Working memory and language network dysfunctions in logopenic aphasia: A task-free fMRI comparison with Alzheimer's dementia

Jennifer L. Whitwell, David T. Jones, Joseph R. Duffy, Edythe A. Strand, Mary M. Machulda, Scott A. Przybelski, Prashanthi Vemuri, Brian E. Gregg, Jeffrey L. Gunter, Matthew L. Senjem, Ronald C. Petersen, Clifford R. Jack, Keith A. Josephs

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

We aimed to determine whether network-level functional connectivity differs in 2 clinical variants of Alzheimer's disease: logopenic primary progressive aphasia (lvPPA) and dementia of the Alzheimer's type (DAT). Twenty-four lvPPA subjects with amyloid deposition on positron emission tomography and task-free functional magnetic resonance imaging were matched to 24 amyloid-positive DAT subjects and 24 amyloid-negative controls. Independent-component analysis and spatial-temporal dual regression were used to assess functional connectivity within the language network, left and right working memory networks, and ventral default mode network. lvPPA showed reduced connectivity in left temporal language network and inferior parietal and prefrontal regions of the left working memory network compared with controls and DAT. Both groups showed reduced connectivity in the parietal regions of the right working memory network compared with controls. Only DAT showed reduced ventral default mode network connectivity compared with controls. Aphasia severity correlated with connectivity in the left working memory network within lvPPA. Patterns of network dysfunction differ across these 2 clinical variants of Alzheimer's disease, with lvPPA particularly associated with disruptions in the language and left working memory networks.

Original languageEnglish (US)
Pages (from-to)1245-1252
Number of pages8
JournalNeurobiology of aging
Volume36
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • Alzheimer's disease
  • Functional imaging
  • Language
  • MRI
  • Primary progressive aphasia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Working memory and language network dysfunctions in logopenic aphasia: A task-free fMRI comparison with Alzheimer's dementia'. Together they form a unique fingerprint.

  • Cite this