Debabrata Mukhopadhyay, PhD

  • 15555 Citations
  • 62 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2020

HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Glasgow Precision Oncology Laboratory & Australian Pancreatic Cancer Genome Initiative, May 12 2020, In : Cell reports. 31, 6, 107625.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Molecular inhibitor of QSOX1 suppresses tumor growth in vivo

Fifield, A. L., Hanavan, P. D., Faigel, D. O., Sergienko, E., Bobkov, A., Meurice, N., Petit, J. L., Polito, A., Caulfield, T. R., Castle, E. P., Copland, J. A., Mukhopadhyay, D., Pal, K., Dutta, S. K., Luo, H., Ho, T. H. & Lake, D. F., 2020, In : Molecular cancer therapeutics. 19, 1, p. 112-122 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Ovatodiolide suppresses oral cancer malignancy by down-regulating exosomal mir-21/STAT3/β-catenin cargo and preventing oncogenic transformation of normal gingival fibroblasts

Chen, J. H., Wu, A. T. H., Bamodu, O. A., Yadav, V. K., Chao, T. Y., Tzeng, Y. M., Mukhopadhyay, D., Hsiao, M. & Lee, J. C., Jan 2020, In : Cancers. 12, 1, 56.

Research output: Contribution to journalArticle

Open Access

Safety of bovine milk derived extracellular vesicles used for delivery of RNA therapeutics in zebrafish and mice

Matsuda, A., Moirangthem, A., Angom, R. S., Ishiguro, K., Driscoll, J., Yan, I. K., Mukhopadhyay, D. & Patel, T., May 1 2020, In : Journal of Applied Toxicology. 40, 5, p. 706-718 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeted dual intervention-oriented drug-encapsulated (Diode) nanoformulations for improved treatment of pancreatic cancer

Madamsetty, V. S., Pal, K., Dutta, S. K., Wang, E. & Mukhopadhyay, D., May 2020, In : Cancers. 12, 5, 1189.

Research output: Contribution to journalArticle

Open Access

Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H

Gui, F., Zhang, Y., Wan, J., Zhan, X., Yao, Y., Li, Y., Haddock, A. N., Shi, J., Guo, J., Chen, J., Zhu, X., Edenfield, B. H., Zhuang, L., Hu, C., Wang, Y., Mukhopadhyay, D., Radisky, E. S., Zhang, L., Lugea, A., Pandol, S. J. & 2 others, Bi, Y. & Ji, B., Jan 2 2020, In : Journal of Clinical Investigation. 130, 1, p. 189-202 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

AFM study: Cell cycle and probe geometry influences nanomechanical characterization of Panc1 cells

Kulkarni, T., Tam, A., Mukhopadhyay, D. & Bhattacharya, S., May 1 2019, In : Biochimica et Biophysica Acta - General Subjects. 1863, 5, p. 802-812 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

A novel multi-target small molecule, LCC-09, inhibits stemness and therapy-resistant phenotypes of glioblastoma cells by increasing MIR-34a and deregulating the DRD4/AKT/MTOR signaling axis

Wen, Y. T., Wu, A. T., Bamodu, O. A., Wei, L., Lin, C. M., Yen, Y., Chao, T. Y., Mukhopadhyay, D., Hsiao, M. & Huang, H. S., Oct 2019, In : Cancers. 11, 10, 1442.

Research output: Contribution to journalArticle

Open Access

BRAF V600E-induced, tumor intrinsic PD-L1 can regulate chemotherapy-induced apoptosis in human colon cancer cells and in tumor xenografts

Feng, D., Qin, B., Pal, K., Sun, L., Dutta, S., Dong, H., Liu, X., Mukhopadhyay, D., Huang, S. & Sinicrope, F. A., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

6 Scopus citations

Co-delivery of everolimus and vinorelbine via a tumor-targeted liposomal formulation inhibits tumor growth and metastasis in RCC

Pal, K., Madamsetty, V. S., Dutta, S. K. & Mukhopadhyay, D., 2019, In : International journal of nanomedicine. 14, p. 5109-5123 15 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Correction: The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine (Oncotarget (2015) 6 (4992–5004) DOI: 10.18632/oncotarget.3214)

