TY - JOUR
T1 - Why should dialysis benefit schizophrenia?
AU - Cohen, Irvin M.
AU - Scheiber, Stephen C.
AU - Yamamura, Henry
PY - 1979/8
Y1 - 1979/8
N2 - If dialysis is successful for the treatment of schizophrenia, the artificial kidney must be removing something which the human kidney cannot, unless other nonspecific factors are involved. Either there is an abnormal compound present which is retained by normal renal tubular transport processes, or the kidney of a schizophrenic must be abnormal in that it fails to excrete a normally present compound. Since the latter explanation is less probable, biochemical research should focus on classes of compounds which are known to be handled differently by the artificial kidney than by the human kidney. A dialyzable “schizophrenic toxin” might be a nonprotein, nonprotein-bound compound of molecular weight below 500 daltons such as an organic acid or base. Proteins, peptides, amino acids, and trace elements are less likely possibilities.
AB - If dialysis is successful for the treatment of schizophrenia, the artificial kidney must be removing something which the human kidney cannot, unless other nonspecific factors are involved. Either there is an abnormal compound present which is retained by normal renal tubular transport processes, or the kidney of a schizophrenic must be abnormal in that it fails to excrete a normally present compound. Since the latter explanation is less probable, biochemical research should focus on classes of compounds which are known to be handled differently by the artificial kidney than by the human kidney. A dialyzable “schizophrenic toxin” might be a nonprotein, nonprotein-bound compound of molecular weight below 500 daltons such as an organic acid or base. Proteins, peptides, amino acids, and trace elements are less likely possibilities.
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U2 - 10.1097/00005053-197908000-00003
DO - 10.1097/00005053-197908000-00003
M3 - Article
C2 - 469510
AN - SCOPUS:0018388142
SN - 0022-3018
VL - 167
SP - 475
EP - 477
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 8
ER -