• 589 Citations
  • 15 Scopus h-Index
20052020

Research output per year

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Research Output

  • 589 Citations
  • 15 Scopus h-Index
  • 29 Article
  • 3 Conference contribution
  • 1 Review article
2020

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss

Chandra, A., Lagnado, A. B., Farr, J. N., Monroe, D. G., Park, S., Hachfeld, C., Tchkonia, T., Kirkland, J. L., Khosla, S., Passos, J. F. & Pignolo, R. J., Jan 1 2020, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Feasibility of medical image-based bio 3D printing of variable tissue compositions

Shinde, R., Nigh, D. J. P., Miguez, S. M., Rhodes, S. S., Udupa, J. K., Shetye, S., Chandra, A., Pignolo, R. & Rajapakse, C. S., Jan 1 2019, Medical Imaging 2019: Imaging Informatics for Healthcare, Research, and Applications. Bak, P. R. & Chen, P-H. (eds.). SPIE, 1095409. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10954).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Periosteal Mesenchymal Progenitor Dysfunction and Extraskeletally-Derived Fibrosis Contribute to Atrophic Fracture Nonunion

Wang, L., Tower, R. J., Chandra, A., Yao, L., Tong, W., Xiong, Z., Tang, K., Zhang, Y., Liu, X. S., Boerckel, J. D., Guo, X., Ahn, J. & Qin, L., Jan 1 2019, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Potential role of senescence in radiation-induced damage of the aged skeleton

Chandra, A., Park, S. S. & Pignolo, R., Mar 1 2019, In : Bone. 120, p. 423-431 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Targeting Cell Senescence for the Treatment of Age-Related Bone Loss

Pignolo, R., Samsonraj, R. M., Law, S. F., Wang, H. & Chandra, A., Apr 15 2019, In : Current Osteoporosis Reports. 17, 2, p. 70-85 16 p.

Research output: Contribution to journalReview article

4 Scopus citations
2018

Loading-Induced Reduction in Sclerostin as a Mechanism of Subchondral Bone Plate Sclerosis in Mouse Knee Joints During Late-Stage Osteoarthritis

Jia, H., Ma, X., Wei, Y., Tong, W., Tower, R. J., Chandra, A., Wang, L., Sun, Z., Yang, Z., Badar, F., Zhang, K., Tseng, W. J., Kramer, I., Kneissel, M., Xia, Y., Liu, X. S., Wang, J. H. C., Han, L., Enomoto-Iwamoto, M. & Qin, L., Feb 1 2018, In : Arthritis and Rheumatology. 70, 2, p. 230-241 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis

Chandra, A., Wang, L., Young, T., Zhong, L., Tseng, W. J., Levine, M. A., Cengel, K., Sherry Liu, X., Zhang, Y., Pignolo, R. J. & Qin, L., Jan 2018, In : FASEB Journal. 32, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2017

IL15RA is required for osteoblast function and bone mineralization

Loro, E., Ramaswamy, G., Chandra, A., Tseng, W. J., Mishra, M. K., Shore, E. M. & Khurana, T. S., Oct 1 2017, In : Bone. 103, p. 20-30 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Suppression of Sclerostin Alleviates Radiation-Induced Bone Loss by Protecting Bone-Forming Cells and Their Progenitors Through Distinct Mechanisms

Chandra, A., Lin, T., Young, T., Tong, W., Ma, X., Tseng, W. J., Kramer, I., Kneissel, M., Levine, M. A., Zhang, Y., Cengel, K., Liu, X. S. & Qin, L., Feb 1 2017, In : Journal of Bone and Mineral Research. 32, 2, p. 360-372 13 p.

Research output: Contribution to journalArticle

38 Scopus citations
2016

EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation

Jia, H., Ma, X., Tong, W., Doyran, B., Sun, Z., Wang, L., Zhang, X., Zhou, Y., Badar, F., Chandra, A., Lucas Lu, X., Xia, Y., Han, L., Enomoto-Iwamoto, M. & Qina, L., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14360-14365 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015

A comprehensive study of long-term skeletal changes after spinal cord injury in adult rats

Lin, T., Tong, W., Chandra, A., Hsu, S. Y., Jia, H., Zhu, J., Tseng, W. J., Levine, M. A., Zhang, Y., Yan, S. G., Liu, X. S., Sun, D., Young, W. & Qin, L., Oct 27 2015, In : Bone Research. 3, 15028.