Jung, D. B., Yun, M., Kim, E. O., Kim, J., Kim, B., Jung, J. H., Wang, E., Mukhopadhyay, D., Hammond, E., Dredge, K., Shridhar, V. & Kim, S. H., Sep 1 2019, In : Oncotarget. 10, 54, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Design and Evaluation of PEGylated Liposomal Formulation of a Novel Multikinase Inhibitor for Enhanced Chemosensitivity and Inhibition of Metastatic Pancreatic Ductal Adenocarcinoma

Madamsetty, V. S., Pal, K., Dutta, S. K., Wang, E., Thompson, J. R., Banerjee, R. K., Caulfield, T. R., Mody, K., Yen, Y., Mukhopadhyay, D. & Huang, H. S., Oct 16 2019, In : Bioconjugate Chemistry. 30, 10, p. 2703-2713 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Development of multi-drug loaded PEGylated nanodiamonds to inhibit tumor growth and metastasis in genetically engineered mouse models of pancreatic cancer

Madamsetty, V. S., Pal, K., Keshavan, S., Caulfield, T. R., Dutta, S. K., Wang, E., Fadeel, B. & Mukhopadhyay, D., Dec 7 2019, In : Nanoscale. 11, 45, p. 22006-22018 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Divergent roles of Plexin D1 in cancer

Vivekanadhan, S. & Mukhopadhyay, D., Aug 1 2019, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1872, 1, p. 103-110 8 p.

Research output: Contribution to journalReview article

2 Scopus citations

DNA-SWCNT biosensors allow real-time monitoring of therapeutic responses in pancreatic ductal adenocarcinoma

Bhattacharya, S., Gong, X., Wang, E., Dutta, S. K., Caplette, J. R., Son, M., Nguyen, F. T., Strano, M. S. & Mukhopadhyay, D., Sep 1 2019, In : Cancer research. 79, 17, p. 4515-4523 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Erratum: Chemically-Modified Peptides Targeting the PDZ Domain of GIPC as a Therapeutic Approach for Cancer (ACS Chemical Biology (2012) 7:4 (770-779) DOI: 10.1021/cb200536r)

Patra, C. R., Rupasinghe, C. N., Dutta, S. K., Bhattacharya, S., Wang, E., Spaller, M. R. & Mukhopadhyay, D., Oct 18 2019, In : ACS Chemical Biology. 14, 10, 1 p.

Research output: Contribution to journalComment/debate

Evaluation of the in vivo genotoxicity of liposomal formulation for delivering anticancer estrogenic derivative (ESC8) in a mouse model

Ahmad, A., Jan, B. L., Raish, M., Rachamalla, H. K. R., Banerjee, R., Mukhopadhyay, D. & Alkharfy, K. M., Jan 1 2019, In : Saudi Pharmaceutical Journal.

Research output: Contribution to journalArticle

Open Access

Glycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to chemotherapy by abrogating the ToPBP1/ATR-mediated DNA damage response

Ding, L., Madamsetty, V. S., Kiers, S., Alekhina, O., Ugolkov, A., Dube, J., Zhang, Y., Zhang, J. S., Wang, E., Dutta, S. K., Schmitt, D. M., Giles, F. J., Kozikowski, A. P., Mazar, A. P., Mukhopadhyay, D. & Billadeau, D. D., Nov 1 2019, In : Clinical Cancer Research. 25, 21, p. 6452-6462 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells

Kulkarni, T., Angom, R. S., Das, P., Bhattacharya, S. & Mukhopadhyay, D., Dec 1 2019, In : Biochimica et Biophysica Acta - Biomembranes. 1861, 12, 183061.

