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  • Clifford R Jr. Jack
Article

Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin

Mielke, M. M., Syrjanen, J. A., Blennow, K., Zetterberg, H., Skoog, I., Vemuri, P., Machulda, M. M., Graff-Radford, J., Knopman, D. S., Jack, C. R., Petersen, R. C. & Kern, S., Nov 2019, In : Alzheimer's and Dementia. 15, 11, p. 1437-1447 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Connectivity network measures predict volumetric atrophy in mild cognitive impairment

Alzheimer's Disease Neuroimaging Initiative (ADNI), Jan 1 2015, In : Neurobiology of aging. 36, S1, p. S113-S120

Research output: Contribution to journalArticle

23 Scopus citations

Considerations for performing level-2 centiloid transformations for amyloid PET SUVR values

Schwarz, C. G., Tosakulwong, N., Senjem, M. L., Gunter, J. L., Therneau, T. M., Vemuri, P., Lowe, V. J. & Jack, C. R., Dec 1 2018, In : Scientific reports. 8, 1, 7421.

Research output: Contribution to journalArticle

1 Scopus citations

Contributions of imprecision in PET-MRI rigid registration to imprecision in amyloid PET SUVR measurements

Alzheimer’s Disease Neuroimaging Initiative, 2017, In : Human Brain Mapping. 38, 7, p. 3323-3336 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging

Machulda, M. M., Lundt, E. S., Albertson, S. M., Spychalla, A. J., Schwarz, C. G., Mielke, M. M., Jack, C. R., Kremers, W. K., Vemuri, P., Knopman, D. S., Jones, D. T., Bondi, M. W. & Petersen, R. C., Jul 1 2020, In : Alzheimer's and Dementia. 16, 7, p. 1013-1022 10 p.

Research output: Contribution to journalArticle

Open Access

Cortical thickness and anxiety symptoms among cognitively normal elderly persons: The mayo clinic study of aging

Pink, A., Przybelski, S. A., Krell-Roesch, J., Stokin, G. B., Roberts, R. O., Mielke, M. M., Spangehl, K. A., Knopman, D. S., Jack, C. R., Petersen, R. C. & Geda, Y. E., 2017, In : Journal of Neuropsychiatry and Clinical Neurosciences. 29, 1, p. 60-66 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cortical Thickness and Depressive Symptoms in Cognitively Normal Individuals: The Mayo Clinic Study of Aging

Pink, A., Przybelski, S. A., Krell-Roesch, J., Stokin, G. B., Roberts, R. O., Mielke, M. M., Knopman, D. S., Jack, C. R., Petersen, R. C. & Geda, Y. E., 2017, In : Journal of Alzheimer's Disease. 58, 4, p. 1273-1281 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging

Krell-Roesch, J., Vassilaki, M., Mielke, M. M., Kremers, W. K., Lowe, V. J., Vemuri, P., Machulda, M. M., Christianson, T. J., Syrjanen, J. A., Stokin, G. B., Butler, L. M., Traber, M., Jack, C. R., Knopman, D. S., Roberts, R. O., Petersen, R. C. & Geda, Y. E., Dec 1 2019, In : Translational psychiatry. 9, 1, 123.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
23 Scopus citations

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V. J., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M. K., Murray, M. E., Kantarci, K., Jones, D. T., Vemuri, P., Graff-Radford, J., Schwarz, C. G., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R., Jul 2 2019, In : Neurology. 93, 1, p. E29-E39

Research output: Contribution to journalArticle

7 Scopus citations

CSF biomarkers in Olmsted County: Evidence of 2 subclasses and associations with demographics

Van Harten, A. C., Wiste, H. J., Weigand, S. D., Mielke, M. M., Kremers, W. K., Eichenlaub, U., Batrla-Utermann, R., Dyer, R. B., Algeciras-Schimnich, A., Knopman, D. S., Jack, C. R. & Petersen, R. C., Jul 21 2020, In : Neurology. 95, 3, p. E256-E267

Research output: Contribution to journalArticle

Davunetide in patients with progressive supranuclear palsy: A randomised, double-blind, placebo-controlled phase 2/3 trial

