Aneel Paulus, MD

  • 451 Citations
  • 13 Scopus h-Index
20112019
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Research Output 2011 2019

  • 451 Citations
  • 13 Scopus h-Index
  • 30 Article
  • 4 Chapter
  • 3 Review article
2019

Monoclonal antibody utilization characteristics in patients with multiple myeloma

Ailawadhi, S., Sher, T., Azzouqa, A. G., Meghji, Z., Jain, T., Jani, P., Ahmed, S., Diehl, N., Roy, V., Shah, V., Hodge, D., Ailawadhi, M., Alegria, V. R., Paulus, A., Chanan Khan, A. A. & Fonseca, R., Sep 1 2019, In : Anti-cancer drugs. 30, 8, p. 859-865 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Monoclonal Antibodies
Premedication
Clinical Trials
Drug Utilization

Survival trends in glioblastoma and association with treating facility volume

Aulakh, S., DeDeo, M. R., Free, J., Rosenfeld, S., Quinones-Hinojosa, A., Paulus, A., Manna, A., Manochakian, R., Chanan Khan, A. A. & Ailawadhi, S., Jan 1 2019, In : Journal of Clinical Neuroscience.

Research output: Contribution to journalArticle

Glioblastoma
temozolomide
Survival
Therapeutics
Neoplasms

Survival Trends in Young Patients With Multiple Myeloma: A Focus on Racial-Ethnic Minorities

Ailawadhi, S., Azzouqa, A. G., Hodge, D., Cochuyt, J., Jani, P., Ahmed, S., Sher, T., Roy, V., Ailawadhi, M., Alegria, V. R., Manochakian, R., Vishnu, P., Grover, A., Abdulazeez, M. F., Paulus, A. & Chanan Khan, A. A., Jan 1 2019, (Accepted/In press) In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

Multiple Myeloma
Survival
Survival Rate
Hispanic Americans
Epidemiology
1 Citation (Scopus)

Targeting CD38 enhances the antileukemic activity of ibrutinib in chronic lymphocytic leukemia

Manna, A., Aulakh, S., Jani, P., Ahmed, S., Akhtar, S., Coignet, M., Heckman, M., Meghji, Z., Bhatia, K., Sharma, A., Sher, T., Alegria, V., Malavasi, F., Chini, E. N., Chanan Khan, A. A., Ailawadhi, S. & Paulus, A., Jan 1 2019, In : Clinical Cancer Research. 25, 13, p. 3974-3985 12 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Heterografts
B-Lymphocytes
Antibody-Dependent Cell Cytotoxicity
PCI 32765
1 Citation (Scopus)

Trends in the risk of second primary malignancies among survivors of chronic lymphocytic leukemia

Kumar, V., Ailawadhi, S., Bojanini, L., Mehta, A., Biswas, S., Sher, T., Roy, V., Vishnu, P., Marin-Acevedo, J., Alegria, V. R., Paulus, A., Aulakh, S., Iqbal, M., Manochakian, R., Tan, W., Chanan-Khan, A. & Ailawadhi, M., Oct 1 2019, In : Blood cancer journal. 9, 10, 75.

Research output: Contribution to journalArticle

Open Access
Second Primary Neoplasms
B-Cell Chronic Lymphocytic Leukemia
Survivors
Incidence
Survival Rate
Open Access
Waldenstrom Macroglobulinemia
B-Cell Chronic Lymphocytic Leukemia
Therapeutic Human Experimentation
United States Food and Drug Administration
Therapeutics
2018
8 Citations (Scopus)

Novel fluorinated curcuminoids and their pyrazole and isoxazole derivatives: Synthesis, structural studies, Computational/Docking and in-vitro bioassay

Laali, K. K., Greves, W. J., Correa-Smits, S. J., Zwarycz, A. T., Bunge, S. D., Borosky, G. L., Manna, A., Paulus, A. & Chanan Khan, A. A., Feb 1 2018, In : Journal of Fluorine Chemistry. 206, p. 82-98 17 p.

Research output: Contribution to journalArticle

Isoxazoles
bioassay
Bioassay
Bearings (structural)
Biological Assay

Outcomes of patients with simultaneous diagnosis of chronic lymphocytic leukaemia/small lymphocytic lymphoma and multiple myeloma

Ailawadhi, S., Dholaria, B. R., Khurana, S., Sher, T., Alegria, V., Paulus, A., Ailawadhi, M., Mehta, A., Chanan Khan, A. A. & Roy, V., Jan 1 2018, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Multiple Myeloma
3 Citations (Scopus)

Synthesis, Computational Docking Study, and Biological Evaluation of a Library of Heterocyclic Curcuminoids with Remarkable Antitumor Activity

Laali, K. K., Greves, W. J., Zwarycz, A. T., Correa Smits, S. J., Troendle, F. J., Borosky, G. L., Akhtar, S., Manna, A., Paulus, A., Chanan Khan, A. A., Nukaya, M. & Kennedy, G. D., Sep 19 2018, In : ChemMedChem. 13, 18, p. 1895-1908 14 p.

