Chia-Chen Liu, PhD

  • 2798 Citations
  • 26 Scopus h-Index
20082019
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Research Output 2008 2019

  • 2798 Citations
  • 26 Scopus h-Index
  • 49 Article
  • 2 Review article
  • 1 Comment/debate
2019

5-HT3 antagonist ondansetron increases apoE secretion by modulating the LXR-ABCA1 pathway

Shinohara, M., Shinohara, M., Zhao, J., Fu, Y., Liu, C-C., Kanekiyo, T. & Bu, G. D., Mar 2 2019, In : International Journal of Molecular Sciences. 20, 6, 1488.

Research output: Contribution to journalArticle

Open Access
Serotonin 5-HT3 Receptor Antagonists
Ondansetron
secretions
Apolipoproteins E
liver
4 Citations (Scopus)

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

Tachibana, M., Holm, M. L., Liu, C-C., Shinohara, M., Aikawa, T., Oue, H., Yamazaki, Y., Martens, Y. A., Murray, M. E., Sullivan, P. M., Weyer, K., Glerup, S., Dickson, D. W., Bu, G. D. & Kanekiyo, T., Mar 1 2019, In : Journal of Clinical Investigation. 129, 3, p. 1272-1277 6 p.

Research output: Contribution to journalArticle

LDL Receptors
Amyloid
Apolipoprotein E4
Pathology
Alzheimer Disease
4 Citations (Scopus)

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yamazaki, Y., Zhao, N., Caulfield, T., Liu, C-C. & Bu, G. D., Sep 1 2019, In : Nature Reviews Neurology. 15, 9, p. 501-518 18 p.

Research output: Contribution to journalReview article

Apolipoproteins E
Alzheimer Disease
Apolipoprotein E4
Alleles
Pathology
1 Citation (Scopus)

Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model (Nature Communications, (2019), 10, 1, (1365), 10.1038/s41467-019-09118-9)

Zhong, L., Xu, Y., Zhuo, R., Wang, T., Wang, K., Huang, R., Wang, D., Gao, Y., Zhu, Y., Sheng, X., Chen, K., Wang, N., Zhu, L., Can, D., Marten, Y., Shinohara, M., Liu, C-C., Du, D., Sun, H., Wen, L. & 3 others, Xu, H., Bu, G. D. & Chen, X. F., Dec 1 2019, In : Nature communications. 10, 1, 2923.

Research output: Contribution to journalComment/debate

Open Access
document markup languages
phenotype
HTML
Alzheimer Disease
communication
10 Citations (Scopus)

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

Zhong, L., Xu, Y., Zhuo, R., Wang, T., Wang, K., Huang, R., Wang, D., Gao, Y., Zhu, Y., Sheng, X., Chen, K., Wang, N., Zhu, L., Can, D., Marten, Y., Shinohara, M., Liu, C-C., Du, D., Sun, H., Wen, L. & 3 others, Xu, H., Bu, G. D. & Chen, X. F., Dec 1 2019, In : Nature communications. 10, 1, 1365.

Research output: Contribution to journalArticle

Open Access
phenotype
Myeloid Cells
Amyloid
Alzheimer Disease
Amyloid Plaques
2018
6 Citations (Scopus)
Amyloid
Alzheimer Disease
Infection
Disease Progression
Microbial Interactions
13 Citations (Scopus)

APOE ε2 is associated with increased tau pathology in primary tauopathy

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R. V., Murray, M. E., Koga, S. & 3 others, Dickson, D. W., Ross, O. A. & Bu, G. D., Dec 1 2018, In : Nature Communications. 9, 1, 4388.

Research output: Contribution to journalArticle

Apolipoprotein E2
Tauopathies
pathology
Pathology
mice
11 Citations (Scopus)

Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

Kang, S., Kurti, A., Baker, K. E., Liu, C-C., Colonna, M., Ulrich, J. D., Holtzman, D. M., Bu, G. D. & Fryer, J. D., Jan 15 2018, In : Human Molecular Genetics. 27, 2, p. 211-223 13 p.

