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  • Clifford R Jr. Jack
Article

Brain imaging measurements of fibrillar amyloid-β burden, paired helical filament tau burden, and atrophy in cognitively unimpaired persons with two, one, and no copies of the APOE ε4 allele

Ghisays, V., Goradia, D. D., Protas, H., Bauer, R. J., Devadas, V., Tariot, P. N., Lowe, V. J., Knopman, D. S., Petersen, R. C., Jack, C. R., Caselli, R. J., Su, Y., Chen, K. & Reiman, E. M., Apr 1 2020, In : Alzheimer's and Dementia. 16, 4, p. 598-609 12 p.

Research output: Contribution to journalArticle

Brain injury biomarkers are not dependent on β-amyloid in normal elderly

Knopman, D. S., Jack, C. R., Wiste, H. J., Weigand, S. D., Vemuri, P., Lowe, V. J., Kantarci, K., Gunter, J. L., Senjem, M. L., Mielke, M. M., Roberts, R. O., Boeve, B. F. & Petersen, R. C., Apr 2013, In : Annals of neurology. 73, 4, p. 472-480 9 p.

Research output: Contribution to journalArticle

126 Scopus citations

Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states

Mahjoub, I., Mahjoub, M. A., Rekik, I., Weiner, M., Aisen, P., Petersen, R., Jack, C., Jagust, W., Trojanowki, J., Toga, A., Beckett, L., Green, R., Saykin, A., Morris, J., Shaw, L., Kaye, J., Quinn, J., Silbert, L., Lind, B., Carter, R. & 221 others, Dolen, S., Schneider, L., Pawluczyk, S., Beccera, M., Teodoro, L., Spann, B., Brewer, J., Vanderswag, H., Fleisher, A., Heidebrink, J., Lord, J., Mason, S., Albers, C., Knopman, D., Johnson, K., Doody, R., Villanueva-Meyer, J., Chowdhury, M., Rountree, S., Dang, M., Stern, Y., Honig, L., Bell, K., Ances, B., Carroll, M., Creech, M., Franklin, E., Mintun, M., Schneider, S., Oliver, A., Marson, D., Grifth, R., Clark, D., Geldmacher, D., Brockington, J., Roberson, E., Natelson Love, M., Grossman, H., Mitsis, E., Shah, R., Detoledo-Morrell, L., Duara, R., Varon, D., Greig, M., Roberts, P., Albert, M., Onyike, C., D'Agostino, D., Kielb, S., Galvin, J., Cerbone, B., Michel, C., Pogorelec, D., Rusinek, H., De Leon, M., Glodzik, L., De Santi, S., Doraiswamy, P., Petrella, J., Borges-Neto, S., Wong, T., Coleman, E., Smith, C., Jicha, G., Hardy, P., Sinha, P., Oates, E., Conrad, G., Porsteinsson, A., Goldstein, B., Martin, K., Makino, K., Ismail, M., Brand, C., Mulnard, R., Thai, G., Mc-Adams-Ortiz, C., Womack, K., Mathews, D., Quiceno, M., Levey, A., Lah, J., Cellar, J., Burns, J., Swerdlow, R., Brooks, W., Apostolova, L., Tingus, K., Woo, E., Silverman, D., Lu, P., Bartzokis, G., Graf-Radford, N., Parftt, F., Kendall, T., Johnson, H., Farlow, M., Hake, A. M., Matthews, B., Brosch, J., Herring, S., Hunt, C., Dyck, C., Carson, R., MacAvoy, M., Varma, P., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Robin Hsiung, G. Y., Feldman, H., Mudge, B., Assaly, M., Finger, E., Pasternack, S., Rachisky, I., Trost, D., Kertesz, A., Bernick, C., Munic, D., Mesulam, M. M., Lipowski, K., Weintraub, S., Bonakdarpour, B., Kerwin, D., Wu, C. K., Johnson, N., Sadowsky, C., Villena, T., Turner, R. S., Johnson, K., Reynolds, B., Sperling, R., Johnson, K., Marshall, G., Yesavage, J., Taylor, J., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M., Belden, C., Jacobson, S., Sirrel, S., Kowall, N., Killiany, R., Budson, A., Norbash, A., Johnson, P. L., Obisesan, T., Wolday, S., Allard, J., Lerner, A., Ogrocki, P., Tatsuoka, C., Fatica, P., Fletcher, E., Maillard, P., Olichney, J., Decarli, C., Carmichael, O., Kittur, S., Borrie, M., Lee, T. Y., Bartha, R., Johnson, S., Asthana, S., Carlsson, C., Potkin, S., Preda, A., Nguyen, D., Tariot, P., Burke, A., Trncic, N., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D., Kataki, M., Adeli, A., Zimmerman, E., Celmins, D., Brown, A., Pearlson, G., Blank, K., Anderson, K., Flashman, L., Seltzer, M., Hynes, M., Santulli, R., Sink, K., Gordineer, L., Williamson, J., Garg, P., Watkins, F., Ott, B., Querfurth, H., Tremont, G., Salloway, S., Malloy, P., Correia, S., Rosen, H., Miller, B., Perry, D., Mintzer, J., Spicer, K., Bachman, D., Pomara, N., Hernando, R., Sarrael, A., Relkin, N., Chaing, G., Lin, M., Ravdin, L., Smith, A., Raj, B. A. & Fargher, K., Dec 1 2018, In : Scientific reports. 8, 1, 4103.

