Why Does My Patient Have Thrombocytosis?

Nanna H. Sulai, Ayalew Tefferi

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Thrombocytosis is a common clinical problem frequently encountered during routine evaluation. The diagnostic workup entails a step-by-step approach, which allows for an accurate assessment of the underlying cause. A thorough clinical history and physical examination may help differentiate thrombocytosis secondary to a reactive process versus an underlying clonal proliferation process. Once essential thrombocytosis is evident, relevant laboratory evaluation for an ongoing myeloproliferative disorder is paramount. Various treatment modalities have been proven to be beneficial. With further scientific investigation underway, molecular therapies may soon be cornerstones of therapy in essential thrombocytosis.

Original languageEnglish (US)
Pages (from-to)285-301
Number of pages17
JournalHematology/Oncology Clinics of North America
Volume26
Issue number2
DOIs
StatePublished - Apr 1 2012

Keywords

  • Gene mutation
  • Molecular therapy
  • Platelets
  • Thrombocytosis

ASJC Scopus subject areas

  • Hematology
  • Oncology

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