Research output: Contribution to journalArticle

Knockout Mice
Lipopolysaccharides
Myeloid Cells
Neurodegenerative Diseases
Up-Regulation
9 Citations (Scopus)

Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice

Tachibana, M., Yamazaki, Y., Liu, C-C., Bu, G. D. & Kanekiyo, T., Feb 1 2018, In : Experimental Neurology. 300, p. 13-21 9 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Pericytes
Amyloid
Pathology
Brain
2017
52 Citations (Scopus)

ApoE4 Accelerates Early Seeding of Amyloid Pathology

Liu, C-C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C. W. & Bu, G. D., Dec 6 2017, In : Neuron. 96, 5, p. 1024-1032.e3

Research output: Contribution to journalArticle

Apolipoprotein E4
Amyloid
Pathology
Apolipoprotein E3
Apolipoproteins E
67 Citations (Scopus)

Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease

Zhao, N., Liu, C-C., Qiao, W. & Bu, G. D., Feb 1 2017, (Accepted/In press) In : Biological Psychiatry.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Apolipoproteins E
Alzheimer Disease
Lipids
Amyloid
52 Citations (Scopus)

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Martens, Y. A., Linares, C., Knight, J. A., Painter, M. M., Sullivan, P. M. & Bu, G. D., Sep 27 2017, In : Neuron. 96, 1, p. 115-129 15 p.

Research output: Contribution to journalArticle

Apolipoprotein E4
Endosomes
Insulin Receptor
Insulin
Alzheimer Disease
39 Citations (Scopus)

Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition

Liu, C-C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M. & Bu, G. D., Apr 12 2017, In : Journal of Neuroscience. 37, 15, p. 4023-4031 9 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Amyloid
Astrocytes
Alzheimer Disease
Brain
26 Citations (Scopus)

Lipocalin-2 protects the brain during inflammatory conditions

Kang, S., Ren, Y., Liu, C-C., Kurti, A., Baker, K. E., Bu, G. D., Asmann, Y. & Fryer, J. D., Jan 10 2017, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Lipopolysaccharides
Central Nervous System
Brain
Cytokines
Sepsis
29 Citations (Scopus)

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Wojtas, A. M., Kang, S., Olley, B. M., Gatherer, M., Shinohara, M., Lozano, P. A., Liu, C-C., Kurti, A., Baker, K. E., Dickson, D. W., Yue, M., Petrucelli, L., Bu, G. D., Carare, R. O. & Fryer, J. D., Aug 15 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 33, p. E6962-E6971

Research output: Contribution to journalArticle

Clusterin
Cerebral Amyloid Angiopathy
Amyloid
Drainage
Alzheimer Disease
56 Citations (Scopus)

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C-C., Zhang, Y. W., Fryer, J. D., Xu, H. & Bu, G. D., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 597-607 11 p.

Research output: Contribution to journalArticle

Microglia
Myeloid Cells
Cytokines
Cell Surface Receptors
Phosphatidylinositol 3-Kinases
8 Citations (Scopus)

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

Rogers, J. T., Liu, C-C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T. & Bu, G. D., May 1 2017, In : Neurobiology of Aging. 53, p. 112-121 10 p.

Research output: Contribution to journalArticle

Ibuprofen
Cognition
Neuronal Plasticity
Astrocytes
Anti-Inflammatory Agents
52 Citations (Scopus)

TREM2 promotes microglial survival by activating wnt/β-catenin pathway

Zheng, H., Jia, L., Liu, C-C., Rong, Z., Zhong, L., Yang, L., Chen, X. F., Fryer, J. D., Wang, X., Zhang, Y. W., Xu, H. & Bu, G. D., Feb 15 2017, In : Journal of Neuroscience. 37, 7, p. 1772-1784 13 p.

