• 11948 Citations
  • 61 Scopus h-Index
1991 …2020
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1991 2019

  • 11948 Citations
  • 61 Scopus h-Index
  • 289 Article
  • 3 Chapter
  • 2 Conference contribution
  • 2 Review article
2019
1 Citation (Scopus)

Abdominal Pain in Patients with Gastroparesis: Associations with Gastroparesis Symptoms, Etiology of Gastroparesis, Gastric Emptying, Somatization, and Quality of Life

Parkman, H. P., Wilson, L. A., Hasler, W. L., McCallum, R. W., Sarosiek, I., Koch, K. L., Abell, T. L., Schey, R., Kuo, B., Snape, W. J., Nguyen, L., Farrugia, G., Grover, M., Clarke, J., Miriel, L., Tonascia, J., Hamilton, F. & Pasricha, P. J., Jan 1 2019, In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Gastroparesis
Gastric Emptying
Abdominal Pain
Quality of Life
Opiate Alkaloids

Delayed Gastric Emptying Associates With Diabetic Complications in Diabetic Patients With Symptoms of Gastroparesis

NIDDK Gastroparesis Clinical Research Consortium (GpCRC), Nov 1 2019, In : The American Journal of Gastroenterology. 114, 11, p. 1778-1794 17 p.

Research output: Contribution to journalArticle

Gastroparesis
Gastric Emptying
Diabetes Complications
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
2 Citations (Scopus)

Direct repression of anoctamin 1 (ANO1) gene transcription by Gli proteins

Mazzone, A., Gibbons, S. J., Eisenman, S. T., Strege, P. R., Zheng, T., D'Amato, M., Ordog, T., Fernandez-Zapico, M. E. & Farrugia, G., May 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 5, p. 6632-6642 11 p.

Research output: Contribution to journalArticle

Transcription
Genes
Polymorphism
Hylobates
Kidney

Effectiveness of gastric electrical stimulation in gastroparesis: Results from a large prospectively collected database of national gastroparesis registries

Abell, T. L., Yamada, G., McCallum, R. W., Van Natta, M. L., Tonascia, J., Parkman, H. P., Koch, K. L., Sarosiek, I., Farrugia, G., Grover, M., Hasler, W., Nguyen, L., Snape, W., Kuo, B., Shulman, R., Hamilton, F. A. & Pasricha, P. J., Jan 1 2019, (Accepted/In press) In : Neurogastroenterology and Motility. e13714.

Research output: Contribution to journalArticle

Gastroparesis
Electric Stimulation
Registries
Stomach
Databases

Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq

Zhong, J., Ye, Z., Clark, C. R., Lenz, S. W., Nguyen, J. H., Yan, H. D., Robertson, K. D., Farrugia, G., Zhang, Z., Ordog, T. & Lee, J. H., Mar 29 2019, In : BMC genomics. 20, 1, 249.

Research output: Contribution to journalArticle

Paraffin
Formaldehyde
Chromatin
Epigenomics
Temperature
4 Citations (Scopus)

Ethnic, Racial, and Sex Differences in Etiology, Symptoms, Treatment, and Symptom Outcomes of Patients With Gastroparesis

Parkman, H. P., Yamada, G., Van Natta, M. L., Yates, K., Hasler, W. L., Sarosiek, I., Grover, M., Schey, R., Abell, T. L., Koch, K. L., Kuo, B., Clarke, J., Farrugia, G., Nguyen, L., Snape, W. J., Miriel, L., Tonascia, J., Hamilton, F., Pasricha, P. J. & McCallum, R. W., Jan 1 2019, In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

Gastroparesis
Sex Characteristics
Hispanic Americans
Stomach
Nausea

Gastroparesis: A turning point in understanding and treatment

Grover, M., Farrugia, G. & Stanghellini, V., Jan 1 2019, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

Gastroparesis
Gastric Emptying
prucalopride
aprepitant
Nausea

Heme oxygenase-2 protects against ischemic acute kidney injury: influence of age and sex

