Wine: Does the colour count?

David M. Goldberg, Vesna D Garovic, Eleftherios P. Diamandis, Cecil R. Pace-Asciak

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The objective of this study was to determine whether} phenolic constituents present in red wine and grape juice modulate plasma lipid and lipoprotein concentrations in healthy human subjects. All subjects consumed in random order 375 ml of red or white wine per day or 500 ml of two different grape juices (high and low phenols) per day for periods of 4 weeks separated by 2-week periods of abstention while continuing normal activity and food intake, and their normal lives in a community setting. The subjects were 24 healthy males aged 26-45 years screened by clinical examination and laboratory tests to exclude hypertension, diabetes mellitus, hyperlipidemia and obesity, among others. Fasting blood was collected at the beginning and end of each beverage schedule for analysis of lipids and lipoproteins. Changes in plasma lipids and lipoproteins in response to each beverage were measured to determine whether these were altered by red wine and grape juice phenolics independently of the effects of ethanol. Both grape juices had virtually no effect. Red and white wines raised plasma HDL-cholesterol and apo A-I and apo A-II concentrations as well as the apo A-I:apo B ratio to a similar extent. Red wine also raised plasma triglyceride and total cholesterol concentrations. Neither wine affected plasma apo B or apo (a) concentrations. The favourable effects of wines in modulating plasma lipid and lipoprotein concentrations are probably due to their alcohol content and cannot be reproduced by grape juices.

Original languageEnglish (US)
Pages (from-to)183-193
Number of pages11
JournalClinica Chimica Acta
Volume246
Issue number1-2
DOIs
StatePublished - Mar 15 1996
Externally publishedYes

Fingerprint

Wine
Vitis
Color
Plasmas
Lipoproteins
Lipids
Beverages
Apolipoprotein A-I
Apolipoproteins B
Apolipoprotein A-II
Phenols
Medical problems
Hyperlipidemias
HDL Cholesterol
Fasting
Diabetes Mellitus
Appointments and Schedules
Healthy Volunteers
Triglycerides
Blood

Keywords

  • Coronary heart disease
  • Flavonoids
  • HDL-cholesterol
  • Lipoproteins
  • Plasma lipids
  • Polyphenols
  • Wine

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Goldberg, D. M., Garovic, V. D., Diamandis, E. P., & Pace-Asciak, C. R. (1996). Wine: Does the colour count? Clinica Chimica Acta, 246(1-2), 183-193. https://doi.org/10.1016/0009-8981(96)06229-8

Wine : Does the colour count? / Goldberg, David M.; Garovic, Vesna D; Diamandis, Eleftherios P.; Pace-Asciak, Cecil R.

In: Clinica Chimica Acta, Vol. 246, No. 1-2, 15.03.1996, p. 183-193.

Research output: Contribution to journalArticle

Goldberg, DM, Garovic, VD, Diamandis, EP & Pace-Asciak, CR 1996, 'Wine: Does the colour count?', Clinica Chimica Acta, vol. 246, no. 1-2, pp. 183-193. https://doi.org/10.1016/0009-8981(96)06229-8
Goldberg DM, Garovic VD, Diamandis EP, Pace-Asciak CR. Wine: Does the colour count? Clinica Chimica Acta. 1996 Mar 15;246(1-2):183-193. https://doi.org/10.1016/0009-8981(96)06229-8
Goldberg, David M. ; Garovic, Vesna D ; Diamandis, Eleftherios P. ; Pace-Asciak, Cecil R. / Wine : Does the colour count?. In: Clinica Chimica Acta. 1996 ; Vol. 246, No. 1-2. pp. 183-193.
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