ACTH and indomethacin-induced antidiuresis in low salt Brattleboro strain rats: Induction and escape

Sundeep Khosla, L. B. Kinter, R. Zusman, R. Beeuwkes

Research output: Contribution to journalArticle


Both ACTH and indomethacin induce antidiuresis when administered to conscious rats maintained on a sodium-deficient diet for at least two weeks. The present studies show that the ACTH-induced antidiuresis requires the presence of endogenous vasopressin whereas the indomethacin-induced antidiuresis apparently does not. Finally, endogenous vasopressin may play a role in the chronic adaptation to imposed salt states in rats.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalAnnals of the New York Academy of Sciences
VolumeVol. 394
StatePublished - 1982
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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