Wound-healing properties of transforming growth factor β (TGF-β) inducible early gene 1 (TIEG1) knockout mice

Manabu Taguchi, Steven L. Moran, Mark E. Zobitz, Chunfeng Zhao, Malayannan Subramaniam, Thomas C. Spelsberg, Peter C. Amadio

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Transforming growth factor beta (TGF-β) has a broad effect on wound healing, but many questions remain about the regulation of TGF-β during the healing process. TGF-β inducible early gene 1 (TIEG1) is a primary response gene for TGF-β that controls the activities of the TGF-β/Smad pathway, the primary TGF-β signaling pathway. The purpose of this study was to investigate the role of TIEG1 in cutaneous wound healing using TIEG1 knockout mice. The wound healing in TIEG1 knockout mice and wild-type controls was evaluated by wound breaking strength, Western blot, and histology at postoperative days 3, 7, and 14. Although re-epithelialization of both groups was similarly complete at day 7, the TIEG1 knockout mice had a significantly lower wound breaking strength than the controls at postoperative day 14. These results suggest that TIEG1 expression may be an important factor involved in the initiation and support of normal cutaneous wound healing.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalJournal of Musculoskeletal Research
Volume11
Issue number2
DOIs
StatePublished - 2008

Keywords

  • Breaking strength
  • Smad
  • TGF-β
  • TIEG
  • Wound healing

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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