Wolfgang Singer, MD

  • 2535 Citations
  • 28 Scopus h-Index
19992020

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2020

Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies

Singer, W., Schmeichel, A. M., Shahnawaz, M., Schmelzer, J. D., Boeve, B. F., Sletten, D. M., Gehrking, T. L., Gehrking, J. A., Olson, A. D., Savica, R., Suarez, M. D., Soto, C. & Low, P. A., Sep 1 2020, In : Annals of neurology. 88, 3, p. 503-512 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Autonomic dysfunction and phenoconversion in idiopathic REM sleep behavior disorder

McCarter, S. J., Gehrking, T. L., St. Louis, E. K., Suarez, M. D., Boeve, B. F., Silber, M. H., Low, P. A. & Singer, W., Jun 1 2020, In : Clinical Autonomic Research. 30, 3, p. 207-213 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy

Shahnawaz, M., Mukherjee, A., Pritzkow, S., Mendez, N., Rabadia, P., Liu, X., Hu, B., Schmeichel, A., Singer, W., Wu, G., Tsai, A. L., Shirani, H., Nilsson, K. P. R., Low, P. A. & Soto, C., Feb 13 2020, In : Nature. 578, 7794, p. 273-277 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society

on behalf of the American Autonomic Society, Jan 2020, In : Autonomic Neuroscience: Basic and Clinical. 223, 102550.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society

on behalf of the American Autonomic Society, Feb 1 2020, In : Clinical Autonomic Research. 30, 1, p. 13-18 6 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Lower Vitamin B12 Level at Multiple System Atrophy Diagnosis Is Associated With Shorter Survival

McCarter, S. J., Coon, E. A., Savica, R., St Louis, E. K., Bower, J. H., Benarroch, E. E., Sandroni, P., Low, P. & Singer, W., Aug 1 2020, In : Movement Disorders. 35, 8, p. 1462-1466 5 p.

Research output: Contribution to journalArticle

Predicting phenoconversion in pure autonomic failure

Coon, E. A., Mandrekar, J. N., Berini, S. E., Benarroch, E. E., Sandroni, P., Low, P. A. & Singer, W., Aug 18 2020, In : Neurology. 95, 7, p. e889-e897

Research output: Contribution to journalArticle

2019

A critique of the second consensus criteria for multiple system atrophy

on behalf of the Movement Disorder Society Multiple System Atrophy Study Group, Jul 2019, In : Movement Disorders. 34, 7, p. 975-984 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Conjugal multiple system atrophy: Chance, shared risk factors, or evidence of transmissibility?

Coon, E. A., Rocca, W., Melson, C. S., Ahlskog, J. E., Matsumoto, J. Y., Low, P. A. & Singer, W., Oct 2019, In : Parkinsonism and Related Disorders. 67, p. 10-13 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Earlier age of onset in multiple system atrophy with smoking and heavy alcohol use

Jackson, L., Coon, E. A., Ahlskog, J. E., Bower, J. H., Sandroni, P., Benarroch, E. E., Mandrekar, J. N., Low, P. A. & Singer, W., Sep 2019, In : Parkinsonism and Related Disorders. 66, p. 212-215 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Elimination of spurious absent sweat response in QSWEAT recordings

Corfits, J., Singer, W., Sandroni, P., Fealey, R. D., Coon, E. A., Benarroch, E. E., Berini, S. E., Mauermann, M. L., Sletten, D. M., Cutsforth-Gregory, J. K., Schmelzer, J. D. & Low, P. A., Dec 2019, In : Autonomic Neuroscience: Basic and Clinical. 222, 102589.

Research output: Contribution to journalArticle

Gi dysfunctions in diabetic gastroenteropathy, their relationships with symptoms, and effects of a GLP-1 antagonist

Chakraborty, S., Halland, M., Burton, D., Desai, A., Neja, B., Low, P., Singer, W., Camilleri, M., Zinsmeister, A. R. & Bharucha, A. E., Jun 1 2019, In : Journal of Clinical Endocrinology and Metabolism. 104, 6, p. 1967-1977 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Human papillomavirus vaccine (HPV) and autonomic disorders: A position statement from the American Autonomic Society

on behalf of the American Autonomic Society, Jan 1 2019, In : Autonomic Neuroscience: Basic and Clinical. 102550.

