Immunology

Projects

Projects per year 1975 2004 2006 2009 2010 2012 2013 2014 2015 2016 2021

• 4 Active
• 53 Finished
• 76 Not started

Projects per year

Search results

• Active

  Immunity in healthy and neoplastic gut mucosa

  Khazaie, K.

  National Cancer Institute

  8/12/02 → …

  Project: Research project

  • antigens 100%
  • digestive system 99%
  • mucosa 96%
  • immunity 88%
  • immune response 55%

• MOLECULAR CLONING OF BILE ACID BIOSYNTHESIS GENES

  Jelinek, D. F. & Jelinek, D. F.

  National Institutes of Health, National Institute of General Medical Sciences

  2/28/89 → …

  Project: Research project

• MECHANISM OF DEHYDROQUINATE SYNTHASE

  Pease, L. R., Bender, S., Shapiro, V. M., Kinney, L. & Kinney, L.

  National Institute of Allergy and Infectious Diseases

  10/1/86 → 8/31/21

  Project: Research project

  • training program 100%
  • student 27%
  • graduate 27%
  • trainee 18%
  • career 17%

• ENZYME-MEDIATED SYNTHESIS OF TUMOR-RELATED CARBOHYDRATES

  David, C. S. & Sparks, M.

  National Cancer Institute United States

  7/1/80 → …

  Project: Research project

  • immunomodulation 100%
  • immunology 93%
  • neoplasms 57%
  • peptides 23%
  • T-lymphocytes 18%
• Not started

  Regulation of programmed necrosis by CYLD cleavage.

  Ting, A. & Kinney, L.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Caspase 8 100%
  • Necrosis 61%
  • Ubiquitination 31%
  • Initiator Caspases 22%
  • Polyubiquitin 21%

• Auto-necroptosis in macrophages

  Ting, A.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Necroptosis 100%
  • Macrophages 42%
  • Ubiquitination 25%
  • Receptors, Tumor Necrosis Factor, Type I 22%
  • Infections 15%

• T CELLS AND AGING

  Goronzy, J. & Kinney, L.

  National Institute on Aging

  Project: Research project

  • T-Lymphocytes 76%
  • KIR Receptors 62%
  • Immunosenescence 34%
  • Gene Expression 24%
  • Elderly 21%

• Immune Memory

  Goronzy, J., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L., Kinney, L. & Kinney, L.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • T-Lymphocytes 100%
  • Vaccines 40%
  • Epigenomics 35%
  • Cell Differentiation 29%
  • Immunologic Memory 25%

• Cell Death Pathways and Heart Transplant Rejection

  Ting, A.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Cold Ischemia 100%
  • Necroptosis 91%
  • Graft Rejection 82%
  • Tissue Donors 67%
  • Cell Death 57%

• Regulation of erythroid maturation by the transcriptional repressor NKAP

  Medina, K. L., Shapiro, V. M. & Shapiro, V. M.

  Project: Research project

  • Erythropoiesis 100%
  • Erythroblasts 55%
  • Embryonic Structures 43%
  • Iron 17%
  • Mitochondria 17%

• Regulation of hematopoietic stem cell maintenance and survival by NKAP

  Shapiro, V. M.

  Project: Research project

  • Hematopoietic Stem Cells 100%
  • Polycomb Repressive Complex 1 86%
  • Maintenance 41%
  • Critical Pathways 9%
  • Ubiquitin-Protein Ligases 9%

• Regulation of Notch signaling by NKAP

  Shapiro, V. M.

  Project: Research project

  • T-Lymphocytes 100%
  • Co-Repressor Proteins 51%
  • Jurkat Cells 48%
  • Lymphocyte Activation 43%
  • Costimulatory and Inhibitory T-Cell Receptors 33%

• Genetic complementation screen to identify novel regulators of T cell activation

  Shapiro, V. M.

  Project: Research project

  • T-Lymphocytes 100%
  • T-Cell Antigen Receptor 38%
  • Cell Line 28%
  • Jurkat Cells 23%
  • Interleukin-2 16%

• Ph. D. Training Program in Basic Immunology

  Pease, L. R. & Shapiro, V. M.

  Project: Research project

  • training program 100%
  • trainee 77%
  • grant 69%
  • student 61%
  • career 53%

• CXCR4 Chemokine Receptor Regulation of ERK MAP Kinase

  Hedin, K. E.

  Project: Research project

  • T-Lymphocytes 100%
  • Cell Movement 39%
  • Chemokine Receptors 36%
  • Extracellular Signal-Regulated MAP Kinases 35%
  • Interleukin-10 28%

• How beta-catenin expands Foxp3+RORgammat+ Pro-inflammatory T-regulatory cells

  Khazaie, K. & Khazaie, K.

  Project: Research project

  • Catenins 100%
  • Regulatory T-Lymphocytes 33%
  • Nuclear Receptor Subfamily 1, Group F, Member 3 21%
  • Chromatin 20%
  • Genetic Enhancer Elements 14%

• Pro-inflammatory T-regulatory Cells in Colon Cancer

  Khazaie, K.

