Working memory and language network dysfunctions in logopenic aphasia: A task-free fMRI comparison with Alzheimer's dementia

Jennifer Lynn Whitwell, David T Jones, Joseph R. Duffy, Edythe A. Strand, Mary Margaret Machulda, Scott A. Przybelski, Prashanthi D Vemuri, Brian E. Gregg, Jeffrey L. Gunter, Matthew L. Senjem, Ronald Carl Petersen, Clifford R Jr. Jack, Keith Anthony Josephs

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We aimed to determine whether network-level functional connectivity differs in 2 clinical variants of Alzheimer's disease: logopenic primary progressive aphasia (lvPPA) and dementia of the Alzheimer's type (DAT). Twenty-four lvPPA subjects with amyloid deposition on positron emission tomography and task-free functional magnetic resonance imaging were matched to 24 amyloid-positive DAT subjects and 24 amyloid-negative controls. Independent-component analysis and spatial-temporal dual regression were used to assess functional connectivity within the language network, left and right working memory networks, and ventral default mode network. lvPPA showed reduced connectivity in left temporal language network and inferior parietal and prefrontal regions of the left working memory network compared with controls and DAT. Both groups showed reduced connectivity in the parietal regions of the right working memory network compared with controls. Only DAT showed reduced ventral default mode network connectivity compared with controls. Aphasia severity correlated with connectivity in the left working memory network within lvPPA. Patterns of network dysfunction differ across these 2 clinical variants of Alzheimer's disease, with lvPPA particularly associated with disruptions in the language and left working memory networks.

Original languageEnglish (US)
Pages (from-to)1245-1252
Number of pages8
JournalNeurobiology of Aging
Volume36
Issue number3
DOIs
StatePublished - Mar 1 2015

Fingerprint

Aphasia
Short-Term Memory
Alzheimer Disease
Language
Magnetic Resonance Imaging
Amyloid
Parietal Lobe
Primary Progressive Aphasia
Spatio-Temporal Analysis
Positron-Emission Tomography

Keywords

  • Alzheimer's disease
  • Functional imaging
  • Language
  • MRI
  • Primary progressive aphasia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Working memory and language network dysfunctions in logopenic aphasia : A task-free fMRI comparison with Alzheimer's dementia. / Whitwell, Jennifer Lynn; Jones, David T; Duffy, Joseph R.; Strand, Edythe A.; Machulda, Mary Margaret; Przybelski, Scott A.; Vemuri, Prashanthi D; Gregg, Brian E.; Gunter, Jeffrey L.; Senjem, Matthew L.; Petersen, Ronald Carl; Jack, Clifford R Jr.; Josephs, Keith Anthony.

In: Neurobiology of Aging, Vol. 36, No. 3, 01.03.2015, p. 1245-1252.

Research output: Contribution to journalArticle

@article{e38766fe180145f8a26935a581a62383,
title = "Working memory and language network dysfunctions in logopenic aphasia: A task-free fMRI comparison with Alzheimer's dementia",
abstract = "We aimed to determine whether network-level functional connectivity differs in 2 clinical variants of Alzheimer's disease: logopenic primary progressive aphasia (lvPPA) and dementia of the Alzheimer's type (DAT). Twenty-four lvPPA subjects with amyloid deposition on positron emission tomography and task-free functional magnetic resonance imaging were matched to 24 amyloid-positive DAT subjects and 24 amyloid-negative controls. Independent-component analysis and spatial-temporal dual regression were used to assess functional connectivity within the language network, left and right working memory networks, and ventral default mode network. lvPPA showed reduced connectivity in left temporal language network and inferior parietal and prefrontal regions of the left working memory network compared with controls and DAT. Both groups showed reduced connectivity in the parietal regions of the right working memory network compared with controls. Only DAT showed reduced ventral default mode network connectivity compared with controls. Aphasia severity correlated with connectivity in the left working memory network within lvPPA. Patterns of network dysfunction differ across these 2 clinical variants of Alzheimer's disease, with lvPPA particularly associated with disruptions in the language and left working memory networks.",
keywords = "Alzheimer's disease, Functional imaging, Language, MRI, Primary progressive aphasia",
author = "Whitwell, {Jennifer Lynn} and Jones, {David T} and Duffy, {Joseph R.} and Strand, {Edythe A.} and Machulda, {Mary Margaret} and Przybelski, {Scott A.} and Vemuri, {Prashanthi D} and Gregg, {Brian E.} and Gunter, {Jeffrey L.} and Senjem, {Matthew L.} and Petersen, {Ronald Carl} and Jack, {Clifford R Jr.} and Josephs, {Keith Anthony}",
year = "2015",
month = "3",
day = "1",
doi = "10.1016/j.neurobiolaging.2014.12.013",
language = "English (US)",
volume = "36",
pages = "1245--1252",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Working memory and language network dysfunctions in logopenic aphasia