Research output: Contribution to journalArticle

Intrathecal administration of autologous mesenchymal stem cells in multiple system atrophy

Singer, W., Dietz, A. B., Zeller, A. D., Gehrking, T. L., Schmelzer, J. D., Schmeichel, A. M., Gehrking, J. A., Suarez, M. D., Sletten, D. M., Minota Pacheco, K. V., Coon, E. A., Sandroni, P., Benarroch, E. E., Fealey, R. D., Matsumoto, J. Y., Bower, J. H., Hassan, A., Mckeon, A., Windebank, A. J., Mandrekar, J. N. & 1 others, Low, P. A., Jul 2 2019, In : Neurology. 93, 1, p. E77-E87

Research output: Contribution to journalArticle

10 Scopus citations

Progressive supranuclear palsy is not associated with neurogenic orthostatic hypotension

Van Gerpen, J. A., Al-Shaikh, R. H., Tipton, P. W., Wszolek, Z. K., Uitti, R. J., Ferman, T. J., Dickson, D. W., Benarroch, E. E., Singer, W., Cutsforth-Gregory, J. K., Heckman, M. G., Brushaber, D. E., Josephs, K. A., Low, P. A., Ahlskog, J. E. & Cheshire, W. P., Oct 1 2019, In : Neurology. 93, 14, p. E1339-E1347

Research output: Contribution to journalArticle

4 Scopus citations

Refined quantitation of sweat gland innervation

Minota, K., Schmeichel, A. M., Gehrking, J. A., Mandrekar, J. N., Low, P. A. & Singer, W., 2019, In : Journal of Neuropathology and Experimental Neurology. 78, 5, p. 453-459 7 p.

Research output: Contribution to journalArticle

Sex and gender influence symptom manifestation and survival in multiple system atrophy

Coon, E. A., Nelson, R. M., Sletten, D. M., Suarez, M. D., Ahlskog, J. E., Benarroch, E. E., Sandroni, P., Mandrekar, J. N., Low, P. A. & Singer, W., Jul 2019, In : Autonomic Neuroscience: Basic and Clinical. 219, p. 49-52 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy

McCarter, S. J., Feemster, J. C., Tabatabai, G. M., Sandness, D. J., Timm, P. C., McCarter, A. R., Talley, H. N., Junna, M. R., Savica, R., Singer, W., Coon, E. A., Benarroch, E. E., Josephs, K. A., Boeve, B. F., Silber, M. H. & St. Louis, E. K., Dec 1 2019, In : Annals of neurology. 86, 6, p. 969-974 6 p.

Research output: Contribution to journalArticle

2018

Association study between multiple system atrophy and TREM2 p.R47H

Ogaki, K., Heckman, M. G., Koga, S., Martens, Y. A., Labbé, C., Lorenzo-Betancor, O., Walton, R. L., Soto, A. I., Vargas, E. R., Fujioka, S., Uitti, R. J., Van Gerpen, J. A., Cheshire, W. P., Younkin, S. G., Wszolek, Z. K., Low, P. A., Singer, W., Bu, G., Dickson, D. W. & Ross, O. A., Aug 1 2018, In : Neurology: Genetics. 4, 4, e257.

Research output: Contribution to journalArticle

3 Scopus citations

Do selective serotonin reuptake inhibitors improve survival in multiple system atrophy?

Coon, E. A., Ahlskog, J. E., Silber, M. H., Fealey, R. D., Benarroch, E. E., Sandroni, P., Mandrekar, J. N., Low, P. A. & Singer, W., Mar 2018, In : Parkinsonism and Related Disorders. 48, p. 51-53 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Ganglionic Antibody Level as a Predictor of Severity of Autonomic Failure

Cutsforth-Gregory, J. K., McKeon, A., Coon, E. A., Sletten, D. M., Suarez, M., Sandroni, P., Singer, W., Benarroch, E. E., Fealey, R. D. & Low, P. A., Oct 2018, In : Mayo Clinic proceedings. 93, 10, p. 1440-1447 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Multiple system atrophy and apolipoprotein E

Ogaki, K., Martens, Y. A., Heckman, M. G., Koga, S., Labbé, C., Lorenzo-Betancor, O., Wernick, A. I., Walton, R. L., Soto, A. I., Vargas, E. R., Nielsen, H. M., Fujioka, S., Kanekiyo, T., Uitti, R. J., van Gerpen, J. A., Cheshire, W. P., Wszolek, Z. K., Low, P. A., Singer, W., Dickson, D. W. & 2 others, Bu, G. & Ross, O. A., Apr 2018, In : Movement Disorders. 33, 4, p. 647-650 4 p.

Research output: Contribution to journalArticle

7 Scopus citations

Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies

Autonomic Disorders Consortium, Mar 2018, In : Annals of neurology. 83, 3, p. 522-531 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
2017

Anhidrosis in multiple system atrophy involves pre- and postganglionic sudomotor dysfunction

Coon, E. A., Fealey, R. D., Sletten, D. M., Mandrekar, J. N., Benarroch, E. E., Sandroni, P., Low, P. A. & Singer, W., Mar 1 2017, In : Movement Disorders. 32, 3, p. 397-404 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Autonomic function testing: Compliance and consequences

Rasmussen, T. K., Hansen, J., Low, P. A., Sandroni, P., Singer, W., Jensen, T. S. & Terkelsen, A. J., 2017, (Accepted/In press) In : Autonomic Neuroscience: Basic and Clinical.

