When Gross Total Resection of a Glioblastoma Is Possible, How Much Resection Should Be Achieved?

Kaisorn L. Chaichana, Eibar Ernesto Cabrera-Aldana, Ignacio Jusue-Torres, Olindi Wijesekera, Alessandro Olivi, Maryam Rahman, Alfredo Quinones-Hinojosa

Research output: Contribution to journalReview article

60 Citations (Scopus)

Abstract

Objective The efficacy of extensive resection on prolonging survival for patients with glioblastoma (GBM) is controversial because prior studies have included tumors with dissimilar resection capabilities. The true isolated effect of increasing resection on survival for GBM therefore remains unclear. Methods Adult patients who underwent surgery of an intracranial newly diagnosed GBM at an academic tertiary-care institution from 2007 to 2011 were reviewed. Preoperative images were reviewed by 3 neurosurgeons independently. Tumors considered amenable to gross total resection based on preoperative imaging by all neurosurgeons were included. Multivariate proportional hazards regression analysis was used to identify if an association existed between residual volume (RV) and extent of resection (EOR) with survival. Results Of the 292 patients with newly diagnosed GBM, 84 (29%) were amenable to gross total resection. The median (interquartile range) pre and postoperative tumor volumes were 27 (13.8-54.4) and 0.9 (0-2.7) cm3, respectively. The mean percent resection was 91.7% ± 1.3%. In multivariate analysis, after controlling for age, functional status, and adjuvant therapies, RV (hazards ratio [HR] [95% confidence interval (CI)] = 1.114 [1.033-1.193], P = 0.006) and EOR (HR [95% CI] = 0.959 [0.934-0.985], P = 0.003) were each independently associated with survival. The RV and EOR with the greatest reduction in the risk of death was <2 cm3 and >95%, respectively. Likewise, RV (HR [95% CI] = 1.085 [1.010-1.178], P = 0.01) and EOR (HR [95% CI] = 0.962 [0.930-0.998], P = 0.04) each remained independently associated with recurrence. Conclusion This is the first study to evaluate RV and EOR in a more uniform population of patients with tumors of similar surgical capabilities. This study shows that achieving a decreased RV and/or an increased EOR is independently associated with survival and recurrence in those patients with tumors with similar resection capacities.

Original languageEnglish (US)
Pages (from-to)e257-e265
JournalWorld Neurosurgery
Volume82
Issue number1-2
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Residual Volume
Glioblastoma
Survival
Confidence Intervals
Neoplasms
Recurrence
Tertiary Healthcare
Risk Reduction Behavior
Tumor Burden
Multivariate Analysis
Regression Analysis
Population

Keywords

  • Extent of resection
  • GBM
  • Glioblastoma
  • Residual
  • Surgery
  • Survival
  • Volumetric

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Chaichana, K. L., Cabrera-Aldana, E. E., Jusue-Torres, I., Wijesekera, O., Olivi, A., Rahman, M., & Quinones-Hinojosa, A. (2014). When Gross Total Resection of a Glioblastoma Is Possible, How Much Resection Should Be Achieved? World Neurosurgery, 82(1-2), e257-e265. https://doi.org/10.1016/j.wneu.2014.01.019

When Gross Total Resection of a Glioblastoma Is Possible, How Much Resection Should Be Achieved? / Chaichana, Kaisorn L.; Cabrera-Aldana, Eibar Ernesto; Jusue-Torres, Ignacio; Wijesekera, Olindi; Olivi, Alessandro; Rahman, Maryam; Quinones-Hinojosa, Alfredo.

In: World Neurosurgery, Vol. 82, No. 1-2, 2014, p. e257-e265.