Boxer, A. L., Lang, A. E., Grossman, M., Knopman, D. S., Miller, B. L., Schneider, L. S., Doody, R. S., Lees, A., Golbe, L. I., Williams, D. R., Corvol, J. C., Ludolph, A., Burn, D., Lorenzl, S., Litvan, I., Roberson, E. D., Höglinger, G. U., Koestler, M., Jack, C. R., Van Deerlin, V. & 10 others, Randolph, C., Lobach, I. V., Heuer, H. W., Gozes, I., Parker, L., Whitaker, S., Hirman, J., Stewart, A. J., Gold, M. & Morimoto, B. H., Jul 2014, In : The Lancet Neurology. 13, 7, p. 676-685 10 p.

Research output: Contribution to journalArticle

150 Scopus citations

Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography

Murphy, M. C., Huston, J., Jack, C. R., Glaser, K. J., Manduca, A., Felmlee, J. P. & Ehman, R. L., Sep 2011, In : Journal of Magnetic Resonance Imaging. 34, 3, p. 494-498 5 p.

Research output: Contribution to journalArticle

164 Scopus citations

Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB-PET Study

Zeydan, B., Deelchand, D. K., Tosakulwong, N., Lesnick, T. G., Kantarci, O. H., Machulda, M. M., Knopman, D. S., Lowe, V. J., Jack, C. R., Petersen, R. C., Öz, G. & Kantarci, K., Nov 1 2017, In : Journal of Neuroimaging. 27, 6, p. 630-636 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Default mode network disruption secondary to a lesion in the anterior thalamus

Jones, D. T., Mateen, F. J., Lucchinetti, C. F., Jack, C. R. & Welker, K. M., Feb 1 2011, In : Archives of neurology. 68, 2, p. 242-247 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Defining imaging biomarker cut points for brain aging and Alzheimer's disease

Jack, C. R., Wiste, H. J., Weigand, S. D., Therneau, T. M., Lowe, V. J., Knopman, D. S., Gunter, J. L., Senjem, M. L., Jones, D. T., Kantarci, K., Machulda, M. M., Mielke, M. M., Roberts, R. O., Vemuri, P., Reyes, D. A. & Petersen, R. C., Mar 1 2017, In : Alzheimer's and Dementia. 13, 3, p. 205-216 12 p.

Research output: Contribution to journalArticle

163 Scopus citations

Delphi definition of the EADC-ADNI harmonized protocol for hippocampal segmentation on magnetic resonance

Boccardi, M., Bocchetta, M., Apostolova, L. G., Barnes, J., Bartzokis, G., Corbetta, G., Decarli, C., Detoledo-Morrell, L., Firbank, M., Ganzola, R., Gerritsen, L., Henneman, W., Killiany, R. J., Malykhin, N., Pasqualetti, P., Pruessner, J. C., Redolfi, A., Robitaille, N., Soininen, H., Tolomeo, D. & 7 others, Wang, L., Watson, C., Wolf, H., Duvernoy, H., Duchesne, S., Jack, C. R. & Frisoni, G. B., 2015, In : Alzheimer's and Dementia. 11, 2, p. 126-138 13 p.

Research output: Contribution to journalArticle

81 Scopus citations

Dementia with Lewy bodies: Basis of cingulate island sign

Graff-Radford, J., Murray, M. E., Lowe, V. J., Boeve, B. F., Ferman, T. J., Przybelski, S. A., Lesnick, T. G., Senjem, M. L., Gunter, J. L., Smith, G. E., Knopman, D. S., Jack, C. R., Dickson, D. W., Petersen, R. C. & Kantarci, K., 2014, In : Neurology. 83, 9, p. 801-809 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: The Mayo Clinic Study of Aging

Krell-Roesch, J., Lowe, V. J., Neureiter, J., Pink, A., Roberts, R. O., Mielke, M. M., Vemuri, P., Stokin, G. B., Christianson, T. J., Jack, C. R., Knopman, D. S., Boeve, B. F., Kremers, W. K., Petersen, R. C. & Geda, Y. E., Feb 1 2018, In : International psychogeriatrics. 30, 2, p. 245-251 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Depressive symptoms in mild cognitive impairment predict greater atrophy in alzheimer's disease-related regions