Nath, K. A., Garovic, V. D., Grande, J. P., Croatt, A. J., Ackerman, A. W., Farrugia, G., Katusic, Z. S., Belcher, J. D. & Vercellotti, G. M., Sep 1 2019, In : American journal of physiology. Renal physiology. 317, 3, p. F695-F704

Research output: Contribution to journalArticle

Acute Kidney Injury
Ischemia
Heme Oxygenase-1
Heme Oxygenase (Decyclizing)
Kidney

Marijuana Use in Patients with Symptoms of Gastroparesis: Prevalence, Patient Characteristics, and Perceived Benefit

Frank A. Hamilton for the NIH Gastroparesis Consortium, Jan 1 2019, (Accepted/In press) In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Gastroparesis
Cannabis
Gastric Emptying
Nausea
Abdominal Pain

MicroRNA overexpression in slow transit constipation leads to reduced NaV1.5 current and altered smooth muscle contractility

Mazzone, A., Strege, P. R., Gibbons, S. J., Alcaino, C., Joshi, V., Haak, A. J., Tschumperlin, D. J., Bernard, C. E., Cima, R. R., Larson, D. W., Chua, H. K., Graham, R. P., El Refaey, M., Mohler, P. J., Hayashi, Y., Ordog, T., Calder, S., Du, P., Farrugia, G. & Beyder, A., Jan 1 2019, (Accepted/In press) In : Gut. 318747.

Research output: Contribution to journalArticle

Open Access
Constipation
MicroRNAs
Smooth Muscle
Reverse Transcription
Smooth Muscle Myocytes
2 Citations (Scopus)

Muscularis Propria Macrophages Alter the Proportion of Nitrergic but Not Cholinergic Gastric Myenteric Neurons

Cipriani, G., Terhaar, M. L., Eisenman, S. T., Ji, S., Linden, D. R., Wright, A. M., Sha, L., Ordog, T., Szurszewski, J. H., Gibbons, S. J. & Farrugia, G., Jan 1 2019, In : CMGH.

Research output: Contribution to journalArticle

Open Access
Cholinergic Agents
Stomach
Macrophages
Neurons
4 Citations (Scopus)
Gastroparesis
Opioid Analgesics
Quality of Life
Abdominal Pain
Gastric Emptying

Proteomics in gastroparesis: unique and overlapping protein signatures in diabetic and idiopathic gastroparesis

Grover, M., Dasari, S., Bernard, C. E., Chikkamenahalli, L. L., Yates, K. P., Pasricha, P. J., Sarosiek, I., McCallum, R., Koch, K. L., Abell, T. L., Kuo, B., Shulman, R. J., Gibbons, S. J., McKenzie, T. J., Kellogg, T. A., Kendrick, M. L., Tonascia, J., Hamilton, F. A., Parkman, H. P. & Farrugia, G., Nov 1 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 317, 5, p. G716-G726

Research output: Contribution to journalArticle

Open Access
Gastroparesis
Proteomics
Proteins
Gastric Emptying
Macrophages

Satiety testing in diabetic gastroparesis: Effects of insulin pump therapy with continuous glucose monitoring on upper gastrointestinal symptoms and gastric myoelectrical activity

the NIDDK Gastroparesis Clinical Research Consortium, Jan 1 2019, (Accepted/In press) In : Neurogastroenterology and Motility. e13720.

Research output: Contribution to journalArticle

Gastroparesis
Meals
Stomach
Insulin
Glucose

SCN5A mutation G615E results in NaV1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity

Strege, P. R., Mercado-Perez, A., Mazzone, A., Saito Loftus, Y. A., Bernard, C. E., Farrugia, G. & Beyder, A., Dec 1 2019, In : Channels (Austin, Tex.). 13, 1, p. 287-298 12 p.

