Abstract
This report describes the development of acute myeloblastic leukemia in a patient after long-term alkylator therapy for multiple myeloma. Despite chromosome deletions -5, -7, the patient lacked the histochemistry and clinical findings characteristic of therapy-induced leukemia. In double-labeled surface marker studies by flow cytometry, the leukemic blast cells co-expressed myeloid and plasma cell surface markers. The findings may support the hypothesis of a single stem cell abnormality's being responsible for both the malignant plasma cells and the myeloid leukemic cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 210-214 |
| Number of pages | 5 |
| Journal | American Journal of Hematology |
| Volume | 34 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1990 |
| Externally published | Yes |
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Keywords
- Alkylator therapy
- Chromosome deletions
- Flow cytometry
ASJC Scopus subject areas
- Hematology
Cite this
Acute leukemia evolving from multipe myeloma and co-expressing myeloid and plasma cell antigens. / Stewart, Alexander Keith; Freedman, J.; Garvey, M. B.
In: American Journal of Hematology, Vol. 34, No. 3, 1990, p. 210-214.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute leukemia evolving from multipe myeloma and co-expressing myeloid and plasma cell antigens
AU - Stewart, Alexander Keith
AU - Freedman, J.
AU - Garvey, M. B.
PY - 1990
Y1 - 1990
N2 - This report describes the development of acute myeloblastic leukemia in a patient after long-term alkylator therapy for multiple myeloma. Despite chromosome deletions -5, -7, the patient lacked the histochemistry and clinical findings characteristic of therapy-induced leukemia. In double-labeled surface marker studies by flow cytometry, the leukemic blast cells co-expressed myeloid and plasma cell surface markers. The findings may support the hypothesis of a single stem cell abnormality's being responsible for both the malignant plasma cells and the myeloid leukemic cells.
AB - This report describes the development of acute myeloblastic leukemia in a patient after long-term alkylator therapy for multiple myeloma. Despite chromosome deletions -5, -7, the patient lacked the histochemistry and clinical findings characteristic of therapy-induced leukemia. In double-labeled surface marker studies by flow cytometry, the leukemic blast cells co-expressed myeloid and plasma cell surface markers. The findings may support the hypothesis of a single stem cell abnormality's being responsible for both the malignant plasma cells and the myeloid leukemic cells.
KW - Alkylator therapy
KW - Chromosome deletions
KW - Flow cytometry
UR - http://www.scopus.com/inward/record.url?scp=0025358574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025358574&partnerID=8YFLogxK
U2 - 10.1002/ajh.2830340311
DO - 10.1002/ajh.2830340311
M3 - Article
VL - 34
SP - 210
EP - 214
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 3
ER -