Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation

Su-Youne Chang, Inyong Kim, Michael P. Marsh, Dong Pyo Jang, Sun Chul Hwang, Jamie Van Gompel, Stephan J. Goerss, Christopher J. Kimble, Kevin E. Bennet, Paul A. Garris, Charles D. Blaha, Kendall H Lee

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Abstract

Essential tremor is often markedly reduced during deep brain stimulation simply by implanting the stimulating electrode before activating neurostimulation. Referred to as the microthalamotomy effect, the mechanisms of this unexpected consequence are thought to be related to microlesioning targeted brain tissue, that is, a microscopic version of tissue ablation in thalamotomy. An alternate possibility is that implanting the electrode induces immediate neurochemical release. Herein, we report the experiment performing with real-time fast-scan cyclic voltammetry to quantify neurotransmitter concentrations in human subjects with essential tremor during deep brain stimulation. The results show that the microthalamotomy effect is accompanied by local neurochemical changes, including adenosine release.

Original languageEnglish (US)
Pages (from-to)760-765
Number of pages6
JournalMayo Clinic Proceedings
Volume87
Issue number8
DOIs
StatePublished - Aug 2012

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Essential Tremor
Deep Brain Stimulation
Adenosine
Electrodes
Neurotransmitter Agents
Brain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation. / Chang, Su-Youne; Kim, Inyong; Marsh, Michael P.; Jang, Dong Pyo; Hwang, Sun Chul; Van Gompel, Jamie; Goerss, Stephan J.; Kimble, Christopher J.; Bennet, Kevin E.; Garris, Paul A.; Blaha, Charles D.; Lee, Kendall H.

In: Mayo Clinic Proceedings, Vol. 87, No. 8, 08.2012, p. 760-765.

Research output: Contribution to journalArticle

Chang, Su-Youne ; Kim, Inyong ; Marsh, Michael P. ; Jang, Dong Pyo ; Hwang, Sun Chul ; Van Gompel, Jamie ; Goerss, Stephan J. ; Kimble, Christopher J. ; Bennet, Kevin E. ; Garris, Paul A. ; Blaha, Charles D. ; Lee, Kendall H. / Wireless fast-scan cyclic voltammetry to monitor adenosine in patients with essential tremor during deep brain stimulation. In: Mayo Clinic Proceedings. 2012 ; Vol. 87, No. 8. pp. 760-765.
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AU - Goerss, Stephan J.

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