Research output: Contribution to journalArticle

Open Access
NAV1.5 Voltage-Gated Sodium Channel
Cardiac Myocytes
Smooth Muscle
Channelopathies
Pressure

Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS

Edogawa, S., Edwinson, A. L., Peters, S. A., Chikkamenahalli, L. L., Sundt, W., Graves, S., Gurunathan, S. V., Breen-Lyles, M., Johnson, S., Dyer, R., Graham, R., Chen, J., Kashyap, P., Farrugia, G. & Grover, M., Jan 1 2019, In : Gut.

Research output: Contribution to journalArticle

Serine Proteases
Microbiota
Permeability
Occludin
Healthy Volunteers
5 Citations (Scopus)

Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

Saffouri, G. B., Shields-Cutler, R. R., Chen, J., Yang, Y., Lekatz, H. R., Hale, V. L., Cho, J. M., Battaglioli, E. J., Bhattarai, Y., Thompson, K. J., Kalari, K. K., Behera, G., Berry, J. C., Peters, S. A., Patel, R., Schuetz, A. N., Faith, J. J., Camilleri, M., Sonnenburg, J. L., Farrugia, G. & 4 others, Swann, J. R., Grover, M., Knights, D. & Kashyap, P. C., Dec 1 2019, In : Nature communications. 10, 1, 2012.

Research output: Contribution to journalArticle

Open Access
Dysbiosis
Gastrointestinal Diseases
Nutrition
diets
disorders
2018
12 Citations (Scopus)

A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release

Alcaino, C., Knutson, K. R., Treichel, A. J., Yildiz, G., Strege, P. R., Linden, D. R., Li, J. H., Leiter, A. B., Szurszewski, J. H., Farrugia, G. & Beyder, A., Aug 7 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 32, p. E7632-E7641

Research output: Contribution to journalArticle

Enterochromaffin Cells
Enteroendocrine Cells
Serotonin
Epithelial Cells
Population
24 Citations (Scopus)

Aprepitant Has Mixed Effects on Nausea and Reduces Other Symptoms in Patients With Gastroparesis and Related Disorders

For the, NIDDK Gastroparesis Clinical Research Consortium (GpCRC) & NIDDK Gastroparesis Clinical Research Consortium (GpCRC), Jan 1 2018, In : Gastroenterology. 154, 1, p. 65-76.e11

Research output: Contribution to journalArticle

aprepitant
Gastroparesis
Nausea
Vomiting
Visual Analog Scale
13 Citations (Scopus)

Change in Populations of Macrophages Promotes Development of Delayed Gastric Emptying in Mice

Cipriani, G., Gibbons, S. J., Miller, K. E., Yang, D. S., Terhaar, M. L., Eisenman, S. T., Ordog, T., Linden, D. R., Gajdos, G. B., Szurszewski, J. H. & Farrugia, G., Jun 1 2018, In : Gastroenterology. 154, 8, p. 2122-2136.e12

Research output: Contribution to journalArticle

Gastric Emptying
Interstitial Cells of Cajal
Macrophages
Population
Stomach
11 Citations (Scopus)

Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea

Battaglioli, E. J., Hale, V. L., Chen, J., Jeraldo, P., Ruiz-Mojica, C., Schmidt, B. A., Rekdal, V. M., Till, L. M., Huq, L., Smits, S. A., Moor, W. J., Jones-Hall, Y., Smyrk, T. C., Khanna, S., Pardi, D. S., Grover, M., Patel, R., Chia, N. D., Nelson, H., Sonnenburg, J. L. & 2 others, Farrugia, G. & Kashyap, P. C., Oct 24 2018, In : Science Translational Medicine. 10, 464, eaam7019.

Research output: Contribution to journalArticle

Dysbiosis
Diarrhea
Amino Acids
Infection
Proline
1 Citation (Scopus)

Curriculum for neurogastroenterology and motility training: A report from the joint ANMS-ESNM task force

Gyawali, C. P., Savarino, E., Lazarescu, A., Bor, S., Patel, A., Dickman, R., Pressman, A., Drewes, A. M., Rosen, J., Drug, V., Saps, M., Novais, L., Vazquez Roque, M. I., Pohl, D., van Tilburg, M. A. L., Smout, A., Yoon, S., Pandolfino, J., Farrugia, G., Barbara, G. & 1 others, Roman, S., Sep 1 2018, In : Neurogastroenterology and Motility. 30, 9, e13341.