Research output: Contribution to journalArticle

Catenins
Wnt Signaling Pathway
Myeloid Cells
Microglia
Alzheimer Disease
2016
43 Citations (Scopus)

ABCA7 deficiency accelerates amyloid-βgeneration and alzheimer’s neuronal pathology

Sakae, N., Liu, C-C., Shinohara, M., Frisch-Daiello, J., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L., Kurti, A., Carrasquillo, M. M., Zou, F., Sevlever, D., Bisceglio, G., Gan, M., Fol, R., Knight, P., Wang, M., Han, X., Fryer, J. D., Fitzgerald, M. L. & 4 others, Ohyagi, Y., Younkin, S. G., Bu, G. D. & Kanekiyo, T., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid
Pathology
Alzheimer Disease
Brain
19 Citations (Scopus)

Apolipoprotein e lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

Fu, Y., Zhao, J., Atagi, Y., Nielsen, H. M., Liu, C-C., Zheng, H., Shinohara, M., Kanekiyo, T. & Bu, G. D., May 5 2016, In : Molecular Neurodegeneration. 11, 1, 99.

Research output: Contribution to journalArticle

Heparan Sulfate Proteoglycans
Apolipoproteins
Apolipoproteins E
Amyloid
Lipoproteins
23 Citations (Scopus)

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., Deture, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C-C., Zhao, N., Painter, M. M., Petersen, R. C., Fryer, J. D., Crook, J., Dickson, D. W., Bu, G. D. & Kanekiyo, T., May 14 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-10 10 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Alzheimer Disease
Apolipoproteins E
Temporal Lobe
Amyloid
28 Citations (Scopus)

LRP1 modulates the microglial immune response via regulation of JNK and NF-ΚB signaling pathways

Yang, L., Liu, C-C., Zheng, H., Kanekiyo, T., Atagi, Y., Jia, L., Wang, D., N'songo, A., Can, D., Xu, H., Chen, X. F. & Bu, G. D., Dec 8 2016, In : Journal of Neuroinflammation. 13, 1, 304.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Phosphotransferases
Microglia
Proteins
Alzheimer Disease
35 Citations (Scopus)

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease

Liu, C-C., Zhao, N., Yamaguchi, Y., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M. & Bu, G. D., Mar 30 2016, In : Science Translational Medicine. 8, 332, 332ra44.

Research output: Contribution to journalArticle

Heparitin Sulfate
Amyloid
Alzheimer Disease
Pathology
Brain
26 Citations (Scopus)

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

Zheng, H., Liu, C-C., Atagi, Y., Chen, X. F., Jia, L., Yang, L., He, W., Zhang, X., Kang, S., Rosenberry, T. L., Fryer, J. D., Zhang, Y. W., Xu, H. & Bu, G. D., Jun 1 2016, In : Neurobiology of Aging. 42, p. 132-141 10 p.

Research output: Contribution to journalArticle

Microglia
Myeloid Cells
Alzheimer Disease
Lipopolysaccharides
Amyloid
16 Citations (Scopus)

Quercetin stabilizes apolipoprotein e and reduces brain Aβ levels in amyloid model mice

Zhang, X., Hu, J., Zhong, L., Wang, N., Yang, L., Liu, C-C., Li, H., Wang, X., Zhou, Y., Zhang, Y., Xu, H., Bu, G. D. & Zhuang, J., Sep 1 2016, In : Neuropharmacology. 108, p. 179-192 14 p.

Research output: Contribution to journalArticle

Apolipoproteins
Quercetin
Apolipoproteins E
Amyloid
Brain
28 Citations (Scopus)

Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1

Tachibana, M., Shinohara, M., Yamazaki, Y., Liu, C-C., Rogers, J., Bu, G. D. & Kanekiyo, T., Mar 1 2016, In : Experimental Neurology. 277, p. 1-9 9 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Retinoid X Receptors
Synapses
Apolipoproteins E
Proteins
31 Citations (Scopus)

Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

Yamazaki, Y., Baker, D. J., Tachibana, M., Liu, C-C., Van Deursen, J., Brott, T. G., Bu, G. D. & Kanekiyo, T., Feb 16 2016, (Accepted/In press) In : Stroke.

