WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions

Kendall H Lee, Jose Lujan, James K. Trevathan, Erika K. Ross, John J. Bartoletta, Hyung Ook Park, Seungleal Brian Paek, Evan N. Nicolai, Jannifer H. Lee, Hoon Ki Min, Christopher J. Kimble, Charles D. Blaha, Kevin E. Bennet

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed at improving therapeutic interventions do not take advantage of real-time in vivo neurochemical changes in dynamic brain processes such as disease progression and response to pharmacologic, cognitive, behavioral, and neuromodulation therapies. This is due in part to a lack of flexible research tools that allow in vivo measurement of the dynamic changes in brain chemistry. Here, we present a research platform, WINCS Harmoni, which can measure in vivo neurochemical activity simultaneously across multiple anatomical targets to study normal and pathologic brain function. In addition, WINCS Harmoni can provide real-time neurochemical feedback for closed-loop control of neurochemical levels via its synchronized stimulation and neurochemical sensing capabilities. We demonstrate these and other key features of this platform in non-human primate, swine, and rodent models of deep brain stimulation (DBS). Ultimately, systems like the one described here will improve our understanding of the dynamics of brain physiology in the context of neurologic disease and therapeutic interventions, which may lead to the development of precision medicine and personalized therapies for optimal therapeutic efficacy.

Original languageEnglish (US)
Article number46675
JournalScientific Reports
Volume7
DOIs
StatePublished - Jan 1 2017

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Brain
Brain Chemistry
Precision Medicine
Deep Brain Stimulation
Cognitive Therapy
Therapeutics
Nervous System Diseases
Research
Primates
Neurotransmitter Agents
Disease Progression
Rodentia
Swine

ASJC Scopus subject areas

  • General

Cite this

Lee, K. H., Lujan, J., Trevathan, J. K., Ross, E. K., Bartoletta, J. J., Park, H. O., ... Bennet, K. E. (2017). WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions. Scientific Reports, 7, [46675]. https://doi.org/10.1038/srep46675

WINCS Harmoni : Closed-loop dynamic neurochemical control of therapeutic interventions. / Lee, Kendall H; Lujan, Jose; Trevathan, James K.; Ross, Erika K.; Bartoletta, John J.; Park, Hyung Ook; Paek, Seungleal Brian; Nicolai, Evan N.; Lee, Jannifer H.; Min, Hoon Ki; Kimble, Christopher J.; Blaha, Charles D.; Bennet, Kevin E.

In: Scientific Reports, Vol. 7, 46675, 01.01.2017.

Research output: Contribution to journalArticle

Lee, KH, Lujan, J, Trevathan, JK, Ross, EK, Bartoletta, JJ, Park, HO, Paek, SB, Nicolai, EN, Lee, JH, Min, HK, Kimble, CJ, Blaha, CD & Bennet, KE 2017, 'WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions', Scientific Reports, vol. 7, 46675. https://doi.org/10.1038/srep46675
Lee, Kendall H ; Lujan, Jose ; Trevathan, James K. ; Ross, Erika K. ; Bartoletta, John J. ; Park, Hyung Ook ; Paek, Seungleal Brian ; Nicolai, Evan N. ; Lee, Jannifer H. ; Min, Hoon Ki ; Kimble, Christopher J. ; Blaha, Charles D. ; Bennet, Kevin E. / WINCS Harmoni : Closed-loop dynamic neurochemical control of therapeutic interventions. In: Scientific Reports. 2017 ; Vol. 7.
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