Widespread cytoskeletal pathology characterizes corticobasal degeneration

M. B. Feany, Dennis W Dickson

Research output: Contribution to journalArticle

249 Citations (Scopus)

Abstract

Corticobasal degeneration (CBD) is a rare, progressive neurological disorder characterized by widespread neuronal and glial pathology. Using immunohistochemistry and laser confocal microscopy, we demonstrate that the nonamyloid cortical plaques of CBD are actually collections of abnormal tau in the distal processes of astrocytes. These glial cells express both vimentin and CD44, markers of astrocyte activation. Glial pathology also includes tau-positive cytoplasmic inclusions, here localized to Leu 7- expressing oligodendrocytes. In addition, a wide array of neuronal pathology is defined with tau-positive inclusions in multiple domains of a variety of cortical neurons. CBD thus exhibits widespread glial and neuronal cytoskeletal pathology, including a novel structure, the astrocytic plaque. CBD is a disease of generalized cytoskeletal disruption affecting several cell types and multiple domains of these cells. The further definition of CBD pathology refines the diagnosis and pathophysiological understanding of this unique disease and has important implications for other neurodegenerative diseases, like Alzheimer's disease, characterized by abnormal tau deposition.

Original languageEnglish (US)
Pages (from-to)1388-1396
Number of pages9
JournalAmerican Journal of Pathology
Volume146
Issue number6
StatePublished - 1995
Externally publishedYes

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Neuroglia
Pathology
Confocal Microscopy
Astrocytes
Inclusion Bodies
Oligodendroglia
Vimentin
Nervous System Diseases
Neurodegenerative Diseases
Alzheimer Disease
Immunohistochemistry
Neurons

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Widespread cytoskeletal pathology characterizes corticobasal degeneration. / Feany, M. B.; Dickson, Dennis W.

In: American Journal of Pathology, Vol. 146, No. 6, 1995, p. 1388-1396.

Research output: Contribution to journalArticle

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