White-matter integrity on DTI and the pathologic staging of Alzheimer's disease

Kejal Kantarci; Melissa E. Murray; Christopher G. Schwarz; Robert I. Reid; Scott A. Przybelski; Timothy Lesnick; Samantha M. Zuk; Mekala R. Raman; Matthew L. Senjem; Jeffrey L. Gunter; Bradley F. Boeve; David S. Knopman; Joseph E. Parisi; Ronald C. Petersen; Clifford R. Jack; Dennis W. Dickson

doi:10.1016/j.neurobiolaging.2017.04.024

White-matter integrity on DTI and the pathologic staging of Alzheimer's disease

Kejal Kantarci, Melissa E. Murray, Christopher G. Schwarz, Robert I. Reid, Scott A. Przybelski, Timothy Lesnick, Samantha M. Zuk, Mekala R. Raman, Matthew L. Senjem, Jeffrey L. Gunter, Bradley F. Boeve, David S. Knopman, Joseph E. Parisi, Ronald C. Petersen, Clifford R. Jack, Dennis W. Dickson

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69 Scopus citations

Abstract

Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged Alzheimer's disease (AD) patients (n = 46). Patients with antemortem DTI studies and a range of AD pathology at autopsy were included. Patients with a high neurofibrillary tangle (NFT) stage (Braak IV–VI) had significantly elevated mean diffusivity (MD) in the crus of fornix and ventral cingulum tracts, precuneus, and entorhinal white matter on voxel-based analysis after adjusting for age and time from MRI to death (p < 0.001). Higher MD and lower fractional anisotropy in the ventral cingulum tract, entorhinal, and precuneus white matter was associated with higher Braak NFT stage and clinical disease severity. There were no MD and fractional anisotropy differences among the low (none and sparse) and high (moderate and frequent) β-amyloid neuritic plaque groups. The NFT pathology of AD is associated with DTI alterations involving the medial temporal limbic connections and medial parietal white matter. This pattern of diffusion abnormalities is also associated with clinical disease severity.

Original language	English (US)
Pages (from-to)	172-179
Number of pages	8
Journal	Neurobiology of aging
Volume	56
DOIs	https://doi.org/10.1016/j.neurobiolaging.2017.04.024
State	Published - Aug 2017

Keywords

Alzheimer's disease
DTI
Diffusion tensor imaging
Limbic tracts
Pathology
White matter

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/j.neurobiolaging.2017.04.024

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Kantarci, K., Murray, M. E., Schwarz, C. G., Reid, R. I., Przybelski, S. A., Lesnick, T., Zuk, S. M., Raman, M. R., Senjem, M. L., Gunter, J. L., Boeve, B. F., Knopman, D. S., Parisi, J. E., Petersen, R. C., Jack, C. R., & Dickson, D. W. (2017). White-matter integrity on DTI and the pathologic staging of Alzheimer's disease. Neurobiology of aging, 56, 172-179. https://doi.org/10.1016/j.neurobiolaging.2017.04.024

Kantarci, K , Murray, ME , Schwarz, CG, Reid, RI, Przybelski, SA, Lesnick, T, Zuk, SM, Raman, MR, Senjem, ML, Gunter, JL, Boeve, BF , Knopman, DS, Parisi, JE, Petersen, RC , Jack, CR & Dickson, DW 2017, 'White-matter integrity on DTI and the pathologic staging of Alzheimer's disease', Neurobiology of aging, vol. 56, pp. 172-179. https://doi.org/10.1016/j.neurobiolaging.2017.04.024

