White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

Jessica Alber, Suvarna Alladi, Hee Joon Bae, David A. Barton, Laurel A. Beckett, Joanne M. Bell, Sara E. Berman, Geert Jan Biessels, Sandra E. Black, Isabelle Bos, Gene L. Bowman, Emanuele Brai, Adam M. Brickman, Brandy L. Callahan, Roderick A. Corriveau, Silvia Fossati, Rebecca F. Gottesman, Deborah R. Gustafson, Vladimir Hachinski, Kathleen M. HaydenAlex M. Helman, Timothy M. Hughes, Jeremy D. Isaacs, Angela L. Jefferson, Sterling C. Johnson, Alifiya Kapasi, Silke Kern, Jay C. Kwon, Juraj Kukolja, Athene Lee, Samuel N. Lockhart, Anne Murray, Katie E. Osborn, Melinda C. Power, Brittani R. Price, Hanneke F.M. Rhodius-Meester, Jacqueline A. Rondeau, Allyson C. Rosen, Douglas L. Rosene, Julie A. Schneider, Henrieta Scholtzova, C. Elizabeth Shaaban, Narlon C.B.S. Silva, Heather M. Snyder, Walter Swardfager, Aron M. Troen, Susanne J. van Veluw, Prashanthi D Vemuri, Anders Wallin, Cheryl Wellington, Donna M. Wilcock, Sharon Xiangwen Xie, Atticus H. Hainsworth

Research output: Contribution to journalShort survey

3 Citations (Scopus)

Abstract

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.

Original languageEnglish (US)
Pages (from-to)107-117
Number of pages11
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume5
DOIs
StatePublished - Jan 1 2019

Fingerprint

Blood Vessels
Dementia
Alzheimer Disease
White Matter
Cognitive Dysfunction
Cerebral Small Vessel Diseases
Drug Industry
Demyelinating Diseases
Cognition
Magnetic Resonance Imaging
Inflammation
Brain

Keywords

  • Leukoaraiosis
  • Small vessel disease
  • Vascular cognitive impairment
  • Vascular dementia
  • White matter lesions

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID) : Knowledge gaps and opportunities. / Alber, Jessica; Alladi, Suvarna; Bae, Hee Joon; Barton, David A.; Beckett, Laurel A.; Bell, Joanne M.; Berman, Sara E.; Biessels, Geert Jan; Black, Sandra E.; Bos, Isabelle; Bowman, Gene L.; Brai, Emanuele; Brickman, Adam M.; Callahan, Brandy L.; Corriveau, Roderick A.; Fossati, Silvia; Gottesman, Rebecca F.; Gustafson, Deborah R.; Hachinski, Vladimir; Hayden, Kathleen M.; Helman, Alex M.; Hughes, Timothy M.; Isaacs, Jeremy D.; Jefferson, Angela L.; Johnson, Sterling C.; Kapasi, Alifiya; Kern, Silke; Kwon, Jay C.; Kukolja, Juraj; Lee, Athene; Lockhart, Samuel N.; Murray, Anne; Osborn, Katie E.; Power, Melinda C.; Price, Brittani R.; Rhodius-Meester, Hanneke F.M.; Rondeau, Jacqueline A.; Rosen, Allyson C.; Rosene, Douglas L.; Schneider, Julie A.; Scholtzova, Henrieta; Shaaban, C. Elizabeth; Silva, Narlon C.B.S.; Snyder, Heather M.; Swardfager, Walter; Troen, Aron M.; van Veluw, Susanne J.; Vemuri, Prashanthi D; Wallin, Anders; Wellington, Cheryl; Wilcock, Donna M.; Xie, Sharon Xiangwen; Hainsworth, Atticus H.

In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 5, 01.01.2019, p. 107-117.

