White cells 2: Impact of understanding the molecular basis of haematological malignant disorders on clinical practice

A. K. Stewart, A. C. Schuh

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

The molecular basis of many leukaemias is now known, allowing precise diagnosis. Treatment of chronic myeloid leukaemia is now possible by targeting of the BCR-ABL tyrosine kinase. The underlying molecular abnormalities in acute leukaemias allow the outlook for individual patients to be assessed at diagnosis and therapy tailored accordingly. Analysis of V(H) genes in B-cell malignant disorders allows these to be placed in the hierarchy of B-cell development and may provide prognostically valuable information.

Original languageEnglish (US)
Pages (from-to)1447-1453
Number of pages7
JournalLancet
Volume355
Issue number9213
DOIs
StatePublished - Apr 22 2000

ASJC Scopus subject areas

  • Medicine(all)

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