Whipple's disease: Clinical, biochemical, and histopathologic features and assessment of treatment in 29 patients

J. L. Fleming, R. H. Wiesner, R. G. Shorter

Research output: Contribution to journalArticle

242 Citations (Scopus)

Abstract

Whipple's disease is a chronic systemic illness, the optimal treatment of which remains poorly defined. In our analysis of a 30-year, 29-patient experience with Whipple's disease at the Mayo Clinic, the frequent initial manifestations of diarrhea, weight loss, arthritis, and lymphadenopathy correlated with findings reported previously by other investigators. Antibiotic therapy yielded rapid symptomatic and biochemical improvement, and histologic changes in the small bowel occurred subsequently. Despite antimicrobial therapy, relapses in patients with Whipple's disease are common, and the central nervous system is considered the most serious site of involvement for recurrence. Administration of an antibiotic agent that is able to cross the blood-brain barrier may be more important in preventing relapse than prolonged duration of initial antimicrobial therapy.

Original languageEnglish (US)
Pages (from-to)539-551
Number of pages13
JournalMayo Clinic Proceedings
Volume63
Issue number6
StatePublished - 1988

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Whipple Disease
Recurrence
Anti-Bacterial Agents
Therapeutics
Blood-Brain Barrier
Arthritis
Weight Loss
Diarrhea
Chronic Disease
Central Nervous System
Research Personnel

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Whipple's disease : Clinical, biochemical, and histopathologic features and assessment of treatment in 29 patients. / Fleming, J. L.; Wiesner, R. H.; Shorter, R. G.

In: Mayo Clinic Proceedings, Vol. 63, No. 6, 1988, p. 539-551.

Research output: Contribution to journalArticle

Fleming, J. L. ; Wiesner, R. H. ; Shorter, R. G. / Whipple's disease : Clinical, biochemical, and histopathologic features and assessment of treatment in 29 patients. In: Mayo Clinic Proceedings. 1988 ; Vol. 63, No. 6. pp. 539-551.
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