Research output: Contribution to journalReview article

Chaichana, KL, Cabrera-Aldana, EE, Jusue-Torres, I, Wijesekera, O, Olivi, A, Rahman, M & Quinones-Hinojosa, A 2014, 'When Gross Total Resection of a Glioblastoma Is Possible, How Much Resection Should Be Achieved?', World Neurosurgery, vol. 82, no. 1-2, pp. e257-e265. https://doi.org/10.1016/j.wneu.2014.01.019
Chaichana KL, Cabrera-Aldana EE, Jusue-Torres I, Wijesekera O, Olivi A, Rahman M et al. When Gross Total Resection of a Glioblastoma Is Possible, How Much Resection Should Be Achieved? World Neurosurgery. 2014;82(1-2):e257-e265. https://doi.org/10.1016/j.wneu.2014.01.019
Chaichana, Kaisorn L. ; Cabrera-Aldana, Eibar Ernesto ; Jusue-Torres, Ignacio ; Wijesekera, Olindi ; Olivi, Alessandro ; Rahman, Maryam ; Quinones-Hinojosa, Alfredo. / When Gross Total Resection of a Glioblastoma Is Possible, How Much Resection Should Be Achieved?. In: World Neurosurgery. 2014 ; Vol. 82, No. 1-2. pp. e257-e265.
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title = "When Gross Total Resection of a Glioblastoma Is Possible, How Much Resection Should Be Achieved?",
abstract = "Objective The efficacy of extensive resection on prolonging survival for patients with glioblastoma (GBM) is controversial because prior studies have included tumors with dissimilar resection capabilities. The true isolated effect of increasing resection on survival for GBM therefore remains unclear. Methods Adult patients who underwent surgery of an intracranial newly diagnosed GBM at an academic tertiary-care institution from 2007 to 2011 were reviewed. Preoperative images were reviewed by 3 neurosurgeons independently. Tumors considered amenable to gross total resection based on preoperative imaging by all neurosurgeons were included. Multivariate proportional hazards regression analysis was used to identify if an association existed between residual volume (RV) and extent of resection (EOR) with survival. Results Of the 292 patients with newly diagnosed GBM, 84 (29{\%}) were amenable to gross total resection. The median (interquartile range) pre and postoperative tumor volumes were 27 (13.8-54.4) and 0.9 (0-2.7) cm3, respectively. The mean percent resection was 91.7{\%} ± 1.3{\%}. In multivariate analysis, after controlling for age, functional status, and adjuvant therapies, RV (hazards ratio [HR] [95{\%} confidence interval (CI)] = 1.114 [1.033-1.193], P = 0.006) and EOR (HR [95{\%} CI] = 0.959 [0.934-0.985], P = 0.003) were each independently associated with survival. The RV and EOR with the greatest reduction in the risk of death was <2 cm3 and >95{\%}, respectively. Likewise, RV (HR [95{\%} CI] = 1.085 [1.010-1.178], P = 0.01) and EOR (HR [95{\%} CI] = 0.962 [0.930-0.998], P = 0.04) each remained independently associated with recurrence. Conclusion This is the first study to evaluate RV and EOR in a more uniform population of patients with tumors of similar surgical capabilities. This study shows that achieving a decreased RV and/or an increased EOR is independently associated with survival and recurrence in those patients with tumors with similar resection capacities.",
keywords = "Extent of resection, GBM, Glioblastoma, Residual, Surgery, Survival, Volumetric",
author = "Chaichana, {Kaisorn L.} and Cabrera-Aldana, {Eibar Ernesto} and Ignacio Jusue-Torres and Olindi Wijesekera and Alessandro Olivi and Maryam Rahman and Alfredo Quinones-Hinojosa",
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T1 - When Gross Total Resection of a Glioblastoma Is Possible, How Much Resection Should Be Achieved?

AU - Chaichana, Kaisorn L.

