• 54464 Citations
  • 131 Scopus h-Index
1976 …2020
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Personal profile

Research Interests

The laboratory-based research program of Gregory J. Gores, M.D., is focused on mechanisms of liver cell death, especially apoptosis. He employs disease-relevant models to unravel the fundamental cellular processes contributing to liver injury during cholestasis and fatty liver diseases. In addition, Dr. Gores' lab is also interested in the mechanisms by which cancer cells escape from cell death in order to undergo malignant transformation and metastases.

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Research Interests

The laboratory-based research program of Gregory J. Gores, M.D., is focused on mechanisms of liver cell death, especially apoptosis. He employs disease-relevant models to unravel the fundamental cellular processes contributing to liver injury during cholestasis and fatty liver diseases. In addition, Dr. Gores' lab is also interested in the mechanisms by which cancer cells escape from cell death in order to undergo malignant transformation and metastases.

URL

Education/Academic qualification

Mayo Graduate School of Medicine, Mayo Clinic College of Medicine

University of North Dakota

Fingerprint Dive into the research topics where Gregory James Gores is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Cholangiocarcinoma Medicine & Life Sciences
Apoptosis Medicine & Life Sciences
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Hepatocytes Medicine & Life Sciences
Sclerosing Cholangitis Medicine & Life Sciences
Hepatocellular Carcinoma Medicine & Life Sciences
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Projects 1976 2020

Liver
Wounds and Injuries
Apoptosis
Bile Acids and Salts
Hepatocytes
Organelles
Epithelium
Apoptosis
Cathepsin B
Liver
Cholangiocarcinoma
Carcinogenesis
Epithelium
Apoptosis
Nitric Oxide Synthase Type II

Research Output 1979 2019

1 Citation (Scopus)

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice

Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., Nelson, G., Bronk, S., Fierro Velasco, R. O., van Deursen, E. J., O'Brien, D. R., Kocher, J-P., Youssef, S. A., van Ree, J. H., de Bruin, A., van den Bos, H., Spierings, D. C. J., Foijer, F., van de Sluis, B., Roberts, L. R. & 3 others, Gores, G. J., Li, H. & Van Deursen, J., Jul 1 2019, In : Gastroenterology. 157, 1, p. 210-226.e12

Research output: Contribution to journalArticle

Chromosomal Instability
Cyclins
Liver
Neoplasms
Chromosomes
3 Citations (Scopus)

Cholangiocyte pathobiology

Banales, J. M., Huebert, R. C., Karlsen, T., Strazzabosco, M., La Russo, N. F. & Gores, G. J., Jan 1 2019, In : Nature Reviews Gastroenterology and Hepatology.

Research output: Contribution to journalReview article

Liver Regeneration
Inflammation
Intrahepatic Bile Ducts
Extrahepatic Bile Ducts
Liver Failure
2 Citations (Scopus)

GALAD score for hepatocellular carcinoma detection in comparison with liver ultrasound and proposal of Galadus score

Yang, J. D., Addissie, B. D., Mara, K. C., Harmsen, W. S., Dai, J., Zhang, N., Wongjarupong, N., Ali, H. M., Ali, H. A., Hassan, F. A., Lavu, S., Cvinar, J. L., Giama, N. H., Moser, C. D., Miyabe, K., Allotey, L. K., Algeciras-Schimnich, A., Theobald, J. P., Ward, M. M., Nguyen, M. H. & 11 others, Befeler, A. S., Reddy, K. R., Schwartz, M., Harnois, D., Yamada, H., Srivastava, S., Rinaudo, J. A., Gores, G. J., Feng, Z., Marrero, J. A. & Roberts, L. R., Mar 1 2019, In : Cancer Epidemiology Biomarkers and Prevention. 28, 3, p. 531-538 8 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Liver
ROC Curve
Area Under Curve
Fibrosis
4 Citations (Scopus)

Intrahepatic Cholangiocarcinoma: Continuing Challenges and Translational Advances

Sirica, A. E., Gores, G. J., Groopman, J. D., Selaru, F. M., Strazzabosco, M., Wei Wang, X. & Zhu, A. X., Apr 1 2019, In : Hepatology. 69, 4, p. 1803-1815 13 p.

Research output: Contribution to journalReview article

Cholangiocarcinoma
Translational Medical Research
Biomarkers
Therapeutics
Neoplasms
Cholangitis
6-ethylchenodeoxycholic acid