Research output: Contribution to journalArticle

26 Scopus citations

Brain structure and cognition 3 years after the end of an early menopausal hormone therapy trial

Kantarci, K., Tosakulwong, N., Lesnick, T. G., Zuk, S. M., Lowe, V. J., Fields, J. A., Gunter, J. L., Senjem, M. L., Settell, M. L., Gleason, C. E., Shuster, L. T., Bailey, K. R., Dowling, N. M., Asthana, S., Jack, C. R., Rocca, W. A. & Miller, V. M., 2018, In : Neurology. 90, 16, p. E1404-E1412

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants

Whitwell, J. L., Tosakulwong, N., Botha, H., Ali, F., Clark, H. M., Duffy, J. R., Utianski, R. L., Stevens, C. A., Weigand, S. D., Schwarz, C. G., Senjem, M. L., Jack, C. R., Lowe, V. J., Ahlskog, J. E., Dickson, D. W. & Josephs, K. A., 2020, In : NeuroImage: Clinical. 25, 102152.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Brain β-amyloid load approaches a plateau

Jack, C. R., Wiste, H. J., Lesnick, T. G., Weigand, S. D., Knopman, D. S., Vemuri, P., Pankratz, V. S., Senjem, M. L., Gunter, J. L., Mielke, M. M., Lowe, V. J., Boeve, B. F. & Petersen, R. C., Mar 5 2013, In : Neurology. 80, 10, p. 890-896 7 p.

Research output: Contribution to journalArticle

194 Scopus citations

Breakdown of brain connectivity between normal aging and Alzheimer's disease: A structural k-Core network analysis

Daianu, M., Jahanshad, N., Nir, T. M., Toga, A. W., Jack, C. R., Weiner, M. W. & Thompson, P. M., Aug 1 2013, In : Unknown Journal. 3, 4, p. 407-422 16 p.

Research output: Contribution to journalArticle

106 Scopus citations

Cardiometabolic Health and Longitudinal Progression of White Matter Hyperintensity: The Mayo Clinic Study of Aging

Scharf, E. L., Graff-Radford, J., Przybelski, S. A., Lesnick, T. G., Mielke, M. M., Knopman, D. S., Preboske, G. M., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Machulda, M., Kantarci, K., Petersen, R. C., Jack, C. R. & Vemuri, P., Nov 1 2019, In : Stroke. 50, 11, p. 3037-3044 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative

Toledo, J. B., Toledo, E., Weiner, M. W., Jack, C. R., Jagust, W., Lee, V. M. Y., Shaw, L. M. & Trojanowski, J. Q., Nov 2012, In : Alzheimer's and Dementia. 8, 6, p. 483-489 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer's Disease via Fusion of Clinical, Imaging and Omic Features

Singanamalli, A., Wang, H., Madabhushi, A., Weiner, M., Aisen, P., Petersen, R., Jack, C., Jagust, W., Trojanowki, J., Toga, A., Beckett, L., Green, R., Saykin, A., Morris, J., Shaw, L., Kaye, J., Quinn, J., Silbert, L., Lind, B., Carter, R. & 221 others, Dolen, S., Schneider, L., Pawluczyk, S., Beccera, M., Teodoro, L., Spann, B., Brewer, J., Vanderswag, H., Fleisher, A., Heidebrink, J., Lord, J., Mason, S., Albers, C., Knopman, D., Johnson, K., Doody, R., Villanueva-Meyer, J., Chowdhury, M., Rountree, S., Dang, M., Stern, Y., Honig, L., Bell, K., Ances, B., Carroll, M., Creech, M., Franklin, E., Mintun, M., Schneider, S., Oliver, A., Marson, D., Griffith, R., Clark, D., Geldmacher, D., Brockington, J., Roberson, E., Natelson Love, M., Grossman, H., Mitsis, E., Shah, R., Detoledo-Morrell, L., Duara, R., Varon, D., Greig, M., Roberts, P., Albert, M., Onyike, C., D'Agostino, D., Kielb, S., Galvin, J., Cerbone, B., Michel, C., Pogorelec, D., Rusinek, H., De Leon, M., Glodzik, L., De Santi, S., Doraiswamy, P., Petrella, J., Borges-Neto, S., Wong, T., Coleman, E., Smith, C., Jicha, G., Hardy, P., Sinha, P., Oates, E., Conrad, G., Porsteinsson, A., Goldstein, B., Martin, K., Makino, K., Ismail, M., Brand, C., Mulnard, R., Thai, G., Mc-Adams-Ortiz, C., Womack, K., Mathews, D., Quiceno, M., Levey, A., Lah, J., Cellar, J., Burns, J., Swerdlow, R., Brooks, W., Apostolova, L., Tingus, K., Woo, E., Silverman, D., Lu, P., Bartzokis, G., Graff-Radford, N., Parfitt, F., Kendall, T., Johnson, H., Farlow, M., Marie Hake, A., Matthews, B., Brosch, J., Herring, S., Hunt, C., Dyck, C., Carson, R., MacAvoy, M., Varma, P., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Robin Hsiung, G. Y., Feldman, H., Mudge, B., Assaly, M., Finger, E., Pasternack, S., Rachisky, I., Trost, D., Kertesz, A., Bernick, C., Munic, D., Mesulam, M. M., Lipowski, K., Weintraub, S., Bonakdarpour, B., Kerwin, D., Wu, C. K., Johnson, N., Sadowsky, C., Villena, T., Scott Turner, R., Johnson, K., Reynolds, B., Sperling, R., Johnson, K., Marshall, G., Yesavage, J., Taylor, J., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M., Belden, C., Jacobson, S., Sirrel, S., Kowall, N., Killiany, R., Budson, A., Norbash, A., Lynn Johnson, P., Obisesan, T., Wolday, S., Allard, J., Lerner, A., Ogrocki, P., Tatsuoka, C., Fatica, P., Fletcher, E., Maillard, P., Olichney, J., Decarli, C., Carmichael, O., Kittur, S., Borrie, M., Lee, T. Y., Robbartha, Johnson, S., Asthana, S., Carlsson, C., Potkin, S., Preda, A., Nguyen, D., Tariot, P., Burke, A., Trncic, N., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D., Kataki, M., Adeli, A., Zimmerman, E., Celmins, D., Brown, A., Pearlson, G., Blank, K., Anderson, K., Flashman, L., Seltzer, M., Hynes, M., Santulli, R., Sink, K., Gordineer, L., Williamson, J., Garg, P., Watkins, F., Ott, B., Querfurth, H., Tremont, G., Salloway, S., Malloy, P., Correia, S., Rosen, H., Miller, B., Perry, D., Mintzer, J., Spicer, K., Bachman, D., Pomara, N., Hernando, R., Sarrael, A., Relkin, N., Chaing, G., Lin, M., Ravdin, L., Smith, A., Ashok Raj, B. & Fargher, K., Dec 1 2017, In : Scientific reports. 7, 1, 8137.

