Aktuelle Aspekte zur Histopathologie im Rahmen der Lebertransplantation

Translated title of the contribution: Current aspects of liver allograft pathology

U. Drebber, M. Torbenson, I. Wedemeyer, H. P. Dienes

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Liver allograft pathology continues to play an important role in the diagnosis and management of complications in the course of liver transplantation. This article summarizes important patterns of liver damage and also considers new aspects of transplant pathology from the literature. In the context of transplant rejection, late cellular rejection has aroused new interest. Histopathological changes in late rejection differ from acute cellular rejection and there seem to be similarities to de novo autoimmune hepatitis and idiopathic post-transplant hepatitis. Central perivenulitis is a typical change in late cellular rejection and should be differentiated from central toxic necrosis. Other important areas of transplant pathology include vascular and biliary changes resulting from surgical complications or as sequelae of immunosuppressive therapy. Furthermore, disease recurrence plays an important role and combined patterns of disease poses a challenge for the pathologist.

Translated title of the contributionCurrent aspects of liver allograft pathology
Original languageGerman
Pages (from-to)113-123
Number of pages11
JournalPathologe
Volume32
Issue number2
DOIs
StatePublished - Mar 1 2011

Keywords

  • De novo autoimmune hepatitis
  • Liver allograft pathology
  • Liver biopsy
  • Post-transplant hepatitis
  • Transplant rejection

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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