Research output: Contribution to journalArticle

Advisory Committees
Curriculum
Joints
North America
Esophageal Diseases

Expression of RAD21 immunoreactivity in myenteric neurons of the human and mouse small intestine

Bianco, F., Eisenman, S. T., Colmenares Aguilar, M. G., Bonora, E., Clavenzani, P., Linden, D. R., De Giorgio, R., Farrugia, G. & Gibbons, S. J., Jan 1 2018, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Small Intestine
Neurons
Nitric Oxide Synthase Type I
Transferases
Choline
1 Citation (Scopus)

Extracellular Cl regulates electrical slow waves and setting of smooth muscle membrane potential by interstitial cells of Cajal in mouse jejunum

Saravanaperumal, S. A., Gibbons, S. J., Malysz, J., Sha, L., Linden, D. R., Szurszewski, J. H. & Farrugia, G., Jan 1 2018, In : Experimental Physiology. 103, 1, p. 40-57 18 p.

Research output: Contribution to journalArticle

Interstitial Cells of Cajal
Jejunum
Membrane Potentials
Smooth Muscle
Smooth Muscle Myocytes
8 Citations (Scopus)

Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research

Chang, L., Di Lorenzo, C., Farrugia, G., Hamilton, F. A., Mawe, G. M., Pasricha, P. J. & Wiley, J. W., Feb 1 2018, In : Gastroenterology. 154, 3, p. 723-735 13 p.

Research output: Contribution to journalArticle

Research
Endophenotypes
Education
Combined Modality Therapy
Irritable Bowel Syndrome
11 Citations (Scopus)

Glucose sensor-augmented continuous subcutaneous insulin infusion in patients with diabetic gastroparesis: An open-label pilot prospective study

Calles-Escandón, J., Koch, K. L., Hasler, W. L., Van Natta, M. L., Pasricha, P. J., Tonascia, J., Parkman, H. P., Hamilton, F., Herman, W. H., Basina, M., Buckingham, B., Earle, K., Kirkeby, K., Hairston, K., Bright, T., Rothberg, A. E., Kraftson, A. T., Siraj, E. S., Subauste, A., Lee, L. A. & 9 others, Abell, T. L., McCallum, R. W., Sarosiek, I., Nguyen, L., Fass, R., Snape, W. J., Vaughn, I. A., Miriel, L. A. & Farrugia, G., Apr 1 2018, In : PLoS One. 13, 4, e0194759.

Research output: Contribution to journalArticle

Gastroparesis
Glucose sensors
Subcutaneous Infusions
prospective studies
Labels
28 Citations (Scopus)

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N. C., Kaunitz, J. D., Sonnenburg, J. L., Fischbach, M. A., Farrugia, G. & Kashyap, P. C., Jun 13 2018, In : Cell Host and Microbe. 23, 6, p. 775-785.e5

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT4
G-Protein-Coupled Receptors
Gastrointestinal Transit
Fluids and Secretions
Tryptophan
2 Citations (Scopus)

High temporal resolution gastric emptying breath tests in mice

Miller, K. E., Bajzer, Hein, S. S., Phillips, J. E., Syed, S., Wright, A. M., Cipriani, G., Gibbons, S. J., Szurszewski, J. H., Farrugia, G., Ordog, T. & Linden, D. R., Jan 1 2018, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Breath Tests
Gastric Emptying
Meals
Physiological Phenomena
Experimental Diabetes Mellitus
9 Citations (Scopus)

Intragastric meal distribution during gastric emptying scintigraphy for assessment of fundic accommodation: Correlation with symptoms of gastroparesis

NIH Gastroparesis Consortium, Apr 1 2018, In : Journal of Nuclear Medicine. 59, 4, p. 691-697 7 p.