Research output: Contribution to journalArticle

3 Scopus citations

Cascading network failure across the Alzheimer's disease spectrum

Jones, D. T., Knopman, D. S., Gunter, J. L., Graff-Radford, J., Vemuri, P., Boeve, B. F., Petersen, R. C., Weiner, M. W. & Jack, C. R., Feb 1 2016, In : Brain. 139, 2, p. 547-562 16 p.

Research output: Contribution to journalArticle

166 Scopus citations

Central arterial stiffness is associated with structural brain damage and poorer cognitive performance: The ARIC study

Palta, P., Sharrett, A. R., Wei, J., Meyer, M. L., Kucharska-Newton, A., Power, M. C., Deal, J. A., Jack, C. R., Knopman, D., Wright, J., Griswold, M., Tanaka, H., Mosley, T. H. & Heiss, G., Jan 1 2019, In : Journal of the American Heart Association. 8, 2, e011045.

Research output: Contribution to journalArticle

6 Scopus citations

Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging

Wennberg, A. M. V., Savica, R., Hagen, C. E., Roberts, R. O., Knopman, D. S., Hollman, J. H., Vemuri, P., Jack, C. R., Petersen, R. C. & Mielke, M. M., Apr 2017, In : Journal of the American Geriatrics Society. 65, 4, p. 792-799 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Cerebral microbleed incidence, relationship to amyloid burden: The Mayo Clinic Study of Aging

Graff-Radford, J., Lesnick, T., Rabinstein, A. A., Gunter, J., Aakre, J., Przybelski, S. A., Spychalla, A. J., Huston, J., Brown, R. D., Mielke, M. M., Lowe, V. J., Knopman, D. S., Petersen, R. C., Jack, C. R., Vemuri, P., Kremers, W. & Kantarci, K., Jan 14 2020, In : Neurology. 94, 2, p. e190-e199

Research output: Contribution to journalArticle

Cerebral microbleeds: Prevalence and relationship to amyloid burden

Graff-Radford, J., Botha, H., Rabinstein, A. A., Gunter, J. L., Przybelski, S. A., Lesnick, T., Huston, J., Flemming, K. D., Preboske, G. M., Senjem, M. L., Brown, R. D., Mielke, M. M., Roberts, R. O., Lowe, V. J., Knopman, D. S., Petersen, R. C., Kremers, W., Vemuri, P., Jack, C. R. & Kantarci, K., Jan 15 2019, In : Neurology. 92, 3, p. E253-E262

Research output: Contribution to journalArticle

9 Scopus citations

Cerebral microbleeds, CSF p-tau, and cognitive decline: Significance of anatomic distribution

Chiang, G. C., Cruz Hernandez, J. C., Kantarci, K., Jack, C. R. & Weiner, M. W., Sep 1 2015, In : American Journal of Neuroradiology. 36, 9, p. 1635-1641 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Cerebrospinal fluid dynamics disorders: Relationship to Alzheimer biomarkers and cognition

Graff-Radford, J., Gunter, J. L., Jones, D. T., Przybelski, S. A., Schwarz, C. G., Huston, J., Lowe, V., Elder, B. D., MacHulda, M. M., Gunter, N. B., Petersen, R. C., Kantarci, K., Vemuri, P., Mielke, M. M., Knopman, D. S., Graff-Radford, N. R. & Jack, C. R., Dec 10 2019, In : Neurology. 93, 24, p. E2237-E2246

Research output: Contribution to journalArticle

Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology

The Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2020, In : Scientific reports. 10, 1, 2975.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

For the Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2018, In : Scientific reports. 8, 1, 13807.

Research output: Contribution to journalArticle

4 Scopus citations
17 Scopus citations
242 Scopus citations

Characterizing Alzheimer's disease using a hypometabolic convergence index

Chen, K., Ayutyanont, N., Langbaum, J. B. S., Fleisher, A. S., Reschke, C., Lee, W., Liu, X., Bandy, D., Alexander, G. E., Thompson, P. M., Shaw, L., Trojanowski, J. Q., Jack, C. R., Landau, S. M., Foster, N. L., Harvey, D. J., Weiner, M. W., Koeppe, R. A., Jagust, W. J. & Reiman, E. M., May 1 2011, In : NeuroImage. 56, 1, p. 52-60 9 p.

Research output: Contribution to journalArticle

113 Scopus citations

Characterizing a neurodegenerative syndrome: Primary progressive apraxia of speech

Josephs, K. A., Duffy, J. R., Strand, E. A., MacHulda, M. M., Senjem, M. L., Master, A. V., Lowe, V. J., Jack, C. R. & Whitwell, J. L., May 2012, In : Brain. 135, 5, p. 1522-1536 15 p.

