Whole brain radiotherapy plus stereotactic radiosurgery (WBRT + SRS) versus surgery plus whole brain radiotherapy (OP + WBRT) for 1-3 brain metastases: Results of a matched pair analysis

Dirk Rades, Jan Dirk Kueter, Theo Veninga, Jan Gliemroth, Steven E. Schild

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

This study is the first one to compare WBRT + SRS to OP + WBRT for 1-3 brain metastases. Survival (OS), intracerebral control (IC) and local control (LC) of the treated metastases were retrospectively evaluated in 52 patients undergoing WBRT + SRS and in 52 patients undergoing OP + WBRT. Both groups were matched for WBRT schedule, age, gender, performance status, tumour, number of brain metastases, extracerebral metastases, RPA class and interval from tumour diagnosis to WBRT. One-year OS was 56% after WBRT + SRS and 47% after OP + WBRT (p = 0.034). One-year IC was 66% and 50% (p = 0.003). One-year LC was 82% and 66% (p = 0.006). On multivariate analyses, it was found that improved OS was associated with younger age (p = 0.044), no extracerebral metastases (p < 0.001), RPA class 1 (p < 0.001) and longer interval from tumour diagnosis to WBRT (p = 0.001). IC was associated with younger age (p = 0.002) and longer interval (p = 0.004); WBRT + SRS achieved borderline significance (p = 0.052). Improved LC was associated with longer interval (p = 0.017); WBRT + SRS showed a trend (p = 0.09). WBRT + SRS appears at least as effective as OP + WBRT.

Original languageEnglish (US)
Pages (from-to)400-404
Number of pages5
JournalEuropean Journal of Cancer
Volume45
Issue number3
DOIs
StatePublished - Feb 1 2009

Keywords

  • Brain metastases
  • Brain surgery
  • Stereotactic radiosurgery
  • Treatment outcome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Whole brain radiotherapy plus stereotactic radiosurgery (WBRT + SRS) versus surgery plus whole brain radiotherapy (OP + WBRT) for 1-3 brain metastases: Results of a matched pair analysis'. Together they form a unique fingerprint.

Cite this