Worsening left ventricular performance on serial exercise radionuclide angiography does not identify high-risk patients

Hari P Chaliki, Timothy F. Christian

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

• Objective: To determine whether worsening exercise performance on serial exercise radionuclide angiography identifies patients at increased risk of future cardiac events. • Material and Methods: One hundred nine medically treated patients with previous Q-wave myocardial infarction underwent two exercise radionuclide angiographic studies at least 6 months apart (median, 16 months) without an intervening clinical event. Worsening exercise performance between the two studies was defined by five criteria: (1) lower (5% or more) peak exercise ejection fraction; (2) worsening peak exercise wall motion score; (3) combination of criteria 1 and 2; (4) worsening serial delta (exercise rest) ejection fraction; or (5) increasing exercise STsegment depression of 1 mm or more. Patients were followed up for a median duration of 3.9 years after the second exercise study. • Results: Five cardiac deaths and 10 nonfatal myocardial infarctions occurred during follow-up. A Cox proportional hazards analysis failed to show an association between any of the aforementioned variables and cardiac events. Of the 15 patients with cardiac events, 4 (27%) had a lower (5% or more) exercise ejection fraction and 2 (13%) had a worsening exercise wall motion score. Of the 94 patients without cardiac events, 37 (39%) had a lower (5% or more) exercise ejection fraction and 28 (30%) had a worsening serial exercise wall motion score (not a statistically significant difference). • Conclusion: Worsening exercise performance on serial exercise radionuclide angiography does not identify patients at increased risk of future cardiac events.

Original languageEnglish (US)
Pages (from-to)711-718
Number of pages8
JournalMayo Clinic Proceedings
Volume72
Issue number8
StatePublished - 1997

Fingerprint

Radionuclide Angiography
Exercise
Myocardial Infarction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Worsening left ventricular performance on serial exercise radionuclide angiography does not identify high-risk patients. / Chaliki, Hari P; Christian, Timothy F.

In: Mayo Clinic Proceedings, Vol. 72, No. 8, 1997, p. 711-718.

Research output: Contribution to journalArticle

@article{92d29386969f4668a84ff4c80d92fe97,
title = "Worsening left ventricular performance on serial exercise radionuclide angiography does not identify high-risk patients",
abstract = "• Objective: To determine whether worsening exercise performance on serial exercise radionuclide angiography identifies patients at increased risk of future cardiac events. • Material and Methods: One hundred nine medically treated patients with previous Q-wave myocardial infarction underwent two exercise radionuclide angiographic studies at least 6 months apart (median, 16 months) without an intervening clinical event. Worsening exercise performance between the two studies was defined by five criteria: (1) lower (5{\%} or more) peak exercise ejection fraction; (2) worsening peak exercise wall motion score; (3) combination of criteria 1 and 2; (4) worsening serial delta (exercise rest) ejection fraction; or (5) increasing exercise STsegment depression of 1 mm or more. Patients were followed up for a median duration of 3.9 years after the second exercise study. • Results: Five cardiac deaths and 10 nonfatal myocardial infarctions occurred during follow-up. A Cox proportional hazards analysis failed to show an association between any of the aforementioned variables and cardiac events. Of the 15 patients with cardiac events, 4 (27{\%}) had a lower (5{\%} or more) exercise ejection fraction and 2 (13{\%}) had a worsening exercise wall motion score. Of the 94 patients without cardiac events, 37 (39{\%}) had a lower (5{\%} or more) exercise ejection fraction and 28 (30{\%}) had a worsening serial exercise wall motion score (not a statistically significant difference). • Conclusion: Worsening exercise performance on serial exercise radionuclide angiography does not identify patients at increased risk of future cardiac events.",
author = "Chaliki, {Hari P} and Christian, {Timothy F.}",
year = "1997",
language = "English (US)",
volume = "72",
pages = "711--718",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "8",

}

TY - JOUR

T1 - Worsening left ventricular performance on serial exercise radionuclide angiography does not identify high-risk patients

AU - Chaliki, Hari P

AU - Christian, Timothy F.

PY - 1997

Y1 - 1997

N2 - • Objective: To determine whether worsening exercise performance on serial exercise radionuclide angiography identifies patients at increased risk of future cardiac events. • Material and Methods: One hundred nine medically treated patients with previous Q-wave myocardial infarction underwent two exercise radionuclide angiographic studies at least 6 months apart (median, 16 months) without an intervening clinical event. Worsening exercise performance between the two studies was defined by five criteria: (1) lower (5% or more) peak exercise ejection fraction; (2) worsening peak exercise wall motion score; (3) combination of criteria 1 and 2; (4) worsening serial delta (exercise rest) ejection fraction; or (5) increasing exercise STsegment depression of 1 mm or more. Patients were followed up for a median duration of 3.9 years after the second exercise study. • Results: Five cardiac deaths and 10 nonfatal myocardial infarctions occurred during follow-up. A Cox proportional hazards analysis failed to show an association between any of the aforementioned variables and cardiac events. Of the 15 patients with cardiac events, 4 (27%) had a lower (5% or more) exercise ejection fraction and 2 (13%) had a worsening exercise wall motion score. Of the 94 patients without cardiac events, 37 (39%) had a lower (5% or more) exercise ejection fraction and 28 (30%) had a worsening serial exercise wall motion score (not a statistically significant difference). • Conclusion: Worsening exercise performance on serial exercise radionuclide angiography does not identify patients at increased risk of future cardiac events.

AB - • Objective: To determine whether worsening exercise performance on serial exercise radionuclide angiography identifies patients at increased risk of future cardiac events. • Material and Methods: One hundred nine medically treated patients with previous Q-wave myocardial infarction underwent two exercise radionuclide angiographic studies at least 6 months apart (median, 16 months) without an intervening clinical event. Worsening exercise performance between the two studies was defined by five criteria: (1) lower (5% or more) peak exercise ejection fraction; (2) worsening peak exercise wall motion score; (3) combination of criteria 1 and 2; (4) worsening serial delta (exercise rest) ejection fraction; or (5) increasing exercise STsegment depression of 1 mm or more. Patients were followed up for a median duration of 3.9 years after the second exercise study. • Results: Five cardiac deaths and 10 nonfatal myocardial infarctions occurred during follow-up. A Cox proportional hazards analysis failed to show an association between any of the aforementioned variables and cardiac events. Of the 15 patients with cardiac events, 4 (27%) had a lower (5% or more) exercise ejection fraction and 2 (13%) had a worsening exercise wall motion score. Of the 94 patients without cardiac events, 37 (39%) had a lower (5% or more) exercise ejection fraction and 28 (30%) had a worsening serial exercise wall motion score (not a statistically significant difference). • Conclusion: Worsening exercise performance on serial exercise radionuclide angiography does not identify patients at increased risk of future cardiac events.

UR - http://www.scopus.com/inward/record.url?scp=0031204555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031204555&partnerID=8YFLogxK

M3 - Article

C2 - 9276597

AN - SCOPUS:0031204555

VL - 72

SP - 711

EP - 718

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 8

ER -