Research output: Contribution to journalArticle

Gastroparesis
Gastric Emptying
Radionuclide Imaging
Meals
Stomach
9 Citations (Scopus)

Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Nav1.5 current and mechanosensitivity

Strege, P. R., Mazzone, A., Bernard, C. E., Neshatian, L., Gibbons, S. J., Saito Loftus, Y. A., Tester, D. J., Calvert, M. L., Mayer, E. A., Chang, L., Ackerman, M. J., Beyder, A. & Farrugia, G., Apr 1 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 314, 4, p. G494-G503

Research output: Contribution to journalArticle

Channelopathies
Irritable Bowel Syndrome
Mutation
Missense Mutation
Smooth Muscle
3 Citations (Scopus)

Islet cell associated autoantibodies and C-peptide levels in patients with diabetes and symptoms of gastroparesis

Siraj, E. S., Homko, C., Wilson, L. A., May, P., Rao, A. D., Calles, J., Farrugia, G., Hasler, W. L., Koch, K. L., Nguyen, L., Snape, W. J., Abell, T. L., Sarosiek, I., McCallum, R. W., Pasricha, P. J., Clarke, J., Tonascia, J., Hamilton, F. & Parkman, H. P., Feb 13 2018, In : Frontiers in Endocrinology. 9, FEB, 32.

Research output: Contribution to journalArticle

Gastroparesis
C-Peptide
Islets of Langerhans
Glutamate Decarboxylase
Autoantibodies
8 Citations (Scopus)

Sex differences in NSAID-induced perturbation of human intestinal barrier function and microbiota

Edogawa, S., Peters, S. A., Jenkins, G. D., Gurunathan, S. V., Sundt, W. J., Johnson, S., Lennon, R. J., Dyer, R. B., Camilleri, M., Kashyap, P. C., Farrugia, G., Chen, J., Singh, R. J. & Grover, M., Dec 1 2018, In : FASEB Journal. 32, 12, p. 6615-6625 11 p.

Research output: Contribution to journalArticle

Microbiota
Non-Steroidal Anti-Inflammatory Agents
Indomethacin
Sex Characteristics
Permeability
2 Citations (Scopus)

The touchy business of gastrointestinal (GI) mechanosensitivity

Treichel, A. J., Farrugia, G. & Beyder, A., Aug 15 2018, In : Brain Research. 1693, p. 197-200 4 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Enterochromaffin Cells
Gastrointestinal Tract
Aptitude
Epithelial Cells
5 Citations (Scopus)

Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis

Grover, M., Gibbons, S. J., Nair, A. A., Bernard, C. E., Zubair, A. S., Eisenman, S. T., Wilson, L. A., Miriel, L., Pasricha, P. J., Parkman, H. P., Sarosiek, I., McCallum, R. W., Koch, K. L., Abell, T. L., Snape, W. J., Kuo, B., Shulman, R. J., McKenzie, T. J., Kellogg, T. A., Kendrick, M. L. & 3 others, Tonascia, J., Hamilton, F. A. & Farrugia, G., Aug 7 2018, In : BMC Medical Genomics. 11, 1, 62.

Research output: Contribution to journalArticle

Gastroparesis
Genes
Macrophages
Transendothelial and Transepithelial Migration
Interleukin-17
1 Citation (Scopus)

Whole cell electrophysiology of primary cultured murine enterochromaffin cells

Knutson, K., Strege, P. R., Li, J., Leiter, A. B., Farrugia, G. & Beyder, A., Sep 26 2018, In : Journal of Visualized Experiments. 2018, 139, e58112.