Research output: Contribution to journalArticle

2 Scopus citations

Natural history of pure autonomic failure: A United States prospective cohort

on behalf of the Autonomic Disorders Consortium, Feb 1 2017, In : Annals of neurology. 81, 2, p. 287-297 11 p.

Research output: Contribution to journalArticle

105 Scopus citations

Pure autonomic failure: Predictors of conversion to clinical CNS involvement

Singer, W., Berini, S. E., Sandroni, P., Fealey, R. D., Coon, E. A., Suarez, M. D., Benarroch, E. E. & Low, P. A., Mar 21 2017, In : Neurology. 88, 12, p. 1129-1136 8 p.

Research output: Contribution to journalArticle

36 Scopus citations
2016

MAPT haplotype diversity in multiple system atrophy

Labbé, C., Heckman, M. G., Lorenzo-Betancor, O., Murray, M. E., Ogaki, K., Soto-Ortolaza, A. I., Walton, R. L., Fujioka, S., Koga, S., Uitti, R. J., van Gerpen, J. A., Petersen, R. C., Graff-Radford, N. R., Younkin, S. G., Boeve, B. F., Cheshire, W. P., Low, P. A., Sandroni, P., Coon, E. A., Singer, W. & 3 others, Wszolek, Z. K., Dickson, D. W. & Ross, O. A., Sep 1 2016, In : Parkinsonism and Related Disorders. 30, p. 40-45 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
9 Scopus citations
2015

Clinical features and autonomic testing predict survival in multiple system atrophy

Coon, E. A., Sletten, D. M., Suarez, M. D., Mandrekar, J. N., Ahlskog, J. E., Bower, J. H., Matsumoto, J. Y., Silber, M. H., Benarroch, E. E., Fealey, R. D., Sandroni, P., Low, P. A. & Singer, W., Dec 1 2015, In : Brain. 138, 12, p. 3623-3631 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

Disturbances of gastrointestinal transit and autonomic functions in postural orthostatic tachycardia syndrome

Loavenbruck, A., Iturrino, J., Singer, W., Sletten, D. M., Low, P. A., Zinsmeister, A. R. & Bharucha, A. E., Jan 1 2015, In : Neurogastroenterology and Motility. 27, 1, p. 92-98 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults with orthostatic hypotension

Figueroa, J. J., Singer, W., Sandroni, P., Sletten, D. M., Gehrking, T. L., Gehrking, J. A., Low, P. & Basford, J. R., Mar 1 2015, In : Archives of Physical Medicine and Rehabilitation. 96, 3, p. 505-510 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Natural history of multiple system atrophy in the USA: A prospective cohort study

Low, P. A., Reich, S. G., Jankovic, J., Shults, C. W., Stern, M. B., Novak, P., Tanner, C. M., Gilman, S., Marshall, F. J., Wooten, F., Racette, B., Chelimsky, T., Singer, W., Sletten, D. M., Sandroni, P. & Mandrekar, J., Jul 1 2015, In : The Lancet Neurology. 14, 7, p. 710-719 10 p.

Research output: Contribution to journalArticle

117 Scopus citations
2014

A report of the autonomic symptom profile in patients with fibromyalgia

Vincent, A., McAllister, S. J., Singer, W., Toussaint, L. L., Sletten, D. M., Whipple, M. O. & Low, P. A., Mar 2014, In : Journal of Clinical Rheumatology. 20, 2, p. 106-108 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Comparison of baroreflex sensitivity with a fall and rise in blood pressure induced by the valsalva manoeuvre

Wada, N., Singer, W., Gehrking, T. L., Sletten, D. M., Schmelzer, J. D. & Low, P. A., 2014, In : Clinical Science. 127, 5, p. 307-313 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Decreased orthostatic adrenergic reactivity in non-dipping postural tachycardia syndrome

Figueroa, J. J., Bott-Kitslaar, D. M., Mercado, J. A., Basford, J. R., Sandroni, P., Shen, W. K., Sletten, D. M., Gehrking, T. L., Gehrking, J. A., Low, P. A. & Singer, W., Oct 1 2014, In : Autonomic Neuroscience: Basic and Clinical. 185, p. 107-111 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Determination of vagal baroreflex sensitivity in normal subjects

Wada, N., Singer, W., Gehrking, T. L., Sletten, D. M., Schmelzer, J. D., Kihara, M. & Low, P. A., Oct 1 2014, In : Muscle and Nerve. 50, 4, p. 535-540 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Efficacy and safety of rifampicin for multiple system atrophy: A randomised, double-blind, placebo-controlled trial

Low, P. A., Robertson, D., Gilman, S., Kaufmann, H., Singer, W., Biaggioni, I., Freeman, R., Perlman, S., Hauser, R. A., Cheshire, W., Lessig, S., Vernino, S., Mandrekar, J., Dupont, W. D., Chelimsky, T. & Galpern, W. R., Mar 2014, In : The Lancet Neurology. 13, 3, p. 268-275 8 p.