Research output: Contribution to journalArticle

1 Scopus citations
4 Scopus citations

Phases of Metabolic and Soft Tissue Changes in Months Preceding a Diagnosis of Pancreatic Ductal Adenocarcinoma

Sah, R. P., Sharma, A., Nagpal, S., Patlolla, S. H., Sharma, A., Kandlakunta, H., Anani, V., Angom, R. S., Kamboj, A. K., Ahmed, N., Mohapatra, S., Vivekanandhan, S., Philbrick, K. A., Weston, A., Takahashi, N., Kirkland, J., Javeed, N., Matveyenko, A., Levy, M. J., Mukhopadhyay, D. & 1 others, Chari, S. T., May 2019, In : Gastroenterology. 156, 6, p. 1742-1752 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Protein kinase D up-regulates transcription of VEGF receptor-2 in endothelial cells by suppressing nuclear localization of the transcription factor AP2β

Wang, Y., Hoeppner, L. H., Angom, R. S., Wang, E., Dutta, S., Doeppler, H. R., Wang, F., Shen, T., Scarisbrick, I. A., Guha, S., Storz, P., Bhattacharya, R. D. & Mukhopadhyay, D., Oct 25 2019, In : Journal of Biological Chemistry. 294, 43, p. 15759-15767 9 p.

Research output: Contribution to journalArticle

Tumor selective uptake of drug-nanodiamond complexes improves therapeutic outcome in pancreatic cancer

Madamsetty, V. S., Sharma, A., Toma, M., Samaniego, S., Gallud, A., Wang, E., Pal, K., Mukhopadhyay, D. & Fadeel, B., Jun 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 18, p. 112-121 10 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

VEGF receptor-1 modulates amyloid β 1–42 oligomer-induced senescence in brain endothelial cells

Angom, R. S., Wang, Y., Wang, E., Pal, K., Bhattacharya, S., Watzlawik, J. O., Rosenberry, T. L., Das, P. & Mukhopadhyay, D., Mar 1 2019, In : FASEB Journal. 33, 3, p. 4626-4637 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Correction: RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells [J. Cell Sci., 128, (3556-3568)] doi:10.1242/jcs.167601

Hoeppner, L. H., Sinha, S., Wang, Y., Bhattacharya, R. D., Dutta, S., Gong, X., Bedell, V. M., Suresh, S., Chun, C., Ramchandran, R., Ekker, S. C. & Mukhopadhyay, D., Mar 1 2018, In : Journal of Cell Science. 131, 6, jcs217604.

Research output: Contribution to journalComment/debate

1 Scopus citations
9 Scopus citations

Translational potential of tumor exosomes in diagnosis and therapy

Javeed, N. & Mukhopadhyay, D., Jan 1 2018, Diagnostic and Therapeutic Applications of Exosomes in Cancer. Elsevier, p. 343-353 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2017

CorMatrix Wrapped Around the Adventitia of the Arteriovenous Fistula Outflow Vein Attenuates Venous Neointimal Hyperplasia

Yang, B., Kilari, S., Brahmbhatt, A., McCall, D. L., Torres, E. N., Leof, E. B., Mukhopadhyay, D. & Misra, S., Dec 1 2017, In : Scientific Reports. 7, 1, 14298.

Research output: Contribution to journalArticle

4 Scopus citations

Exosomes and their role in the micro-/macro-environment: A comprehensive review

Javeed, N. & Mukhopadhyay, D., 2017, In : Journal of Biomedical Research. 31, 5, p. 386-394 9 p.

Research output: Contribution to journalReview article

33 Scopus citations

Genetic status of KRAS modulates the role of Neuropilin-1 in tumorigenesis

Vivekanandhan, S., Yang, L., Cao, Y., Wang, E., Dutta, S. K., Sharma, A. K. & Mukhopadhyay, D., Dec 1 2017, In : Scientific Reports. 7, 1, 12877.

Research output: Contribution to journalArticle

9 Scopus citations

Mixed poly(vinyl pyrrolidone)-based drug-loaded nanomicelles shows enhanced efficacy against pancreatic cancer cell lines

Veeren, A., Bhaw-Luximon, A., Mukhopadhyay, D. & Jhurry, D., May 1 2017, In : European Journal of Pharmaceutical Sciences. 102, p. 250-260 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer

Espindola-Netto, J. M., Chini, C. C. S., Tarragó, M., Wang, E., Dutta, S., Pal, K., Mukhopadhyay, D., Sola-Penna, M. & Chini, E. N., Oct 17 2017, In : Oncotarget. 8, 49, p. 85054-85067 14 p.