Research output: Contribution to journalArticle

Enterochromaffin Cells
Electrophysiology
Clamping devices
Enteroendocrine Cells
Cell culture
2017
23 Citations (Scopus)

Conditional genetic deletion of Ano1 in interstitial cells of cajal impairs Ca2+ transients and slow waves in adult mouse small intestine

Malysz, J., Gibbons, S. J., Saravanaperumal, S. A., Du, P., Eisenman, S. T., Cao, C., Oh, U., Saur, D., Klein, S., Ordog, T. & Farrugia, G., Mar 1 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 3, p. G228-G245

Research output: Contribution to journalArticle

Interstitial Cells of Cajal
Small Intestine
Myenteric Plexus
Gastrointestinal Motility
Tamoxifen
10 Citations (Scopus)

Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function

Peters, S. A., Edogawa, S., Sundt, W. J., Dyer, R. B., Dalenberg, D. A., Mazzone, A., Singh, R. J., Moses, N., Smyrk, T. C., Weber, C., Linden, D. R., MacNaughton, W. K., Turner, J. R., Camilleri, M., Katzka, D. A., Farrugia, G. & Grover, M., Mar 21 2017, (Accepted/In press) In : American Journal of Gastroenterology.

Research output: Contribution to journalArticle

Lactulose
Irritable Bowel Syndrome
Tight Junctions
Mannitol
Constipation
2 Citations (Scopus)

EAVK segment “c” sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1

Strege, P. R., Gibbons, S. J., Mazzone, A., Bernard, C. E., Beyder, A. & Farrugia, G., Jun 1 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 6, p. G572-G579

Research output: Contribution to journalArticle

Exons
Interstitial Cells of Cajal
Stomach
Calcium
Chloride Channels
5 Citations (Scopus)

Endoscopic muscle biopsy sampling of the duodenum and rectum: A pilot survival study in a porcine model to detect myenteric neurons

Rajan, E., Al-Bawardy, B., Gostout, C. J., Wong Kee Song, L. M., Deters, J. L., Knipschield, M. A., Bernard, C. E. & Farrugia, G., 2017, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

Duodenum
Rectum
Swine
Biopsy
Neurons
13 Citations (Scopus)

Experience with precision genomics and tumor board, indicates frequent target identification, but barriers to delivery

Bryce, A. H., Egan, J. B., Borad, M. J., Stewart, A. K., Nowakowski, G. S., Chanan Khan, A. A., Patnaik, M. M., Ansell, S. M., Banck, M. S., Robinson, S., Mansfield, A., Klee, E. W., Oliver, G. R., McCormick, J. B., Huneke, N. E., Tagtow, C. M., Jenkins, R. B., Rumilla, K. M., Kerr, S. E., Kocher, J-P. & 5 others, Beck, S. A., Fernandez-Zapico, M. E., Farrugia, G., Lazaridis, K. N. & Mc Williams, R. R., 2017, In : Oncotarget. 8, 16, p. 27145-27154 10 p.

Research output: Contribution to journalArticle

Genomics
Neoplasms
Precision Medicine
Standard of Care
Therapeutics
22 Citations (Scopus)
Receptors, Serotonin, 5-HT3
Serotonin
Acetates
Intestinal Secretions
Ondansetron
21 Citations (Scopus)

Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying

Hayashi, Y., Toyomasu, Y., Saravanaperumal, S. A., Bardsley, M. R., Smestad, J. A., Lorincz, A., Eisenman, S. T., Cipriani, G., Nelson Holte, M. H., Al Khazal, F. J., Syed, S. A., Gajdos, G. B., Choi, K. M., Stoltz, G. J., Miller, K. E., Kendrick, M. L., Rubin, B. P., Gibbons, S. J., Bharucha, A. E., Linden, D. R. & 3 others, Maher III, L. J., Farrugia, G. & Ordog, T., Aug 1 2017, In : Gastroenterology. 153, 2, p. 521-535.e20

Research output: Contribution to journalArticle

Interstitial Cells of Cajal
Gastric Emptying
Mitogen-Activated Protein Kinase 1
Hyperglycemia
Cell Lineage
10 Citations (Scopus)

Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4

Alcaino, C., Knutson, K., Gottlieb, P. A., Farrugia, G. & Beyder, A., Feb 7 2017, (Accepted/In press) In : Channels. p. 1-9 9 p.

