Abstract
This report describes the development of acute myeloblastic leukemia in a patient after long-term alkylator therapy for multiple myeloma. Despite chromosome deletions -5, -7, the patient lacked the histochemistry and clinical findings characteristic of therapy-induced leukemia. In double-labeled surface marker studies by flow cytometry, the leukemic blast cells co-expressed myeloid and plasma cell surface markers. The findings may support the hypothesis of a single stem cell abnormality's being responsible for both the malignant plasma cells and the myeloid leukemic cells.
Original language | English (US) |
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Pages (from-to) | 210-214 |
Number of pages | 5 |
Journal | American Journal of Hematology |
Volume | 34 |
Issue number | 3 |
DOIs | |
State | Published - 1990 |
Externally published | Yes |
Keywords
- Alkylator therapy
- Chromosome deletions
- Flow cytometry
ASJC Scopus subject areas
- Hematology