Research output: Contribution to journalArticle

64 Scopus citations

Multicenter trial of the proficiency of smart quantitative sensation tests

Dyck, P. J., Argyros, B., Russell, J. W., Gahnstrom, L. E., Nalepa, S., Albers, J. W., Lodermeier, K. A., Zafft, A. J., Dyck, P. J. B., Klein, C. J., Litchy, W. J., Davies, J. L., Carter, R. E., Melton, L. J., Low, P. A., Overland, C. J., Andersen, H., England, J. D., Llewelyn, G., Mauermann, M. L. & 5 others, Selvarajah, D., Singer, W., Smith, G., Tesfaye, S. & Vella, A., May 2014, In : Muscle and Nerve. 49, 5, p. 645-653 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Multiple system atrophy: Prognostic indicators of survival

Figueroa, J. J., Singer, W., Parsaik, A., Benarroch, E. E., Ahlskog, J. E., Fealey, R. D., Parisi, J. E., Sandroni, P., Mandrekar, J., Iodice, V., Low, P. A. & Bower, J. H., Aug 2014, In : Movement Disorders. 29, 9, p. 1151-1157 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Proficiency of nerve conduction using standard methods and reference values (cl. NPhys Trial 4)

The CI. Nphys Trial 4 Investigators, Dec 1 2014, In : Muscle and Nerve. 50, 6, p. 900-908 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Retinal and pontine striations: Neurodiagnostic signs of autosomal recessive spastic ataxia of charlevoix-saguenay

Leavitt, J. A., Singer, W., Brown, W. L., Pulido, J. S. & Brodsky, M. C., Dec 8 2014, In : Journal of Neuro-Ophthalmology. 34, 4, p. 369-371 3 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Central hyperadrenergic state after lightning strike

Parsaik, A. K., Ahlskog, J. E., Singer, W., Gelfman, R., Sheldon, S. H., Seime, R. J., Craft, J. M., Staab, J. P., Kantor, B. & Low, P. A., Aug 2013, In : Clinical Autonomic Research. 23, 4, p. 169-173 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Gastric emptying in postural tachycardia syndrome: A preliminary report

Park, K. J., Singer, W., Sletten, D. M., Low, P. A. & Bharucha, A. E., Aug 2013, In : Clinical Autonomic Research. 23, 4, p. 163-167 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Orthostatic intolerance without postural tachycardia: How much dysautonomia?

Parsaik, A. K., Singer, W., Allison, T. G., Sletten, D. M., Joyner, M. J., Benarroch, E. E., Low, P. A. & Sandroni, P., Aug 2013, In : Clinical Autonomic Research. 23, 4, p. 181-188 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012

Amyloid-like IgM deposition neuropathy: A distinct clinico-pathologic and proteomic profiled disorder

Figueroa, J. J., Bosch, E. P., Dyck, P. J. B., Singer, W., Vrana, J. A., Theis, J. D., Dogan, A. & Klein, C. J., Jun 2012, In : Journal of the Peripheral Nervous System. 17, 2, p. 182-190 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

A prospective, 1-year follow-up study of postural tachycardia syndrome

Kimpinski, K., Figueroa, J. J., Singer, W., Sletten, D. M., Iodice, V., Sandroni, P., Fischer, P. R., Opfer-Gehrking, T. L., Gehrking, J. A. & Low, P. A., Aug 2012, In : Mayo Clinic proceedings. 87, 8, p. 746-752 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

Autopsy confirmed multiple system atrophy cases: Mayo experience and role of autonomic function tests

Iodice, V., Lipp, A., Ahlskog, J. E., Sandroni, P., Fealey, R. D., Parisi, J. E., Matsumoto, J. Y., Benarroch, E. E., Kimpinski, K., Singer, W., Gehrking, T. L., Gehrking, J. A., Sletten, D. M., Schmeichel, A. M., Bower, J. H., Gilman, S., Figueroa, J. & Low, P. A., Apr 2012, In : Journal of Neurology, Neurosurgery and Psychiatry. 83, 4, p. 453-459 7 p.

Research output: Contribution to journalArticle

73 Scopus citations

COMPASS 31: A refined and abbreviated composite autonomic symptom score

Sletten, D. M., Suarez, G. A., Low, P. A., Mandrekar, J. & Singer, W., Dec 2012, In : Mayo Clinic proceedings. 87, 12, p. 1196-1201 6 p.

Research output: Contribution to journalArticle

130 Scopus citations