Serum creatinine levels correlate with plasma amyloid β protein

Zoe Arvanitakis; John A. Lucas; Linda H. Younkin; Steven G. Younkin; Neill R. Graff-Radford

doi:10.1097/00002093-200207000-00009

Serum creatinine levels correlate with plasma amyloid β protein

Zoe Arvanitakis, John A. Lucas, Linda H. Younkin, Steven G. Younkin, Neill R. Graff-Radford

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

The authors investigated the effect of renal function on plasma amyloid β protein (Aβ) by analyzing the relationship between creatinine (Cr) and Aβ40 or Aβ42 in plasma from 59 normal control subjects (NC) and 220 Alzheimer disease (AD) patients. In all 279 subjects, Cr was significantly associated with Aβ40 (p < 0.001) and Aβ42 (p < 0.01), accounting for 7.3% and 3.1% of shared variance, respectively. Significant associations were also present in NC and AD groups separately. These results indicate that it may be useful to consider Cr levels when measuring plasma Aβ.

Original language	English (US)
Pages (from-to)	187-190
Number of pages	4
Journal	Alzheimer disease and associated disorders
Volume	16
Issue number	3
DOIs	https://doi.org/10.1097/00002093-200207000-00009
State	Published - Jul 2002

Keywords

Alzheimer disease
Amyloid β protein
Creatinine

ASJC Scopus subject areas

Clinical Psychology
Gerontology
Geriatrics and Gerontology
Psychiatry and Mental health

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title = "Serum creatinine levels correlate with plasma amyloid β protein",

abstract = "The authors investigated the effect of renal function on plasma amyloid β protein (Aβ) by analyzing the relationship between creatinine (Cr) and Aβ40 or Aβ42 in plasma from 59 normal control subjects (NC) and 220 Alzheimer disease (AD) patients. In all 279 subjects, Cr was significantly associated with Aβ40 (p < 0.001) and Aβ42 (p < 0.01), accounting for 7.3% and 3.1% of shared variance, respectively. Significant associations were also present in NC and AD groups separately. These results indicate that it may be useful to consider Cr levels when measuring plasma Aβ.",

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AU - Lucas, John A.

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AU - Younkin, Steven G.

AU - Graff-Radford, Neill R.

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N2 - The authors investigated the effect of renal function on plasma amyloid β protein (Aβ) by analyzing the relationship between creatinine (Cr) and Aβ40 or Aβ42 in plasma from 59 normal control subjects (NC) and 220 Alzheimer disease (AD) patients. In all 279 subjects, Cr was significantly associated with Aβ40 (p < 0.001) and Aβ42 (p < 0.01), accounting for 7.3% and 3.1% of shared variance, respectively. Significant associations were also present in NC and AD groups separately. These results indicate that it may be useful to consider Cr levels when measuring plasma Aβ.

AB - The authors investigated the effect of renal function on plasma amyloid β protein (Aβ) by analyzing the relationship between creatinine (Cr) and Aβ40 or Aβ42 in plasma from 59 normal control subjects (NC) and 220 Alzheimer disease (AD) patients. In all 279 subjects, Cr was significantly associated with Aβ40 (p < 0.001) and Aβ42 (p < 0.01), accounting for 7.3% and 3.1% of shared variance, respectively. Significant associations were also present in NC and AD groups separately. These results indicate that it may be useful to consider Cr levels when measuring plasma Aβ.

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KW - Amyloid β protein

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Serum creatinine levels correlate with plasma amyloid β protein

Abstract

Keywords

ASJC Scopus subject areas

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