Research output: Contribution to journalArticle

Libraries
Cells
Pyrazoles
HCT116 Cells
Cell Line
1 Citation (Scopus)

Targeting CD38 with daratumumab is lethal to Waldenström macroglobulinaemia cells

Paulus, A., Manna, A., Akhtar, S., Paulus, S. M., Sharma, M., Coignet, M. V., Jiang, L., Roy, V., Witzig, T. E., Ansell, S. M., Allan, J., Furman, R., Aulakh, S., Manochakian, R., Ailawadhi, S., Chanan Khan, A. A. & Sher, T., Jan 1 2018, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Cytophagocytosis
Antibodies
B-Lymphocytes
Cell Death
8 Citations (Scopus)

Trends in multiple myeloma presentation, management, cost of care, and outcomes in the Medicare population: A comprehensive look at racial disparities

Ailawadhi, S., Frank, R. D., Sharma, M., Menghani, R., Temkit, M., Paulus, S., Khera, N. D., Hashmi, S., Advani, P., Swaika, A., Paulus, A., Aslam, N., Sher, T., Roy, V., Colon-Otero, G. & Chanan Khan, A. A., Jan 1 2018, (Accepted/In press) In : Cancer.

Research output: Contribution to journalArticle

Medicare
Multiple Myeloma
Costs and Cost Analysis
Survival
Hispanic Americans
2017
11 Citations (Scopus)

Racial disparity in utilization of therapeutic modalities among multiple myeloma patients: A SEER-medicare analysis

Ailawadhi, S., Frank, R. D., Advani, P., Swaika, A., Temkit, M., Menghani, R., Sharma, M., Meghji, Z., Paulus, S., Khera, N. D., Hashmi, S. K., Paulus, A., Kakar, T. S., Hodge, D. O., Colibaseanu, D. T., Vizzini, M. R., Roy, V., Colon-Otero, G. & Chanan Khan, A. A., 2017, (Accepted/In press) In : Cancer Medicine.

Research output: Contribution to journalArticle

Medicare
Multiple Myeloma
Stem Cells
Thalidomide
Transplants
13 Citations (Scopus)
Waldenstrom Macroglobulinemia
Up-Regulation
Mutation
Therapeutics
Phosphatidylinositol 3-Kinases
2016
15 Citations (Scopus)

Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells

Paulus, A., Akhtar, S., Caulfield, T., Samuel, K., Yousaf, H., Bashir, Y., Paulus, S. M., Tran, D., Hudec, R., Cogen, D., Jiang, J., Edenfield, B., Novak, A. J., Ansell, S. M., Witzig, T. E., Martin, P., Coleman, M., Roy, V., Ailawadhi, S., Chitta, K. & 2 others, Linder, S. & Chanan Khan, A. A., Nov 4 2016, In : Blood Cancer Journal. 6, 11, e492.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Waldenstrom Macroglobulinemia
Hydrolases
Ubiquitin
Isoenzymes
3 Citations (Scopus)

Novel therapeutic targets in Waldenstrom macroglobulinemia

Paulus, A., Ailawadhi, S. & Chanan Khan, A. A., Jun 1 2016, In : Best Practice and Research: Clinical Haematology. 29, 2, p. 216-228 13 p.

Research output: Contribution to journalReview article

Waldenstrom Macroglobulinemia
Cells
Aurora Kinase A
Proteasome Endopeptidase Complex
T-Cell Antigen Receptor
2 Citations (Scopus)
Waldenstrom Macroglobulinemia
Drug Resistance
Pharmaceutical Preparations
Rare Diseases
Therapeutics
59 Citations (Scopus)

The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

Wang, X., Mazurkiewicz, M., Hillert, E. K., Olofsson, M. H., Pierrou, S., Hillertz, P., Gullbo, J., Selvaraju, K., Paulus, A., Akhtar, S., Bossler, F., Chanan Khan, A. A., Linder, S. & D'Arcy, P., Jun 6 2016, In : Scientific Reports. 6, 26979.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Proteasome Inhibitors
Multiple Myeloma
Apoptosis
Ubiquitin Thiolesterase
2015
6 Citations (Scopus)

Immunophenotyping of Waldenströms macroglobulinemia cell lines reveals distinct patterns of surface antigen expression: Potential biological and therapeutic implications