Research output: Contribution to journalArticle

181 Scopus citations

Characterizing white matter tract degeneration in syndromic variants of Alzheimer's disease: A diffusion tensor imaging study

Madhavan, A., Schwarz, C., Duffy, J. R., Strand, E. A., Machulda, M. M., Drubach, D., Kantarci, K. M., Przybelski, S. A., Reid, R. I., Senjem, M. L., Gunter, J. L., Apostolova, L. G., Lowe, V., Petersen, R. C., Jack, C. R. J., Josephs, K. A. & Whitwell, J. L., 2016, In : Journal of Alzheimer's Disease. 49, 3, p. 633-643 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Chronic depressive symptomatology in mild cognitive impairment is associated with frontal atrophy rate which hastens conversion to Alzheimer dementia

Sacuiu, S., Insel, P. S., Mueller, S., Tosun, D., Mattsson, N., Jack, C. R., DeCarli, C., Petersen, R., Aisen, P. S., Weiner, M. W. & Scott MacKin, R., Feb 1 2016, In : American Journal of Geriatric Psychiatry. 24, 2, p. 126-135 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease

Tariot, P. N., Schneider, L. S., Cummings, J., Thomas, R. G., Raman, R., Jakimovich, L. J., Loy, R., Bartocci, B., Fleisher, A., Ismail, M. S., Porsteinsson, A., Weiner, M., Jack, C. R., Thal, L. & Aisen, P. S., Aug 2011, In : Archives of General Psychiatry. 68, 8, p. 853-861 9 p.

Research output: Contribution to journalArticle

112 Scopus citations

Chronic divalproex sodium use and brain atrophy in Alzheimer disease

Fleisher, A. S., Truran, D., Mai, J. T., Langbaum, J. B. S., Aisen, P. S., Cummings, J. L., Jack, C. R., Weiner, M. W., Thomas, R. G., Schneider, L. S. & Tariot, P. N., Sep 27 2011, In : Neurology. 77, 13, p. 1263-1271 9 p.

Research output: Contribution to journalArticle

80 Scopus citations

Classification and clinicoradiologic features of primary progressive aphasia (PPA) and apraxia of speech

Botha, H., Duffy, J. R., Whitwell, J. L., Strand, E. A., Machulda, M. M., Schwarz, C. G., Reid, R. I., Spychalla, A. J., Senjem, M. L., Jones, D. T., Lowe, V., Jack, C. R. & Josephs, K. A., Aug 1 2015, In : Cortex. 69, p. 220-236 17 p.

Research output: Contribution to journalArticle

53 Scopus citations

Clinical and MRI models predicting amyloid deposition in progressive aphasia and apraxia of speech

Whitwell, J. L., Weigand, S. D., Duffy, J. R., Strand, E. A., MacHulda, M. M., Senjem, M. L., Gunter, J. L., Lowe, V. J., Jack, C. R. & Josephs, K. A., 2016, In : NeuroImage: Clinical. 11, p. 90-98 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia

Whitwell, J. L., Duffy, J. R., Strand, E. A., Machulda, M. M., Senjem, M. L., Schwarz, C. G., Reid, R., Baker, M. C., Perkerson, R. B., Lowe, V. J., Rademakers, R., Jack, C. R. & Josephs, K. A., Mar 1 2015, In : Brain and Language. 142, p. 45-53 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Clinical and neuroimaging characteristics of clinically unclassifiable primary progressive aphasia

Utianski, R. L., Botha, H., Martin, P. R., Schwarz, C. G., Duffy, J. R., Clark, H. M., Machulda, M. M., Butts, A. M., Lowe, V. J., Jack, C. R., Senjem, M. L., Spychalla, A. J., Whitwell, J. L. & Josephs, K. A., Oct 2019, In : Brain and Language. 197, 104676.

Research output: Contribution to journalArticle

4 Scopus citations

Clinical characterization of a kindred with a novel 12-octapeptide repeat insertion in the prion protein gene

Kumar, N., Boeve, B. F., Boot, B. P., Orr, C. F., Duffy, J., Woodruff, B. K., Nair, A. K., Ellison, J., Kuntz, K., Kantarci, K., Jack, C. R., Westmoreland, B. F., Fields, J. A., Baker, M., Rademakers, R., Parisi, J. E. & Dickson, D. W., Sep 2011, In : Archives of neurology. 68, 9, p. 1165-1170 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Clinical correlates of longitudinal brain atrophy in progressive supranuclear palsy

AL-108-231 Investigators, Jul 1 2016, In : Parkinsonism and Related Disorders. 28, p. 29-35 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Clinical correlates of white matter tract degeneration in progressive supranuclear palsy

Whitwell, J. L., Master, A. V., Avula, R., Kantarci, K., Eggers, S. D., Edmonson, H. A., Jack, C. R. & Josephs, K. A., Jun 2011, In : Archives of neurology. 68, 6, p. 753-760 8 p.

Research output: Contribution to journalArticle

75 Scopus citations
4 Scopus citations

Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum

Murray, M. E., Lowe, V. J., Graff-Radford, N. R., Liesinger, A. M., Cannon, A., Przybelski, S. A., Rawal, B., Parisi, J. E., Petersen, R. C., Kantarci, K., Ross, O. A., Duara, R., Knopman, D. S., Jack, C. R. & Dickson, D. W., May 1 2015, In : Brain. 138, 5, p. 1370-1381 12 p.