Lee, G. J., Lu, P. H., Hua, X., Lee, S., Wu, S., Nguyen, K., Teng, E., Leow, A. D., Jack, C. R., Toga, A. W., Weiner, M. W., Bartzokis, G. & Thompson, P. M., May 1 2012, In : Biological psychiatry. 71, 9, p. 814-821 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging

Vemuri, P., Lesnick, T. G., Przybelski, S. A., Graff-Radford, J., Reid, R. I., Lowe, V. J., Zuk, S. M., Senjem, M. L., Schwarz, C. G., Gunter, J. L., Kantarci, K., Machulda, M. M., Mielke, M. M., Petersen, R. C., Knopman, D. S. & Jack, C. R., Nov 2018, In : Annals of neurology. 84, 5, p. 705-716 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Diabetes, prediabetes, and brain volumes and subclinical cerebrovascular disease on MRI: The atherosclerosis risk in communities neurocognitive study (ARIC-NCS)

Schneider, A. L. C., Selvin, E., Sharrett, A. R., Griswold, M., Coresh, J., Jack, C. R., Knopman, D., Mosley, T. & Gottesman, R. F., Nov 1 2017, In : Diabetes care. 40, 11, p. 1514-1521 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Diabetes and elevated hemoglobin a1c levels are associated with brain hypometabolism but not amyloid accumulation

Roberts, R. O., Knopman, D. S., Cha, R. H., Mielke, M. M., Pankratz, V. S., Boeve, B. F., Kantarci, K., Geda, Y. E., Jack, C. R., Petersen, R. C. & Lowe, V. J., May 1 2014, In : Journal of Nuclear Medicine. 55, 5, p. 759-764 6 p.

Research output: Contribution to journalArticle

91 Scopus citations

Different definitions of neurodegeneration produce similar amyloid/neurodegeneration biomarker group findings

Jack, C. R., Wiste, H. J., Weigand, S. D., Knopman, D. S., Mielke, M. M., Vemuri, P., Lowe, V., Senjem, M. L., Gunter, J. L., Reyes, D., Machulda, M. M., Roberts, R. & Petersen, R. C., Dec 1 2015, In : Brain. 138, 12, p. 3747-3759 13 p.

Research output: Contribution to journalArticle

82 Scopus citations

Diffusion MRI indices and their relation to cognitive impairment in brain aging: The updated multi-protocol approach in ADNI3

Zavaliangos-Petropulu, A., Nir, T. M., Thomopoulos, S. I., Reid, R. I., Bernstein, M. A., Borowski, B., Jack, C. R., Weiner, M. W., Jahanshad, N. & Thompson, P. M., Feb 7 2019, In : Frontiers in Neuroinformatics. 13, 2.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Diffusion tensor imaging and cognitive function in older adults with no dementia

Kantarci, K., Senjem, M. L., Avula, R., Zhang, B., Samikoglu, A. R., Weigand, S. D., Przybelski, S. A., Edmonson, H. A., Vemuri, P., Knopman, D. S., Boeve, B. F., Ivnik, R. J., Smith, G. E., Petersen, R. C. & Jack, C. R., Jul 5 2011, In : Neurology. 77, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

102 Scopus citations
28 Scopus citations

Diffusion weighted imaging-based maximum density path analysis and classification of Alzheimer's disease

Alzheimer's Disease Neuroimaging Initiative (ADNI), Jan 1 2015, In : Neurobiology of aging. 36, S1, p. S132-S140

Research output: Contribution to journalArticle

36 Scopus citations

Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N1198) using genome-wide search

Stein, J. L., Hibar, D. P., Madsen, S. K., Khamis, M., McMahon, K. L., De Zubicaray, G. I., Hansell, N. K., Montgomery, G. W., Martin, N. G., Wright, M. J., Saykin, A. J., Jack, C. R., Weiner, M. W., Toga, A. W. & Thompson, P. M., Sep 2011, In : Molecular Psychiatry. 16, 9, p. 927-937 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Discovery and replication of gene influences on brain structure using LASSO regression

Kohannim, O., Hibar, D. P., Stein, J. L., Jahansha, N., Hua, X., Rajagopalan, P., Toga, A. W., Jack, C. R., Weiner, M. W., de Zubicaray, G. I., McMahon, K. L., Hansell, N. K., Martin, N. G., Wright, M. J. & Thompson, P. M., 2012, In : Frontiers in Neuroscience. AUG, Article 115.