Research output: Contribution to journalShort survey

Alber, J, Alladi, S, Bae, HJ, Barton, DA, Beckett, LA, Bell, JM, Berman, SE, Biessels, GJ, Black, SE, Bos, I, Bowman, GL, Brai, E, Brickman, AM, Callahan, BL, Corriveau, RA, Fossati, S, Gottesman, RF, Gustafson, DR, Hachinski, V, Hayden, KM, Helman, AM, Hughes, TM, Isaacs, JD, Jefferson, AL, Johnson, SC, Kapasi, A, Kern, S, Kwon, JC, Kukolja, J, Lee, A, Lockhart, SN, Murray, A, Osborn, KE, Power, MC, Price, BR, Rhodius-Meester, HFM, Rondeau, JA, Rosen, AC, Rosene, DL, Schneider, JA, Scholtzova, H, Shaaban, CE, Silva, NCBS, Snyder, HM, Swardfager, W, Troen, AM, van Veluw, SJ, Vemuri, PD, Wallin, A, Wellington, C, Wilcock, DM, Xie, SX & Hainsworth, AH 2019, 'White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 5, pp. 107-117. https://doi.org/10.1016/j.trci.2019.02.001
Alber, Jessica ; Alladi, Suvarna ; Bae, Hee Joon ; Barton, David A. ; Beckett, Laurel A. ; Bell, Joanne M. ; Berman, Sara E. ; Biessels, Geert Jan ; Black, Sandra E. ; Bos, Isabelle ; Bowman, Gene L. ; Brai, Emanuele ; Brickman, Adam M. ; Callahan, Brandy L. ; Corriveau, Roderick A. ; Fossati, Silvia ; Gottesman, Rebecca F. ; Gustafson, Deborah R. ; Hachinski, Vladimir ; Hayden, Kathleen M. ; Helman, Alex M. ; Hughes, Timothy M. ; Isaacs, Jeremy D. ; Jefferson, Angela L. ; Johnson, Sterling C. ; Kapasi, Alifiya ; Kern, Silke ; Kwon, Jay C. ; Kukolja, Juraj ; Lee, Athene ; Lockhart, Samuel N. ; Murray, Anne ; Osborn, Katie E. ; Power, Melinda C. ; Price, Brittani R. ; Rhodius-Meester, Hanneke F.M. ; Rondeau, Jacqueline A. ; Rosen, Allyson C. ; Rosene, Douglas L. ; Schneider, Julie A. ; Scholtzova, Henrieta ; Shaaban, C. Elizabeth ; Silva, Narlon C.B.S. ; Snyder, Heather M. ; Swardfager, Walter ; Troen, Aron M. ; van Veluw, Susanne J. ; Vemuri, Prashanthi D ; Wallin, Anders ; Wellington, Cheryl ; Wilcock, Donna M. ; Xie, Sharon Xiangwen ; Hainsworth, Atticus H. / White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID) : Knowledge gaps and opportunities. In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2019 ; Vol. 5. pp. 107-117.
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title = "White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities",
abstract = "White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.",
keywords = "Leukoaraiosis, Small vessel disease, Vascular cognitive impairment, Vascular dementia, White matter lesions",
author = "Jessica Alber and Suvarna Alladi and Bae, {Hee Joon} and Barton, {David A.} and Beckett, {Laurel A.} and Bell, {Joanne M.} and Berman, {Sara E.} and Biessels, {Geert Jan} and Black, {Sandra E.} and Isabelle Bos and Bowman, {Gene L.} and Emanuele Brai and Brickman, {Adam M.} and Callahan, {Brandy L.} and Corriveau, {Roderick A.} and Silvia Fossati and Gottesman, {Rebecca F.} and Gustafson, {Deborah R.} and Vladimir Hachinski and Hayden, {Kathleen M.} and Helman, {Alex M.} and Hughes, {Timothy M.} and Isaacs, {Jeremy D.} and Jefferson, {Angela L.} and Johnson, {Sterling C.} and Alifiya Kapasi and Silke Kern and Kwon, {Jay C.} and Juraj Kukolja and Athene Lee and Lockhart, {Samuel N.} and Anne Murray and Osborn, {Katie E.} and Power, {Melinda C.} and Price, {Brittani R.} and Rhodius-Meester, {Hanneke F.M.} and Rondeau, {Jacqueline A.} and Rosen, {Allyson C.} and Rosene, {Douglas L.} and Schneider, {Julie A.} and Henrieta Scholtzova and Shaaban, {C. Elizabeth} and Silva, {Narlon C.B.S.} and Snyder, {Heather M.} and Walter Swardfager and Troen, {Aron M.} and {van Veluw}, {Susanne J.} and Vemuri, {Prashanthi D} and Anders Wallin and Cheryl Wellington and Wilcock, {Donna M.} and Xie, {Sharon Xiangwen} and Hainsworth, {Atticus H.}",
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TY - JOUR

T1 - White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID)

T2 - Knowledge gaps and opportunities

AU - Alber, Jessica

AU - Alladi, Suvarna

AU - Bae, Hee Joon

AU - Barton, David A.

AU - Beckett, Laurel A.

AU - Bell, Joanne M.

AU - Berman, Sara E.

AU - Biessels, Geert Jan

AU - Black, Sandra E.

AU - Bos, Isabelle

AU - Bowman, Gene L.

AU - Brai, Emanuele

AU - Brickman, Adam M.

AU - Callahan, Brandy L.

AU - Corriveau, Roderick A.

AU - Fossati, Silvia

AU - Gottesman, Rebecca F.

AU - Gustafson, Deborah R.

AU - Hachinski, Vladimir

AU - Hayden, Kathleen M.

AU - Helman, Alex M.

AU - Hughes, Timothy M.

AU - Isaacs, Jeremy D.

AU - Jefferson, Angela L.

AU - Johnson, Sterling C.

AU - Kapasi, Alifiya

AU - Kern, Silke

AU - Kwon, Jay C.

AU - Kukolja, Juraj

AU - Lee, Athene

AU - Lockhart, Samuel N.

AU - Murray, Anne

AU - Osborn, Katie E.

AU - Power, Melinda C.

AU - Price, Brittani R.

AU - Rhodius-Meester, Hanneke F.M.

AU - Rondeau, Jacqueline A.

AU - Rosen, Allyson C.

AU - Rosene, Douglas L.

AU - Schneider, Julie A.

AU - Scholtzova, Henrieta

AU - Shaaban, C. Elizabeth

AU - Silva, Narlon C.B.S.

AU - Snyder, Heather M.

AU - Swardfager, Walter

AU - Troen, Aron M.

AU - van Veluw, Susanne J.

AU - Vemuri, Prashanthi D

AU - Wallin, Anders

AU - Wellington, Cheryl

AU - Wilcock, Donna M.

AU - Xie, Sharon Xiangwen

AU - Hainsworth, Atticus H.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.

AB - White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.

KW - Leukoaraiosis

KW - Small vessel disease

KW - Vascular cognitive impairment

KW - Vascular dementia

KW - White matter lesions

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U2 - 10.1016/j.trci.2019.02.001

DO - 10.1016/j.trci.2019.02.001

M3 - Short survey

AN - SCOPUS:85063999193

VL - 5

SP - 107

EP - 117

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

SN - 2352-8737

ER -