Research output: Contribution to journalArticle

178 Scopus citations

Coalition Against Major Diseases: Precompetitive Collaborations and Regulatory Paths to Accelerating Drug Development for Neurodegenerative Diseases

Stephenson, D., Aviles, E., Bain, L. J., Brumfield, M., Carrillo, M., Comery, T. A., Compton, C., Corrigan, B., Gordon, M. F., Jack, C. R., Katz, R., Logovinsky, V., Satlin, A., Marek, K., Nicholas, T., Polhamus, D., Angersbach, B. S., Raghavan, N., Romano, G., Romero, K. & 4 others, Shaw, L., Woodcock, J., Vradenburg, G. & Isaac, M., Nov 1 2013, In : Therapeutic Innovation and Regulatory Science. 47, 6, p. 632-638 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Coalition Against Major Diseases/European Medicines Agency biomarker qualification of hippocampal volume for enrichment of clinical trials in predementia stages of Alzheimer's disease

Hill, D. L. G., Schwarz, A. J., Isaac, M., Pani, L., Vamvakas, S., Hemmings, R., Carrillo, M. C., Yu, P., Sun, J., Beckett, L., Boccardi, M., Brewer, J., Brumfield, M., Cantillon, M., Cole, P. E., Fox, N., Frisoni, G. B., Jack, C., Kelleher, T., Luo, F. & 12 others, Novak, G., Maguire, P., Meibach, R., Patterson, P., Bain, L., Sampaio, C., Raunig, D., Soares, H., Suhy, J., Wang, H., Wolz, R. & Stephenson, D., Jul 2014, In : Alzheimer's and Dementia. 10, 4, p. 421-429.e3

Research output: Contribution to journalArticle

50 Scopus citations

Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition

Vemuri, P., Weigand, S. D., Przybelski, S. A., Knopman, D. S., Smith, G. E., Trojanowski, J. Q., Shaw, L. M., Decarli, C. S., Carmichael, O., Bernstein, M. A., Aisen, P. S., Weiner, M., Petersen, R. C. & Jack, C. R., May 2011, In : Brain. 134, 5, p. 1479-1492 14 p.

Research output: Contribution to journalArticle

89 Scopus citations

Commonfolate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment

Rajagopalan, P., Jahanshad, N., Stein, J. L., Hua, X., Madsen, S. K., Kohannim, O., Hibar, D. P., Toga, A. W., Jack, C. R., Saykin, A. J., Green, R. C., Weiner, M. W., Bis, J. C., Kuller, L. H., Riverol, M., Becker, J. T., Lopez, O. L. & Thompson, P. M., 2012, In : NeuroImage: Clinical. 1, 1, p. 179-187 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Common genetic variants influence human subcortical brain structures

Hibar, D. P., Stein, J. L., Renteria, M. E., Arias-Vasquez, A., Desrivières, S., Jahanshad, N., Toro, R., Wittfeld, K., Abramovic, L., Andersson, M., Aribisala, B. S., Armstrong, N. J., Bernard, M., Bohlken, M. M., Boks, M. P., Bralten, J., Brown, A. A., Mallar Chakravarty, M., Chen, Q., Ching, C. R. K. & 267 others, Cuellar-Partida, G., Den Braber, A., Giddaluru, S., Goldman, A. L., Grimm, O., Guadalupe, T., Hass, J., Woldehawariat, G., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Olde Loohuis, L. M., Luciano, M., MacAre, C., Mather, K. A., Mattheisen, M., Milaneschi, Y., Nho, K., Papmeyer, M., Ramasamy, A., Risacher, S. L., Roiz-Santiañez, R., Rose, E. J., Salami, A., Sämann, P. G., Schmaal, L., Schork, A. J., Shin, J., Strike, L. T., Teumer, A., Van Donkelaar, M. M. J., Van Eijk, K. R., Walters, R. K., Westlye, L. T., Whelan, C. D., Winkler, A. M., Zwiers, M. P., Alhusaini, S., Athanasiu, L., Ehrlich, S., Hakobjan, M. M. H., Hartberg, C. B., Haukvik, U. K., Heister, A. J. G. A. M., Hoehn, D., Kasperaviciute, D., Liewald, D. C. M., Lopez, L. M., Makkinje, R. R. R., Matarin, M., Naber, M. A. M., Reese McKay, D., Needham, M., Nugent, A. C., Pütz, B., Royle, N. A., Shen, L., Sprooten, E., Trabzuni, D., Van Der Marel, S. S. L., Van Hulzen, K. J. E., Walton, E., Wolf, C., Almasy, L., Ames, D., Arepalli, S., Assareh, A. A., Bastin, M. E., Brodaty, H., Bulayeva, K. B., Carless, M. A., Cichon, S., Corvin, A., Curran, J. E., Czisch, M., De Zubicaray, G. I., Dillman, A., Duggirala, R., Dyer, T. D., Erk, S., Fedko, I. O., Ferrucci, L., Foroud, T. M., Fox, P. T., Fukunaga, M., Raphael Gibbs, J., Göring, H. H. H., Green, R. C., Guelfi, S., Hansell, N. K., Hartman, C. A., Hegenscheid, K., Heinz, A., Hernandez, D. G., Heslenfeld, D. J., Hoekstra, P. J., Holsboer, F., Homuth, G., Hottenga, J. J., Ikeda, M., Jack, C. R., Jenkinson, M., Johnson, R., Kanai, R., Keil, M., Kent, J. W., Kochunov, P., Kwok, J. B., Lawrie, S. M., Liu, X., Longo, D. L., McMahon, K. L., Meisenzahl, E., Melle, I., Mohnke, S., Montgomery, G. W., Mostert, J. C., Mühleisen, T. W., Nalls, M. A., Nichols, T. E., Nilsson, L. G., Nöthen, M. M., Ohi, K., Olvera, R. L., Perez-Iglesias, R., Bruce Pike, G., Potkin, S. G., Reinvang, I., Reppermund, S., Rietschel, M., Romanczuk-Seiferth, N., Rosen, G. D., Rujescu, D., Schnell, K., Schofield, P. R., Smith, C., Steen, V. M., Sussmann, J. E., Thalamuthu, A., Toga, A. W., Traynor, B. J., Troncoso, J., Turner, J. A., Valdés Hernández, M. C., Van 'T Ent, D., Van Der Brug, M., Van Der Wee, N. J. A., Van Tol, M. J., Veltman, D. J., Wassink, T. H., Westman, E., Zielke, R. H., Zonderman, A. B., Ashbrook, D. G., Hager, R., Lu, L., McMahon, F. J., Morris, D. W., Williams, R. W., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Cahn, W., Calhoun, V. D., Cavalleri, G. L., Crespo-Facorro, B., Dale, A. M., Davies, G. E., Delanty, N., Depondt, C., Djurovic, S., Drevets, W. C., Espeseth, T., Gollub, R. L., Ho, B. C., Hoffmann, W., Hosten, N., Kahn, R. S., Le Hellard, S., Meyer-Lindenberg, A., Müller-Myhsok, B., Nauck, M., Nyberg, L., Pandolfo, M., Penninx, B. W. J. H., Roffman, J. L., Sisodiya, S. M., Smoller, J. W., Van Bokhoven, H., Van Haren, N. E. M., Völzke, H., Walter, H., Weiner, M. W., Wen, W., White, T., Agartz, I., Andreassen, O. A., Blangero, J., Boomsma, D. I., Brouwer, R. M., Cannon, D. M., Cookson, M. R., De Geus, E. J. C., Deary, I. J., Donohoe, G., Fernández, G., Fisher, S. E., Francks, C., Glahn, D. C., Grabe, H. J., Gruber, O., Hardy, J., Hashimoto, R., Hulshoff Pol, H. E., Jönsson, E. G., Kloszewska, I., Lovestone, S., Mattay, V. S., Mecocci, P., McDonald, C., McIntosh, A. M., Ophoff, R. A., Paus, T., Pausova, Z., Ryten, M., Sachdev, P. S., Saykin, A. J., Simmons, A., Singleton, A., Soininen, H., Wardlaw, J. M., Weale, M. E., Weinberger, D. R., Adams, H. H. H., Launer, L. J., Seiler, S., Schmidt, R., Chauhan, G., Satizabal, C. L., Becker, J. T., Yanek, L., Van Der Lee, S. J., Ebling, M., Fischl, B., Longstreth, W. T., Greve, D., Schmidt, H., Nyquist, P., Vinke, L. N., Van Duijn, C. M., Xue, L., Mazoyer, B., Bis, J. C., Gudnason, V., Seshadri, S., Ikram, M. A., Martin, N. G., Wright, M. J., Schumann, G., Franke, B., Thompson, P. M. & Medland, S. E., Apr 9 2015, In : Nature. 520, 7546, p. 224-229 6 p.