Research output: Contribution to journalArticle

Cell Aging
Pericytes
Blood Vessels
Tight Junctions
Microvessels
2015
138 Citations (Scopus)

Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)

Atagi, Y., Liu, C-C., Painter, M. M., Chen, X. F., Verbeeck, C., Zheng, H., Li, X., Rademakers, R. V., Kang, S., Xu, H., Younkin, S. G., Das, P., Fryer, J. D. & Bu, G. D., Oct 23 2015, In : Journal of Biological Chemistry. 290, 43, p. 26043-26050 8 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Myeloid Cells
Ligands
Microglia
Phagocytosis
13 Citations (Scopus)

Decreased platelet 5-hydroxytryptamin (5-HT) levels: A response to antidepressants

Li, X., Fan, Y., Xiao, S., Peng, S., Dong, X., Zheng, X., Liu, C-C., Li, H. & Xiao, Z., Nov 15 2015, In : Journal of Affective Disorders. 187, p. 84-90 7 p.

Research output: Contribution to journalArticle

Citalopram
Antidepressive Agents
Blood Platelets
Depression
Pharmaceutical Preparations
27 Citations (Scopus)

Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

Wren, M. C., Zhao, J., Liu, C-C., Murray, M. E., Atagi, Y., Davis, M. D., Fu, Y., Okano, H. J., Ogaki, K., Strongosky, A. J., Tacik, P., Rademakers, R. V., Ross, O. A., Dickson, D. W., Wszolek, Z. K., Kanekiyo, T. & Bu, G. D., Sep 15 2015, In : Molecular Neurodegeneration. 10, 1, 42.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Frontotemporal Dementia
Neural Stem Cells
Mutation
Substantia Nigra
5 Citations (Scopus)

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes

Kang, S., Kurti, A., Wojtas, A., Baker, K. E., Liu, C-C., Kanekiyo, T., Deming, Y., Cruchaga, C., Estus, S., Bu, G. D. & Fryer, J. D., 2015, In : Human Molecular Genetics. 25, 16, p. 3467-3475 9 p.

Research output: Contribution to journalArticle

Clusterin
Alzheimer Disease
Genes
Brain
Cerebrospinal Fluid
5 Citations (Scopus)

Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk

Harriott, A. M., Heckman, M. G., Rayaprolu, S., Soto-Ortolaza, A. I., Diehl, N. N., Kanekiyo, T., Liu, C-C., Bu, G. D., Malik, R., Cole, J. W., Meschia, J. F., Ross, O. A. & for the METASTROKE Consortium, T. METASTROKE. C., Aug 1 2015, In : European Journal of Neurology. 22, 8, p. 1235-1241 7 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-6
Low Density Lipoprotein Receptor-Related Protein-1
Stroke
Genes
Odds Ratio
48 Citations (Scopus)

Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain

Liu, C-C., Hu, J., Tsai, C. W., Yue, M., Melrose, H. L., Kanekiyo, T. & Bu, G. D., Apr 8 2015, In : Journal of Neuroscience. 35, 14, p. 5851-5859 9 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Alzheimer Disease
Insulin
Glucose
Brain
42 Citations (Scopus)

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

Hu, J., Liu, C-C., Chen, X. F., Zhang, Y. W., Xu, H. & Bu, G. D., Mar 5 2015, (Accepted/In press) In : Molecular Neurodegeneration. p. 1-11 11 p.