Research output: Contribution to journalArticle

12 Scopus citations
2016

Development of Liposomal Formulation for Delivering Anticancer Drug to Breast Cancer Stem-Cell-Like Cells and its Pharmacokinetics in an Animal Model

Ahmad, A., Mondal, S. K., Mukhopadhyay, D., Banerjee, R. & Alkharfy, K. M., Mar 7 2016, In : Molecular Pharmaceutics. 13, 3, p. 1081-1088 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53

Alam, S. K., Yadav, V. K., Bajaj, S., Datta, A., Dutta, S. K., Bhattacharyya, M., Bhattacharya, S., Debnath, S., Roy, S., Boardman, L. A., Smyrk, T. C., Molina, J. R., Chakrabarti, S., Chowdhury, S., Mukhopadhyay, D. & Roychoudhury, S., Apr 1 2016, In : Cell Death and Differentiation. 23, 4, p. 707-722 16 p.

Research output: Contribution to journalArticle

40 Scopus citations

Genomic analyses identify molecular subtypes of pancreatic cancer

Australian Pancreatic Cancer Genome Initiative, Mar 3 2016, In : Nature. 531, 7592, p. 47-52 6 p.

Research output: Contribution to journalArticle

996 Scopus citations

Glucocorticoid receptor-targeted liposomal codelivery of lipophilic drug and anti-Hsp90 gene: Strategy to induce drug-sensitivity, EMT-reversal, and reduced malignancy in aggressive tumors

Mondal, S. K., Jinka, S., Pal, K., Nelli, S., Dutta, S. K., Wang, E., Ahmad, A., Alkharfy, K. M., Mukhopadhyay, D. & Banerjee, R., Jul 5 2016, In : Molecular Pharmaceutics. 13, 7, p. 2507-2523 17 p.

Research output: Contribution to journalArticle

7 Scopus citations

Immunosuppressive CD14+HLA-DRlo/neg monocytes are elevated in pancreatic cancer and “primed” by tumor-derived exosomes

Javeed, N., Gustafson, M., Dutta, S. K., Lin, Y., Bamlet, W. R., Oberg, A. L., Petersen, G. M., Chari, S. T., Dietz, A. B. & Mukhopadhyay, D., Dec 23 2016, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

18 Scopus citations

Mutant BRAF upregulates MCL-1 to confer apoptosis resistance that is reversed by MCL-1 antagonism and cobimetinib in colorectal cancer

Kawakami, H., Huang, S., Pal, K., Dutta, S. K., Mukhopadhyay, D. & Sinicrope, F. A., Dec 1 2016, In : Molecular Cancer Therapeutics. 15, 12, p. 3015-3027 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells

Wang, Y., Cao, Y., Mangalam, A. K., Guo, Y., LaFrance-Corey, R. G., Gamez, J. D., Atanga, P. A., Clarkson, B. D., Zhang, Y., Wang, E., Angom, R. S., Dutta, K., Ji, B., Pirko, I., Lucchinetti, C. F., Howe, C. L. & Mukhopadhyay, D., 2016, In : Journal of cell science. 129, 20, p. 3911-3921 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Quantification of lipid modified estrogenic derivative (ESC8) in rat plasma by LC-MS: application to a pharmacokinetic study

Ahmad, A., Mondal, S. K., Jan, B. L., Mukhopadhyay, D., Banerjee, R. & Alkharfy, K. M., Dec 1 2016, In : Biomedical Chromatography. 30, 12, p. 2024-2030 7 p.

Research output: Contribution to journalArticle

Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells

Somasundaram, V., Hemalatha, S. K., Pal, K., Sinha, S., Nair, A. S., Mukhopadhyay, D. & Srinivas, P., May 26 2016, In : BMC Cancer. 16, 1, 336.

