Xanthomatous neuropathy of liver

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Abstract

A 36-year-old man with juvenile-onset diabetes mellitus developed cholestatic hepatitis of unknown cause, possibly drug-induced. He remained jaundiced for four months, until he died unexpectedly. At autopsy, severe and macroscopically identifiable xanthomatous neuropathy was found in the liver; it involved the unmyelinated nerves in the hilus and in all portal tracts examined. Microscopic evidence of minimal extrahepatic involvement of unmyelinated nerves was also found. Somatic nerves were affected by diabetic neuropathy but not by xanthomatous neuropathy. The condition seems to be a rare complication of diseases that are characterized by accumulations of lipids.

Original languageEnglish (US)
Pages (from-to)1049-1051
Number of pages3
JournalHuman Pathology
Volume13
Issue number11
DOIs
StatePublished - Nov 1982

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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