TY - JOUR
T1 - When kidneys get old
T2 - an essay on nephro-geriatrics
AU - Glassock, Richard
AU - Denic, Aleksandar
AU - Rule, Andrew D.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Aging is a nearly universal phenomenon in biology only partially controlled by genetic endowment. Individuals and their organs age at varying rates. The kidneys manifest the aging process by steady loss of nephrons and a corresponding decrease in glomerular filtration rate (GFR) beginning about age 30 years. The mechanisms responsible for this observation is are elusive. However, defining chronic kidney disease based on arbitrary, fixed thresholds of GFR in the later phases of life can be problematical as it may over-diagnosis CKD in the elderly. A modest, persisting reduction of GFR (around 45-59 ml/min/1.73m2) without abnormal proteinuria does not seem to confer much of an adverse effect on mortality and remaining life expectancy in older adults and the development of end-stage renal disease in such subjects is very uncommon. Old kidneys should not be equated with "diseased" kidneys.
AB - Aging is a nearly universal phenomenon in biology only partially controlled by genetic endowment. Individuals and their organs age at varying rates. The kidneys manifest the aging process by steady loss of nephrons and a corresponding decrease in glomerular filtration rate (GFR) beginning about age 30 years. The mechanisms responsible for this observation is are elusive. However, defining chronic kidney disease based on arbitrary, fixed thresholds of GFR in the later phases of life can be problematical as it may over-diagnosis CKD in the elderly. A modest, persisting reduction of GFR (around 45-59 ml/min/1.73m2) without abnormal proteinuria does not seem to confer much of an adverse effect on mortality and remaining life expectancy in older adults and the development of end-stage renal disease in such subjects is very uncommon. Old kidneys should not be equated with "diseased" kidneys.
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U2 - 10.5935/0101-2800.20170010
DO - 10.5935/0101-2800.20170010
M3 - Review article
C2 - 28355403
AN - SCOPUS:85032800102
SN - 0101-2800
VL - 39
SP - 59
EP - 64
JO - Jornal brasileiro de nefrologia : orgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
JF - Jornal brasileiro de nefrologia : orgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
IS - 1
ER -