Abstract
Although chromosome mis-segregation is a hallmark of cancer cells, its genetic basis and role in malignant transformation remain poorly understood. In recent years, several mouse models have been generated that harbor gene defects that perturb high-fidelity chromosome segregation. Analysis of these models has revealed that whole chromosome instability (W-CIN) can cause, inhibit or have no effect on tumorigenesis. Here we propose that the effect of W-CIN on tumor development depends on the particular W-CIN gene that is defective, including its other cellular functions, the extent or nature of the gene defect, the affected tissue or cell type and the context of other cancer gene mutations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 457-466 |
| Number of pages | 10 |
| Journal | Trends in Genetics |
| Volume | 24 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2008 |
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ASJC Scopus subject areas
- Genetics
Cite this
Whole chromosome instability and cancer : a complex relationship. / Ricke, Robin M.; van Ree, Janine H.; Van Deursen, Jan.
In: Trends in Genetics, Vol. 24, No. 9, 09.2008, p. 457-466.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Whole chromosome instability and cancer
T2 - a complex relationship
AU - Ricke, Robin M.
AU - van Ree, Janine H.
AU - Van Deursen, Jan
PY - 2008/9
Y1 - 2008/9
N2 - Although chromosome mis-segregation is a hallmark of cancer cells, its genetic basis and role in malignant transformation remain poorly understood. In recent years, several mouse models have been generated that harbor gene defects that perturb high-fidelity chromosome segregation. Analysis of these models has revealed that whole chromosome instability (W-CIN) can cause, inhibit or have no effect on tumorigenesis. Here we propose that the effect of W-CIN on tumor development depends on the particular W-CIN gene that is defective, including its other cellular functions, the extent or nature of the gene defect, the affected tissue or cell type and the context of other cancer gene mutations.
AB - Although chromosome mis-segregation is a hallmark of cancer cells, its genetic basis and role in malignant transformation remain poorly understood. In recent years, several mouse models have been generated that harbor gene defects that perturb high-fidelity chromosome segregation. Analysis of these models has revealed that whole chromosome instability (W-CIN) can cause, inhibit or have no effect on tumorigenesis. Here we propose that the effect of W-CIN on tumor development depends on the particular W-CIN gene that is defective, including its other cellular functions, the extent or nature of the gene defect, the affected tissue or cell type and the context of other cancer gene mutations.
UR - http://www.scopus.com/inward/record.url?scp=49849083943&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49849083943&partnerID=8YFLogxK
U2 - 10.1016/j.tig.2008.07.002
DO - 10.1016/j.tig.2008.07.002
M3 - Article
C2 - 18675487
AN - SCOPUS:49849083943
VL - 24
SP - 457
EP - 466
JO - Trends in Genetics
JF - Trends in Genetics
SN - 0168-9525
IS - 9
ER -