TY - JOUR
T1 - Worsening left ventricular performance on serial exercise radionuclide angiography does not identify high-risk patients
AU - Chaliki, Hari P.
AU - Christian, Timothy F.
PY - 1997
Y1 - 1997
N2 - • Objective: To determine whether worsening exercise performance on serial exercise radionuclide angiography identifies patients at increased risk of future cardiac events. • Material and Methods: One hundred nine medically treated patients with previous Q-wave myocardial infarction underwent two exercise radionuclide angiographic studies at least 6 months apart (median, 16 months) without an intervening clinical event. Worsening exercise performance between the two studies was defined by five criteria: (1) lower (5% or more) peak exercise ejection fraction; (2) worsening peak exercise wall motion score; (3) combination of criteria 1 and 2; (4) worsening serial delta (exercise rest) ejection fraction; or (5) increasing exercise STsegment depression of 1 mm or more. Patients were followed up for a median duration of 3.9 years after the second exercise study. • Results: Five cardiac deaths and 10 nonfatal myocardial infarctions occurred during follow-up. A Cox proportional hazards analysis failed to show an association between any of the aforementioned variables and cardiac events. Of the 15 patients with cardiac events, 4 (27%) had a lower (5% or more) exercise ejection fraction and 2 (13%) had a worsening exercise wall motion score. Of the 94 patients without cardiac events, 37 (39%) had a lower (5% or more) exercise ejection fraction and 28 (30%) had a worsening serial exercise wall motion score (not a statistically significant difference). • Conclusion: Worsening exercise performance on serial exercise radionuclide angiography does not identify patients at increased risk of future cardiac events.
AB - • Objective: To determine whether worsening exercise performance on serial exercise radionuclide angiography identifies patients at increased risk of future cardiac events. • Material and Methods: One hundred nine medically treated patients with previous Q-wave myocardial infarction underwent two exercise radionuclide angiographic studies at least 6 months apart (median, 16 months) without an intervening clinical event. Worsening exercise performance between the two studies was defined by five criteria: (1) lower (5% or more) peak exercise ejection fraction; (2) worsening peak exercise wall motion score; (3) combination of criteria 1 and 2; (4) worsening serial delta (exercise rest) ejection fraction; or (5) increasing exercise STsegment depression of 1 mm or more. Patients were followed up for a median duration of 3.9 years after the second exercise study. • Results: Five cardiac deaths and 10 nonfatal myocardial infarctions occurred during follow-up. A Cox proportional hazards analysis failed to show an association between any of the aforementioned variables and cardiac events. Of the 15 patients with cardiac events, 4 (27%) had a lower (5% or more) exercise ejection fraction and 2 (13%) had a worsening exercise wall motion score. Of the 94 patients without cardiac events, 37 (39%) had a lower (5% or more) exercise ejection fraction and 28 (30%) had a worsening serial exercise wall motion score (not a statistically significant difference). • Conclusion: Worsening exercise performance on serial exercise radionuclide angiography does not identify patients at increased risk of future cardiac events.
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U2 - 10.1016/S0025-6196(11)63589-1
DO - 10.1016/S0025-6196(11)63589-1
M3 - Article
C2 - 9276597
AN - SCOPUS:0031204555
SN - 0025-6196
VL - 72
SP - 711
EP - 718
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 8
ER -