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title = "White-matter integrity on DTI and the pathologic staging of Alzheimer's disease",

abstract = "Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged Alzheimer's disease (AD) patients (n = 46). Patients with antemortem DTI studies and a range of AD pathology at autopsy were included. Patients with a high neurofibrillary tangle (NFT) stage (Braak IV–VI) had significantly elevated mean diffusivity (MD) in the crus of fornix and ventral cingulum tracts, precuneus, and entorhinal white matter on voxel-based analysis after adjusting for age and time from MRI to death (p < 0.001). Higher MD and lower fractional anisotropy in the ventral cingulum tract, entorhinal, and precuneus white matter was associated with higher Braak NFT stage and clinical disease severity. There were no MD and fractional anisotropy differences among the low (none and sparse) and high (moderate and frequent) β-amyloid neuritic plaque groups. The NFT pathology of AD is associated with DTI alterations involving the medial temporal limbic connections and medial parietal white matter. This pattern of diffusion abnormalities is also associated with clinical disease severity.",

keywords = "Alzheimer's disease, DTI, Diffusion tensor imaging, Limbic tracts, Pathology, White matter",

author = "Kejal Kantarci and Murray, {Melissa E.} and Schwarz, {Christopher G.} and Reid, {Robert I.} and Przybelski, {Scott A.} and Timothy Lesnick and Zuk, {Samantha M.} and Raman, {Mekala R.} and Senjem, {Matthew L.} and Gunter, {Jeffrey L.} and Boeve, {Bradley F.} and Knopman, {David S.} and Parisi, {Joseph E.} and Petersen, {Ronald C.} and Jack, {Clifford R.} and Dickson, {Dennis W.}",

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month = aug,

doi = "10.1016/j.neurobiolaging.2017.04.024",

language = "English (US)",

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AU - Kantarci, Kejal

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AU - Schwarz, Christopher G.

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AU - Przybelski, Scott A.

AU - Lesnick, Timothy

AU - Zuk, Samantha M.

AU - Raman, Mekala R.

AU - Senjem, Matthew L.

AU - Gunter, Jeffrey L.

AU - Boeve, Bradley F.

AU - Knopman, David S.

AU - Parisi, Joseph E.

AU - Petersen, Ronald C.

AU - Jack, Clifford R.

AU - Dickson, Dennis W.

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N2 - Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged Alzheimer's disease (AD) patients (n = 46). Patients with antemortem DTI studies and a range of AD pathology at autopsy were included. Patients with a high neurofibrillary tangle (NFT) stage (Braak IV–VI) had significantly elevated mean diffusivity (MD) in the crus of fornix and ventral cingulum tracts, precuneus, and entorhinal white matter on voxel-based analysis after adjusting for age and time from MRI to death (p < 0.001). Higher MD and lower fractional anisotropy in the ventral cingulum tract, entorhinal, and precuneus white matter was associated with higher Braak NFT stage and clinical disease severity. There were no MD and fractional anisotropy differences among the low (none and sparse) and high (moderate and frequent) β-amyloid neuritic plaque groups. The NFT pathology of AD is associated with DTI alterations involving the medial temporal limbic connections and medial parietal white matter. This pattern of diffusion abnormalities is also associated with clinical disease severity.

AB - Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged Alzheimer's disease (AD) patients (n = 46). Patients with antemortem DTI studies and a range of AD pathology at autopsy were included. Patients with a high neurofibrillary tangle (NFT) stage (Braak IV–VI) had significantly elevated mean diffusivity (MD) in the crus of fornix and ventral cingulum tracts, precuneus, and entorhinal white matter on voxel-based analysis after adjusting for age and time from MRI to death (p < 0.001). Higher MD and lower fractional anisotropy in the ventral cingulum tract, entorhinal, and precuneus white matter was associated with higher Braak NFT stage and clinical disease severity. There were no MD and fractional anisotropy differences among the low (none and sparse) and high (moderate and frequent) β-amyloid neuritic plaque groups. The NFT pathology of AD is associated with DTI alterations involving the medial temporal limbic connections and medial parietal white matter. This pattern of diffusion abnormalities is also associated with clinical disease severity.

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KW - DTI

KW - Diffusion tensor imaging

KW - Limbic tracts

KW - Pathology

KW - White matter

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JF - Neurobiology of aging

ER -

White-matter integrity on DTI and the pathologic staging of Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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