Paulus, A., Chitta, K. S., Wallace, P. K., Advani, P. P., Akhtar, S., Kuranz-Blake, M., Ailawadhi, S. & Chanan Khan, A. A., Apr 8 2015, In : PLoS One. 10, 4, e0122338.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Immunophenotyping
surface antigens
Surface Antigens
Cells
39 Citations (Scopus)

Synthesis and Evaluation of Derivatives of the Proteasome Deubiquitinase Inhibitor b-AP15

Wang, X., D'Arcy, P., Caulfield, T., Paulus, A., Chitta, K., Mohanty, C., Gullbo, J., Chanan Khan, A. A. & Linder, S., Nov 1 2015, In : Chemical Biology and Drug Design. 86, 5, p. 1036-1048 13 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Proteasome Endopeptidase Complex
Derivatives
Ubiquitin
Catalytic Domain
28 Citations (Scopus)
Waldenstrom Macroglobulinemia
Apoptosis
Proteasome Endopeptidase Complex
Neoplasms
Ubiquitinated Proteins
2014
4 Citations (Scopus)

A Rare Case of Primary High-Grade Large B-Cell Lymphoma of the Sciatic Nerve

Advani, P., Paulus, A., Murray, P., Jiang, L., Goff, R., Pooley, R., Jain, M., Garner, H. & Foran, J. M., Sep 18 2014, (Accepted/In press) In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Peripheral Nervous System Neoplasms
Multimodal Imaging
Marek Disease
X Ray Computed Tomography
19 Citations (Scopus)

AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia

Paulus, A., Chitta, K., Akhtar, S., Personett, D., Miller, K. C., Thompson, K. J., Carr, J., Kumar, S. K., Roy, V., Ansell, S. M., Mikhael, J. R., Dispenzieri, A., Reeder, C. B., Rivera, C. E., Foran, J. M. & Chanan Khan, A. A., Feb 2014, In : British Journal of Haematology. 164, 3, p. 352-365 14 p.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Multiple Myeloma
Dexamethasone
Plasma Cells
Down-Regulation
13 Citations (Scopus)

Neem leaf extract induces cell death by apoptosis and autophagy in B-chronic lymphocytic leukemia cells

Chitta, K. S., Khan, A. N. H., Ersing, N., Swaika, A., Masood, A., Paulus, A., Qadeer, A., Advani, P., Sher, T., Miller, K. C., Lee, K. & Chanan Khan, A. A., Mar 2014, In : Leukemia and Lymphoma. 55, 3, p. 652-661 10 p.

Research output: Contribution to journalArticle

Autophagy
B-Cell Chronic Lymphocytic Leukemia
Cell Death
Apoptosis
Apoptosis Inducing Factor
13 Citations (Scopus)

Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

Chitta, K., Paulus, A., Caulfield, T., Akhtar, S., Blake, M. K. K., Ailawadhi, S., Knight, J., Heckman, M. G., Pinkerton, A. & Chanan Khan, A. A., Jan 1 2014, In : Blood Cancer Journal. 4, 11, e260.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Apoptosis
Limonins
Neoplasms
Computer Simulation
6 Citations (Scopus)

The investigational agent MLN2238 induces apoptosis and is cytotoxic to CLL cells in vitro, as a single agent and in combination with other drugs

Paulus, A., Masood, A., Miller, K. C., Nazmul H. Khan, A. N. M., Akhtar, D., Advani, P., Foran, J. M., Rivera, C. E., Roy, V., Colon-Otero, G., Chitta, K. & Chanan Khan, A. A., 2014, In : British Journal of Haematology. 165, 1, p. 78-88 11 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Apoptosis
Pharmaceutical Preparations
Cell Death
Down-Regulation
2013
16 Citations (Scopus)

Development and characterization of a novel human Waldenström macroglobulinemia cell line: RPCI-WM1, Roswell Park Cancer Institute- Waldenström Macroglobulinemia 1

Chitta, K. S., Paulus, A., Ailawadhi, S., Foster, B. A., Moser, M. T., Starostik, P., Masood, A., Sher, T., Miller, K. C., Iancu, D. M., Conroy, J., Nowak, N. J., Sait, S. N., Personett, D. A., Coleman, M., Furman, R. R., Martin, P., Ansell, S. M., Lee, K. & Chanan Khan, A. A., Feb 2013, In : Leukemia and Lymphoma. 54, 2, p. 387-396 10 p.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Cell Line
Neoplasms
Immunoglobulin Heavy Chains
Tumor Cell Line
53 Citations (Scopus)
Multiple Myeloma
Therapeutics
Thalidomide
Hematologic Neoplasms
PubMed
2012
23 Citations (Scopus)

Acyclovir Prophylaxis Against Varicella Zoster Virus Reactivation in Multiple Myeloma Patients Treated With Bortezomib-Based Therapies: A Retrospective Analysis of 100 Patients

Swaika, A., Paulus, A., Miller, K. C., Sher, T., Almyroudis, N. G., Ball, D., Wood, M., Masood, A., Lee, K. & Chanan Khan, A. A., Jul 2012, In : Journal of Supportive Oncology. 10, 4, p. 155-159 5 p.

