Yield and Predictors of Epilepsy Surgery Candidacy in Children Admitted for Surgical Evaluation

Omar J. Haque, Jayawant Mandrekar, Kirk Wyatt, Katherine C Nickels, Lily Wong-Kisiel, Nicholas Wetjen, Elaine C Wirrell

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Abstract Objective The aim of this study was to identify preadmission variables that are prognostic of epilepsy surgical candidacy for children admitted into an epilepsy-monitoring unit. Methods This study is a retrospective review of patients 0-18 years who were admitted into the pediatric epilepsy-monitoring unit at Mayo Clinic between November 2010 and December 2013 to assess for surgery candidacy for medically intractable epilepsy. Demographic data, epilepsy details, treatments, electroencephalograph and imaging results, and the consensus notes of the epilepsy surgery conferences were collected. Results One hundred and forty eight children underwent inpatient, prolonged video-electroencephalograph monitoring for presurgical evaluation, of which 136 had their typical events recorded. Five recommended for callosotomy alone were excluded and 131 composed the study group. Of these 131, the epilepsy surgery conference consensus deemed that 69 were surgical candidates, of which 45 (65%) underwent resective surgery. Chi-square analysis found seven preadmission predictors of surgical candidacy: single semiology at seizure onset (P <0.001), structural etiology (P <0.001), one or more interictal foci all in the same hemisphere (P <0.004), focal background electroencephalograph slowing (P <0.001), focal or hemispheric abnormality on magnetic resonance imaging (P <0.001), male sex (P = 0.02), and normal development (P = 0.04). Conclusions The presence of fewer than four predictors was suggestive of low likelihood of candidacy (

Original languageEnglish (US)
Article number8635
Pages (from-to)58-64
Number of pages7
JournalPediatric Neurology
Volume53
Issue number1
DOIs
StatePublished - Jul 1 2015

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Epilepsy
Inpatients
Seizures
Magnetic Resonance Imaging
Demography
Pediatrics
Therapeutics

Keywords

  • epilepsy
  • epilepsy surgery
  • evaluation
  • intractable epilepsy
  • pediatric
  • surgical treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Yield and Predictors of Epilepsy Surgery Candidacy in Children Admitted for Surgical Evaluation. / Haque, Omar J.; Mandrekar, Jayawant; Wyatt, Kirk; Nickels, Katherine C; Wong-Kisiel, Lily; Wetjen, Nicholas; Wirrell, Elaine C.

In: Pediatric Neurology, Vol. 53, No. 1, 8635, 01.07.2015, p. 58-64.

Research output: Contribution to journalArticle

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