Research output: Contribution to journalArticle

11 Scopus citations

Tracking and therapeutic value of human adipose tissue-derived mesenchymal stem cell transplantation in reducing venous neointimal hyperplasia associated with arteriovenous fistula

Yang, B., Brahmbhatt, A., Torres, E. N., Thielen, B., McCall, D. L., Engel, S., Bansal, A., Pandey, M., Dietz, A. B., Leof, E. B., DeGrado, T. R., Mukhopadhyay, D. & Misra, S., May 1 2016, In : Radiology. 279, 2, p. 513-522 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice: Dysregulation of PGC1α and Mitochondrial Homeostasis

Wang, Y., Cao, Y., Yamada, S., Thirunavukkarasu, M., Nin, V., Joshi, M., Rishi, M. T., Bhattacharya, S., Camacho-Pereira, J., Sharma, A. K., Shameer, K., Kocher, J-P., Sanchez, J. A., Wang, E., Hoeppner, L. H., Dutta, S. K., Leof, E. B., Shah, V., Claffey, K. P., Chini, E. N. & 4 others, Simons, M., Terzic, A., Maulik, N. & Mukhopadhyay, D., Jun 27 2015, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 35, 6, p. 1401-1412 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Dopamine D2 receptor agonists inhibit lung cancer progression by reducing angiogenesis and tumor infiltrating myeloid derived suppressor cells

Hoeppner, L. H., Wang, Y., Sharma, A., Javeed, N., Van Keulen, V. P., Wang, E., Yang, P., Roden, A. C., Peikert, T., Molina, J. R. & Mukhopadhyay, D., Jan 1 2015, In : Molecular Oncology. 9, 1, p. 270-281 12 p.

Research output: Contribution to journalArticle

30 Scopus citations

Exosome adherence and internalization by hepatic stellate cells triggers sphingosine 1-phosphate-dependent migration

Wang, R., Ding, Q., Yaqoob, U., De Assuncao, T. D. M., Verma, V. K., Hirsova, P., Cao, S., Mukhopadhyay, D., Huebert, R. C. & Shah, V. H., Dec 25 2015, In : Journal of Biological Chemistry. 290, 52, p. 30684-30696 13 p.

Research output: Contribution to journalArticle

68 Scopus citations

Metformin suppresses pancreatic tumor growth with inhibition of NFκB/STAT3 inflammatory signaling

Tan, X. L., Bhattacharyya, K. K., Dutta, S. K., Bamlet, W. R., Rabe, K. G., Wang, E., Smyrk, T. C., Oberg, A. L., Petersen, G. M. & Mukhopadhyay, D., May 25 2015, In : Pancreas. 44, 4, p. 636-647 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Pancreatic cancer-derived exosomes cause paraneoplastic β-cell dysfunction

Javeed, N., Sagar, G., Dutta, S. K., Smyrk, T. C., Lau, J. S., Bhattacharya, S., Truty, M., Petersen, G. M., Kaufman, R. J., Chari, S. T. & Mukhopadhyay, D., Apr 1 2015, In : Clinical Cancer Research. 21, 7, p. 1722-1733 12 p.

Research output: Contribution to journalArticle

78 Scopus citations

Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue

Sagar, G., Sah, R. P., Javeed, N., Dutta, S. K., Smyrk, T. C., Lau, J. S., Giorgadze, N., Tchkonia, T., Kirkland, J. L., Chari, S. T. & Mukhopadhyay, D., Apr 28 2015, (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

72 Scopus citations

RhoC maintains vascular homeostasis by regulating VEGF-induced signaling in endothelial cells

Hoeppner, L. H., Sinha, S., Wang, Y., Bhattacharya, R. D., Dutta, S., Gong, X., Bedell, V. M., Suresh, S., Chun, C., Ramchandran, R., Ekker, S. C. & Mukhopadhyay, D., Jan 1 2015, In : Journal of cell science. 128, 19, p. 3556-3568 13 p.

Research output: Contribution to journalArticle

18 Scopus citations