P., Youssef, S. A., van Ree, J. H., de Bruin, A., van den Bos, H., Spierings, D. C. J., Foijer, F., van de Sluis, B., Roberts, L. R. & 3 others, , Jul 1 2019, In : Gastroenterology. 157, 1, p. 210-226.e12Research output: Contribution to journal › Article
Chromosomal Instability
Cyclins
Liver
Neoplasms
Chromosomes
3
Citations
(Scopus)
Cholangiocyte pathobiology
Banales, J. M., Huebert, R. C., Karlsen, T., Strazzabosco, M., La Russo, N. F. & Gores, G. J., Jan 1 2019, In : Nature Reviews Gastroenterology and Hepatology.Research output: Contribution to journal › Review article
Liver Regeneration
Inflammation
Intrahepatic Bile Ducts
Extrahepatic Bile Ducts
Liver Failure
2
Citations
(Scopus)
GALAD score for hepatocellular carcinoma detection in comparison with liver ultrasound and proposal of Galadus score
Yang, J. D., Addissie, B. D., Mara, K. C., Harmsen, W. S., Dai, J., Zhang, N., Wongjarupong, N., Ali, H. M., Ali, H. A., Hassan, F. A., Lavu, S., Cvinar, J. L., Giama, N. H., Moser, C. D., Miyabe, K., Allotey, L. K., Algeciras-Schimnich, A., Theobald, J. P., Ward, M. M., Nguyen, M. H. & 11 others, , Mar 1 2019, In : Cancer Epidemiology Biomarkers and Prevention. 28, 3, p. 531-538 8 p.Research output: Contribution to journal › Article
Hepatocellular Carcinoma
Liver
ROC Curve
Area Under Curve
Fibrosis
4
Citations
(Scopus)
Intrahepatic Cholangiocarcinoma: Continuing Challenges and Translational Advances
Sirica, A. E., Gores, G. J., Groopman, J. D., Selaru, F. M., Strazzabosco, M., Wei Wang, X. & Zhu, A. X., Apr 1 2019, In : Hepatology. 69, 4, p. 1803-1815 13 p.Research output: Contribution to journal › Review article
Cholangiocarcinoma
Translational Medical Research
Biomarkers
Therapeutics
Neoplasms
Long-term outcomes with obeticholic acid in primary biliary cholangitis: reassuring, but still an itch we need to scratch
Eaton, J. E. & Gores, G. J., Jun 1 2019, In : The Lancet Gastroenterology and Hepatology. 4, 6, p. 417-418 2 p.Research output: Contribution to journal › Comment/debate
Cholangitis
6-ethylchenodeoxycholic acid