Projects per year
Personal profile
Research Interests
The laboratory-based research program of Gregory J. Gores, M.D., is focused on mechanisms of liver cell death, especially apoptosis. He employs disease-relevant models to unravel the fundamental cellular processes contributing to liver injury during cholestasis and fatty liver diseases. In addition, Dr. Gores' lab is also interested in the mechanisms by which cancer cells escape from cell death in order to undergo malignant transformation and metastases.
URL
Areas of Research
- Gastrointestinal Cancer Program
- Cholestatic Liver Diseases
- Mayo Clinic Cancer Center - Research
- Advanced Liver Diseases: Patrick S. Kamath, Vijay Shah
- Center for Clinical and Translational Science (CCaTS)
- Liver Pathobiology - Gregory J. Gores
- Center for Cell Signaling in Gastroenterology (C-SiG)
- Physiology and Biomedical Engineering
- Gastroenterology and Hepatology Research
- Transplant Research Center
- Center for Regenerative Medicine
Faculty Profile:
Clinical Profile:
Gastroenterologist, Internist
Research Interests
The laboratory-based research program of Gregory J. Gores, M.D., is focused on mechanisms of liver cell death, especially apoptosis. He employs disease-relevant models to unravel the fundamental cellular processes contributing to liver injury during cholestasis and fatty liver diseases. In addition, Dr. Gores' lab is also interested in the mechanisms by which cancer cells escape from cell death in order to undergo malignant transformation and metastases.
URL
Areas of Research
- Gastrointestinal Cancer Program
- Cholestatic Liver Diseases
- Mayo Clinic Cancer Center - Research
- Advanced Liver Diseases: Patrick S. Kamath, Vijay Shah
- Center for Clinical and Translational Science (CCaTS)
- Liver Pathobiology - Gregory J. Gores
- Center for Cell Signaling in Gastroenterology (C-SiG)
- Physiology and Biomedical Engineering
- Gastroenterology and Hepatology Research
- Transplant Research Center
- Center for Regenerative Medicine
Faculty Profile:
Clinical Profile:
Gastroenterologist, Internist
Education/Academic qualification
Mayo Graduate School of Medicine, Mayo Clinic College of Medicine
University of North Dakota
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Mayo Clinic Hepatobiliary SPORE
Mc Niven, M. A., Mandrekar, S. J., Torbenson, M., Gores, G. J., Alberts, S. R., Vile, R. G., Leof, E. B., Roberts, L. R., Roberts, L. R. & Gores, G. J.
9/10/18 → 8/31/22
Project: Research project
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Mayo Center for Cell Signaling in Gastroenterology
Larusso, N., Boardman, L. A., Ekker, S. C., Ekker, S. C., Farrugia, G., Faubion, W. A., Gores, G. J., Larusso, N., Mc Niven, M. A., Mcniven, M. & Shah, V.
National Institute of Diabetes and Digestive and Kidney Diseases
9/1/09 → 6/30/22
Project: Research project
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Multidisciplinary Training in Digestive Diseases
Gores, G. J., Shah, V., Larusso, N., Faubion, W. A., Faubion, W. A., Larusso, N. & Shah, V.
National Institute of Diabetes and Digestive and Kidney Diseases
1/1/90 → 12/31/22
Project: Research project
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Mechanisms of Carcinogenesis in Biliary Epithelia
National Institute of Diabetes and Digestive and Kidney Diseases
6/1/06 → 4/30/07
Project: Research project
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Organelle Dysfunction and Apoptosis in Liver Epithelia
National Institute of Diabetes and Digestive and Kidney Diseases
8/1/03 → 5/31/16
Project: Research project
Research output
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A pilot study of Pan-FGFR inhibitor ponatinib in patients with FGFR-altered advanced cholangiocarcinoma
Ahn, D. H., Uson Junior, P. L. S., Masci, P., Kosiorek, H., Halfdanarson, T. R., Mody, K., Babiker, H., DeLeon, T., Sonbol, M. B., Gores, G., Smoot, R., Bekaii-Saab, T., Mahipal, A., Mansfield, A., Tran, N. H., Hubbard, J. M. & Borad, M. J., Feb 2022, In: Investigational New Drugs. 40, 1, p. 134-141 8 p.Research output: Contribution to journal › Article › peer-review
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Burning, but Not Dying: the Failure of Pyroptotic Cell Death in Hepatocytes
Guicciardi, M. E. & Gores, G. J., Jan 2022, In: CMGH. 13, 3, p. 974-976 3 p.Research output: Contribution to journal › Editorial › peer-review
Open Access -
DNA methylation profile of liver tissue in end-stage cholestatic liver disease
Cheung, A. C., Juran, B. D., Schlicht, E. M., McCauley, B. M., Atkinson, E. J., Moore, R., Heimbach, J. K., Watt, K. D., Wu, T. T., Larusso, N. F., Gores, G. J., Sun, Z. & Lazaridis, K. N., Apr 2022, In: Epigenomics. 14, 8, p. 481-497 17 p.Research output: Contribution to journal › Article › peer-review
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High-Resolution Exposomics and Metabolomics Reveals Specific Associations in Cholestatic Liver Diseases
Walker, D. I., Juran, B. D., Cheung, A. C., Schlicht, E. M., Liang, Y., Niedzwiecki, M., LaRusso, N. F., Gores, G. J., Jones, D. P., Miller, G. W. & Lazaridis, K. N., May 2022, In: Hepatology Communications. 6, 5, p. 965-979 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Impact of trimodality sampling on detection of malignant biliary strictures compared with patients with primary sclerosing cholangitis
Baroud, S., Sahakian, A. J., Sawas, T., Storm, A. C., Martin, J. A., Abu Dayyeh, B. K., Topazian, M. D., Levy, M. J., Roberts, L. R., Gores, G. J., Petersen, B. T. & Chandrasekhara, V., May 2022, In: Gastrointestinal endoscopy. 95, 5, p. 884-892 9 p.Research output: Contribution to journal › Article › peer-review