Whole chromosome instability and cancer: a complex relationship

Robin M. Ricke, Janine H. van Ree, Jan Van Deursen

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Although chromosome mis-segregation is a hallmark of cancer cells, its genetic basis and role in malignant transformation remain poorly understood. In recent years, several mouse models have been generated that harbor gene defects that perturb high-fidelity chromosome segregation. Analysis of these models has revealed that whole chromosome instability (W-CIN) can cause, inhibit or have no effect on tumorigenesis. Here we propose that the effect of W-CIN on tumor development depends on the particular W-CIN gene that is defective, including its other cellular functions, the extent or nature of the gene defect, the affected tissue or cell type and the context of other cancer gene mutations.

Original languageEnglish (US)
Pages (from-to)457-466
Number of pages10
JournalTrends in Genetics
Volume24
Issue number9
DOIs
StatePublished - Sep 2008

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Chromosomal Instability
Chromosome Segregation
Genes
Neoplasms
Neoplasm Genes
Carcinogenesis
Mutation

ASJC Scopus subject areas

  • Genetics

Cite this

Whole chromosome instability and cancer : a complex relationship. / Ricke, Robin M.; van Ree, Janine H.; Van Deursen, Jan.

In: Trends in Genetics, Vol. 24, No. 9, 09.2008, p. 457-466.

Research output: Contribution to journalArticle

Ricke, Robin M. ; van Ree, Janine H. ; Van Deursen, Jan. / Whole chromosome instability and cancer : a complex relationship. In: Trends in Genetics. 2008 ; Vol. 24, No. 9. pp. 457-466.
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