AU - Cabrera-Aldana, Eibar Ernesto

AU - Jusue-Torres, Ignacio

AU - Wijesekera, Olindi

AU - Olivi, Alessandro

AU - Rahman, Maryam

AU - Quinones-Hinojosa, Alfredo

PY - 2014

Y1 - 2014

N2 - Objective The efficacy of extensive resection on prolonging survival for patients with glioblastoma (GBM) is controversial because prior studies have included tumors with dissimilar resection capabilities. The true isolated effect of increasing resection on survival for GBM therefore remains unclear. Methods Adult patients who underwent surgery of an intracranial newly diagnosed GBM at an academic tertiary-care institution from 2007 to 2011 were reviewed. Preoperative images were reviewed by 3 neurosurgeons independently. Tumors considered amenable to gross total resection based on preoperative imaging by all neurosurgeons were included. Multivariate proportional hazards regression analysis was used to identify if an association existed between residual volume (RV) and extent of resection (EOR) with survival. Results Of the 292 patients with newly diagnosed GBM, 84 (29%) were amenable to gross total resection. The median (interquartile range) pre and postoperative tumor volumes were 27 (13.8-54.4) and 0.9 (0-2.7) cm3, respectively. The mean percent resection was 91.7% ± 1.3%. In multivariate analysis, after controlling for age, functional status, and adjuvant therapies, RV (hazards ratio [HR] [95% confidence interval (CI)] = 1.114 [1.033-1.193], P = 0.006) and EOR (HR [95% CI] = 0.959 [0.934-0.985], P = 0.003) were each independently associated with survival. The RV and EOR with the greatest reduction in the risk of death was <2 cm3 and >95%, respectively. Likewise, RV (HR [95% CI] = 1.085 [1.010-1.178], P = 0.01) and EOR (HR [95% CI] = 0.962 [0.930-0.998], P = 0.04) each remained independently associated with recurrence. Conclusion This is the first study to evaluate RV and EOR in a more uniform population of patients with tumors of similar surgical capabilities. This study shows that achieving a decreased RV and/or an increased EOR is independently associated with survival and recurrence in those patients with tumors with similar resection capacities.

AB - Objective The efficacy of extensive resection on prolonging survival for patients with glioblastoma (GBM) is controversial because prior studies have included tumors with dissimilar resection capabilities. The true isolated effect of increasing resection on survival for GBM therefore remains unclear. Methods Adult patients who underwent surgery of an intracranial newly diagnosed GBM at an academic tertiary-care institution from 2007 to 2011 were reviewed. Preoperative images were reviewed by 3 neurosurgeons independently. Tumors considered amenable to gross total resection based on preoperative imaging by all neurosurgeons were included. Multivariate proportional hazards regression analysis was used to identify if an association existed between residual volume (RV) and extent of resection (EOR) with survival. Results Of the 292 patients with newly diagnosed GBM, 84 (29%) were amenable to gross total resection. The median (interquartile range) pre and postoperative tumor volumes were 27 (13.8-54.4) and 0.9 (0-2.7) cm3, respectively. The mean percent resection was 91.7% ± 1.3%. In multivariate analysis, after controlling for age, functional status, and adjuvant therapies, RV (hazards ratio [HR] [95% confidence interval (CI)] = 1.114 [1.033-1.193], P = 0.006) and EOR (HR [95% CI] = 0.959 [0.934-0.985], P = 0.003) were each independently associated with survival. The RV and EOR with the greatest reduction in the risk of death was <2 cm3 and >95%, respectively. Likewise, RV (HR [95% CI] = 1.085 [1.010-1.178], P = 0.01) and EOR (HR [95% CI] = 0.962 [0.930-0.998], P = 0.04) each remained independently associated with recurrence. Conclusion This is the first study to evaluate RV and EOR in a more uniform population of patients with tumors of similar surgical capabilities. This study shows that achieving a decreased RV and/or an increased EOR is independently associated with survival and recurrence in those patients with tumors with similar resection capacities.

KW - Extent of resection

KW - GBM

KW - Glioblastoma

KW - Residual

KW - Surgery

KW - Survival

KW - Volumetric

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