  Project: Research project

  • Regulatory T-Lymphocytes 100%
  • Colonic Neoplasms 47%
  • Inflammation 28%
  • Neoplasms 20%
  • T-Lymphocytes 6%

• Impact of smoking on immune response and arthritis in humanized mice

  Taneja, V. D.

  Project: Research project

  • Arthritis 100%
  • Anti-Citrullinated Protein Antibodies 78%
  • Smoking 77%
  • Transgenic Mice 31%
  • Citrullination 22%

• MOLECULAR AND BIOLOGICAL FUNCTION OF CD40 IN MYELOMA

  Jelinek, D. F.

  Project: Research project

  • Interleukin-6 100%
  • IGF Type 1 Receptor 82%
  • Research Personnel 45%
  • Insulin-Like Growth Factor I 43%
  • Cell Proliferation 28%

• Role of the BCR in B Cell Chronic Lymphocytic Leukemia

  Jelinek, D. F.

  Project: Research project

  • B-Lymphocytes 100%
  • B-Cell Chronic Lymphocytic Leukemia 50%
  • Immunoglobulin Heavy Chains 30%
  • Complementarity Determining Regions 8%
  • B-Cell Antigen Receptors 7%

• CD147 Biological Function and Role as a Biomarker of MGUS to Myeloma Progression

  Jelinek, D. F.

  Project: Research project

  • Monoclonal Gammopathy of Undetermined Significance 100%
  • Multiple Myeloma 77%
  • Plasma Cells 31%
  • Biomarkers 20%
  • Disease Progression 18%

• microRNA Regulation of T Cell Senescence

  Goronzy, J.

  Project: Research project

  • MicroRNAs 100%
  • T-Lymphocytes 80%
  • Cell Differentiation 38%
  • Helper-Inducer T-Lymphocytes 36%
  • Histones 22%

• T CELL DIVERSITY &TURNOVER IN HUMAN AUTOIMMUNE DISEASE

  Goronzy, J.

  Project: Research project

  • T-Lymphocytes 100%
  • Autoimmune Diseases 43%
  • Research Personnel 28%
  • Clone Cells 16%
  • To autoantigen 14%

• Vaccine Induced Immunity in the Young and Aged

  Goronzy, J.

  Project: Research project

  • T-Lymphocytes 100%
  • Immunity 99%
  • Viruses 80%
  • Cell Differentiation 65%
  • Vaccination 64%

• Cloning Negative Regulators of TNF Signaling

  Ting, A.

  Project: Research project

  • Tumor Necrosis Factor-alpha 100%
  • NF-kappa B 89%
  • Tumor Necrosis Factor Receptors 64%
  • Apoptosis 60%
  • Complementary DNA 45%

• Regulation of TNF Receptor-mediated Cell Death

  Ting, A.

  Project: Research project

  • Necroptosis 100%
  • Ubiquitination 92%
  • Receptors, Tumor Necrosis Factor, Type I 79%
  • Cell Death 43%
  • Receptors, Tumor Necrosis Factor, Type II 39%

• T CELL DIVERSITY &TURNOVER IN HUMAN AUTOIMMUNE DISEASE

  Goronzy, J.

  National Institute of General Medical Sciences

  Project: Research project

  • Autoimmune Diseases 100%
  • T-Lymphocytes 92%
  • Research Personnel 27%
  • Clone Cells 15%
  • To autoantigen 14%

• ST8Sia6 protects against the immune response

  Shapiro, V. M.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Type 1 Diabetes Mellitus 28%
  • Islets of Langerhans Transplantation 26%
  • N-Acetylneuraminic Acid 24%
  • Streptozocin 21%

• GUT INFLUENCES ON IMMUNE DEVELOPMENT IN EARLY LIFE

  Knoop, K.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • goblet cells 100%
  • antigen-presenting cells 90%
  • early development 64%
  • antigens 61%
  • digestive system 60%

• ST8Sia6 expression on tumors inhibits the immune response

  Shapiro, V. M.

  Project: Research project

  • Sialic Acid Binding Immunoglobulin-like Lectins 100%
  • Neoplasms 96%
  • N-Acetylneuraminic Acid 90%
  • Growth 39%
  • Transferases 32%

• The Role of COTL1 in T cell development and activation

  Billadeau, D. D. & Shapiro, V. M.

  Project: Research project

  • T-Lymphocytes 100%
  • Actins 58%
  • Proteins 50%
  • T-Cell Antigen Receptor 47%
  • Interleukin-2 30%

• T Cells and Aging

  Goronzy, J.