Research output: Contribution to journalArticle

420 Scopus citations

Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

Armstrong, N. J., Mather, K. A., Mather, K. A., Sargurupremraj, M., Knol, M. J., Malik, R., Satizabal, C. L., Satizabal, C. L., Yanek, L. R., Wen, W., Gudnason, V. G., Dueker, N. D., Elliott, L. T., Hofer, E., Hofer, E., Bis, J., Jahanshad, N., Li, S., Logue, M. A., Logue, M. A. & 106 others, Luciano, M., Scholz, M., Smith, A. V., Trompet, S., Trompet, S., Vojinovic, D., Xia, R., Alfaro-Almagro, F., Ames, D., Ames, D., Amin, N., Amouyel, P., Amouyel, P., Beiser, A. S., Beiser, A. S., Brodaty, H., Brodaty, H., Deary, I. J., Fennema-Notestine, C., Fennema-Notestine, C., Gampawar, P. G., Gottesman, R., Griffanti, L., Jack, C. R., Jenkinson, M., Jiang, J., Kral, B. G., Kwok, J. B., Kwok, J. B., Lampe, L., Liewald, D. C. M., Maillard, P., Marchini, J., Bastin, M. E., Bastin, M. E., Mazoyer, B., Pirpamer, L., Rafael Romero, J., Rafael Romero, J., Roshchupkin, G. V., Roshchupkin, G. V., Schofield, P. R., Schofield, P. R., Schroeter, M. L., Schroeter, M. L., Stott, D. J., Thalamuthu, A., Thalamuthu, A., Trollor, J., Trollor, J., Tzourio, C., Tzourio, C., Van Der Grond, J., Vernooij, M. W., Vernooij, M. W., Witte, V. A., Wright, M. J., Wright, M. J., Yang, Q., Morris, Z., Siggurdsson, S., Siggurdsson, S., Psaty, B., Villringer, A., Villringer, A., Schmidt, H., Haberg, A. K., Haberg, A. K., Van Duijn, C. M., Van Duijn, C. M., Jukema, J. W., Jukema, J. W., Dichgans, M., Dichgans, M., Dichgans, M., Sacco, R. L., Sacco, R. L., Sacco, R. L., Sacco, R. L., Wright, C. B., Kremen, W. S., Kremen, W. S., Becker, L. C., Thompson, P. M., Mosley, T. H., Wardlaw, J. M., Wardlaw, J. M., Ikram, M. A., Adams, H. H. H., Adams, H. H. H., Adams, H. H. H., Seshadri, S., Sachdev, P. S., Sachdev, P. S., Smith, S. M., Launer, L., Longstreth, W., Decarli, C., Schmidt, R., Fornage, M., Fornage, M., Debette, S., Debette, S., Nyquist, P. A., Nyquist, P. A. & Nyquist, P. A., 2020, (Accepted/In press) In : Stroke. p. 2111-2121 11 p.

