Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation

Su Youne Chang; Inyong Kim; Michael P. Marsh; Dong Pyo Jang; Sun Chul Hwang; Jamie J. Van Gompel; Stephan J. Goerss; Christopher J. Kimble; Kevin E. Bennet; Paul A. Garris; Charles D. Blaha; Kendall H. Lee

doi:10.1016/j.mayocp.2012.05.006

Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation

Su Youne Chang, Inyong Kim, Michael P. Marsh, Dong Pyo Jang, Sun Chul Hwang, Jamie J. Van Gompel, Stephan J. Goerss, Christopher J. Kimble, Kevin E. Bennet, Paul A. Garris, Charles D. Blaha, Kendall H. Lee

Neurosurgery

Research output: Contribution to journal › Review article › peer-review

64 Scopus citations

Abstract

Essential tremor is often markedly reduced during deep brain stimulation simply by implanting the stimulating electrode before activating neurostimulation. Referred to as the microthalamotomy effect, the mechanisms of this unexpected consequence are thought to be related to microlesioning targeted brain tissue, that is, a microscopic version of tissue ablation in thalamotomy. An alternate possibility is that implanting the electrode induces immediate neurochemical release. Herein, we report the experiment performing with real-time fast-scan cyclic voltammetry to quantify neurotransmitter concentrations in human subjects with essential tremor during deep brain stimulation. The results show that the microthalamotomy effect is accompanied by local neurochemical changes, including adenosine release.

Original language	English (US)
Pages (from-to)	760-765
Number of pages	6
Journal	Mayo Clinic proceedings
Volume	87
Issue number	8
DOIs	https://doi.org/10.1016/j.mayocp.2012.05.006
State	Published - Aug 2012

ASJC Scopus subject areas

General Medicine

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Chang, S. Y., Kim, I., Marsh, M. P., Jang, D. P., Hwang, S. C., Van Gompel, J. J., Goerss, S. J., Kimble, C. J., Bennet, K. E., Garris, P. A., Blaha, C. D., & Lee, K. H. (2012). Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation. Mayo Clinic proceedings, 87(8), 760-765. https://doi.org/10.1016/j.mayocp.2012.05.006

@article{c6192e70320643589ae962ed23282aa4,

title = "Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation",

abstract = "Essential tremor is often markedly reduced during deep brain stimulation simply by implanting the stimulating electrode before activating neurostimulation. Referred to as the microthalamotomy effect, the mechanisms of this unexpected consequence are thought to be related to microlesioning targeted brain tissue, that is, a microscopic version of tissue ablation in thalamotomy. An alternate possibility is that implanting the electrode induces immediate neurochemical release. Herein, we report the experiment performing with real-time fast-scan cyclic voltammetry to quantify neurotransmitter concentrations in human subjects with essential tremor during deep brain stimulation. The results show that the microthalamotomy effect is accompanied by local neurochemical changes, including adenosine release.",

author = "Chang, {Su Youne} and Inyong Kim and Marsh, {Michael P.} and Jang, {Dong Pyo} and Hwang, {Sun Chul} and {Van Gompel}, {Jamie J.} and Goerss, {Stephan J.} and Kimble, {Christopher J.} and Bennet, {Kevin E.} and Garris, {Paul A.} and Blaha, {Charles D.} and Lee, {Kendall H.}",

note = "Funding Information: Grant Support: This work was supported in part by National Institutes of Health grants K08 NS 52232 , R01 NS 70872 , and R01 NS 75013 (K.H.L.) and The Grainger Foundation . ",

year = "2012",

month = aug,

doi = "10.1016/j.mayocp.2012.05.006",

language = "English (US)",

volume = "87",

pages = "760--765",

journal = "Mayo Clinic proceedings",

issn = "0025-6196",

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TY - JOUR

T1 - Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation

AU - Chang, Su Youne

AU - Kim, Inyong

AU - Marsh, Michael P.

AU - Jang, Dong Pyo

AU - Hwang, Sun Chul

AU - Van Gompel, Jamie J.

AU - Goerss, Stephan J.

AU - Kimble, Christopher J.

AU - Bennet, Kevin E.

AU - Garris, Paul A.

AU - Blaha, Charles D.

AU - Lee, Kendall H.

N1 - Funding Information: Grant Support: This work was supported in part by National Institutes of Health grants K08 NS 52232 , R01 NS 70872 , and R01 NS 75013 (K.H.L.) and The Grainger Foundation .

PY - 2012/8

Y1 - 2012/8

N2 - Essential tremor is often markedly reduced during deep brain stimulation simply by implanting the stimulating electrode before activating neurostimulation. Referred to as the microthalamotomy effect, the mechanisms of this unexpected consequence are thought to be related to microlesioning targeted brain tissue, that is, a microscopic version of tissue ablation in thalamotomy. An alternate possibility is that implanting the electrode induces immediate neurochemical release. Herein, we report the experiment performing with real-time fast-scan cyclic voltammetry to quantify neurotransmitter concentrations in human subjects with essential tremor during deep brain stimulation. The results show that the microthalamotomy effect is accompanied by local neurochemical changes, including adenosine release.

AB - Essential tremor is often markedly reduced during deep brain stimulation simply by implanting the stimulating electrode before activating neurostimulation. Referred to as the microthalamotomy effect, the mechanisms of this unexpected consequence are thought to be related to microlesioning targeted brain tissue, that is, a microscopic version of tissue ablation in thalamotomy. An alternate possibility is that implanting the electrode induces immediate neurochemical release. Herein, we report the experiment performing with real-time fast-scan cyclic voltammetry to quantify neurotransmitter concentrations in human subjects with essential tremor during deep brain stimulation. The results show that the microthalamotomy effect is accompanied by local neurochemical changes, including adenosine release.

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DO - 10.1016/j.mayocp.2012.05.006

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VL - 87

SP - 760

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JO - Mayo Clinic proceedings

JF - Mayo Clinic proceedings

IS - 8

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Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation

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