Research output: Contribution to journalArticle

Apolipoprotein E2
Apolipoproteins A
Apolipoprotein E4
Apolipoproteins E
Brain
49 Citations (Scopus)

TREM2 in CNS homeostasis and neurodegenerative disease

Painter, M. M., Atagi, Y., Liu, C-C., Rademakers, R. V., Xu, H., Fryer, J. D. & Bu, G. D., Sep 4 2015, In : Molecular Neurodegeneration. 10, 1, 43.

Research output: Contribution to journalArticle

Central Nervous System Diseases
Myeloid Cells
Neurodegenerative Diseases
Homeostasis
Proteins
2014
78 Citations (Scopus)

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer's Disease

Liu, C-C., Tsai, C. W., Deak, F., Rogers, J., Penuliar, M., Sung, Y. M., Maher, J. N., Fu, Y., Li, X., Xu, H., Estus, S., Hoe, H. S., Fryer, J. D., Kanekiyo, T. & Bu, G. D., Oct 1 2014, In : Neuron. 84, 1, p. 63-77 15 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-6
Amyloid
Alzheimer Disease
Pathology
Protein Deficiency
24 Citations (Scopus)

Retinoic acid isomers facilitate apolipoprotein e production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway

Zhao, J., Fu, Y., Liu, C-C., Shinohara, M., Nielsen, H. M., Dong, Q., Kanekiyo, T. & Bu, G. D., Apr 18 2014, In : Journal of Biological Chemistry. 289, 16, p. 11282-11292 11 p.

Research output: Contribution to journalArticle

Retinoid X Receptors
Retinoic Acid Receptors
Apolipoproteins
Apolipoproteins E
Tretinoin
17 Citations (Scopus)

Tyrosine-based signal mediates lrp6 receptor endocytosis and desensitization of wnt/β-catenin pathway signaling

Liu, C-C., Kanekiyo, T., Roth, B. & Bu, G. D., Oct 3 2014, In : Journal of Biological Chemistry. 289, 40, p. 7562-27570 20009 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-1
Catenins
Wnt Signaling Pathway
Endocytosis
Tyrosine
2013
1028 Citations (Scopus)

Apolipoprotein e and Alzheimer disease: Risk, mechanisms and therapy

Liu, C-C., Kanekiyo, T., Xu, H. & Bu, G. D., Feb 2013, In : Nature Reviews Neurology. 9, 2, p. 106-118 13 p.

Research output: Contribution to journalArticle

Apolipoproteins
Apolipoproteins E
Alzheimer Disease
Alleles
Lipids
8 Citations (Scopus)
Apolipoproteins
Neurology
Alzheimer Disease
Therapeutics
109 Citations (Scopus)

Neuronal clearance of amyloid-β by endocytic receptor LRP1

Kanekiyo, T., Cirrito, J. R., Liu, C-C., Shinohara, M., Li, J., Schuler, D. R., Shinohara, M., Holtzman, D. M. & Bu, G. D., 2013, In : Journal of Neuroscience. 33, 49, p. 19276-19283 8 p.

Research output: Contribution to journalArticle

Lipoprotein Receptors
Amyloid
Alzheimer Disease
Neurons
Amyloid beta-Protein Precursor
2012
8 Citations (Scopus)

Epistasis Analysis for Estrogen Metabolic and Signaling Pathway Genes on Young Ischemic Stroke Patients