Research output: Contribution to journalArticle

61 Scopus citations

Disrupted brain connectivity in Alzheimer’s disease: Effects of network thresholding

Daianu, M., Dennis, E. L., Jahanshad, N., Nir, T. M., Toga, A., Jack, C. R. J., Weiner, M. W. & Thompson, P. M., 2014, In : Mathematics and Visualization. p. 199-208 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Disrupted functional connectivity in primary progressive apraxia of speech

Botha, H., Utianski, R. L., Whitwell, J. L., Duffy, J. R., Clark, H. M., Strand, E. A., Machulda, M. M., Tosakulwong, N., Knopman, D. S., Petersen, R. C., Jack, C. R., Josephs, K. A. & Jones, D. T., 2018, In : NeuroImage: Clinical. 18, p. 617-629 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Disrupted thalamocortical connectivity in PSP: A resting-state fMRI, DTI, and VBM study

Whitwell, J. L., Avula, R., Master, A., Vemuri, P., Senjem, M. L., Jones, D. T., Jack, C. R. & Josephs, K. A., Sep 2011, In : Parkinsonism and Related Disorders. 17, 8, p. 599-605 7 p.

Research output: Contribution to journalArticle

104 Scopus citations

Distinct regional anatomic and functional correlates of neurodegenerative apraxia of speech and aphasia: An MRI and FDG-PET study

Whitwell, J. L., Duffy, J. R., Strand, E. A., Xia, R., Mandrekar, J., Machulda, M. M., Senjem, M. L., Lowe, V. J., Jack, C. R. & Josephs, K. A., Jun 2013, In : Brain and Language. 125, 3, p. 245-252 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Does amyloid deposition produce a specific atrophic signature in cognitively normal subjects?

Whitwell, J. L., Tosakulwong, N., Weigand, S. D., Senjem, M. L., Lowe, V. J., Gunter, J. L., Boeve, B. F., Knopman, D. S., Dickerson, B. C., Petersen, R. C. & Jack, C. R., 2013, In : NeuroImage: Clinical. 2, 1, p. 249-257 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Does MRI scan acceleration affect power to track brain change?

Alzheimer's Disease Neuroimaging Initiative, Jan 1 2015, In : Neurobiology of aging. 36, S1, p. S167-S177

Research output: Contribution to journalArticle

6 Scopus citations

Drug development in Alzheimer's disease: The path to 2025

Cummings, J., Aisen, P. S., Dubois, B., Frölich, L., Jack, C. R., Jones, R. W., Morris, J. C., Raskin, J., Dowsett, S. A. & Scheltens, P., Sep 20 2016, In : Alzheimer's Research and Therapy. 8, 1, 39.

Research output: Contribution to journalArticle

162 Scopus citations

Early Alzheimer’s disease neuropathology detected by proton MR spectroscopy

Murray, M. E., Przybelski, S. A., Lesnick, T. G., Liesinger, A. M., Spychalla, A., Zhang, B., Gunter, J. L., Parisi, J. E., Boeve, B. F., Knopman, D. S., Petersen, R. C., Jack, C. R., Dickson, D. W. & Kantarci, K., Dec 3 2014, In : Journal of Neuroscience. 34, 49, p. 16247-16255 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Early Indications of Future Cognitive Decline: Stable versus Declining Controls

Rizk-Jackson, A., Insel, P., Petersen, R., Aisen, P., Jack, C. & Weiner, M., Sep 9 2013, In : PloS one. 8, 9, e74062.