  National Institute on Aging

  Project: Research project

  • T-Lymphocytes 100%
  • Research Personnel 61%
  • Immunosenescence 42%
  • CD40 Ligand 27%
  • Clone Cells 26%

• IL-10/IL10R in the Regulation of Self-Reactive CTL by CD8+ T-cells

  Pease, L. R.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Interleukin-10 100%
  • Regulatory T-Lymphocytes 61%
  • T-Lymphocytes 57%
  • Perforin 39%
  • T-Cell Antigen Receptor Specificity 22%

• BACTERIAL;EPITHELIAL;T-CELL INTERACTIONS IN GUT MUCOSA

  Ting, A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Regulatory T-Lymphocytes 100%
  • Th17 Cells 39%
  • Cues 21%
  • Rezafungin 16%
  • Ileitis 12%

• DIVERSITY OF T-LYMPHOCYTES IN EARLY RHEUMATOID ARTHRITIS

  Goronzy, J. & Kinney, L.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  Project: Research project

  • Rheumatoid Arthritis 100%
  • T-Lymphocytes 98%
  • T-Cell Antigen Receptor Specificity 42%
  • Superantigens 24%
  • Synovitis 19%

• Influence of Age on CD4 T Memory Cells

  Goronzy, J. & Kinney, L.

  National Institute on Aging

  Project: Research project

  • T-Lymphocytes 100%
  • Adaptive Immunity 32%
  • Phosphoric Monoester Hydrolases 31%
  • Elderly 31%
  • Cell Differentiation 25%

• Regulation of T cell development by HDAC3

  Shapiro, V. M.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • histone deacetylase 3 100%
  • T-Lymphocytes 34%
  • Thymocytes 31%
  • Histones 16%
  • Acetylation 12%

• Cloning Negative Regulators of TNF Signaling

  Ting, A. & Kinney, L.

  National Institute of Allergy and Infectious Diseases

  Project: Research project

  • Tumor Necrosis Factor-alpha 100%
  • Organism Cloning 99%
  • NF-kappa B 96%
  • Tumor Necrosis Factor Receptors 69%
  • Apoptosis 64%

• Role of ALX in CD28 signaling

  Shapiro, V. M.

  Project: Research project

  • T-Cell Antigen Receptor 100%
  • T-Lymphocytes 98%
  • Interleukin-2 54%
  • MAP Kinase Kinase Kinases 50%
  • Jurkat Cells 29%

• Regulation of T cell maturation

  Shapiro, V. M.

  Project: Research project

  • T-Lymphocytes 100%
  • Sialic Acids 29%
  • Immunoglobulin M 26%
  • N-Acetylneuraminic Acid 23%
  • Thymocytes 21%

• Targeting osteoblasts to inhibit AML

  Hedin, K. E.

  Project: Research project

  • leukemia 100%
  • osteoblasts 74%
  • CXCR4 receptor 34%
  • chemokine CXCL12 34%
  • bone marrow 33%

• Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized Mice

  Taneja, V. D.

  Project: Research project

  • B-lymphocytes 100%
  • arthritis 71%
  • rheumatoid arthritis 34%
  • mice 33%
  • collagen 23%

• Immunogenetics of Collagen Induced Arthritis in Mice

  David, C. S. & Taneja, V. D.

  Project: Research project

  • arthritis 100%
  • mice 34%
  • genetically modified organisms 22%
  • antigen presentation 22%
  • collagen 19%

• Immunogenetics of Collagen Induced Arthritis in Mice

  David, C. S. & Taneja, V. D.

  Project: Research project

  • arthritis 100%
  • mice 37%
  • rheumatoid arthritis 31%
  • calreticulin 23%
  • T-lymphocytes 22%

• Maintenance and targeting of bone marrow derived allo-reactive human plasma cells

  Medina, K. L., Stegall, M. D. & Stegall, M. D.

  Project: Research project

  • Plasma Cells 100%
  • Isoantibodies 65%
  • Tissue Donors 52%
  • Bone Marrow 48%
  • Stromal Cells 33%

• Role of Alcohol and Circadian Disruption in Inflammation and Colon Cancer

  Khazaie, K. & Khazaie, K.

  Project: Research project

  • Alcohols 100%
  • Circadian Rhythm 93%
  • Inflammation 91%
  • Colonic Neoplasms 80%
  • Shift Work Schedule 67%

• Studies on Monoclonal Gammopathies

  Jelinek, D. F.

  Project: Research project

  • Monoclonal Gammopathy of Undetermined Significance 100%
  • Multiple Myeloma 69%
  • Smoldering Multiple Myeloma 34%
  • Paraproteinemias 26%
  • Plasma Cells 14%

• role of BLyS/April in Normal and Malignant Plasma Cells

  Jelinek, D. F.

  Project: Research project

  • B-Cell Activating Factor 100%
  • B-Cell Maturation Antigen 34%
  • Ligands 31%
  • Plasma Cells 29%
  • B-Lymphocytes 22%

• Tumor Cell-Intrinsic/Extrinsic Mechanisms Underlying Myeloma Disease Progression

  Jelinek, D. F.

  Project: Research project

  • Smoldering Multiple Myeloma 100%
  • Monoclonal Gammopathy of Undetermined Significance 76%
  • Multiple Myeloma 76%
  • Plasma Cells 31%
  • Disease Progression 30%

• Regulation of programmed necrosis by CYLD cleavage.

  Ting, A.

  Project: Research project

  • Caspase 8 100%
  • Necrosis 55%
  • Ubiquitination 31%
  • Initiator Caspases 22%
  • Polyubiquitin 21%