Research output: Contribution to journalArticle

Common variants at 12q14 and 12q24 are associated with hippocampal volume

Bis, J. C., Decarli, C., Smith, A. V., Van Der Lijn, F., Crivello, F., Fornage, M., Debette, S., Shulman, J. M., Schmidt, H., Srikanth, V., Schuur, M., Yu, L., Choi, S. H., Sigurdsson, S., Verhaaren, B. F. J., Destefano, A. L., Lambert, J. C., Jack, C. R., Struchalin, M., Stankovich, J. & 62 others, Ibrahim-Verbaas, C. A., Fleischman, D., Zijdenbos, A., Den Heijer, T., Mazoyer, B., Coker, L. H., Enzinger, C., Danoy, P., Amin, N., Arfanakis, K., Van Buchem, M. A., De Bruijn, R. F. A. G., Beiser, A., Dufouil, C., Huang, J., Cavalieri, M., Thomson, R., Niessen, W. J., Chibnik, L. B., Gislason, G. K., Hofman, A., Pikula, A., Amouyel, P., Freeman, K. B., Phan, T. G., Oostra, B. A., Stein, J. L., Medland, S. E., Vasquez, A. A., Hibar, D. P., Wright, M. J., Franke, B., Martin, N. G., Thompson, P. M., Nalls, M. A., Uitterlinden, A. G., Au, R., Elbaz, A., Beare, R. J., Van Swieten, J. C., Lopez, O. L., Harris, T. B., Chouraki, V., Breteler, M. M. B., De Jager, P. L., Becker, J. T., Vernooij, M. W., Knopman, D., Fazekas, F., Wolf, P. A., Van Der Lugt, A., Gudnason, V., Longstreth, W. T., Brown, M. A., Bennett, D. A., Van Duijn, C. M., Mosley, T. H., Schmidt, R., Tzourio, C., Launer, L. J., Ikram, M. A. & Seshadri, S., May 2012, In : Nature Genetics. 44, 5, p. 545-551 7 p.

Research output: Contribution to journalArticle

158 Scopus citations

Common variants at 12q15 and 12q24 are associated with infant head circumference

Rob Taal, H., St Pourcain, B., Thiering, E., Das, S., Mook-Kanamori, D. O., Warrington, N. M., Kaakinen, M., Kreiner-Møller, E., Bradfield, J. P., Freathy, R. M., Geller, F., Guxens, M., Cousminer, D. L., Kerkhof, M., Timpson, N. J., Ikram, M. A., Beilin, L. J., Bønnelykke, K., Buxton, J. L., Charoen, P. & 164 others, Chawes, B. L. K., Eriksson, J., Evans, D. M., Hofman, A., Kemp, J. P., Kim, C. E., Klopp, N., Lahti, J., Lye, S. J., Mcmahon, G., Mentch, F. D., Müller-Nurasyid, M., O'reilly, P. F., Prokopenko, I., Rivadeneira, F., Steegers, E. A. P., Sunyer, J., Tiesler, C., Yaghootkar, H., Fornage, M., Smith, A. V., Seshadri, S., Schmidt, R., Debette, S., Vrooman, H. A., Sigurdsson, S., Ropele, S., Coker, L. H., Longstreth, W. T., Niessen, W. J., Destefano, A. L., Beiser, A., Zijdenbos, A. P., Struchalin, M., Jack, C. R., Nalls, M. A., Au, R., Gudnason, H., Van Der Lugt, A., Harris, T. B., Meeks, W. M., Vernooij, M. W., Van Buchem, M. A., Catellier, D., Gudnason, V., Windham, B. G., Wolf, P. A., Van Duijn, C. M., Mosley, T. H., Schmidt, H., Launer, L. J., Breteler, M. M. B., Ang, W., Van Beijsterveldt, T., Bergen, N., Benke, K., Berry, D., Coin, L., Elliott, P., Frayling, T., Gaillard, R., Groen-Blokhuis, M., Hadley, D., Hottenga, J. J., Huikari, V., Hypponen, E., Kowgier, M., Lawlor, D. A., Lewin, A., Lindgren, C., Marsh, J., Middeldorp, C., Millwood, I., Nivard, M., Palmer, L. J., Rodriguez, A., Sebert, S., Sovio, U., Standl, M., Strachan, D. P., Rob Taal, H., Uitterlinden, A. G., Valcárcel, B., White, S., Willemsen, G., Boomsma, D. I., Estivill, X., Grant, S. F. A., Hattersley, A. T., Heinrich, J., Jaddoe, V. W. V., Jarvelin, M. R., Mccarthy, M. I., Pennell, C. E., Power, C., Widen, E., Blakemore, A. I. F., Chiavacci, R. M., Feenstra, B., Fernandez-Banet, J., Hartikainen, A. L., Van Der Heijden, A. J., Iñiguez, C., Lathrop, M., Mcardle, W. L., Mølgaard, A., Newnham, J. P., Palotie, A., Pouta, A., Ring, S. M., Wichmann, H. E., Vissing, N. H., Decarli, C., Koppelman, G. H., Melbye, M., Bisgaard, H., Hakonarson, H., Smith, G. D., Jaddoe, V. W. V., Adair, L. S., Atalay, M., Davis, O. S. P., Flexeder, C., Goh, L. K., Haworth, C. M. A., Hedebrand, J., Hinney, A., Hirschhorn, J. N., Holloway, J. W., Holst, C., Horikoshi, M., Kilpeläinen, T. O., Kirin, M., Lakka, H. M., Lange, L. A., Lehtimäki, T., Lindi, V., Maggi, R., Murray, J. C., Nohr, E. A., Ntalla, I., Oken, E., Panoutsopoulou, K., Pararajasingham, J., Salem, R. M., Siitonen, N., Rob Taal, H., Teo, Y. Y., Zeggini, E., Cooper, C., Gillman, M., Hocher, B., Lakka, T. A., Mohlke, K. L., Dedoussis, G. V., Ong, K. K., Pearson, E. R., Price, T. S., Raitakari, O. T., Saw, S. M., Scherag, A., Simell, O., Sørensen, T. I. A. & Wilson, J. F., May 2012, In : Nature Genetics. 44, 5, p. 532-538 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Common variants at 6q22 and 17q21 are associated with intracranial volume

