Working memory and language network dysfunctions in logopenic aphasia: A task-free fMRI comparison with Alzheimer's dementia

Jennifer L. Whitwell; David T. Jones; Joseph R. Duffy; Edythe A. Strand; Mary M. Machulda; Scott A. Przybelski; Prashanthi Vemuri; Brian E. Gregg; Jeffrey L. Gunter; Matthew L. Senjem; Ronald C. Petersen; Clifford R. Jack; Keith A. Josephs

doi:10.1016/j.neurobiolaging.2014.12.013

Working memory and language network dysfunctions in logopenic aphasia: A task-free fMRI comparison with Alzheimer's dementia

Jennifer L. Whitwell, David T. Jones, Joseph R. Duffy, Edythe A. Strand, Mary M. Machulda, Scott A. Przybelski, Prashanthi Vemuri, Brian E. Gregg, Jeffrey L. Gunter, Matthew L. Senjem, Ronald C. Petersen, Clifford R. Jack, Keith A. Josephs

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Abstract

We aimed to determine whether network-level functional connectivity differs in 2 clinical variants of Alzheimer's disease: logopenic primary progressive aphasia (lvPPA) and dementia of the Alzheimer's type (DAT). Twenty-four lvPPA subjects with amyloid deposition on positron emission tomography and task-free functional magnetic resonance imaging were matched to 24 amyloid-positive DAT subjects and 24 amyloid-negative controls. Independent-component analysis and spatial-temporal dual regression were used to assess functional connectivity within the language network, left and right working memory networks, and ventral default mode network. lvPPA showed reduced connectivity in left temporal language network and inferior parietal and prefrontal regions of the left working memory network compared with controls and DAT. Both groups showed reduced connectivity in the parietal regions of the right working memory network compared with controls. Only DAT showed reduced ventral default mode network connectivity compared with controls. Aphasia severity correlated with connectivity in the left working memory network within lvPPA. Patterns of network dysfunction differ across these 2 clinical variants of Alzheimer's disease, with lvPPA particularly associated with disruptions in the language and left working memory networks.

Original language	English (US)
Pages (from-to)	1245-1252
Number of pages	8
Journal	Neurobiology of aging
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/j.neurobiolaging.2014.12.013
State	Published - Mar 1 2015

Keywords

Alzheimer's disease
Functional imaging
Language
MRI
Primary progressive aphasia

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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Whitwell, J. L., Jones, D. T., Duffy, J. R., Strand, E. A., Machulda, M. M., Przybelski, S. A., Vemuri, P., Gregg, B. E., Gunter, J. L., Senjem, M. L., Petersen, R. C., Jack, C. R., & Josephs, K. A. (2015). Working memory and language network dysfunctions in logopenic aphasia: A task-free fMRI comparison with Alzheimer's dementia. Neurobiology of aging, 36(3), 1245-1252. https://doi.org/10.1016/j.neurobiolaging.2014.12.013

Whitwell, JL , Jones, DT, Duffy, JR, Strand, EA, Machulda, MM, Przybelski, SA, Vemuri, P, Gregg, BE, Gunter, JL, Senjem, ML, Petersen, RC , Jack, CR & Josephs, KA 2015, 'Working memory and language network dysfunctions in logopenic aphasia: A task-free fMRI comparison with Alzheimer's dementia', Neurobiology of aging, vol. 36, no. 3, pp. 1245-1252. https://doi.org/10.1016/j.neurobiolaging.2014.12.013

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abstract = "We aimed to determine whether network-level functional connectivity differs in 2 clinical variants of Alzheimer's disease: logopenic primary progressive aphasia (lvPPA) and dementia of the Alzheimer's type (DAT). Twenty-four lvPPA subjects with amyloid deposition on positron emission tomography and task-free functional magnetic resonance imaging were matched to 24 amyloid-positive DAT subjects and 24 amyloid-negative controls. Independent-component analysis and spatial-temporal dual regression were used to assess functional connectivity within the language network, left and right working memory networks, and ventral default mode network. lvPPA showed reduced connectivity in left temporal language network and inferior parietal and prefrontal regions of the left working memory network compared with controls and DAT. Both groups showed reduced connectivity in the parietal regions of the right working memory network compared with controls. Only DAT showed reduced ventral default mode network connectivity compared with controls. Aphasia severity correlated with connectivity in the left working memory network within lvPPA. Patterns of network dysfunction differ across these 2 clinical variants of Alzheimer's disease, with lvPPA particularly associated with disruptions in the language and left working memory networks.",

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Working memory and language network dysfunctions in logopenic aphasia: A task-free fMRI comparison with Alzheimer's dementia

Abstract

Keywords

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