White cells 2: Impact of understanding the molecular basis of haematological malignant disorders on clinical practice

A. K. Stewart; A. C. Schuh

doi:10.1016/S0140-6736(00)02150-4

White cells 2: Impact of understanding the molecular basis of haematological malignant disorders on clinical practice

A. K. Stewart, A. C. Schuh

Hematology/Oncology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

The molecular basis of many leukaemias is now known, allowing precise diagnosis. Treatment of chronic myeloid leukaemia is now possible by targeting of the BCR-ABL tyrosine kinase. The underlying molecular abnormalities in acute leukaemias allow the outlook for individual patients to be assessed at diagnosis and therapy tailored accordingly. Analysis of V(H) genes in B-cell malignant disorders allows these to be placed in the hierarchy of B-cell development and may provide prognostically valuable information.

Original language	English (US)
Pages (from-to)	1447-1453
Number of pages	7
Journal	Lancet
Volume	355
Issue number	9213
DOIs	https://doi.org/10.1016/S0140-6736(00)02150-4
State	Published - Apr 22 2000

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(00)02150-4

Cite this

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title = "White cells 2: Impact of understanding the molecular basis of haematological malignant disorders on clinical practice",

abstract = "The molecular basis of many leukaemias is now known, allowing precise diagnosis. Treatment of chronic myeloid leukaemia is now possible by targeting of the BCR-ABL tyrosine kinase. The underlying molecular abnormalities in acute leukaemias allow the outlook for individual patients to be assessed at diagnosis and therapy tailored accordingly. Analysis of V(H) genes in B-cell malignant disorders allows these to be placed in the hierarchy of B-cell development and may provide prognostically valuable information.",

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AU - Schuh, A. C.

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N2 - The molecular basis of many leukaemias is now known, allowing precise diagnosis. Treatment of chronic myeloid leukaemia is now possible by targeting of the BCR-ABL tyrosine kinase. The underlying molecular abnormalities in acute leukaemias allow the outlook for individual patients to be assessed at diagnosis and therapy tailored accordingly. Analysis of V(H) genes in B-cell malignant disorders allows these to be placed in the hierarchy of B-cell development and may provide prognostically valuable information.

AB - The molecular basis of many leukaemias is now known, allowing precise diagnosis. Treatment of chronic myeloid leukaemia is now possible by targeting of the BCR-ABL tyrosine kinase. The underlying molecular abnormalities in acute leukaemias allow the outlook for individual patients to be assessed at diagnosis and therapy tailored accordingly. Analysis of V(H) genes in B-cell malignant disorders allows these to be placed in the hierarchy of B-cell development and may provide prognostically valuable information.

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White cells 2: Impact of understanding the molecular basis of haematological malignant disorders on clinical practice

Abstract

ASJC Scopus subject areas

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