Research output: Contribution to journalArticle

Ion Channels
Serotonin
Spiders
HEK293 Cells
Peptides
26 Citations (Scopus)

Multidisciplinary model to implement pharmacogenomics at the point of care

Caraballo, P., Hodge, L. S., Bielinski, S. J., Stewart, A. K., Farrugia, G., Schultz, C. G., Rohrer-Vitek, C. R., Olson, J. E., St. Sauver, J., Roger, V. L., Parkulo, M. A., Kullo, I. J., Nicholson, W. T., Elliott, M. A., Black, J. L. & Weinshilboum, R. M., Apr 1 2017, In : Genetics in Medicine. 19, 4, p. 421-429 9 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Clinical Decision Support Systems
Pharmacogenetics
Drug Interactions
Clinical Governance
9 Citations (Scopus)

Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models

Touw, K., Ringus, D. L., Hubert, N., Wang, Y., Leone, V. A., Nadimpalli, A., Theriault, B. R., Huang, Y. E., Tune, J. D., Herring, P. B., Farrugia, G., Kashyap, P. C., Antonopoulos, D. A. & Chang, E. B., Mar 1 2017, In : Physiological Reports. 5, 6, e13182.

Research output: Contribution to journalArticle

Constipation
Loperamide
Microbiota
Dysbiosis
Gastrointestinal Transit
60 Citations (Scopus)

Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: A Systematic Review and Meta-analysis

Klem, F., Wadhwa, A., Prokop, L. J., Sundt, W. J., Farrugia, G., Camilleri, M., Singh, S. & Grover, M., Apr 1 2017, In : Gastroenterology. 152, 5, p. 1042-1054.e1

Research output: Contribution to journalArticle

Enteritis
Irritable Bowel Syndrome
Meta-Analysis
Confidence Intervals
Odds Ratio
5 Citations (Scopus)

Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application

Zhong, J., Ye, Z., Lenz, S. W., Clark, C. R., Bharucha, A. E., Farrugia, G., Robertson, K. D., Zhang, Z., Ordog, T. & Lee, J. H., Dec 21 2017, In : BMC Genomics. 18, 1, 985.

Research output: Contribution to journalArticle

Chromatin Immunoprecipitation
DNA
Gene Library
Libraries
Buffers
18 Citations (Scopus)

Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis

Hasler, W. L., May, K. P., Wilson, L. A., Van Natta, M., Parkman, H. P., Pasricha, P. J., Koch, K. L., Abell, T. L., Mccallum, R. W., Nguyen, L. A., Snape, W. J., Sarosiek, I., Clarke, J. O., Farrugia, G., Calles-Escandon, J., Grover, M., Tonascia, J., Lee, L. A., Miriel, L. & Hamilton, F. A., 2017, (Accepted/In press) In : Neurogastroenterology and Motility.

Research output: Contribution to journalArticle

Gastroparesis
Radionuclide Imaging
Gastric Emptying
Capsules
Stomach
6 Citations (Scopus)

Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis

Gibbons, S. J., Grover, M., Choi, K. M., Wadhwa, A., Zubair, A., Wilson, L. A., Wu, Y., Abell, T. L., Hasler, W. L., Koch, K. L., McCallum, R. W., Nguyen, L. A. B., Parkman, H. P., Sarosiek, I., Snape, W. J., Tonascia, J., Hamilton, F. A., Pasricha, P. J. & Farrugia, G., Nov 1 2017, In : PLoS One. 12, 11, e0187772.

Research output: Contribution to journalArticle

heme oxygenase (biliverdin-producing)
Gastroparesis
Heme Oxygenase-1
Polymorphism
Genes
12 Citations (Scopus)

Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release

Strege, P. R., Knutson, K., Eggers, S. J., Li, J. H., Wang, F., Linden, D. R., Szurszewski, J. H., Milescu, L., Leiter, A. B., Farrugia, G. & Beyder, A., Dec 1 2017, In : Scientific Reports. 7, 1, 15650.

Research output: Contribution to journalArticle

Enterochromaffin Cells
Sodium Channels
Serotonin
NAV1.3 Voltage-Gated Sodium Channel
Action Potentials