Research output: Contribution to journalArticle

13 Scopus citations

Enhanced Individual Trabecular Repair and Its Mechanical Implications in Parathyroid Hormone and Alendronate Treated Rat Tibial Bone

Altman, A. R., De Bakker, C. M. J., Tseng, W. J., Chandra, A., Qin, L. & Sherry Liu, X., Jan 1 2015, In : Journal of Biomechanical Engineering. 137, 1, 011004.

Research output: Contribution to journalArticle

7 Scopus citations

PTH1-34 blocks radiation-induced osteoblast apoptosis by enhancing DNA repair through canonical Wnt pathway

Chandra, A., Lin, T., Zhu, J., Tong, W., Huo, Y., Jia, H., Zhang, Y., Liu, X. S., Cengel, K., Xia, B. & Qin, L., Jan 2 2015, In : Journal of Biological Chemistry. 290, 1, p. 157-167 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Quantification of skeletal growth, modeling, and remodeling by in vivo micro computed tomography

Altman, A. R., Tseng, W. J., de Bakker, C. M. J., Chandra, A., Lan, S., Huh, B. K., Luo, S., Leonard, M. B., Qin, L. & Liu, X. S., Dec 1 2015, In : Bone. 81, p. 370-379 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

μCT-based, in vivo dynamic bone histomorphometry allows 3D evaluation of the early responses of bone resorption and formation to PTH and alendronate combination therapy

de Bakker, C. M. J., Altman, A. R., Tseng, W. J., Tribble, M. B., Li, C., Chandra, A., Qin, L. & Liu, X. S., Apr 1 2015, In : Bone. 73, p. 198-207 10 p.

Research output: Contribution to journalArticle

18 Scopus citations
2014

A closer look at the immediate trabecula response to combined parathyroid hormone and alendronate treatment

Altman, A. R., Tseng, W. J., de Bakker, C. M. J., Huh, B. K., Chandra, A., Qin, L. & Liu, X. S., Apr 1 2014, In : Bone. 61, p. 149-157 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

PTH1-34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival

Chandra, A., Lin, T., Tribble, M. B., Zhu, J., Altman, A. R., Tseng, W. J., Zhang, Y., Akintoye, S. O., Cengel, K., Liu, X. S. & Qin, L., Oct 2014, In : Bone. 67, p. 33-40 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model

Zhang, X., Zhu, J., Liu, F., Li, Y., Chandra, A., Levin, L. S., Beier, F., Enomoto-Iwamoto, M. & Qin, L., Aug 5 2014, In : Bone Research. 2, 14015.

Research output: Contribution to journalArticle

26 Scopus citations
2013

3D image registration is critical to ensure accurate detection of longitudinal changes in trabecular bone density, microstructure, and stiffness measurements in rat tibiae by in vivo microcomputed tomography (μCT)

Lan, S., Luo, S., Huh, B. K., Chandra, A., Altman, A. R., Qin, L. & Liu, X. S., Sep 1 2013, In : Bone. 56, 1, p. 83-90 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

3D in vivo bone dynamic imaging of PTH's anabolic action

Altman, A. R., Huh, B. K., Chandra, A., Tseng, W. J., Qin, L. & Liu, X. S., Dec 1 2013, ASME 2013 Summer Bioengineering Conference, SBC 2013. (ASME 2013 Summer Bioengineering Conference, SBC 2013; vol. 1 A).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression

Chandra, A., Lan, S., Zhu, J., Siclari, V. A. & Qin, L., Jul 12 2013, In : Journal of Biological Chemistry. 288, 28, p. 20488-20498 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through β-catenin-dependent and -independent pathways

Zhang, X., Zhu, J., Li, Y., Lin, T., Siclari, V. A., Chandra, A., Candela, E. M., Koyama, E., Enomoto-Iwamoto, M. & Qin, L., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32229-32240 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow.