Research output: Contribution to journalArticle

Human Herpesvirus 3
Acyclovir
Multiple Myeloma
Herpes Zoster
Therapeutics
19 Citations (Scopus)

Downregulation of BCL2 by AT-101 enhances the antileukaemic effect of lenalidomide both by an immune dependant and independent manner

Masood, A., Chitta, K., Paulus, A., Khan, A. N. H., Sher, T., Ersing, N., Miller, K. C., Manfredi, D., Ailawadhi, S., Borrelo, I., Lee, K. P. & Chanan Khan, A. A., Apr 2012, In : British Journal of Haematology. 157, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Down-Regulation
Therapeutics
Antibodies
Immunologic Factors

Pomalidomide in cancer therapy

Swaika, A., Paulus, A. & Chanan Khan, A. A., Mar 29 2012, Immunomodulating Drugs for the Treatment of Cancer. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Neoplasms
Therapeutics
pomalidomide

Thalidomide and lenalidomide for treatment of primary myelofibrosis

Paulus, A., Masood, A., Griffiths, E., Lee, K. P. & Chanan Khan, A. A., Mar 29 2012, Immunomodulating Drugs for the Treatment of Cancer. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Primary Myelofibrosis
Thalidomide
lenalidomide

Toxicity associated with the immunomodulating agents in patients with chronic lymphocytic leukemia

Sher, T., Musial, L., Paulus, A. & Chanan Khan, A. A., Mar 29 2012, Immunomodulating Drugs for the Treatment of Cancer. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

Proxy
B-Cell Chronic Lymphocytic Leukemia
2011
47 Citations (Scopus)

Biological effects and clinical significance of lenalidomide-induced tumour flare reaction in patients with chronic lymphocytic leukaemia: In vivo evidence of immune activation and antitumour response

Chanan Khan, A. A., Chitta, K., Ersing, N., Paulus, A., Masood, A., Sher, T., Swaika, A., Wallace, P. K., Mashtare, T. L., Wilding, G., Lee, K., Czuczman, M. S., Borrello, I. & Bangia, N., Nov 2011, In : British Journal of Haematology. 155, 4, p. 457-467 11 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Neoplasms
Cytokines
Cellular Microenvironment
Tumor Microenvironment
10 Citations (Scopus)

Clinical relapse in a patient with multiple myeloma presenting as an atrial plasmacytoma

Paulus, A., Swaika, A., Miller, K. C., Spangenthal, E. J., Guo, R., VonFricken, K., Lee, K. & Chanan Khan, A. A., Jan 20 2011, In : Journal of Clinical Oncology. 29, 3

Research output: Contribution to journalArticle

Combined Modality Therapy
Cardiac Tamponade
Heart Neoplasms
Plasmacytoma
Pericardial Effusion

Management of renal failure in multiple myeloma

Paulus, A., Advani, P., Aslam, N. & Chanan Khan, A. A., Jan 1 2011, Myeloma: Pathology, Diagnosis, and Treatment. Cambridge University Press, Vol. 9781107010574. p. 255-275 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Multiple Myeloma
Renal Insufficiency
Kidney
Creatinine
Kidney Diseases
26 Citations (Scopus)

Pharmacokinetic evaluation of oblimersen sodium for the treatment of chronic lymphocytic leukemia

Advani, P. P., Paulus, A., Masood, A., Sher, T. & Chanan Khan, A. A., Jun 2011, In : Expert Opinion on Drug Metabolism and Toxicology. 7, 6, p. 765-774 10 p.

Research output: Contribution to journalArticle

Pharmacokinetics
B-Cell Chronic Lymphocytic Leukemia
Chemotherapy
Phosphorothioate Oligonucleotides
Pharmacodynamics
4 Citations (Scopus)

Targeted treatment for chronic lymphocytic leukemia

Masood, A., Sher, T., Paulus, A., Miller, K. C., Chitta, K. S. & Chanan Khan, A. A., 2011, In : OncoTargets and Therapy. 4, p. 169-183 15 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Therapeutics
Oncogene Proteins
Immunotherapy
Cyclophosphamide