Acute leukemia evolving from multipe myeloma and co-expressing myeloid and plasma cell antigens

Alexander Keith Stewart, J. Freedman, M. B. Garvey

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This report describes the development of acute myeloblastic leukemia in a patient after long-term alkylator therapy for multiple myeloma. Despite chromosome deletions -5, -7, the patient lacked the histochemistry and clinical findings characteristic of therapy-induced leukemia. In double-labeled surface marker studies by flow cytometry, the leukemic blast cells co-expressed myeloid and plasma cell surface markers. The findings may support the hypothesis of a single stem cell abnormality's being responsible for both the malignant plasma cells and the myeloid leukemic cells.

Original languageEnglish (US)
Pages (from-to)210-214
Number of pages5
JournalAmerican Journal of Hematology
Volume34
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Myeloid Cells
Plasma Cells
Leukemia
Antigens
Chromosome Deletion
Chromosomes, Human, Pair 5
Alkylating Agents
Multiple Myeloma
Acute Myeloid Leukemia
Flow Cytometry
Stem Cells
Therapeutics

Keywords

  • Alkylator therapy
  • Chromosome deletions
  • Flow cytometry

ASJC Scopus subject areas

  • Hematology

Cite this

Acute leukemia evolving from multipe myeloma and co-expressing myeloid and plasma cell antigens. / Stewart, Alexander Keith; Freedman, J.; Garvey, M. B.

In: American Journal of Hematology, Vol. 34, No. 3, 1990, p. 210-214.

Research output: Contribution to journalArticle

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