Siclari, V. A., Zhu, J., Akiyama, K., Liu, F., Zhang, X., Chandra, A., Nah, H. D., Shi, S. & Qin, L., Apr 2013, In : Bone. 53, 2, p. 575-586 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

PTH prevents the adverse effects of focal radiation on bone architecture in young rats

Chandra, A., Lan, S., Zhu, J., Lin, T., Zhang, X., Siclari, V. A., Altman, A. R., Cengel, K. A., Liu, X. S. & Qin, L., Aug 1 2013, In : Bone. 55, 2, p. 449-457 9 p.

Research output: Contribution to journalArticle

36 Scopus citations
2012

Amphiregulin-EGFR Signaling Mediates the Migration of Bone Marrow Mesenchymal Progenitors toward PTH-Stimulated Osteoblasts and Osteocytes

Zhu, J., Siclari, V. A., Liu, F., Spatz, J. M., Chandra, A., Divieti Pajevic, P. & Qin, L., Dec 31 2012, In : PloS one. 7, 12, e50099.

Research output: Contribution to journalArticle

27 Scopus citations

Reproducibility of bone microstructure and stiffness measurements in rats by in vivo micro computed tomography and finite element analysis

Lan, S., Chandra, A., Qin, L. & Liu, X. S., Dec 1 2012, ASME 2012 Summer Bioengineering Conference, SBC 2012. p. 45-46 2 p. (ASME 2012 Summer Bioengineering Conference, SBC 2012).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2010

Proteasome assembly influences interaction with ubiquitinated proteins and shuttle factors

Chandra, A., Chen, L., Liang, H. & Madura, K., Mar 12 2010, In : Journal of Biological Chemistry. 285, 11, p. 8330-8339 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Synthetic lethality of rpn11-1 rpn10Δ is linked to altered proteasome assembly and activity

Chandra, A., Chen, L. & Madura, K., Dec 1 2010, In : Current Genetics. 56, 6, p. 543-557 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

The mouse forkhead gene Foxp2 modulates expression of the lung genes

Yang, Z., Hikosaka, K., Sharkar, M. T. K., Tamakoshi, T., Chandra, A., Wang, B., Itakura, T., Xue, X. D., Uezato, T., Kimura, W. & Miura, N., Jul 1 2010, In : Life Sciences. 87, 1-2, p. 17-25 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2008

The medaka FoxP2, a homologue of human language gene FOXP2, has a diverged structure and function

Itakura, T., Chandra, A., Yang, Z., Xue, X., Wang, B., Kimura, W., Hikosaka, K., Inohaya, K., Kudo, A., Uezato, T. & Miura, N., Mar 1 2008, In : Journal of Biochemistry. 143, 3, p. 407-416 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2006

Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells

Chandra, A., Itakura, T., Yang, Z., Tamakoshi, T., Xue, X. D., Wang, B., Ueki, T., Sato, K., Uezato, T. & Miura, N., Jun 9 2006, In : Biochemical and Biophysical Research Communications. 344, 3, p. 786-791 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Roles of the Foxj1 and Inv genes in the left-right determination of internal organs in mice

Tamakoshi, T., Itakura, T., Chandra, A., Uezato, T., Yang, Z., Xue, X. D., Wang, B., Hackett, B. P., Yokoyama, T. & Miura, N., Jan 20 2006, In : Biochemical and Biophysical Research Communications. 339, 3, p. 932-938 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2005

Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor a in cardiovascular morphogenesis

Kanzaki-Kato, N., Tamakoshi, T., Fu, Y., Chandra, A., Itakura, T., Uezato, T., Tanaka, T., Clouthier, D. E., Sugiyama, T., Yanagisawa, M. & Miura, N., Feb 15 2005, In : Cardiovascular research. 65, 3, p. 711-718 8 p.

Research output: Contribution to journalArticle

11 Scopus citations