Ikram, M. A., Fornage, M., Smith, A. V., Seshadri, S., Schmidt, R., Debette, S., Vrooman, H. A., Sigurdsson, S., Ropele, S., Taal, H. R., Mook-Kanamori, D. O., Coker, L. H., Longstreth, W. T., Niessen, W. J., Destefano, A. L., Beiser, A., Zijdenbos, A. P., Struchalin, M., Jack, C. R., Rivadeneira, F. & 109 others, Uitterlinden, A. G., Knopman, D. S., Hartikainen, A. L., Pennell, C. E., Thiering, E., Steegers, E. A. P., Hakonarson, H., Heinrich, J., Palmer, L. J., Jarvelin, M. R., Mccarthy, M. I., Grant, S. F. A., Pourcain, B. S., Timpson, N. J., Smith, G. D., Sovio, U., Nalls, M. A., Au, R., Hofman, A., Gudnason, H., Van Der Lugt, A., Harris, T. B., Meeks, W. M., Vernooij, M. W., Van Buchem, M. A., Catellier, D., Jaddoe, V. W. V., Gudnason, V., Windham, B. G., Wolf, P. A., Van Duijn, C. M., Mosley, T. H., Schmidt, H., Launer, L. J., Breteler, M. M. B., Decarli, C., Adair, L. S., Ang, W., Atalay, M., Van Beijsterveldt, T., Bergen, N., Benke, K., Berry, D., Coin, L., Davis, O. S. P., Elliott, P., Flexeder, C., Frayling, T., Gaillard, R., Groen-Blokhuis, M., Goh, L. K., Haworth, C. M. A., Hadley, D., Hedebrand, J., Hinney, A., Hirschhorn, J. N., Holloway, J. W., Holst, C., Jan Hottenga, J., Horikoshi, M., Huikari, V., Hypponen, E., Kilpeläinen, T. O., Kirin, M., Kowgier, M., Lakka, H. M., Lange, L. A., Lawlor, D. A., Lehtimäki, T., Lewin, A., Lindgren, C., Lindi, V., Maggi, R., Marsh, J., Middeldorp, C., Millwood, I., Murray, J. C., Nivard, M., Nohr, E. A., Ntalla, I., Oken, E., Panoutsopoulou, K., Pararajasingham, J., Rodriguez, A., Salem, R. M., Sebert, S., Siitonen, N., Strachan, D. P., Teo, Y. Y., Valcárcel, B., Willemsen, G., Zeggini, E., Boomsma, D. I., Cooper, C., Gillman, M., Hocher, B., Lakka, T. A., Mohlke, K. L., Dedoussis, G. V., Ong, K. K., Pearson, E. R., Price, T. S., Power, C., Raitakari, O. T., Saw, S. M., Scherag, A., Simell, O., Sørensen, T. I. A. & Wilson, J. F., May 2012, In : Nature Genetics. 44, 5, p. 539-544 6 p.

Research output: Contribution to journalArticle

83 Scopus citations

Comparing 3T and 1.5T MRI for mapping hippocampal atrophy in the Alzheimer's disease neuroimaging initiative

Chow, N., Hwang, K. S., Hurtz, S., Green, A. E., Somme, J. H., Thompson, P. M., Elashoff, D. A., Jack, C. R., Weiner, M. & Apostolova, L. G., Apr 1 2015, In : American Journal of Neuroradiology. 36, 4, p. 653-660 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
13 Scopus citations

Comparison of imaging biomarkers in the Alzheimer Disease Neuroimaging Initiative and the Mayo Clinic Study of Aging

Whitwell, J. L., Wiste, H. J., Weigand, S. D., Rocca, W. A., Knopman, D. S., Roberts, R. O., Boeve, B. F., Petersen, R. C. & Jack, C. R., May 2012, In : Archives of neurology. 69, 5, p. 614-622 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies

Su, Y., Flores, S., Wang, G., Hornbeck, R. C., Speidel, B., Joseph-Mathurin, N., Vlassenko, A. G., Gordon, B. A., Koeppe, R. A., Klunk, W. E., Jack, C. R., Farlow, M. R., Salloway, S., Snider, B. J., Berman, S. B., Roberson, E. D., Brosch, J., Jimenez-Velazques, I., van Dyck, C. H., Galasko, D. & 25 others, Yuan, S. H., Jayadev, S., Honig, L. S., Gauthier, S., Hsiung, G. Y. R., Masellis, M., Brooks, W. S., Fulham, M., Clarnette, R., Masters, C. L., Wallon, D., Hannequin, D., Dubois, B., Pariente, J., Sanchez-Valle, R., Mummery, C., Ringman, J. M., Bottlaender, M., Klein, G., Milosavljevic-Ristic, S., McDade, E., Xiong, C., Morris, J. C., Bateman, R. J. & Benzinger, T. L. S., Dec 2019, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11, p. 180-190 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations