Women's issues and epilepsy

Katherine H. Noe, Alison M. Pack

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Women with epilepsy (WWE) may experience changes in seizure control related to alterations in neuronal excitability mediated by estrogen and progesterone. A third or more of women will reliably note seizures that are linked to menstruation or ovulation. Reproductive hormone-related exacerbation of seizure control is also observed during perimenopause. Seizures and antiepileptic drugs (AEDs) also can adversely affect reproductive health. WWE have higher than expected rates of menstrual disorders and infertility. Enzyme-inducing AEDs interact with hormonal contraceptives, potentially limiting options for birth control. Exposure to AEDs during pregnancy increases the risk of congenital malformations and cognitive impairments in children born to WWE. Chronic AED use increases the risk of vitamin D deficiency, decreased bone quality and density, and fractures. These concerns heighten the need to taper AEDs when appropriate and to manage WWE on the simplest AED regimen that will maintain seizure freedom.

Original languageEnglish (US)
Pages (from-to)159-178
Number of pages20
JournalCONTINUUM Lifelong Learning in Neurology
Volume16
Issue number3
StatePublished - Jun 2010

Fingerprint

Anticonvulsants
Epilepsy
Seizures
Perimenopause
Vitamin D Deficiency
Menstruation
Bone Fractures
Reproductive Health
Contraceptive Agents
Ovulation
Contraception
Bone Density
Infertility
Progesterone
Estrogens
Hormones
Pregnancy
Enzymes

ASJC Scopus subject areas

  • Clinical Neurology
  • Genetics(clinical)

Cite this

Noe, K. H., & Pack, A. M. (2010). Women's issues and epilepsy. CONTINUUM Lifelong Learning in Neurology, 16(3), 159-178.

Women's issues and epilepsy. / Noe, Katherine H.; Pack, Alison M.

In: CONTINUUM Lifelong Learning in Neurology, Vol. 16, No. 3, 06.2010, p. 159-178.

Research output: Contribution to journalArticle

Noe, KH & Pack, AM 2010, 'Women's issues and epilepsy', CONTINUUM Lifelong Learning in Neurology, vol. 16, no. 3, pp. 159-178.
Noe, Katherine H. ; Pack, Alison M. / Women's issues and epilepsy. In: CONTINUUM Lifelong Learning in Neurology. 2010 ; Vol. 16, No. 3. pp. 159-178.
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