Regulation of rat nerve blood flow

Role of epineurial α-receptors

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Transperineurial arterioles connect the extrinsic (epineurial) and the intrinsic (endoneurial) microvasculatures. Our goal was to determine whether the extrinsic system regulated nerve blood flow locally and whether subperineurial and centrifascicular endoneurial nerve blood flows were regulated differentially. The local application of noradrenaline resulted in a dose-dependent reduction of nerve blood flow in subjacent endoneurium. Asymptotes of 78.8 and 76.3% vasoconstriction were recorded for subperineurial and centrifascicular endoneurial nerve blood flow, respectively, indicating near-complete closure of capillaries. Near-identical concentrations required to generate 50% vasoconstriction (EC50) and asymptotes are suggestive of the fact that the two areas are not differentially regulated. Local vasoconstriction cannot be due to a systemic effect of noradrenaline since a significant decrease in nerve blood flow occurs despite undetectable increases in plasma noradrenaline and mean blood pressure, or decrease in contralateral sciatic nerve blood flow. There are small and statistically non-significant reductions of the compound muscle action potential and conduction velocity in the sciatic-tibial nerve following nerve ischaemia. These findings suggest that epineurial arterioles control regional nerve blood flow and are primarily responsible for its regulation in subjacent endoneurial tissue.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalJournal of Physiology
Volume422
StatePublished - 1990

Fingerprint

Vasoconstriction
Norepinephrine
Arterioles
Sciatic Nerve
Tibial Nerve
Regional Blood Flow
Microvessels
Peripheral Nerves
Action Potentials
Ischemia
Blood Pressure
Muscles

ASJC Scopus subject areas

  • Physiology

Cite this

Regulation of rat nerve blood flow : Role of epineurial α-receptors. / Kihara, M.; Low, Phillip Anson.

In: Journal of Physiology, Vol. 422, 1990, p. 145-152.

Research output: Contribution to journalArticle

@article{d00de199884a4e1f9b6d0a00520f225d,
title = "Regulation of rat nerve blood flow: Role of epineurial α-receptors",
abstract = "Transperineurial arterioles connect the extrinsic (epineurial) and the intrinsic (endoneurial) microvasculatures. Our goal was to determine whether the extrinsic system regulated nerve blood flow locally and whether subperineurial and centrifascicular endoneurial nerve blood flows were regulated differentially. The local application of noradrenaline resulted in a dose-dependent reduction of nerve blood flow in subjacent endoneurium. Asymptotes of 78.8 and 76.3{\%} vasoconstriction were recorded for subperineurial and centrifascicular endoneurial nerve blood flow, respectively, indicating near-complete closure of capillaries. Near-identical concentrations required to generate 50{\%} vasoconstriction (EC50) and asymptotes are suggestive of the fact that the two areas are not differentially regulated. Local vasoconstriction cannot be due to a systemic effect of noradrenaline since a significant decrease in nerve blood flow occurs despite undetectable increases in plasma noradrenaline and mean blood pressure, or decrease in contralateral sciatic nerve blood flow. There are small and statistically non-significant reductions of the compound muscle action potential and conduction velocity in the sciatic-tibial nerve following nerve ischaemia. These findings suggest that epineurial arterioles control regional nerve blood flow and are primarily responsible for its regulation in subjacent endoneurial tissue.",
author = "M. Kihara and Low, {Phillip Anson}",
year = "1990",
language = "English (US)",
volume = "422",
pages = "145--152",
journal = "Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Regulation of rat nerve blood flow

T2 - Role of epineurial α-receptors

AU - Kihara, M.

AU - Low, Phillip Anson

PY - 1990

Y1 - 1990

N2 - Transperineurial arterioles connect the extrinsic (epineurial) and the intrinsic (endoneurial) microvasculatures. Our goal was to determine whether the extrinsic system regulated nerve blood flow locally and whether subperineurial and centrifascicular endoneurial nerve blood flows were regulated differentially. The local application of noradrenaline resulted in a dose-dependent reduction of nerve blood flow in subjacent endoneurium. Asymptotes of 78.8 and 76.3% vasoconstriction were recorded for subperineurial and centrifascicular endoneurial nerve blood flow, respectively, indicating near-complete closure of capillaries. Near-identical concentrations required to generate 50% vasoconstriction (EC50) and asymptotes are suggestive of the fact that the two areas are not differentially regulated. Local vasoconstriction cannot be due to a systemic effect of noradrenaline since a significant decrease in nerve blood flow occurs despite undetectable increases in plasma noradrenaline and mean blood pressure, or decrease in contralateral sciatic nerve blood flow. There are small and statistically non-significant reductions of the compound muscle action potential and conduction velocity in the sciatic-tibial nerve following nerve ischaemia. These findings suggest that epineurial arterioles control regional nerve blood flow and are primarily responsible for its regulation in subjacent endoneurial tissue.

AB - Transperineurial arterioles connect the extrinsic (epineurial) and the intrinsic (endoneurial) microvasculatures. Our goal was to determine whether the extrinsic system regulated nerve blood flow locally and whether subperineurial and centrifascicular endoneurial nerve blood flows were regulated differentially. The local application of noradrenaline resulted in a dose-dependent reduction of nerve blood flow in subjacent endoneurium. Asymptotes of 78.8 and 76.3% vasoconstriction were recorded for subperineurial and centrifascicular endoneurial nerve blood flow, respectively, indicating near-complete closure of capillaries. Near-identical concentrations required to generate 50% vasoconstriction (EC50) and asymptotes are suggestive of the fact that the two areas are not differentially regulated. Local vasoconstriction cannot be due to a systemic effect of noradrenaline since a significant decrease in nerve blood flow occurs despite undetectable increases in plasma noradrenaline and mean blood pressure, or decrease in contralateral sciatic nerve blood flow. There are small and statistically non-significant reductions of the compound muscle action potential and conduction velocity in the sciatic-tibial nerve following nerve ischaemia. These findings suggest that epineurial arterioles control regional nerve blood flow and are primarily responsible for its regulation in subjacent endoneurial tissue.

UR - http://www.scopus.com/inward/record.url?scp=0025320416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025320416&partnerID=8YFLogxK

M3 - Article

VL - 422

SP - 145

EP - 152

JO - Journal of Physiology

JF - Journal of Physiology

SN - 0022-3751

ER -