T2 - A task-free fMRI comparison with Alzheimer's dementia

AU - Whitwell, Jennifer Lynn

AU - Jones, David T

AU - Duffy, Joseph R.

AU - Strand, Edythe A.

AU - Machulda, Mary Margaret

AU - Przybelski, Scott A.

AU - Vemuri, Prashanthi D

AU - Gregg, Brian E.

AU - Gunter, Jeffrey L.

AU - Senjem, Matthew L.

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

AU - Josephs, Keith Anthony

PY - 2015/3/1

Y1 - 2015/3/1

N2 - We aimed to determine whether network-level functional connectivity differs in 2 clinical variants of Alzheimer's disease: logopenic primary progressive aphasia (lvPPA) and dementia of the Alzheimer's type (DAT). Twenty-four lvPPA subjects with amyloid deposition on positron emission tomography and task-free functional magnetic resonance imaging were matched to 24 amyloid-positive DAT subjects and 24 amyloid-negative controls. Independent-component analysis and spatial-temporal dual regression were used to assess functional connectivity within the language network, left and right working memory networks, and ventral default mode network. lvPPA showed reduced connectivity in left temporal language network and inferior parietal and prefrontal regions of the left working memory network compared with controls and DAT. Both groups showed reduced connectivity in the parietal regions of the right working memory network compared with controls. Only DAT showed reduced ventral default mode network connectivity compared with controls. Aphasia severity correlated with connectivity in the left working memory network within lvPPA. Patterns of network dysfunction differ across these 2 clinical variants of Alzheimer's disease, with lvPPA particularly associated with disruptions in the language and left working memory networks.

AB - We aimed to determine whether network-level functional connectivity differs in 2 clinical variants of Alzheimer's disease: logopenic primary progressive aphasia (lvPPA) and dementia of the Alzheimer's type (DAT). Twenty-four lvPPA subjects with amyloid deposition on positron emission tomography and task-free functional magnetic resonance imaging were matched to 24 amyloid-positive DAT subjects and 24 amyloid-negative controls. Independent-component analysis and spatial-temporal dual regression were used to assess functional connectivity within the language network, left and right working memory networks, and ventral default mode network. lvPPA showed reduced connectivity in left temporal language network and inferior parietal and prefrontal regions of the left working memory network compared with controls and DAT. Both groups showed reduced connectivity in the parietal regions of the right working memory network compared with controls. Only DAT showed reduced ventral default mode network connectivity compared with controls. Aphasia severity correlated with connectivity in the left working memory network within lvPPA. Patterns of network dysfunction differ across these 2 clinical variants of Alzheimer's disease, with lvPPA particularly associated with disruptions in the language and left working memory networks.

KW - Alzheimer's disease

KW - Functional imaging

KW - Language

KW - MRI

KW - Primary progressive aphasia

UR - http://www.scopus.com/inward/record.url?scp=84923580700&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923580700&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2014.12.013

DO - 10.1016/j.neurobiolaging.2014.12.013

M3 - Article

C2 - 25592958

AN - SCOPUS:84923580700

VL - 36

SP - 1245

EP - 1252

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 3

ER -