Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring

Christopher J. Kimble, David M. Johnson, Bruce A. Winter, Sidney V. Whitlock, Kenneth R. Kressin, April E. Horne, Justin C. Robinson, Jonathan M. Bledsoe, Susannah J Tye, Su-Youne Chang, Filippo Agnesi, Christoph J. Griessenauer, Daniel Covey, Young Min Shon, Kevin E. Bennet, Paul A. Garris, Kendall H Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

30 Citations (Scopus)

Abstract

The Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) measures extracellular neurotransmitter concentration in vivo and displays the data graphically in nearly real time. WINCS implements two electroanalytical methods, fast-scan cyclic voltammetry (FSCV) and fixed-potential amperometry (FPA), to measure neurotransmitter concentrations at an electrochemical sensor, typically a carbon-fiber microelectrode. WINCS comprises a battery-powered patient module and a custom software application (WINCSware) running on a nearby personal computer. The patient module impresses upon the electrochemical sensor either a constant potential (for FPA) or a time-varying waveform (for FSCV). A transimpedance amplifier converts the resulting current to a signal that is digitized and transmitted to the base station via a Bluetooth® radio link. WINCSware controls the operational parameters for FPA or FSCV, and records the transmitted data stream. Filtered data is displayed in various formats, including a background-subtracted plot of sequential FSCV scans - a representation that enables users to distinguish the signatures of various analytes with considerable specificity. Dopamine, glutamate, adenosine and serotonin were selected as analytes for test trials. Proof-of-principle tests included in vitro flow-injection measurements and in vivo measurements in rat and pig. Further testing demonstrated basic functionality in a 3-Tesla MRI unit. WINCS was designed in compliance with consensus standards for medical electrical device safety, and it is anticipated that its capability for real-time intraoperative monitoring of neurotransmitter release at an implanted sensor will prove useful for advancing functional neurosurgery.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Pages4856-4859
Number of pages4
DOIs
StatePublished - 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

Fingerprint

Intraoperative Monitoring
Cyclic voltammetry
Neurotransmitter Agents
Electrochemical sensors
Monitoring
Neurosurgery
Safety devices
Radio links
Microelectrodes
Operational amplifiers
Bluetooth
Application programs
Personal computers
Base stations
Magnetic resonance imaging
Carbon fibers
Rats
Equipment Safety
Data Display
Microcomputers

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Kimble, C. J., Johnson, D. M., Winter, B. A., Whitlock, S. V., Kressin, K. R., Horne, A. E., ... Lee, K. H. (2009). Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 4856-4859). [5332773] https://doi.org/10.1109/IEMBS.2009.5332773

Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. / Kimble, Christopher J.; Johnson, David M.; Winter, Bruce A.; Whitlock, Sidney V.; Kressin, Kenneth R.; Horne, April E.; Robinson, Justin C.; Bledsoe, Jonathan M.; Tye, Susannah J; Chang, Su-Youne; Agnesi, Filippo; Griessenauer, Christoph J.; Covey, Daniel; Shon, Young Min; Bennet, Kevin E.; Garris, Paul A.; Lee, Kendall H.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 4856-4859 5332773.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kimble, CJ, Johnson, DM, Winter, BA, Whitlock, SV, Kressin, KR, Horne, AE, Robinson, JC, Bledsoe, JM, Tye, SJ, Chang, S-Y, Agnesi, F, Griessenauer, CJ, Covey, D, Shon, YM, Bennet, KE, Garris, PA & Lee, KH 2009, Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5332773, pp. 4856-4859, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5332773
Kimble CJ, Johnson DM, Winter BA, Whitlock SV, Kressin KR, Horne AE et al. Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 4856-4859. 5332773 https://doi.org/10.1109/IEMBS.2009.5332773
Kimble, Christopher J. ; Johnson, David M. ; Winter, Bruce A. ; Whitlock, Sidney V. ; Kressin, Kenneth R. ; Horne, April E. ; Robinson, Justin C. ; Bledsoe, Jonathan M. ; Tye, Susannah J ; Chang, Su-Youne ; Agnesi, Filippo ; Griessenauer, Christoph J. ; Covey, Daniel ; Shon, Young Min ; Bennet, Kevin E. ; Garris, Paul A. ; Lee, Kendall H. / Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) for intraoperative neurochemical monitoring. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. pp. 4856-4859
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