Research output: Contribution to journalArticle

18 Scopus citations

Early Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition

Kantarci, K., Lowe, V. J., Lesnick, T. G., Tosakulwong, N., Bailey, K. R., Fields, J. A., Shuster, L. T., Zuk, S. M., Senjem, M. L., Mielke, M. M., Gleason, C., Jack, C. R., Rocca, W. A., Miller, V. M. & Tierney, M., 2016, In : Journal of Alzheimer's Disease. 53, 2, p. 547-556 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

The Alzheimer's Disease Neuroimaging Initiative, Jun 21 2016, In : Nature communications. 7, 11934.

Research output: Contribution to journalArticle

305 Scopus citations

Ecology of the aging human brain

Sonnen, J. A., Santa Cruz, K., Hemmy, L. S., Woltjer, R., Leverenz, J. B., Montine, K. S., Jack, C. R., Kaye, J., Lim, K., Larson, E. B., White, L. & Montine, T. J., Aug 2011, In : Archives of neurology. 68, 8, p. 1049-1056 8 p.

Research output: Contribution to journalArticle

102 Scopus citations

Effectiveness of regional DTI measures in distinguishing Alzheimer's disease, MCI, and normal aging

Nir, T. M., Jahanshad, N., Villalon-Reina, J. E., Toga, A. W., Jack, C. R., Weiner, M. W. & Thompson, P. M., 2013, In : NeuroImage: Clinical. 3, p. 180-195 16 p.

Research output: Contribution to journalArticle

152 Scopus citations

Effect Modifiers of TDP-43-Associated Hippocampal Atrophy Rates in Patients with Alzheimer's Disease Neuropathological Changes

Buciuc, M., Wennberg, A. M., Weigand, S. D., Murray, M. E., Senjem, M. L., Spychalla, A. J., Boeve, B. F., Knopman, D. S., Jack, C. R., Kantarci, K., Parisi, J. E., Dickson, D. W., Petersen, R. C., Whitwell, J. L. & Josephs, K. A., 2020, In : Journal of Alzheimer's Disease. 73, 4, p. 1511-1523 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Effect of APOE ε4 status on intrinsic network connectivity in cognitively normal elderly subjects

Machulda, M. M., Jones, D. T., Vemuri, P., McDade, E., Avula, R., Przybelski, S., Boeve, B. F., Knopman, D. S., Petersen, R. C. & Jack, C. R., Sep 2011, In : Archives of neurology. 68, 9, p. 1131-1136 6 p.

Research output: Contribution to journalArticle

161 Scopus citations

Effect of intellectual enrichment on AD biomarker trajectories

Vemuri, P., Lesnick, T. G., Przybelski, S. A., Knopman, D. S., Machulda, M., Lowe, V. J., Mielke, M. M., Roberts, R. O., Gunter, J. L., Senjem, M. L., Geda, Y. E., Rocca, W. A., Petersen, R. C. & Jack, C. R., Mar 22 2016, In : Neurology. 86, 12, p. 1128-1135 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Effect of lifestyle activities on alzheimer disease biomarkers and cognition

Vemuri, P., Lesnick, T. G., Przybelski, S. A., Knopman, D. S., Roberts, R. O., Lowe, V. J., Kantarci, K., Senjem, M. L., Gunter, J. L., Boeve, B. F., Petersen, R. C. & Jack, C. R., Nov 2012, In : Annals of neurology. 72, 5, p. 730-738 9 p.

Research output: Contribution to journalArticle

98 Scopus citations

Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer's disease: Study protocol of a randomized controlled trial (The FIT-AD trial)

Yu, F., Bronas, U. G., Konety, S., Nelson, N. W., Dysken, M., Jack, C., Wyman, J. F., Vock, D. & Smith, G., Oct 11 2014, In : Trials. 15, 1, 394.

Research output: Contribution to journalArticle

20 Scopus citations

Effects of baseline CSF α-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease

Mattsson, N., Insel, P., Tosun, D., Zhang, J., Jack, C. R., Galasko, D. & Weiner, M., Dec 31 2013, In : PloS one. 8, 12, e85443.

Research output: Contribution to journalArticle

8 Scopus citations