Whipple's disease with destructive arthritis, abdominal lymphadenopathy, and central nervous system involvement

Michael C. DeArment, Timothy A. Woodward, David M. Menke, Paul W. Brazis, Laura W. Bancroft, Scott T. Persellin

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We describe a patient with Whipple's disease who had an unusual erosive and destructive polyarthritis, massive abdominal lymphadenopathy, asymptomatic central nervous system involvement, and rare manifestations of orbital pseudotumor and orchitis with epididymitis. Taking oral therapy with trimethoprim-sulfamethoxazole he had recurrent flares of orbital pseudotumor, an episode of orchitis with epididymitis, and persistent polymerase chain reaction T. whipplei-positive cerebrospinal fluid. Resolution was achieved with a one month course of intravenous ceftriaxone and a 6 month course of azithromycin, and no relapse occurred during 24 months of followup.

Original languageEnglish (US)
Pages (from-to)1347-1350
Number of pages4
JournalJournal of Rheumatology
Volume30
Issue number6
StatePublished - Jun 1 2003

Keywords

  • Arthritis
  • Bacterial Infection
  • Central Nervous System
  • Orchitis
  • Whipple's Disease

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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