Would a right shift of the oxy-hemoglobin dissociation curve improve exercise capacity in patients with heart failure?

Kisuk Min, Dongwook Yeo, Jeung Ki Yoo, Bruce D. Johnson, Chul Ho Kim

Research output: Contribution to journalArticle

Abstract

Exercise intolerance is a hallmark of symptoms in patients with heart failure. In addition to reduced cardiac output, a series of impairments in pulmonary and vascular systems leads to decreases in oxygen delivery and availability in locomotor muscles. This contributes to exercise intolerance in heart failure. The oxy-hemoglobin dissociation curve is essentially a graph illustrating the relationship between the partial pressure of oxygen (PO2, X-axis) and oxygen saturation (SaO2, Y-axis) of hemoglobin. The rightward shift of the curve indicates that hemoglobin's affinity for oxygen decreases and in turn, it may allow the release of more oxygen to tissues. In the present study, we discuss the pathophysiological impairment, which causes exercise intolerance in heart failure patients and suggest a strategy to improve exercise capacity without altering cardiac output via modulating the oxy-hemoglobin dissociation curve.

Original languageEnglish (US)
Article number109423
JournalMedical Hypotheses
Volume134
DOIs
StatePublished - Jan 2020

Fingerprint

Hemoglobins
Heart Failure
Exercise
Oxygen
Cardiac Output
Partial Pressure
Blood Vessels
Muscles
Lung

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Would a right shift of the oxy-hemoglobin dissociation curve improve exercise capacity in patients with heart failure? / Min, Kisuk; Yeo, Dongwook; Yoo, Jeung Ki; Johnson, Bruce D.; Kim, Chul Ho.

In: Medical Hypotheses, Vol. 134, 109423, 01.2020.

Research output: Contribution to journalArticle

@article{da237e2f9da14e5499bad3b1321395e3,
title = "Would a right shift of the oxy-hemoglobin dissociation curve improve exercise capacity in patients with heart failure?",
abstract = "Exercise intolerance is a hallmark of symptoms in patients with heart failure. In addition to reduced cardiac output, a series of impairments in pulmonary and vascular systems leads to decreases in oxygen delivery and availability in locomotor muscles. This contributes to exercise intolerance in heart failure. The oxy-hemoglobin dissociation curve is essentially a graph illustrating the relationship between the partial pressure of oxygen (PO2, X-axis) and oxygen saturation (SaO2, Y-axis) of hemoglobin. The rightward shift of the curve indicates that hemoglobin's affinity for oxygen decreases and in turn, it may allow the release of more oxygen to tissues. In the present study, we discuss the pathophysiological impairment, which causes exercise intolerance in heart failure patients and suggest a strategy to improve exercise capacity without altering cardiac output via modulating the oxy-hemoglobin dissociation curve.",
author = "Kisuk Min and Dongwook Yeo and Yoo, {Jeung Ki} and Johnson, {Bruce D.} and Kim, {Chul Ho}",
year = "2020",
month = "1",
doi = "10.1016/j.mehy.2019.109423",
language = "English (US)",
volume = "134",
journal = "Medical Hypotheses",
issn = "0306-9877",
publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - Would a right shift of the oxy-hemoglobin dissociation curve improve exercise capacity in patients with heart failure?

AU - Min, Kisuk

AU - Yeo, Dongwook

AU - Yoo, Jeung Ki

AU - Johnson, Bruce D.

AU - Kim, Chul Ho

PY - 2020/1

Y1 - 2020/1

N2 - Exercise intolerance is a hallmark of symptoms in patients with heart failure. In addition to reduced cardiac output, a series of impairments in pulmonary and vascular systems leads to decreases in oxygen delivery and availability in locomotor muscles. This contributes to exercise intolerance in heart failure. The oxy-hemoglobin dissociation curve is essentially a graph illustrating the relationship between the partial pressure of oxygen (PO2, X-axis) and oxygen saturation (SaO2, Y-axis) of hemoglobin. The rightward shift of the curve indicates that hemoglobin's affinity for oxygen decreases and in turn, it may allow the release of more oxygen to tissues. In the present study, we discuss the pathophysiological impairment, which causes exercise intolerance in heart failure patients and suggest a strategy to improve exercise capacity without altering cardiac output via modulating the oxy-hemoglobin dissociation curve.

AB - Exercise intolerance is a hallmark of symptoms in patients with heart failure. In addition to reduced cardiac output, a series of impairments in pulmonary and vascular systems leads to decreases in oxygen delivery and availability in locomotor muscles. This contributes to exercise intolerance in heart failure. The oxy-hemoglobin dissociation curve is essentially a graph illustrating the relationship between the partial pressure of oxygen (PO2, X-axis) and oxygen saturation (SaO2, Y-axis) of hemoglobin. The rightward shift of the curve indicates that hemoglobin's affinity for oxygen decreases and in turn, it may allow the release of more oxygen to tissues. In the present study, we discuss the pathophysiological impairment, which causes exercise intolerance in heart failure patients and suggest a strategy to improve exercise capacity without altering cardiac output via modulating the oxy-hemoglobin dissociation curve.

UR - http://www.scopus.com/inward/record.url?scp=85073160465&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073160465&partnerID=8YFLogxK

U2 - 10.1016/j.mehy.2019.109423

DO - 10.1016/j.mehy.2019.109423

M3 - Article

C2 - 31627121

AN - SCOPUS:85073160465

VL - 134

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

M1 - 109423

ER -