Hsieh, Y. C., Jeng, J. S., Lin, H. J., Hu, C. J., Yu, C. C., Lien, L. M., Peng, G. S., Chen, C. I. C. I., Tang, S. C., Chi, N. F., Tseng, H. P., Chern, C. M., Hsieh, F. I. F. I., Bai, C. H., Chen, Y. R., Chiou, H. Y., Jeng, J. S., Tang, S. C., Yeh, S. J., Tsai, L. K. & 63 others, Kong, S., Lien, L. M., Chiu, H. C., Chen, W. H., Bai, C. H., Huang, T. H., Lau, C. I., Wu, Y. Y., Yuan, R. Y., Hu, C. J., Sheu, J. J., Yu, J. M., Ho, C. S., Chen, C. I., Sung, J. Y., Weng, H. Y., Han, Y. H., Huang, C. P., Chung, W. T., Ke, D. S., Lin, H. J., Chang, C. Y., Yeh, P. S., Lin, K. C., Cheng, T. J., Chou, C. H., Yang, C. M., Peng, G. S., Lin, J. C., Hsu, Y. D., Denq, J. C., Lee, J. T., Liu, C-C., Lin, C. C., Yen, C. H., Cheng, C. A., Sung, Y. F., Chen, Y. L., Lien, M. T., Chou, C. H., Liu, C. C., Yang, F. C., Wu, Y. C., Tso, A. C., Lai, Y. H., Chiang, C. I., Tsai, C. K., Liu, M. T., Lin, Y. C., Hsu, Y. C., Chen, C. H., Sung, P. S., Chern, C. M., Hu, H. H., Wong, W. J., Luk, Y. O., Hsu, L. C., Chung, C. P., Tseng, H. P., Liu, C. H., Lin, C. L., Lin, H. C. & Hu, C. J., Oct 24 2012, In : PLoS One. 7, 10, e47773.

Research output: Contribution to journalArticle

catechol O-methyltransferase
Guaiacol
epistasis
Transferases
Metabolic Networks and Pathways
105 Citations (Scopus)

Lrp1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β

Kanekiyo, T., Liu, C-C., Shinohara, M., Li, J. & Bu, G. D., Nov 14 2012, In : Journal of Neuroscience. 32, 46, p. 16458-16465 8 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Amyloid
Smooth Muscle Myocytes
Cerebral Amyloid Angiopathy
Lipoproteins
2011
Biomolecular Nuclear Magnetic Resonance
94 Citations (Scopus)
Low Density Lipoprotein Receptor-Related Protein-1
Lipoprotein Receptors
Heparan Sulfate Proteoglycans
Amyloid
Proteins
9 Citations (Scopus)

Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6

Chen, J., Liu, C-C., Li, Q., Nowak, C., Bu, G. D. & Wang, J., Mar 9 2011, In : Structure. 19, 3, p. 313-323 11 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Protein Folding
Protein Biosynthesis
Histidine
Epidermal Growth Factor
2010
46 Citations (Scopus)

Dkk1 stabilizes wnt co-receptor LRP6: Implication for Wnt ligand-induced LRP6 down-regulation

Li, Y., Lu, W., King, T. D., Liu, C-C., Bijur, G. N. & Bu, G. D., 2010, In : PLoS One. 5, 6, e11014.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-6
Wnt Receptors
lipoproteins
Down-Regulation
Ligands
119 Citations (Scopus)

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

Liu, C-C., Prior, J., Piwnica-Worms, D. & Bu, G. D., Mar 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 11, p. 5136-5141 6 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Therapeutics
Catenins
Neoplasms
Wnt Signaling Pathway
32 Citations (Scopus)

Mesd is a universal inhibitor of wnt coreceptors lrp5 and lrp6 and blocks wnt/β-catenin signaling in cancer cells

Lu, W., Liu, C-C., Thottassery, J. V., Bu, G. D. & Li, Y., Jun 8 2010, In : Biochemistry. 49, 22, p. 4635-4643 9 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-5
Catenins
Cells
Neoplasms
Recombinant proteins
4 Citations (Scopus)

NMR structure note: Solution structure of the core domain of MESD that is essential for proper folding of LRP5/6

Chen, J., Li, Q., Liu, C-C., Zhou, B., Bu, G. D. & Wang, J., Aug 2010, In : Journal of Biomolecular NMR. 47, 4, p. 283-288 6 p.

Research output: Contribution to journalArticle

LDL-Receptor Related Proteins
Static electricity
Drosophila Proteins
Protein folding
Molecular Chaperones